LeishMANIAdb
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Tetratricopeptide repeat protein 39B

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tetratricopeptide repeat protein 39B
Gene product:
Protein of unknown function (DUF3808)/Tetratricopeptide repeat - putative
Species:
Leishmania infantum
UniProt:
A4I660_LEIIN
TriTrypDb:
LINF_300042700
Length:
581

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 5
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4I660
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I660

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 417 421 PF00656 0.433
CLV_C14_Caspase3-7 496 500 PF00656 0.557
CLV_NRD_NRD_1 117 119 PF00675 0.238
CLV_NRD_NRD_1 134 136 PF00675 0.175
CLV_NRD_NRD_1 182 184 PF00675 0.230
CLV_NRD_NRD_1 290 292 PF00675 0.254
CLV_NRD_NRD_1 314 316 PF00675 0.222
CLV_NRD_NRD_1 366 368 PF00675 0.270
CLV_NRD_NRD_1 535 537 PF00675 0.329
CLV_NRD_NRD_1 572 574 PF00675 0.344
CLV_PCSK_FUR_1 288 292 PF00082 0.254
CLV_PCSK_KEX2_1 136 138 PF00082 0.235
CLV_PCSK_KEX2_1 290 292 PF00082 0.240
CLV_PCSK_KEX2_1 366 368 PF00082 0.237
CLV_PCSK_KEX2_1 467 469 PF00082 0.347
CLV_PCSK_KEX2_1 535 537 PF00082 0.330
CLV_PCSK_KEX2_1 572 574 PF00082 0.322
CLV_PCSK_PC1ET2_1 136 138 PF00082 0.332
CLV_PCSK_PC1ET2_1 467 469 PF00082 0.377
CLV_PCSK_SKI1_1 119 123 PF00082 0.276
CLV_PCSK_SKI1_1 129 133 PF00082 0.261
CLV_PCSK_SKI1_1 137 141 PF00082 0.198
CLV_PCSK_SKI1_1 290 294 PF00082 0.217
CLV_PCSK_SKI1_1 325 329 PF00082 0.342
CLV_PCSK_SKI1_1 366 370 PF00082 0.271
CLV_PCSK_SKI1_1 400 404 PF00082 0.238
CLV_PCSK_SKI1_1 467 471 PF00082 0.353
CLV_PCSK_SKI1_1 506 510 PF00082 0.360
CLV_PCSK_SKI1_1 543 547 PF00082 0.316
CLV_PCSK_SKI1_1 57 61 PF00082 0.208
CLV_Separin_Metazoa 46 50 PF03568 0.454
DEG_APCC_DBOX_1 289 297 PF00400 0.519
DEG_APCC_DBOX_1 365 373 PF00400 0.471
DEG_APCC_DBOX_1 78 86 PF00400 0.442
DOC_CYCLIN_RxL_1 540 550 PF00134 0.550
DOC_CYCLIN_yClb5_NLxxxL_5 225 234 PF00134 0.288
DOC_MAPK_DCC_7 336 344 PF00069 0.428
DOC_MAPK_MEF2A_6 336 344 PF00069 0.428
DOC_PP2B_LxvP_1 273 276 PF13499 0.254
DOC_USP7_MATH_1 323 327 PF00917 0.519
DOC_USP7_MATH_1 516 520 PF00917 0.488
DOC_USP7_MATH_1 63 67 PF00917 0.571
DOC_USP7_UBL2_3 112 116 PF12436 0.561
DOC_USP7_UBL2_3 119 123 PF12436 0.438
DOC_USP7_UBL2_3 125 129 PF12436 0.428
DOC_USP7_UBL2_3 209 213 PF12436 0.428
DOC_USP7_UBL2_3 374 378 PF12436 0.497
DOC_USP7_UBL2_3 467 471 PF12436 0.588
DOC_WW_Pin1_4 258 263 PF00397 0.217
DOC_WW_Pin1_4 420 425 PF00397 0.417
LIG_14-3-3_CanoR_1 325 330 PF00244 0.471
LIG_Actin_WH2_2 163 179 PF00022 0.442
LIG_BIR_II_1 1 5 PF00653 0.703
LIG_BRCT_BRCA1_1 422 426 PF00533 0.428
LIG_CtBP_PxDLS_1 179 184 PF00389 0.484
LIG_eIF4E_1 158 164 PF01652 0.442
LIG_eIF4E_1 220 226 PF01652 0.269
LIG_FHA_1 147 153 PF00498 0.519
LIG_FHA_1 268 274 PF00498 0.254
LIG_FHA_1 380 386 PF00498 0.433
LIG_FHA_1 5 11 PF00498 0.599
LIG_FHA_2 16 22 PF00498 0.705
LIG_FHA_2 523 529 PF00498 0.555
LIG_FHA_2 73 79 PF00498 0.519
LIG_LIR_Apic_2 95 101 PF02991 0.484
LIG_LIR_Gen_1 218 228 PF02991 0.288
LIG_LIR_Gen_1 261 271 PF02991 0.222
LIG_LIR_Gen_1 481 491 PF02991 0.453
LIG_LIR_Gen_1 61 68 PF02991 0.460
LIG_LIR_Nem_3 216 222 PF02991 0.418
LIG_LIR_Nem_3 261 266 PF02991 0.249
LIG_LIR_Nem_3 270 275 PF02991 0.285
LIG_LIR_Nem_3 304 309 PF02991 0.417
LIG_LIR_Nem_3 363 368 PF02991 0.544
LIG_LIR_Nem_3 440 446 PF02991 0.483
LIG_LIR_Nem_3 481 487 PF02991 0.454
LIG_LIR_Nem_3 61 65 PF02991 0.460
LIG_MYND_1 434 438 PF01753 0.488
LIG_PCNA_PIPBox_1 169 178 PF02747 0.412
LIG_PCNA_yPIPBox_3 165 176 PF02747 0.417
LIG_Pex14_1 186 190 PF04695 0.503
LIG_Pex14_1 37 41 PF04695 0.428
LIG_Pex14_2 146 150 PF04695 0.428
LIG_PTB_Apo_2 299 306 PF02174 0.541
LIG_PTB_Apo_2 308 315 PF02174 0.490
LIG_PTB_Apo_2 35 42 PF02174 0.484
LIG_PTB_Apo_2 52 59 PF02174 0.484
LIG_PTB_Phospho_1 299 305 PF10480 0.541
LIG_PTB_Phospho_1 35 41 PF10480 0.484
LIG_PTB_Phospho_1 52 58 PF10480 0.484
LIG_SH2_CRK 190 194 PF00017 0.419
LIG_SH2_CRK 220 224 PF00017 0.254
LIG_SH2_CRK 365 369 PF00017 0.442
LIG_SH2_GRB2like 305 308 PF00017 0.428
LIG_SH2_GRB2like 309 312 PF00017 0.406
LIG_SH2_GRB2like 446 449 PF00017 0.454
LIG_SH2_NCK_1 190 194 PF00017 0.428
LIG_SH2_PTP2 393 396 PF00017 0.481
LIG_SH2_SRC 158 161 PF00017 0.417
LIG_SH2_SRC 346 349 PF00017 0.428
LIG_SH2_STAP1 158 162 PF00017 0.417
LIG_SH2_STAP1 206 210 PF00017 0.480
LIG_SH2_STAP1 220 224 PF00017 0.200
LIG_SH2_STAP1 309 313 PF00017 0.417
LIG_SH2_STAP1 348 352 PF00017 0.519
LIG_SH2_STAP1 41 45 PF00017 0.496
LIG_SH2_STAP1 58 62 PF00017 0.379
LIG_SH2_STAT3 145 148 PF00017 0.471
LIG_SH2_STAT3 381 384 PF00017 0.417
LIG_SH2_STAT5 145 148 PF00017 0.471
LIG_SH2_STAT5 175 178 PF00017 0.417
LIG_SH2_STAT5 249 252 PF00017 0.219
LIG_SH2_STAT5 272 275 PF00017 0.287
LIG_SH2_STAT5 305 308 PF00017 0.419
LIG_SH2_STAT5 313 316 PF00017 0.414
LIG_SH2_STAT5 346 349 PF00017 0.430
LIG_SH2_STAT5 381 384 PF00017 0.437
LIG_SH2_STAT5 393 396 PF00017 0.417
LIG_SH2_STAT5 446 449 PF00017 0.457
LIG_SUMO_SIM_anti_2 42 49 PF11976 0.436
LIG_UBA3_1 368 376 PF00899 0.461
LIG_UBA3_1 82 87 PF00899 0.418
MOD_CDK_SPK_2 420 425 PF00069 0.417
MOD_CK1_1 11 17 PF00069 0.668
MOD_CK1_1 4 10 PF00069 0.731
MOD_CK1_1 495 501 PF00069 0.617
MOD_CK1_1 88 94 PF00069 0.433
MOD_CK2_1 473 479 PF00069 0.492
MOD_CK2_1 522 528 PF00069 0.556
MOD_CK2_1 71 77 PF00069 0.428
MOD_GlcNHglycan 439 442 PF01048 0.326
MOD_GlcNHglycan 474 478 PF01048 0.318
MOD_GlcNHglycan 87 90 PF01048 0.285
MOD_GSK3_1 4 11 PF00069 0.728
MOD_GSK3_1 414 421 PF00069 0.493
MOD_GSK3_1 522 529 PF00069 0.537
MOD_GSK3_1 63 70 PF00069 0.466
MOD_GSK3_1 88 95 PF00069 0.484
MOD_N-GLC_1 301 306 PF02516 0.271
MOD_N-GLC_1 556 561 PF02516 0.327
MOD_N-GLC_1 63 68 PF02516 0.256
MOD_NEK2_1 1 6 PF00069 0.710
MOD_NEK2_1 12 17 PF00069 0.711
MOD_NEK2_1 146 151 PF00069 0.468
MOD_NEK2_1 163 168 PF00069 0.359
MOD_NEK2_1 171 176 PF00069 0.428
MOD_NEK2_1 379 384 PF00069 0.445
MOD_NEK2_1 67 72 PF00069 0.429
MOD_NEK2_1 92 97 PF00069 0.464
MOD_NEK2_2 215 220 PF00069 0.442
MOD_NEK2_2 348 353 PF00069 0.519
MOD_PK_1 232 238 PF00069 0.348
MOD_PKA_1 467 473 PF00069 0.535
MOD_PKA_2 467 473 PF00069 0.493
MOD_PKA_2 78 84 PF00069 0.462
MOD_PKB_1 135 143 PF00069 0.437
MOD_Plk_1 12 18 PF00069 0.611
MOD_Plk_1 146 152 PF00069 0.460
MOD_Plk_1 282 288 PF00069 0.443
MOD_Plk_1 301 307 PF00069 0.439
MOD_Plk_1 556 562 PF00069 0.534
MOD_Plk_1 63 69 PF00069 0.519
MOD_Plk_2-3 78 84 PF00069 0.394
MOD_Plk_2-3 8 14 PF00069 0.627
MOD_Plk_4 171 177 PF00069 0.428
MOD_Plk_4 188 194 PF00069 0.428
MOD_Plk_4 215 221 PF00069 0.442
MOD_Plk_4 232 238 PF00069 0.288
MOD_Plk_4 267 273 PF00069 0.254
MOD_Plk_4 301 307 PF00069 0.441
MOD_Plk_4 348 354 PF00069 0.422
MOD_Plk_4 408 414 PF00069 0.453
MOD_Plk_4 516 522 PF00069 0.463
MOD_Plk_4 63 69 PF00069 0.459
MOD_Plk_4 78 84 PF00069 0.419
MOD_ProDKin_1 258 264 PF00069 0.217
MOD_ProDKin_1 420 426 PF00069 0.417
MOD_SUMO_for_1 121 124 PF00179 0.513
MOD_SUMO_rev_2 108 117 PF00179 0.561
MOD_SUMO_rev_2 201 210 PF00179 0.490
MOD_SUMO_rev_2 510 516 PF00179 0.577
TRG_DiLeu_BaEn_1 335 340 PF01217 0.417
TRG_DiLeu_BaEn_1 43 48 PF01217 0.507
TRG_DiLeu_BaLyEn_6 338 343 PF01217 0.460
TRG_DiLeu_BaLyEn_6 432 437 PF01217 0.483
TRG_ENDOCYTIC_2 189 192 PF00928 0.417
TRG_ENDOCYTIC_2 220 223 PF00928 0.254
TRG_ENDOCYTIC_2 272 275 PF00928 0.271
TRG_ENDOCYTIC_2 309 312 PF00928 0.417
TRG_ENDOCYTIC_2 365 368 PF00928 0.417
TRG_ENDOCYTIC_2 393 396 PF00928 0.484
TRG_ENDOCYTIC_2 484 487 PF00928 0.493
TRG_ER_diArg_1 288 291 PF00400 0.454
TRG_ER_diArg_1 365 367 PF00400 0.523
TRG_ER_diArg_1 534 536 PF00400 0.520
TRG_ER_diArg_1 571 573 PF00400 0.570
TRG_NLS_MonoExtC_3 125 130 PF00514 0.489
TRG_NLS_MonoExtN_4 123 130 PF00514 0.491
TRG_Pf-PMV_PEXEL_1 165 169 PF00026 0.319
TRG_Pf-PMV_PEXEL_1 243 247 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.310
TRG_Pf-PMV_PEXEL_1 461 465 PF00026 0.272

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAD2 Leptomonas seymouri 82% 99%
A0A0S4JLL5 Bodo saltans 58% 100%
A0A1X0P173 Trypanosomatidae 65% 99%
A0A3Q8ICA6 Leishmania donovani 100% 100%
A0A3S5IRG7 Trypanosoma rangeli 65% 100%
A1A5Y5 Danio rerio 23% 100%
A2ACP1 Mus musculus 22% 100%
A4HIV5 Leishmania braziliensis 86% 100%
C9ZRI0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
D3ZC96 Rattus norvegicus 21% 94%
E9B1E3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q0VGK2 Rattus norvegicus 23% 100%
Q1LXE6 Danio rerio 21% 100%
Q28D40 Xenopus tropicalis 21% 100%
Q28DB0 Xenopus tropicalis 21% 99%
Q4Q6R9 Leishmania major 95% 100%
Q5SRH9 Homo sapiens 23% 95%
Q5VTQ0 Homo sapiens 20% 85%
Q5XHH9 Xenopus laevis 22% 99%
Q8BYY4 Mus musculus 20% 94%
Q8N584 Homo sapiens 22% 100%
Q8VE09 Mus musculus 22% 100%
Q95LT8 Macaca fascicularis 20% 92%
V5BMN7 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS