Endoplasmic reticulum vesicle transporter-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter - putative

Species:

Leishmania infantum

UniProt:

A4I6C1_LEIIN

TriTrypDb:

LINF_310008100

Length:

341

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, Endoplasmic Reticulum-Golgi Intermediate Compartmen

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	8
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4I6C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.481
CLV_NRD_NRD_1	314	316	PF00675	0.374
CLV_NRD_NRD_1	324	326	PF00675	0.396
CLV_NRD_NRD_1	73	75	PF00675	0.466
CLV_PCSK_FUR_1	312	316	PF00082	0.381
CLV_PCSK_FUR_1	322	326	PF00082	0.399
CLV_PCSK_KEX2_1	314	316	PF00082	0.376
CLV_PCSK_KEX2_1	324	326	PF00082	0.399
CLV_PCSK_SKI1_1	65	69	PF00082	0.568
CLV_PCSK_SKI1_1	92	96	PF00082	0.464
DOC_CKS1_1	23	28	PF01111	0.488
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.259
DOC_MAPK_gen_1	74	85	PF00069	0.252
DOC_PP1_RVXF_1	76	82	PF00149	0.287
DOC_USP7_MATH_1	119	123	PF00917	0.340
DOC_USP7_MATH_1	154	158	PF00917	0.437
DOC_USP7_MATH_1	246	250	PF00917	0.279
DOC_USP7_MATH_1	29	33	PF00917	0.275
DOC_WW_Pin1_4	19	24	PF00397	0.489
DOC_WW_Pin1_4	266	271	PF00397	0.336
DOC_WW_Pin1_4	57	62	PF00397	0.297
LIG_14-3-3_CanoR_1	198	203	PF00244	0.289
LIG_14-3-3_CanoR_1	92	101	PF00244	0.289
LIG_Actin_WH2_2	303	319	PF00022	0.542
LIG_DCNL_PONY_1	1	4	PF03556	0.566
LIG_EH1_1	296	304	PF00400	0.394
LIG_FHA_1	147	153	PF00498	0.334
LIG_FHA_1	228	234	PF00498	0.357
LIG_FHA_1	33	39	PF00498	0.355
LIG_FHA_1	93	99	PF00498	0.303
LIG_FHA_2	227	233	PF00498	0.329
LIG_FHA_2	296	302	PF00498	0.315
LIG_LIR_Apic_2	114	119	PF02991	0.310
LIG_LIR_Apic_2	191	195	PF02991	0.258
LIG_LIR_Gen_1	157	166	PF02991	0.315
LIG_LIR_Gen_1	245	253	PF02991	0.303
LIG_LIR_Nem_3	157	162	PF02991	0.315
LIG_LIR_Nem_3	216	222	PF02991	0.244
LIG_LIR_Nem_3	46	51	PF02991	0.328
LIG_LIR_Nem_3	62	67	PF02991	0.206
LIG_LIR_Nem_3	9	14	PF02991	0.529
LIG_Pex14_2	219	223	PF04695	0.247
LIG_SH2_CRK	116	120	PF00017	0.339
LIG_SH2_CRK	279	283	PF00017	0.257
LIG_SH2_CRK	48	52	PF00017	0.259
LIG_SH2_NCK_1	297	301	PF00017	0.394
LIG_SH2_STAT3	218	221	PF00017	0.272
LIG_SH2_STAT3	253	256	PF00017	0.250
LIG_SH2_STAT5	123	126	PF00017	0.323
LIG_SH2_STAT5	131	134	PF00017	0.357
LIG_SH2_STAT5	218	221	PF00017	0.315
LIG_SH2_STAT5	244	247	PF00017	0.275
LIG_SH2_STAT5	263	266	PF00017	0.186
LIG_SH2_STAT5	297	300	PF00017	0.361
LIG_SH2_STAT5	50	53	PF00017	0.329
LIG_SH3_3	20	26	PF00018	0.489
LIG_SH3_3	83	89	PF00018	0.329
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.361
LIG_TRFH_1	266	270	PF08558	0.373
LIG_TYR_ITIM	277	282	PF00017	0.257
LIG_UBA3_1	1	7	PF00899	0.557
MOD_CK1_1	122	128	PF00069	0.345
MOD_CK1_1	269	275	PF00069	0.329
MOD_CK1_1	32	38	PF00069	0.436
MOD_CK2_1	135	141	PF00069	0.480
MOD_CK2_1	295	301	PF00069	0.329
MOD_GlcNHglycan	127	130	PF01048	0.581
MOD_GlcNHglycan	132	135	PF01048	0.585
MOD_GlcNHglycan	137	140	PF01048	0.604
MOD_GlcNHglycan	183	186	PF01048	0.487
MOD_GlcNHglycan	205	208	PF01048	0.486
MOD_GlcNHglycan	209	212	PF01048	0.493
MOD_GlcNHglycan	318	322	PF01048	0.381
MOD_GlcNHglycan	51	54	PF01048	0.489
MOD_GlcNHglycan	61	64	PF01048	0.489
MOD_GSK3_1	203	210	PF00069	0.273
MOD_GSK3_1	242	249	PF00069	0.274
MOD_GSK3_1	262	269	PF00069	0.293
MOD_GSK3_1	92	99	PF00069	0.306
MOD_N-GLC_1	125	130	PF02516	0.564
MOD_N-GLC_2	288	290	PF02516	0.336
MOD_NEK2_1	262	267	PF00069	0.341
MOD_NEK2_1	79	84	PF00069	0.384
MOD_PKA_2	108	114	PF00069	0.429
MOD_PKB_1	315	323	PF00069	0.567
MOD_Plk_4	119	125	PF00069	0.290
MOD_Plk_4	246	252	PF00069	0.289
MOD_Plk_4	34	40	PF00069	0.384
MOD_Plk_4	96	102	PF00069	0.359
MOD_ProDKin_1	19	25	PF00069	0.489
MOD_ProDKin_1	266	272	PF00069	0.336
MOD_ProDKin_1	57	63	PF00069	0.297
TRG_DiLeu_BaEn_1	141	146	PF01217	0.306
TRG_ENDOCYTIC_2	244	247	PF00928	0.299
TRG_ENDOCYTIC_2	279	282	PF00928	0.289
TRG_ENDOCYTIC_2	48	51	PF00928	0.287
TRG_ER_diArg_1	314	317	PF00400	0.576
TRG_ER_diArg_1	322	325	PF00400	0.598
TRG_NLS_MonoExtC_3	171	176	PF00514	0.287
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T7	Leptomonas seymouri	61%	100%
A0A0N1I377	Leptomonas seymouri	24%	100%
A0A0S4J3I3	Bodo saltans	24%	100%
A0A3Q8IGC2	Leishmania donovani	26%	100%
A0A3S7X427	Leishmania donovani	100%	100%
A4HJ02	Leishmania braziliensis	79%	100%
A4HL28	Leishmania braziliensis	27%	98%
A4I8K9	Leishmania infantum	26%	100%
E9B1H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B3G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q4N1	Leishmania major	26%	100%
Q4Q6N5	Leishmania major	93%	100%
Q4V8Y6	Danio rerio	24%	100%
Q6NS19	Xenopus laevis	25%	100%
Q969X5	Homo sapiens	24%	100%
Q9DC16	Mus musculus	24%	100%