DUF4476 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I663_LEIIN

TriTrypDb:

LINF_300037000

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I663

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I663

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.406
CLV_NRD_NRD_1	210	212	PF00675	0.483
CLV_PCSK_KEX2_1	154	156	PF00082	0.406
CLV_PCSK_KEX2_1	209	211	PF00082	0.434
CLV_PCSK_PC7_1	150	156	PF00082	0.402
CLV_PCSK_SKI1_1	119	123	PF00082	0.555
CLV_PCSK_SKI1_1	168	172	PF00082	0.509
DOC_PP2B_LxvP_1	37	40	PF13499	0.520
DOC_PP4_FxxP_1	141	144	PF00568	0.476
DOC_USP7_MATH_1	121	125	PF00917	0.478
DOC_USP7_MATH_1	177	181	PF00917	0.407
DOC_USP7_MATH_1	93	97	PF00917	0.553
DOC_WW_Pin1_4	171	176	PF00397	0.492
DOC_WW_Pin1_4	18	23	PF00397	0.552
DOC_WW_Pin1_4	67	72	PF00397	0.513
LIG_14-3-3_CanoR_1	133	141	PF00244	0.409
LIG_14-3-3_CanoR_1	92	102	PF00244	0.657
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	44	48	PF00533	0.777
LIG_FHA_2	68	74	PF00498	0.530
LIG_GBD_Chelix_1	181	189	PF00786	0.444
LIG_LIR_Gen_1	176	185	PF02991	0.416
LIG_LIR_Gen_1	27	37	PF02991	0.582
LIG_LIR_Nem_3	176	181	PF02991	0.427
LIG_LIR_Nem_3	27	33	PF02991	0.574
LIG_LYPXL_SIV_4	177	185	PF13949	0.397
LIG_PCNA_yPIPBox_3	106	114	PF02747	0.454
LIG_PDZ_Class_2	224	229	PF00595	0.420
LIG_Pex14_1	198	202	PF04695	0.392
LIG_SH2_STAP1	178	182	PF00017	0.406
LIG_SH2_STAT5	140	143	PF00017	0.465
LIG_SH2_STAT5	202	205	PF00017	0.413
LIG_SUMO_SIM_par_1	9	17	PF11976	0.579
LIG_TRFH_1	171	175	PF08558	0.502
LIG_UBA3_1	156	162	PF00899	0.384
MOD_CK1_1	101	107	PF00069	0.497
MOD_CK1_1	14	20	PF00069	0.597
MOD_CK1_1	205	211	PF00069	0.444
MOD_CK1_1	29	35	PF00069	0.640
MOD_CK1_1	64	70	PF00069	0.608
MOD_CK2_1	67	73	PF00069	0.602
MOD_GlcNHglycan	103	106	PF01048	0.532
MOD_GlcNHglycan	136	139	PF01048	0.446
MOD_GlcNHglycan	222	226	PF01048	0.416
MOD_GSK3_1	115	122	PF00069	0.532
MOD_GSK3_1	14	21	PF00069	0.624
MOD_GSK3_1	29	36	PF00069	0.663
MOD_GSK3_1	42	49	PF00069	0.565
MOD_N-GLC_1	17	22	PF02516	0.598
MOD_N-GLC_1	93	98	PF02516	0.549
MOD_NEK2_1	221	226	PF00069	0.410
MOD_NEK2_1	26	31	PF00069	0.570
MOD_PKA_2	115	121	PF00069	0.474
MOD_PKA_2	145	151	PF00069	0.433
MOD_PKA_2	98	104	PF00069	0.492
MOD_Plk_1	119	125	PF00069	0.574
MOD_Plk_1	26	32	PF00069	0.521
MOD_Plk_2-3	61	67	PF00069	0.553
MOD_Plk_4	177	183	PF00069	0.405
MOD_Plk_4	184	190	PF00069	0.376
MOD_Plk_4	98	104	PF00069	0.454
MOD_ProDKin_1	171	177	PF00069	0.480
MOD_ProDKin_1	18	24	PF00069	0.552
MOD_ProDKin_1	67	73	PF00069	0.509
MOD_SUMO_rev_2	112	121	PF00179	0.520
TRG_DiLeu_BaEn_4	3	9	PF01217	0.607
TRG_ENDOCYTIC_2	178	181	PF00928	0.423
TRG_ER_diArg_1	153	155	PF00400	0.407
TRG_ER_diArg_1	209	211	PF00400	0.479
TRG_ER_diArg_1	84	87	PF00400	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB3	Leptomonas seymouri	72%	97%
A0A3S7X3W4	Leishmania donovani	100%	100%
A4HIP8	Leishmania braziliensis	77%	100%
E9B188	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6X6	Leishmania major	95%	100%