LeishMANIAdb
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TPR_MLP1_2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_MLP1_2 domain-containing protein
Gene product:
TPR/MLP1/MLP2-like protein - putative
Species:
Leishmania infantum
UniProt:
A4I6B5_LEIIN
TriTrypDb:
LINF_310007500
Length:
859

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4I6B5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6B5

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 11
GO:0007017 microtubule-based process 2 11
GO:0007018 microtubule-based movement 3 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0022607 cellular component assembly 4 11
GO:0036159 inner dynein arm assembly 7 11
GO:0043933 protein-containing complex organization 4 11
GO:0065003 protein-containing complex assembly 5 11
GO:0070286 axonemal dynein complex assembly 6 11
GO:0071840 cellular component organization or biogenesis 2 11
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 307 311 PF00656 0.600
CLV_C14_Caspase3-7 4 8 PF00656 0.523
CLV_C14_Caspase3-7 804 808 PF00656 0.411
CLV_C14_Caspase3-7 821 825 PF00656 0.360
CLV_NRD_NRD_1 148 150 PF00675 0.429
CLV_NRD_NRD_1 184 186 PF00675 0.434
CLV_NRD_NRD_1 211 213 PF00675 0.428
CLV_NRD_NRD_1 339 341 PF00675 0.562
CLV_NRD_NRD_1 350 352 PF00675 0.598
CLV_NRD_NRD_1 474 476 PF00675 0.485
CLV_NRD_NRD_1 48 50 PF00675 0.414
CLV_NRD_NRD_1 567 569 PF00675 0.406
CLV_NRD_NRD_1 618 620 PF00675 0.391
CLV_NRD_NRD_1 682 684 PF00675 0.539
CLV_NRD_NRD_1 738 740 PF00675 0.441
CLV_PCSK_FUR_1 321 325 PF00082 0.542
CLV_PCSK_FUR_1 680 684 PF00082 0.536
CLV_PCSK_KEX2_1 148 150 PF00082 0.540
CLV_PCSK_KEX2_1 184 186 PF00082 0.418
CLV_PCSK_KEX2_1 255 257 PF00082 0.388
CLV_PCSK_KEX2_1 323 325 PF00082 0.543
CLV_PCSK_KEX2_1 339 341 PF00082 0.422
CLV_PCSK_KEX2_1 349 351 PF00082 0.468
CLV_PCSK_KEX2_1 461 463 PF00082 0.498
CLV_PCSK_KEX2_1 47 49 PF00082 0.417
CLV_PCSK_KEX2_1 504 506 PF00082 0.398
CLV_PCSK_KEX2_1 525 527 PF00082 0.504
CLV_PCSK_KEX2_1 567 569 PF00082 0.326
CLV_PCSK_KEX2_1 587 589 PF00082 0.524
CLV_PCSK_KEX2_1 620 622 PF00082 0.392
CLV_PCSK_KEX2_1 682 684 PF00082 0.508
CLV_PCSK_KEX2_1 738 740 PF00082 0.488
CLV_PCSK_KEX2_1 75 77 PF00082 0.409
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.413
CLV_PCSK_PC1ET2_1 323 325 PF00082 0.543
CLV_PCSK_PC1ET2_1 349 351 PF00082 0.539
CLV_PCSK_PC1ET2_1 461 463 PF00082 0.498
CLV_PCSK_PC1ET2_1 504 506 PF00082 0.398
CLV_PCSK_PC1ET2_1 525 527 PF00082 0.504
CLV_PCSK_PC1ET2_1 587 589 PF00082 0.492
CLV_PCSK_PC1ET2_1 620 622 PF00082 0.521
CLV_PCSK_PC1ET2_1 75 77 PF00082 0.409
CLV_PCSK_SKI1_1 170 174 PF00082 0.452
CLV_PCSK_SKI1_1 23 27 PF00082 0.420
CLV_PCSK_SKI1_1 342 346 PF00082 0.649
CLV_PCSK_SKI1_1 350 354 PF00082 0.437
CLV_PCSK_SKI1_1 570 574 PF00082 0.566
CLV_PCSK_SKI1_1 606 610 PF00082 0.560
CLV_PCSK_SKI1_1 621 625 PF00082 0.414
CLV_PCSK_SKI1_1 631 635 PF00082 0.452
CLV_PCSK_SKI1_1 686 690 PF00082 0.526
CLV_PCSK_SKI1_1 723 727 PF00082 0.498
CLV_PCSK_SKI1_1 730 734 PF00082 0.399
CLV_PCSK_SKI1_1 738 742 PF00082 0.413
CLV_PCSK_SKI1_1 846 850 PF00082 0.421
DEG_APCC_DBOX_1 109 117 PF00400 0.531
DEG_APCC_DBOX_1 46 54 PF00400 0.410
DEG_APCC_KENBOX_2 802 806 PF00400 0.444
DEG_Nend_UBRbox_3 1 3 PF02207 0.578
DEG_SPOP_SBC_1 413 417 PF00917 0.409
DOC_CYCLIN_RxL_1 45 55 PF00134 0.407
DOC_MAPK_gen_1 148 158 PF00069 0.479
DOC_MAPK_gen_1 321 330 PF00069 0.449
DOC_MAPK_gen_1 546 557 PF00069 0.433
DOC_MAPK_gen_1 574 583 PF00069 0.482
DOC_MAPK_gen_1 637 644 PF00069 0.455
DOC_MAPK_gen_1 682 691 PF00069 0.473
DOC_MAPK_MEF2A_6 550 559 PF00069 0.506
DOC_MAPK_MEF2A_6 653 661 PF00069 0.539
DOC_MAPK_RevD_3 555 568 PF00069 0.411
DOC_PP1_RVXF_1 46 53 PF00149 0.410
DOC_PP1_RVXF_1 756 763 PF00149 0.539
DOC_USP7_UBL2_3 286 290 PF12436 0.552
DOC_USP7_UBL2_3 546 550 PF12436 0.521
DOC_USP7_UBL2_3 609 613 PF12436 0.405
DOC_USP7_UBL2_3 686 690 PF12436 0.414
DOC_USP7_UBL2_3 711 715 PF12436 0.664
LIG_14-3-3_CanoR_1 112 117 PF00244 0.519
LIG_14-3-3_CanoR_1 206 214 PF00244 0.468
LIG_14-3-3_CanoR_1 350 355 PF00244 0.598
LIG_14-3-3_CanoR_1 411 421 PF00244 0.503
LIG_14-3-3_CanoR_1 511 516 PF00244 0.434
LIG_14-3-3_CanoR_1 653 661 PF00244 0.600
LIG_14-3-3_CanoR_1 758 763 PF00244 0.444
LIG_14-3-3_CanoR_1 766 775 PF00244 0.392
LIG_Actin_WH2_2 118 133 PF00022 0.423
LIG_Actin_WH2_2 246 262 PF00022 0.450
LIG_Actin_WH2_2 524 539 PF00022 0.347
LIG_Actin_WH2_2 555 572 PF00022 0.366
LIG_Clathr_ClatBox_1 556 560 PF01394 0.358
LIG_Clathr_ClatBox_1 580 584 PF01394 0.513
LIG_Clathr_ClatBox_1 607 611 PF01394 0.463
LIG_FHA_1 171 177 PF00498 0.489
LIG_FHA_1 195 201 PF00498 0.495
LIG_FHA_1 24 30 PF00498 0.416
LIG_FHA_1 272 278 PF00498 0.473
LIG_FHA_1 297 303 PF00498 0.506
LIG_FHA_1 413 419 PF00498 0.534
LIG_FHA_1 512 518 PF00498 0.423
LIG_FHA_1 559 565 PF00498 0.374
LIG_FHA_1 622 628 PF00498 0.507
LIG_FHA_1 65 71 PF00498 0.386
LIG_FHA_1 692 698 PF00498 0.440
LIG_FHA_1 780 786 PF00498 0.491
LIG_FHA_2 130 136 PF00498 0.518
LIG_FHA_2 19 25 PF00498 0.461
LIG_FHA_2 229 235 PF00498 0.470
LIG_FHA_2 278 284 PF00498 0.495
LIG_FHA_2 28 34 PF00498 0.441
LIG_FHA_2 331 337 PF00498 0.475
LIG_FHA_2 343 349 PF00498 0.634
LIG_FHA_2 351 357 PF00498 0.359
LIG_FHA_2 415 421 PF00498 0.480
LIG_FHA_2 469 475 PF00498 0.458
LIG_FHA_2 486 492 PF00498 0.325
LIG_FHA_2 537 543 PF00498 0.568
LIG_FHA_2 580 586 PF00498 0.516
LIG_FHA_2 785 791 PF00498 0.484
LIG_FHA_2 98 104 PF00498 0.531
LIG_Integrin_RGD_1 673 675 PF01839 0.484
LIG_LIR_Gen_1 223 233 PF02991 0.398
LIG_LIR_Nem_3 209 214 PF02991 0.403
LIG_LIR_Nem_3 223 228 PF02991 0.361
LIG_LIR_Nem_3 726 732 PF02991 0.570
LIG_PDZ_Class_3 854 859 PF00595 0.494
LIG_PTB_Apo_2 448 455 PF02174 0.420
LIG_SH2_CRK 211 215 PF00017 0.410
LIG_SH2_NCK_1 778 782 PF00017 0.455
LIG_SH2_SRC 246 249 PF00017 0.417
LIG_SH2_STAP1 795 799 PF00017 0.448
LIG_SH2_STAT3 279 282 PF00017 0.472
LIG_SH2_STAT5 161 164 PF00017 0.370
LIG_SH2_STAT5 279 282 PF00017 0.532
LIG_SUMO_SIM_anti_2 694 699 PF11976 0.476
LIG_SUMO_SIM_anti_2 813 818 PF11976 0.470
LIG_SUMO_SIM_anti_2 839 846 PF11976 0.443
LIG_SUMO_SIM_par_1 579 585 PF11976 0.514
LIG_SUMO_SIM_par_1 784 792 PF11976 0.514
LIG_SUMO_SIM_par_1 829 834 PF11976 0.443
LIG_TRAF2_1 266 269 PF00917 0.483
LIG_TRAF2_1 270 273 PF00917 0.466
LIG_TRAF2_1 280 283 PF00917 0.462
LIG_TRAF2_1 403 406 PF00917 0.382
LIG_TRAF2_1 471 474 PF00917 0.477
LIG_TRAF2_1 527 530 PF00917 0.465
LIG_TRAF2_1 582 585 PF00917 0.441
LIG_TRAF2_1 615 618 PF00917 0.413
LIG_UBA3_1 516 525 PF00899 0.436
LIG_UBA3_1 580 587 PF00899 0.516
LIG_UBA3_1 607 613 PF00899 0.402
LIG_UBA3_1 688 693 PF00899 0.535
MOD_CK1_1 317 323 PF00069 0.604
MOD_CK1_1 676 682 PF00069 0.345
MOD_CK1_1 734 740 PF00069 0.535
MOD_CK1_1 80 86 PF00069 0.584
MOD_CK2_1 18 24 PF00069 0.462
MOD_CK2_1 228 234 PF00069 0.452
MOD_CK2_1 259 265 PF00069 0.505
MOD_CK2_1 27 33 PF00069 0.411
MOD_CK2_1 277 283 PF00069 0.353
MOD_CK2_1 330 336 PF00069 0.594
MOD_CK2_1 342 348 PF00069 0.599
MOD_CK2_1 350 356 PF00069 0.360
MOD_CK2_1 414 420 PF00069 0.500
MOD_CK2_1 468 474 PF00069 0.447
MOD_CK2_1 485 491 PF00069 0.392
MOD_CK2_1 524 530 PF00069 0.444
MOD_CK2_1 536 542 PF00069 0.534
MOD_CK2_1 579 585 PF00069 0.428
MOD_CK2_1 66 72 PF00069 0.415
MOD_CK2_1 784 790 PF00069 0.509
MOD_CK2_1 97 103 PF00069 0.554
MOD_GlcNHglycan 103 107 PF01048 0.364
MOD_GlcNHglycan 216 221 PF01048 0.542
MOD_GlcNHglycan 420 424 PF01048 0.417
MOD_GlcNHglycan 733 736 PF01048 0.567
MOD_GSK3_1 23 30 PF00069 0.419
MOD_GSK3_1 259 266 PF00069 0.543
MOD_GSK3_1 520 527 PF00069 0.447
MOD_GSK3_1 64 71 PF00069 0.478
MOD_GSK3_1 784 791 PF00069 0.407
MOD_N-GLC_1 18 23 PF02516 0.470
MOD_N-GLC_1 277 282 PF02516 0.533
MOD_N-GLC_1 631 636 PF02516 0.525
MOD_NEK2_1 179 184 PF00069 0.498
MOD_NEK2_1 18 23 PF00069 0.475
MOD_NEK2_1 194 199 PF00069 0.394
MOD_NEK2_1 259 264 PF00069 0.462
MOD_NEK2_1 330 335 PF00069 0.595
MOD_NEK2_1 510 515 PF00069 0.557
MOD_NEK2_1 520 525 PF00069 0.432
MOD_NEK2_1 691 696 PF00069 0.417
MOD_NEK2_1 70 75 PF00069 0.479
MOD_NEK2_1 746 751 PF00069 0.541
MOD_NEK2_1 788 793 PF00069 0.498
MOD_NEK2_1 823 828 PF00069 0.421
MOD_PIKK_1 170 176 PF00454 0.510
MOD_PIKK_1 194 200 PF00454 0.525
MOD_PIKK_1 285 291 PF00454 0.495
MOD_PIKK_1 296 302 PF00454 0.555
MOD_PIKK_1 441 447 PF00454 0.405
MOD_PIKK_1 64 70 PF00454 0.395
MOD_PIKK_1 652 658 PF00454 0.503
MOD_PIKK_1 718 724 PF00454 0.618
MOD_PIKK_1 767 773 PF00454 0.516
MOD_PIKK_1 779 785 PF00454 0.493
MOD_PIKK_1 97 103 PF00454 0.448
MOD_PK_1 112 118 PF00069 0.517
MOD_PK_1 789 795 PF00069 0.415
MOD_PKA_1 350 356 PF00069 0.494
MOD_PKA_1 524 530 PF00069 0.442
MOD_PKA_2 111 117 PF00069 0.497
MOD_PKA_2 317 323 PF00069 0.522
MOD_PKA_2 350 356 PF00069 0.608
MOD_PKA_2 510 516 PF00069 0.550
MOD_PKA_2 536 542 PF00069 0.585
MOD_PKA_2 652 658 PF00069 0.598
MOD_PKA_2 788 794 PF00069 0.379
MOD_PKA_2 97 103 PF00069 0.480
MOD_PKB_1 110 118 PF00069 0.529
MOD_PKB_1 619 627 PF00069 0.451
MOD_Plk_1 179 185 PF00069 0.495
MOD_Plk_1 271 277 PF00069 0.548
MOD_Plk_1 342 348 PF00069 0.645
MOD_Plk_1 452 458 PF00069 0.448
MOD_Plk_1 631 637 PF00069 0.528
MOD_Plk_1 691 697 PF00069 0.443
MOD_Plk_1 789 795 PF00069 0.415
MOD_Plk_1 80 86 PF00069 0.466
MOD_Plk_1 823 829 PF00069 0.448
MOD_Plk_2-3 332 338 PF00069 0.455
MOD_Plk_2-3 579 585 PF00069 0.460
MOD_Plk_2-3 710 716 PF00069 0.593
MOD_Plk_2-3 77 83 PF00069 0.532
MOD_Plk_2-3 784 790 PF00069 0.409
MOD_Plk_4 511 517 PF00069 0.376
MOD_SUMO_for_1 125 128 PF00179 0.536
MOD_SUMO_for_1 270 273 PF00179 0.395
MOD_SUMO_for_1 358 361 PF00179 0.646
MOD_SUMO_for_1 466 469 PF00179 0.471
MOD_SUMO_for_1 608 611 PF00179 0.405
MOD_SUMO_for_1 689 692 PF00179 0.418
MOD_SUMO_rev_2 128 133 PF00179 0.435
MOD_SUMO_rev_2 165 169 PF00179 0.525
MOD_SUMO_rev_2 469 478 PF00179 0.544
MOD_SUMO_rev_2 541 548 PF00179 0.464
MOD_SUMO_rev_2 616 622 PF00179 0.434
TRG_DiLeu_BaEn_1 618 623 PF01217 0.403
TRG_DiLeu_BaEn_4 473 479 PF01217 0.458
TRG_DiLeu_BaEn_4 755 761 PF01217 0.538
TRG_DiLeu_BaLyEn_6 603 608 PF01217 0.511
TRG_ENDOCYTIC_2 161 164 PF00928 0.451
TRG_ENDOCYTIC_2 211 214 PF00928 0.415
TRG_ENDOCYTIC_2 778 781 PF00928 0.522
TRG_ER_diArg_1 183 185 PF00400 0.527
TRG_ER_diArg_1 47 49 PF00400 0.419
TRG_ER_diArg_1 566 568 PF00400 0.385
TRG_ER_diArg_1 619 622 PF00400 0.386
TRG_ER_diArg_1 680 683 PF00400 0.538
TRG_NES_CRM1_1 553 565 PF08389 0.434
TRG_NES_CRM1_1 821 836 PF08389 0.445
TRG_NLS_MonoExtC_3 523 529 PF00514 0.508
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 212 216 PF00026 0.408
TRG_Pf-PMV_PEXEL_1 230 234 PF00026 0.389
TRG_Pf-PMV_PEXEL_1 261 265 PF00026 0.412
TRG_Pf-PMV_PEXEL_1 497 502 PF00026 0.432
TRG_Pf-PMV_PEXEL_1 526 530 PF00026 0.507
TRG_Pf-PMV_PEXEL_1 588 593 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 606 611 PF00026 0.358
TRG_Pf-PMV_PEXEL_1 758 763 PF00026 0.486
TRG_Pf-PMV_PEXEL_1 76 81 PF00026 0.458

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMP4 Leptomonas seymouri 77% 100%
A0A1X0NJ74 Trypanosomatidae 49% 100%
A0A3Q8IFA9 Leishmania donovani 99% 100%
A0A422MZK1 Trypanosoma rangeli 49% 100%
A4HIZ8 Leishmania braziliensis 88% 100%
A8IQE0 Chlamydomonas reinhardtii 30% 96%
C9ZN73 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D3Z8K2 Rattus norvegicus 29% 92%
E1BM70 Bos taurus 28% 91%
E2R1I5 Canis lupus familiaris 29% 91%
E9B1H3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P0CK98 Danio rerio 29% 91%
Q0V9R4 Xenopus tropicalis 31% 91%
Q4Q6P1 Leishmania major 96% 100%
Q9D5Y1 Mus musculus 30% 92%
Q9UFE4 Homo sapiens 29% 91%
V5DEU3 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS