LeishMANIAdb
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Putative FG-GAP repeat protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative FG-GAP repeat protein
Gene product:
intergrin alpha chain protein - putative
Species:
Leishmania infantum
UniProt:
A4I6A4_LEIIN
TriTrypDb:
LINF_310006100
Length:
785

Annotations

Annotations by Jardim et al.

Membrane associated proteins, FG-GAP repeat

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 2
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4I6A4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6A4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 734 738 PF00656 0.413
CLV_C14_Caspase3-7 77 81 PF00656 0.311
CLV_NRD_NRD_1 181 183 PF00675 0.624
CLV_NRD_NRD_1 198 200 PF00675 0.676
CLV_PCSK_KEX2_1 146 148 PF00082 0.608
CLV_PCSK_KEX2_1 181 183 PF00082 0.607
CLV_PCSK_KEX2_1 197 199 PF00082 0.698
CLV_PCSK_KEX2_1 289 291 PF00082 0.720
CLV_PCSK_KEX2_1 682 684 PF00082 0.614
CLV_PCSK_KEX2_1 771 773 PF00082 0.441
CLV_PCSK_PC1ET2_1 146 148 PF00082 0.608
CLV_PCSK_PC1ET2_1 289 291 PF00082 0.709
CLV_PCSK_PC1ET2_1 682 684 PF00082 0.589
CLV_PCSK_PC1ET2_1 771 773 PF00082 0.471
CLV_PCSK_SKI1_1 289 293 PF00082 0.713
CLV_PCSK_SKI1_1 305 309 PF00082 0.544
CLV_PCSK_SKI1_1 65 69 PF00082 0.499
DEG_APCC_DBOX_1 272 280 PF00400 0.490
DEG_APCC_DBOX_1 712 720 PF00400 0.382
DEG_Nend_Nbox_1 1 3 PF02207 0.673
DEG_ODPH_VHL_1 2 15 PF01847 0.563
DEG_SCF_FBW7_1 164 170 PF00400 0.475
DEG_SCF_FBW7_1 323 330 PF00400 0.409
DEG_SPOP_SBC_1 28 32 PF00917 0.477
DOC_CDC14_PxL_1 137 145 PF14671 0.416
DOC_CKS1_1 164 169 PF01111 0.510
DOC_CKS1_1 324 329 PF01111 0.323
DOC_CKS1_1 404 409 PF01111 0.397
DOC_CKS1_1 51 56 PF01111 0.305
DOC_CYCLIN_yCln2_LP_2 404 410 PF00134 0.334
DOC_CYCLIN_yCln2_LP_2 445 451 PF00134 0.440
DOC_CYCLIN_yCln2_LP_2 755 761 PF00134 0.413
DOC_MAPK_DCC_7 752 762 PF00069 0.413
DOC_MAPK_DCC_7 98 108 PF00069 0.340
DOC_MAPK_gen_1 179 188 PF00069 0.430
DOC_MAPK_gen_1 302 312 PF00069 0.454
DOC_MAPK_gen_1 682 689 PF00069 0.327
DOC_MAPK_MEF2A_6 273 280 PF00069 0.448
DOC_MAPK_MEF2A_6 682 691 PF00069 0.337
DOC_MAPK_MEF2A_6 718 727 PF00069 0.330
DOC_MAPK_MEF2A_6 752 759 PF00069 0.413
DOC_MAPK_NFAT4_5 273 281 PF00069 0.448
DOC_MAPK_RevD_3 758 772 PF00069 0.449
DOC_PP1_RVXF_1 495 501 PF00149 0.392
DOC_PP2B_LxvP_1 138 141 PF13499 0.421
DOC_PP2B_LxvP_1 727 730 PF13499 0.378
DOC_PP2B_LxvP_1 755 758 PF13499 0.449
DOC_PP4_FxxP_1 702 705 PF00568 0.406
DOC_PP4_FxxP_1 92 95 PF00568 0.374
DOC_USP7_MATH_1 213 217 PF00917 0.454
DOC_USP7_MATH_1 272 276 PF00917 0.388
DOC_USP7_MATH_1 480 484 PF00917 0.387
DOC_USP7_MATH_1 630 634 PF00917 0.365
DOC_USP7_MATH_1 681 685 PF00917 0.456
DOC_WW_Pin1_4 163 168 PF00397 0.457
DOC_WW_Pin1_4 266 271 PF00397 0.441
DOC_WW_Pin1_4 323 328 PF00397 0.332
DOC_WW_Pin1_4 403 408 PF00397 0.321
DOC_WW_Pin1_4 449 454 PF00397 0.352
DOC_WW_Pin1_4 50 55 PF00397 0.304
DOC_WW_Pin1_4 620 625 PF00397 0.364
DOC_WW_Pin1_4 650 655 PF00397 0.428
DOC_WW_Pin1_4 677 682 PF00397 0.424
DOC_WW_Pin1_4 99 104 PF00397 0.312
LIG_14-3-3_CanoR_1 229 235 PF00244 0.465
LIG_14-3-3_CanoR_1 273 277 PF00244 0.480
LIG_14-3-3_CanoR_1 290 299 PF00244 0.472
LIG_14-3-3_CanoR_1 305 312 PF00244 0.407
LIG_14-3-3_CanoR_1 497 501 PF00244 0.384
LIG_14-3-3_CanoR_1 683 688 PF00244 0.412
LIG_14-3-3_CanoR_1 718 724 PF00244 0.338
LIG_14-3-3_CanoR_1 96 101 PF00244 0.440
LIG_APCC_ABBA_1 695 700 PF00400 0.312
LIG_APCC_ABBAyCdc20_2 694 700 PF00400 0.313
LIG_BRCT_BRCA1_1 308 312 PF00533 0.334
LIG_BRCT_BRCA1_1 344 348 PF00533 0.293
LIG_BRCT_BRCA1_1 424 428 PF00533 0.410
LIG_BRCT_BRCA1_1 652 656 PF00533 0.410
LIG_BRCT_BRCA1_1 739 743 PF00533 0.403
LIG_FHA_1 120 126 PF00498 0.308
LIG_FHA_1 168 174 PF00498 0.499
LIG_FHA_1 189 195 PF00498 0.498
LIG_FHA_1 324 330 PF00498 0.321
LIG_FHA_1 370 376 PF00498 0.337
LIG_FHA_1 404 410 PF00498 0.385
LIG_FHA_1 461 467 PF00498 0.437
LIG_FHA_1 51 57 PF00498 0.324
LIG_FHA_1 514 520 PF00498 0.318
LIG_FHA_1 581 587 PF00498 0.357
LIG_FHA_1 633 639 PF00498 0.393
LIG_FHA_1 664 670 PF00498 0.381
LIG_FHA_1 684 690 PF00498 0.322
LIG_FHA_1 705 711 PF00498 0.353
LIG_FHA_1 734 740 PF00498 0.367
LIG_FHA_1 752 758 PF00498 0.257
LIG_FHA_2 170 176 PF00498 0.497
LIG_FHA_2 187 193 PF00498 0.315
LIG_FHA_2 290 296 PF00498 0.554
LIG_FHA_2 328 334 PF00498 0.404
LIG_FHA_2 452 458 PF00498 0.398
LIG_FHA_2 497 503 PF00498 0.311
LIG_FHA_2 656 662 PF00498 0.415
LIG_FHA_2 670 676 PF00498 0.324
LIG_FHA_2 81 87 PF00498 0.404
LIG_Integrin_isoDGR_2 568 570 PF01839 0.558
LIG_LIR_Apic_2 48 54 PF02991 0.328
LIG_LIR_Apic_2 700 705 PF02991 0.327
LIG_LIR_Apic_2 99 103 PF02991 0.330
LIG_LIR_Gen_1 383 392 PF02991 0.331
LIG_LIR_Gen_1 622 632 PF02991 0.428
LIG_LIR_Gen_1 71 79 PF02991 0.378
LIG_LIR_Gen_1 717 727 PF02991 0.337
LIG_LIR_LC3C_4 122 127 PF02991 0.356
LIG_LIR_LC3C_4 606 609 PF02991 0.315
LIG_LIR_Nem_3 32 38 PF02991 0.433
LIG_LIR_Nem_3 383 389 PF02991 0.332
LIG_LIR_Nem_3 440 445 PF02991 0.438
LIG_LIR_Nem_3 499 503 PF02991 0.315
LIG_LIR_Nem_3 533 537 PF02991 0.402
LIG_LIR_Nem_3 644 650 PF02991 0.351
LIG_LIR_Nem_3 653 659 PF02991 0.383
LIG_LIR_Nem_3 670 674 PF02991 0.352
LIG_LIR_Nem_3 71 75 PF02991 0.320
LIG_LIR_Nem_3 717 723 PF02991 0.338
LIG_LYPXL_yS_3 35 38 PF13949 0.391
LIG_MLH1_MIPbox_1 344 348 PF16413 0.293
LIG_NBox_RRM_1 13 23 PF00076 0.464
LIG_PDZ_Class_2 780 785 PF00595 0.719
LIG_Pex14_2 428 432 PF04695 0.358
LIG_Pex14_2 667 671 PF04695 0.422
LIG_Pex14_2 743 747 PF04695 0.330
LIG_SH2_CRK 100 104 PF00017 0.335
LIG_SH2_CRK 51 55 PF00017 0.385
LIG_SH2_CRK 720 724 PF00017 0.320
LIG_SH2_CRK 753 757 PF00017 0.413
LIG_SH2_GRB2like 556 559 PF00017 0.403
LIG_SH2_PTP2 647 650 PF00017 0.311
LIG_SH2_STAP1 556 560 PF00017 0.393
LIG_SH2_STAP1 685 689 PF00017 0.420
LIG_SH2_STAP1 753 757 PF00017 0.434
LIG_SH2_STAT3 617 620 PF00017 0.355
LIG_SH2_STAT5 121 124 PF00017 0.309
LIG_SH2_STAT5 137 140 PF00017 0.391
LIG_SH2_STAT5 346 349 PF00017 0.310
LIG_SH2_STAT5 572 575 PF00017 0.303
LIG_SH2_STAT5 617 620 PF00017 0.380
LIG_SH2_STAT5 625 628 PF00017 0.404
LIG_SH2_STAT5 647 650 PF00017 0.315
LIG_SH2_STAT5 685 688 PF00017 0.357
LIG_SH2_STAT5 753 756 PF00017 0.387
LIG_SH3_2 164 169 PF14604 0.476
LIG_SH3_2 678 683 PF14604 0.426
LIG_SH3_3 161 167 PF00018 0.451
LIG_SH3_3 529 535 PF00018 0.336
LIG_SH3_3 64 70 PF00018 0.411
LIG_SH3_3 675 681 PF00018 0.412
LIG_SH3_3 709 715 PF00018 0.425
LIG_SH3_3 85 91 PF00018 0.433
LIG_SUMO_SIM_anti_2 275 280 PF11976 0.470
LIG_SUMO_SIM_anti_2 337 342 PF11976 0.328
LIG_SUMO_SIM_anti_2 559 564 PF11976 0.403
LIG_SUMO_SIM_par_1 115 122 PF11976 0.379
LIG_SUMO_SIM_par_1 582 588 PF11976 0.418
LIG_SUMO_SIM_par_1 684 690 PF11976 0.401
LIG_TYR_ITIM 751 756 PF00017 0.413
LIG_WRC_WIRS_1 656 661 PF05994 0.454
LIG_WRC_WIRS_1 69 74 PF05994 0.397
MOD_CDC14_SPxK_1 680 683 PF00782 0.424
MOD_CDK_SPK_2 50 55 PF00069 0.304
MOD_CDK_SPK_2 677 682 PF00069 0.397
MOD_CDK_SPxK_1 163 169 PF00069 0.458
MOD_CDK_SPxK_1 677 683 PF00069 0.419
MOD_CDK_SPxxK_3 266 273 PF00069 0.438
MOD_CDK_SPxxK_3 650 657 PF00069 0.432
MOD_CK1_1 266 272 PF00069 0.475
MOD_CK2_1 169 175 PF00069 0.499
MOD_CK2_1 186 192 PF00069 0.308
MOD_CK2_1 290 296 PF00069 0.563
MOD_DYRK1A_RPxSP_1 163 167 PF00069 0.499
MOD_DYRK1A_RPxSP_1 677 681 PF00069 0.421
MOD_GlcNHglycan 292 295 PF01048 0.725
MOD_GlcNHglycan 42 45 PF01048 0.580
MOD_GlcNHglycan 449 452 PF01048 0.575
MOD_GlcNHglycan 480 483 PF01048 0.587
MOD_GlcNHglycan 516 519 PF01048 0.508
MOD_GlcNHglycan 577 580 PF01048 0.568
MOD_GlcNHglycan 641 644 PF01048 0.572
MOD_GlcNHglycan 762 765 PF01048 0.475
MOD_GSK3_1 163 170 PF00069 0.505
MOD_GSK3_1 184 191 PF00069 0.456
MOD_GSK3_1 323 330 PF00069 0.403
MOD_GSK3_1 390 397 PF00069 0.373
MOD_GSK3_1 447 454 PF00069 0.339
MOD_GSK3_1 456 463 PF00069 0.364
MOD_GSK3_1 46 53 PF00069 0.321
MOD_GSK3_1 478 485 PF00069 0.360
MOD_GSK3_1 619 626 PF00069 0.368
MOD_GSK3_1 669 676 PF00069 0.336
MOD_GSK3_1 677 684 PF00069 0.384
MOD_GSK3_1 731 738 PF00069 0.341
MOD_LATS_1 94 100 PF00433 0.454
MOD_N-GLC_1 28 33 PF02516 0.578
MOD_N-GLC_1 395 400 PF02516 0.587
MOD_N-GLC_1 478 483 PF02516 0.617
MOD_NEK2_1 186 191 PF00069 0.469
MOD_NEK2_1 284 289 PF00069 0.456
MOD_NEK2_1 342 347 PF00069 0.292
MOD_NEK2_1 369 374 PF00069 0.399
MOD_NEK2_1 390 395 PF00069 0.329
MOD_NEK2_1 40 45 PF00069 0.332
MOD_NEK2_1 421 426 PF00069 0.363
MOD_NEK2_1 513 518 PF00069 0.306
MOD_NEK2_1 574 579 PF00069 0.276
MOD_NEK2_1 607 612 PF00069 0.293
MOD_NEK2_1 619 624 PF00069 0.416
MOD_NEK2_1 641 646 PF00069 0.418
MOD_NEK2_1 719 724 PF00069 0.342
MOD_NEK2_1 735 740 PF00069 0.278
MOD_NEK2_1 760 765 PF00069 0.392
MOD_PIKK_1 29 35 PF00454 0.444
MOD_PIKK_1 70 76 PF00454 0.316
MOD_PK_1 198 204 PF00069 0.442
MOD_PKA_1 197 203 PF00069 0.524
MOD_PKA_1 289 295 PF00069 0.478
MOD_PKA_2 197 203 PF00069 0.555
MOD_PKA_2 228 234 PF00069 0.536
MOD_PKA_2 272 278 PF00069 0.447
MOD_PKA_2 289 295 PF00069 0.517
MOD_PKA_2 496 502 PF00069 0.374
MOD_PKA_2 523 529 PF00069 0.399
MOD_PKA_2 574 580 PF00069 0.428
MOD_Plk_1 184 190 PF00069 0.497
MOD_Plk_1 295 301 PF00069 0.527
MOD_Plk_1 414 420 PF00069 0.446
MOD_Plk_1 669 675 PF00069 0.421
MOD_Plk_1 687 693 PF00069 0.399
MOD_Plk_2-3 295 301 PF00069 0.395
MOD_Plk_2-3 414 420 PF00069 0.434
MOD_Plk_2-3 435 441 PF00069 0.418
MOD_Plk_2-3 496 502 PF00069 0.344
MOD_Plk_4 169 175 PF00069 0.511
MOD_Plk_4 342 348 PF00069 0.291
MOD_Plk_4 46 52 PF00069 0.310
MOD_Plk_4 538 544 PF00069 0.363
MOD_Plk_4 589 595 PF00069 0.316
MOD_Plk_4 751 757 PF00069 0.403
MOD_ProDKin_1 163 169 PF00069 0.462
MOD_ProDKin_1 266 272 PF00069 0.436
MOD_ProDKin_1 323 329 PF00069 0.333
MOD_ProDKin_1 403 409 PF00069 0.319
MOD_ProDKin_1 449 455 PF00069 0.351
MOD_ProDKin_1 50 56 PF00069 0.304
MOD_ProDKin_1 620 626 PF00069 0.365
MOD_ProDKin_1 650 656 PF00069 0.429
MOD_ProDKin_1 677 683 PF00069 0.419
MOD_ProDKin_1 99 105 PF00069 0.317
MOD_SUMO_rev_2 227 235 PF00179 0.519
MOD_SUMO_rev_2 314 319 PF00179 0.445
MOD_SUMO_rev_2 470 475 PF00179 0.406
MOD_SUMO_rev_2 585 591 PF00179 0.394
TRG_DiLeu_BaLyEn_6 385 390 PF01217 0.410
TRG_ENDOCYTIC_2 137 140 PF00928 0.413
TRG_ENDOCYTIC_2 35 38 PF00928 0.446
TRG_ENDOCYTIC_2 625 628 PF00928 0.388
TRG_ENDOCYTIC_2 647 650 PF00928 0.311
TRG_ENDOCYTIC_2 720 723 PF00928 0.319
TRG_ENDOCYTIC_2 753 756 PF00928 0.413
TRG_ER_diArg_1 181 183 PF00400 0.428
TRG_ER_diArg_1 197 199 PF00400 0.517
TRG_ER_diArg_1 694 697 PF00400 0.394
TRG_NES_CRM1_1 717 733 PF08389 0.362
TRG_Pf-PMV_PEXEL_1 302 306 PF00026 0.647

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8U3 Leptomonas seymouri 67% 100%
A0A0S4JVN8 Bodo saltans 41% 90%
A0A1X0NSW9 Trypanosomatidae 47% 89%
A0A3S7X408 Leishmania donovani 100% 100%
A0A422NXM6 Trypanosoma rangeli 45% 92%
A4HIX5 Leishmania braziliensis 82% 100%
C9ZTY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 93%
E9B1F9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q6Q3 Leishmania major 95% 100%
V5AJ13 Trypanosoma cruzi 45% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS