LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4I6B9_LEIIN
TriTrypDb:
Length:
167

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6B9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6B9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.687
CLV_NRD_NRD_1 45 47 PF00675 0.588
CLV_NRD_NRD_1 51 53 PF00675 0.549
CLV_NRD_NRD_1 81 83 PF00675 0.654
CLV_PCSK_KEX2_1 38 40 PF00082 0.581
CLV_PCSK_KEX2_1 51 53 PF00082 0.488
CLV_PCSK_KEX2_1 81 83 PF00082 0.654
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.581
CLV_PCSK_SKI1_1 114 118 PF00082 0.476
CLV_PCSK_SKI1_1 33 37 PF00082 0.548
CLV_PCSK_SKI1_1 97 101 PF00082 0.603
CLV_Separin_Metazoa 147 151 PF03568 0.634
DEG_Nend_UBRbox_1 1 4 PF02207 0.658
DOC_CDC14_PxL_1 54 62 PF14671 0.579
DOC_CKS1_1 74 79 PF01111 0.602
DOC_CYCLIN_RxL_1 111 120 PF00134 0.622
DOC_MAPK_gen_1 152 161 PF00069 0.597
DOC_PP1_RVXF_1 67 73 PF00149 0.626
DOC_WW_Pin1_4 107 112 PF00397 0.604
DOC_WW_Pin1_4 73 78 PF00397 0.607
LIG_14-3-3_CanoR_1 154 162 PF00244 0.593
LIG_APCC_ABBAyCdc20_2 101 107 PF00400 0.609
LIG_FHA_2 23 29 PF00498 0.551
LIG_HCF-1_HBM_1 29 32 PF13415 0.554
LIG_NRBOX 14 20 PF00104 0.561
LIG_PDZ_Class_2 162 167 PF00595 0.590
LIG_SH3_3 143 149 PF00018 0.651
LIG_SH3_3 71 77 PF00018 0.618
LIG_SUMO_SIM_par_1 18 26 PF11976 0.554
LIG_UBA3_1 34 38 PF00899 0.555
MOD_CDK_SPxxK_3 107 114 PF00069 0.602
MOD_CK1_1 42 48 PF00069 0.576
MOD_CK2_1 23 29 PF00069 0.551
MOD_GlcNHglycan 156 159 PF01048 0.589
MOD_GlcNHglycan 24 28 PF01048 0.546
MOD_GlcNHglycan 41 44 PF01048 0.510
MOD_NEK2_1 22 27 PF00069 0.542
MOD_OFUCOSY 62 67 PF10250 0.589
MOD_PKB_1 150 158 PF00069 0.602
MOD_Plk_1 152 158 PF00069 0.597
MOD_Plk_1 28 34 PF00069 0.554
MOD_ProDKin_1 107 113 PF00069 0.603
MOD_ProDKin_1 73 79 PF00069 0.604
TRG_ENDOCYTIC_2 32 35 PF00928 0.558
TRG_ER_diArg_1 100 103 PF00400 0.612
TRG_ER_diArg_1 149 152 PF00400 0.618
TRG_ER_diArg_1 50 52 PF00400 0.607

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X452 Leishmania donovani 99% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS