Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6A7_LEIIN

TriTrypDb:

LINF_310006500

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.440
CLV_NRD_NRD_1	185	187	PF00675	0.547
CLV_NRD_NRD_1	258	260	PF00675	0.532
CLV_NRD_NRD_1	282	284	PF00675	0.380
CLV_NRD_NRD_1	292	294	PF00675	0.388
CLV_NRD_NRD_1	61	63	PF00675	0.426
CLV_PCSK_KEX2_1	18	20	PF00082	0.448
CLV_PCSK_KEX2_1	185	187	PF00082	0.517
CLV_PCSK_KEX2_1	257	259	PF00082	0.545
CLV_PCSK_KEX2_1	292	294	PF00082	0.440
CLV_PCSK_KEX2_1	61	63	PF00082	0.501
CLV_PCSK_PC7_1	14	20	PF00082	0.526
CLV_PCSK_PC7_1	57	63	PF00082	0.536
CLV_PCSK_SKI1_1	172	176	PF00082	0.506
CLV_PCSK_SKI1_1	18	22	PF00082	0.429
CLV_PCSK_SKI1_1	186	190	PF00082	0.421
CLV_PCSK_SKI1_1	307	311	PF00082	0.532
CLV_PCSK_SKI1_1	315	319	PF00082	0.499
DEG_APCC_DBOX_1	17	25	PF00400	0.442
DEG_APCC_DBOX_1	291	299	PF00400	0.517
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DOC_AGCK_PIF_1	248	253	PF00069	0.496
DOC_CKS1_1	67	72	PF01111	0.555
DOC_CYCLIN_RxL_1	14	25	PF00134	0.560
DOC_CYCLIN_RxL_1	310	322	PF00134	0.315
DOC_MAPK_gen_1	18	26	PF00069	0.459
DOC_MAPK_gen_1	314	320	PF00069	0.467
DOC_PP1_RVXF_1	313	320	PF00149	0.524
DOC_PP4_FxxP_1	64	67	PF00568	0.561
DOC_USP7_MATH_1	112	116	PF00917	0.385
DOC_USP7_MATH_1	302	306	PF00917	0.463
DOC_USP7_MATH_1	83	87	PF00917	0.437
DOC_USP7_UBL2_3	310	314	PF12436	0.420
DOC_WW_Pin1_4	242	247	PF00397	0.546
DOC_WW_Pin1_4	298	303	PF00397	0.483
DOC_WW_Pin1_4	66	71	PF00397	0.527
LIG_14-3-3_CanoR_1	141	146	PF00244	0.503
LIG_14-3-3_CanoR_1	202	211	PF00244	0.298
LIG_14-3-3_CanoR_1	263	273	PF00244	0.508
LIG_14-3-3_CanoR_1	283	287	PF00244	0.453
LIG_14-3-3_CanoR_1	34	44	PF00244	0.570
LIG_14-3-3_CanoR_1	61	65	PF00244	0.533
LIG_Actin_WH2_2	41	59	PF00022	0.573
LIG_Actin_WH2_2	9	24	PF00022	0.495
LIG_BRCT_BRCA1_1	244	248	PF00533	0.498
LIG_deltaCOP1_diTrp_1	269	278	PF00928	0.568
LIG_DLG_GKlike_1	141	149	PF00625	0.306
LIG_eIF4E_1	108	114	PF01652	0.499
LIG_FHA_1	212	218	PF00498	0.447
LIG_FHA_1	30	36	PF00498	0.577
LIG_FHA_1	7	13	PF00498	0.605
LIG_LIR_Apic_2	46	52	PF02991	0.517
LIG_LIR_Apic_2	63	67	PF02991	0.428
LIG_LIR_Gen_1	191	199	PF02991	0.383
LIG_LIR_Gen_1	232	240	PF02991	0.494
LIG_LIR_Gen_1	275	286	PF02991	0.431
LIG_LIR_Gen_1	38	48	PF02991	0.479
LIG_LIR_Gen_1	95	103	PF02991	0.539
LIG_LIR_Nem_3	103	108	PF02991	0.445
LIG_LIR_Nem_3	15	20	PF02991	0.427
LIG_LIR_Nem_3	191	196	PF02991	0.385
LIG_LIR_Nem_3	230	236	PF02991	0.460
LIG_LIR_Nem_3	270	276	PF02991	0.541
LIG_LIR_Nem_3	38	43	PF02991	0.424
LIG_LIR_Nem_3	95	99	PF02991	0.509
LIG_NRBOX	194	200	PF00104	0.437
LIG_NRBOX	316	322	PF00104	0.314
LIG_PCNA_yPIPBox_3	136	146	PF02747	0.485
LIG_SH2_CRK	17	21	PF00017	0.487
LIG_SH2_CRK	273	277	PF00017	0.584
LIG_SH2_NCK_1	68	72	PF00017	0.549
LIG_SH2_STAT5	145	148	PF00017	0.489
LIG_SH2_STAT5	207	210	PF00017	0.453
LIG_SH2_STAT5	68	71	PF00017	0.556
LIG_SH3_3	296	302	PF00018	0.561
LIG_SH3_3	64	70	PF00018	0.560
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.412
LIG_SUMO_SIM_par_1	22	28	PF11976	0.502
LIG_TRAF2_1	152	155	PF00917	0.548
LIG_WRC_WIRS_1	212	217	PF05994	0.404
MOD_CK1_1	130	136	PF00069	0.519
MOD_CK1_1	194	200	PF00069	0.432
MOD_CK1_1	301	307	PF00069	0.485
MOD_CK1_1	86	92	PF00069	0.485
MOD_CK2_1	149	155	PF00069	0.551
MOD_CK2_1	178	184	PF00069	0.481
MOD_CK2_1	22	28	PF00069	0.519
MOD_GlcNHglycan	114	117	PF01048	0.328
MOD_GlcNHglycan	179	183	PF01048	0.470
MOD_GlcNHglycan	303	307	PF01048	0.518
MOD_GSK3_1	141	148	PF00069	0.469
MOD_GSK3_1	298	305	PF00069	0.484
MOD_N-GLC_1	242	247	PF02516	0.540
MOD_N-GLC_2	201	203	PF02516	0.452
MOD_NEK2_1	12	17	PF00069	0.463
MOD_NEK2_2	229	234	PF00069	0.512
MOD_NEK2_2	83	88	PF00069	0.469
MOD_PIKK_1	29	35	PF00454	0.600
MOD_PK_1	22	28	PF00069	0.459
MOD_PKA_2	282	288	PF00069	0.476
MOD_PKA_2	60	66	PF00069	0.538
MOD_Plk_1	178	184	PF00069	0.487
MOD_Plk_1	191	197	PF00069	0.409
MOD_Plk_1	229	235	PF00069	0.537
MOD_Plk_2-3	158	164	PF00069	0.548
MOD_Plk_4	194	200	PF00069	0.389
MOD_Plk_4	211	217	PF00069	0.360
MOD_Plk_4	222	228	PF00069	0.375
MOD_Plk_4	282	288	PF00069	0.476
MOD_Plk_4	83	89	PF00069	0.447
MOD_ProDKin_1	242	248	PF00069	0.536
MOD_ProDKin_1	298	304	PF00069	0.488
MOD_ProDKin_1	66	72	PF00069	0.523
MOD_SUMO_for_1	188	191	PF00179	0.472
MOD_SUMO_rev_2	181	190	PF00179	0.561
TRG_DiLeu_BaEn_1	191	196	PF01217	0.464
TRG_DiLeu_BaEn_1	260	265	PF01217	0.548
TRG_DiLeu_LyEn_5	260	265	PF01217	0.481
TRG_ENDOCYTIC_2	108	111	PF00928	0.507
TRG_ENDOCYTIC_2	17	20	PF00928	0.435
TRG_ENDOCYTIC_2	253	256	PF00928	0.476
TRG_ENDOCYTIC_2	273	276	PF00928	0.578
TRG_ER_diArg_1	140	143	PF00400	0.509
TRG_ER_diArg_1	17	19	PF00400	0.467
TRG_ER_diArg_1	256	259	PF00400	0.532
TRG_ER_diArg_1	291	293	PF00400	0.507
TRG_ER_diArg_1	60	62	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X3	Leptomonas seymouri	55%	100%
A0A1X0NJP2	Trypanosomatidae	27%	100%
A0A3S5H7P2	Leishmania donovani	99%	100%
A0A422N5I6	Trypanosoma rangeli	29%	99%
A4HIX9	Leishmania braziliensis	76%	100%
C9ZN34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B1G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6P9	Leishmania major	92%	100%
V5DEV4	Trypanosoma cruzi	30%	100%