LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I6E8_LEIIN
TriTrypDb:
LINF_310010200 *
Length:
384

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 10
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Phosphorylation

Amastigote: 183

Expansion

Sequence features

A4I6E8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6E8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 181 183 PF00675 0.498
CLV_NRD_NRD_1 28 30 PF00675 0.508
CLV_PCSK_KEX2_1 125 127 PF00082 0.523
CLV_PCSK_KEX2_1 181 183 PF00082 0.498
CLV_PCSK_KEX2_1 192 194 PF00082 0.528
CLV_PCSK_KEX2_1 373 375 PF00082 0.434
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.493
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.473
CLV_PCSK_PC1ET2_1 373 375 PF00082 0.452
CLV_PCSK_SKI1_1 220 224 PF00082 0.453
CLV_PCSK_SKI1_1 380 384 PF00082 0.477
CLV_PCSK_SKI1_1 97 101 PF00082 0.479
DEG_COP1_1 271 280 PF00400 0.228
DEG_Nend_Nbox_1 1 3 PF02207 0.504
DOC_CYCLIN_RxL_1 8 16 PF00134 0.409
DOC_MAPK_MEF2A_6 275 282 PF00069 0.253
DOC_MAPK_MEF2A_6 3 12 PF00069 0.384
DOC_USP7_MATH_1 154 158 PF00917 0.268
DOC_USP7_MATH_1 160 164 PF00917 0.270
DOC_USP7_MATH_1 268 272 PF00917 0.258
DOC_USP7_MATH_1 276 280 PF00917 0.275
DOC_USP7_UBL2_3 108 112 PF12436 0.275
DOC_USP7_UBL2_3 125 129 PF12436 0.228
DOC_WW_Pin1_4 199 204 PF00397 0.305
DOC_WW_Pin1_4 22 27 PF00397 0.350
DOC_WW_Pin1_4 31 36 PF00397 0.265
LIG_14-3-3_CanoR_1 161 165 PF00244 0.228
LIG_14-3-3_CanoR_1 181 185 PF00244 0.266
LIG_14-3-3_CanoR_1 3 10 PF00244 0.428
LIG_14-3-3_CanoR_1 301 306 PF00244 0.321
LIG_14-3-3_CanoR_1 39 43 PF00244 0.306
LIG_Actin_WH2_2 24 41 PF00022 0.269
LIG_APCC_ABBA_1 241 246 PF00400 0.326
LIG_BIR_III_4 148 152 PF00653 0.248
LIG_BRCT_BRCA1_1 278 282 PF00533 0.273
LIG_CaM_IQ_9 117 133 PF13499 0.311
LIG_deltaCOP1_diTrp_1 264 272 PF00928 0.279
LIG_eIF4E_1 95 101 PF01652 0.269
LIG_FHA_1 23 29 PF00498 0.305
LIG_FHA_1 3 9 PF00498 0.456
LIG_FHA_1 47 53 PF00498 0.299
LIG_FHA_1 60 66 PF00498 0.347
LIG_FHA_1 94 100 PF00498 0.290
LIG_FHA_2 102 108 PF00498 0.273
LIG_FHA_2 113 119 PF00498 0.221
LIG_FHA_2 360 366 PF00498 0.580
LIG_IRF3_LxIS_1 117 123 PF10401 0.273
LIG_KLC1_Yacidic_2 114 118 PF13176 0.208
LIG_LIR_Gen_1 133 144 PF02991 0.296
LIG_LIR_Gen_1 53 58 PF02991 0.296
LIG_LIR_Gen_1 72 80 PF02991 0.289
LIG_LIR_Gen_1 94 101 PF02991 0.280
LIG_LIR_Nem_3 111 116 PF02991 0.229
LIG_LIR_Nem_3 264 269 PF02991 0.295
LIG_LIR_Nem_3 279 285 PF02991 0.279
LIG_LIR_Nem_3 334 339 PF02991 0.565
LIG_LIR_Nem_3 53 57 PF02991 0.296
LIG_LIR_Nem_3 72 76 PF02991 0.289
LIG_LIR_Nem_3 94 98 PF02991 0.278
LIG_MAD2 11 19 PF02301 0.321
LIG_Pex14_1 109 113 PF04695 0.311
LIG_Pex14_2 367 371 PF04695 0.596
LIG_SH2_CRK 73 77 PF00017 0.259
LIG_SH2_CRK 85 89 PF00017 0.229
LIG_SH2_CRK 95 99 PF00017 0.269
LIG_SH2_SRC 244 247 PF00017 0.311
LIG_SH2_SRC 285 288 PF00017 0.311
LIG_SH2_STAP1 113 117 PF00017 0.178
LIG_SH2_STAP1 244 248 PF00017 0.269
LIG_SH2_STAP1 73 77 PF00017 0.259
LIG_SH2_STAP1 85 89 PF00017 0.229
LIG_SH2_STAP1 95 99 PF00017 0.269
LIG_SH2_STAT5 116 119 PF00017 0.248
LIG_SH2_STAT5 307 310 PF00017 0.308
LIG_SH2_STAT5 33 36 PF00017 0.278
LIG_SH2_STAT5 336 339 PF00017 0.572
LIG_SH2_STAT5 95 98 PF00017 0.286
LIG_SH3_1 275 281 PF00018 0.269
LIG_SH3_3 247 253 PF00018 0.310
LIG_SH3_3 275 281 PF00018 0.278
LIG_SH3_3 73 79 PF00018 0.268
LIG_SUMO_SIM_anti_2 96 105 PF11976 0.297
LIG_SUMO_SIM_par_1 96 105 PF11976 0.279
LIG_WRC_WIRS_1 269 274 PF05994 0.236
LIG_WRC_WIRS_1 364 369 PF05994 0.514
MOD_CDK_SPxxK_3 22 29 PF00069 0.388
MOD_CK1_1 162 168 PF00069 0.347
MOD_CK1_1 202 208 PF00069 0.332
MOD_CK1_1 210 216 PF00069 0.346
MOD_CK1_1 226 232 PF00069 0.183
MOD_CK1_1 334 340 PF00069 0.562
MOD_CK2_1 112 118 PF00069 0.208
MOD_CK2_1 226 232 PF00069 0.326
MOD_CK2_1 357 363 PF00069 0.616
MOD_CK2_1 378 384 PF00069 0.675
MOD_GlcNHglycan 148 152 PF01048 0.493
MOD_GlcNHglycan 156 159 PF01048 0.470
MOD_GlcNHglycan 176 179 PF01048 0.448
MOD_GlcNHglycan 204 207 PF01048 0.482
MOD_GlcNHglycan 254 257 PF01048 0.595
MOD_GlcNHglycan 346 349 PF01048 0.505
MOD_GSK3_1 121 128 PF00069 0.352
MOD_GSK3_1 159 166 PF00069 0.368
MOD_GSK3_1 168 175 PF00069 0.233
MOD_GSK3_1 195 202 PF00069 0.327
MOD_GSK3_1 244 251 PF00069 0.336
MOD_GSK3_1 34 41 PF00069 0.343
MOD_GSK3_1 359 366 PF00069 0.739
MOD_GSK3_1 374 381 PF00069 0.585
MOD_LATS_1 221 227 PF00433 0.208
MOD_N-GLC_1 226 231 PF02516 0.408
MOD_NEK2_1 120 125 PF00069 0.273
MOD_NEK2_1 13 18 PF00069 0.413
MOD_NEK2_1 173 178 PF00069 0.372
MOD_NEK2_1 180 185 PF00069 0.347
MOD_NEK2_1 195 200 PF00069 0.311
MOD_NEK2_1 2 7 PF00069 0.515
MOD_NEK2_1 331 336 PF00069 0.588
MOD_NEK2_1 38 43 PF00069 0.304
MOD_NEK2_2 244 249 PF00069 0.273
MOD_PIKK_1 130 136 PF00454 0.268
MOD_PIKK_1 52 58 PF00454 0.293
MOD_PK_1 374 380 PF00069 0.619
MOD_PKA_1 125 131 PF00069 0.323
MOD_PKA_1 223 229 PF00069 0.208
MOD_PKA_2 125 131 PF00069 0.323
MOD_PKA_2 160 166 PF00069 0.300
MOD_PKA_2 180 186 PF00069 0.286
MOD_PKA_2 2 8 PF00069 0.526
MOD_PKA_2 213 219 PF00069 0.389
MOD_PKA_2 248 254 PF00069 0.390
MOD_PKA_2 351 357 PF00069 0.676
MOD_PKA_2 38 44 PF00069 0.311
MOD_Plk_1 244 250 PF00069 0.385
MOD_Plk_1 52 58 PF00069 0.377
MOD_Plk_2-3 363 369 PF00069 0.515
MOD_Plk_4 112 118 PF00069 0.217
MOD_Plk_4 13 19 PF00069 0.354
MOD_Plk_4 268 274 PF00069 0.236
MOD_Plk_4 317 323 PF00069 0.397
MOD_Plk_4 331 337 PF00069 0.524
MOD_ProDKin_1 199 205 PF00069 0.305
MOD_ProDKin_1 22 28 PF00069 0.350
MOD_ProDKin_1 31 37 PF00069 0.265
MOD_SUMO_for_1 222 225 PF00179 0.228
MOD_SUMO_rev_2 53 62 PF00179 0.271
TRG_DiLeu_BaEn_1 53 58 PF01217 0.296
TRG_ENDOCYTIC_2 73 76 PF00928 0.259
TRG_ENDOCYTIC_2 85 88 PF00928 0.229
TRG_ENDOCYTIC_2 95 98 PF00928 0.269
TRG_ER_diArg_1 180 182 PF00400 0.313

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P304 Leptomonas seymouri 27% 88%
A0A0N0P958 Leptomonas seymouri 62% 97%
A0A3Q8IGS5 Leishmania donovani 28% 88%
A0A3S7X466 Leishmania donovani 99% 100%
A4HJ26 Leishmania braziliensis 80% 100%
A4HLE0 Leishmania braziliensis 27% 100%
A4I8U9 Leishmania infantum 28% 88%
C9ZUT2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E8NHM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B1J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B3R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4Q4A6 Leishmania major 26% 100%
Q4Q6L5 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS