Uncharacterized protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6A1_LEIIN

TriTrypDb:

LINF_310005700

Length:

231

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 193, 210
Promastigote/Amastigote: 194

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I6A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6A1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.683
CLV_C14_Caspase3-7	20	24	PF00656	0.621
CLV_NRD_NRD_1	110	112	PF00675	0.533
CLV_PCSK_KEX2_1	110	112	PF00082	0.552
DEG_SCF_SKP2-CKS1_1	190	197	PF00560	0.656
DOC_MAPK_gen_1	101	109	PF00069	0.479
DOC_USP7_MATH_1	190	194	PF00917	0.712
DOC_USP7_UBL2_3	185	189	PF12436	0.687
DOC_USP7_UBL2_3	197	201	PF12436	0.696
DOC_USP7_UBL2_3	205	209	PF12436	0.490
DOC_USP7_UBL2_3	213	217	PF12436	0.653
DOC_WW_Pin1_4	191	196	PF00397	0.719
LIG_14-3-3_CanoR_1	128	136	PF00244	0.484
LIG_14-3-3_CanoR_1	18	22	PF00244	0.626
LIG_BIR_III_4	8	12	PF00653	0.700
LIG_BRCT_BRCA1_1	138	142	PF00533	0.443
LIG_CaM_IQ_9	133	149	PF13499	0.443
LIG_FHA_2	120	126	PF00498	0.537
LIG_FHA_2	167	173	PF00498	0.633
LIG_LIR_Gen_1	90	100	PF02991	0.689
LIG_PTB_Apo_2	55	62	PF02174	0.632
LIG_PTB_Phospho_1	55	61	PF10480	0.633
LIG_SH2_CRK	40	44	PF00017	0.600
LIG_SH2_CRK	48	52	PF00017	0.519
LIG_SH2_CRK	61	65	PF00017	0.607
LIG_SH2_NCK_1	16	20	PF00017	0.616
LIG_SH2_NCK_1	40	44	PF00017	0.586
LIG_SH2_NCK_1	61	65	PF00017	0.628
LIG_SH2_SRC	48	51	PF00017	0.600
LIG_SH2_STAT3	7	10	PF00017	0.640
LIG_SH3_3	212	218	PF00018	0.656
LIG_SH3_3	66	72	PF00018	0.631
MOD_CDK_SPxK_1	191	197	PF00069	0.656
MOD_CK1_1	17	23	PF00069	0.490
MOD_CK1_1	87	93	PF00069	0.566
MOD_CK2_1	119	125	PF00069	0.544
MOD_CK2_1	190	196	PF00069	0.755
MOD_GlcNHglycan	207	212	PF01048	0.700
MOD_GlcNHglycan	86	89	PF01048	0.610
MOD_GSK3_1	191	198	PF00069	0.676
MOD_N-GLC_1	26	31	PF02516	0.677
MOD_NEK2_1	136	141	PF00069	0.491
MOD_OFUCOSY	133	140	PF10250	0.434
MOD_PIKK_1	119	125	PF00454	0.462
MOD_PKA_2	127	133	PF00069	0.430
MOD_PKA_2	17	23	PF00069	0.704
MOD_Plk_1	199	205	PF00069	0.658
MOD_ProDKin_1	191	197	PF00069	0.718
MOD_SUMO_for_1	204	207	PF00179	0.669
MOD_SUMO_rev_2	193	203	PF00179	0.703
TRG_ENDOCYTIC_2	93	96	PF00928	0.603
TRG_ER_diArg_1	109	111	PF00400	0.574
TRG_NLS_MonoExtN_4	108	115	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA54	Leptomonas seymouri	66%	100%
A0A1X0P7C1	Trypanosomatidae	45%	100%
A0A3Q8ISC2	Leishmania donovani	99%	100%
A4HIX2	Leishmania braziliensis	80%	100%
D0A543	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B1F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q6Q6	Leishmania major	96%	100%