LeishMANIAdb
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Flagellar associated protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Flagellar associated protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I659_LEIIN
TriTrypDb:
LINF_300042600
Length:
442

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 244
Promastigote/Amastigote: 202

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I659
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I659

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 198 202 PF00656 0.511
CLV_C14_Caspase3-7 227 231 PF00656 0.537
CLV_NRD_NRD_1 122 124 PF00675 0.581
CLV_NRD_NRD_1 139 141 PF00675 0.600
CLV_NRD_NRD_1 193 195 PF00675 0.506
CLV_NRD_NRD_1 246 248 PF00675 0.604
CLV_NRD_NRD_1 422 424 PF00675 0.523
CLV_NRD_NRD_1 60 62 PF00675 0.563
CLV_PCSK_KEX2_1 122 124 PF00082 0.574
CLV_PCSK_KEX2_1 138 140 PF00082 0.524
CLV_PCSK_KEX2_1 192 194 PF00082 0.503
CLV_PCSK_KEX2_1 288 290 PF00082 0.529
CLV_PCSK_KEX2_1 421 423 PF00082 0.564
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.527
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.476
CLV_PCSK_PC7_1 418 424 PF00082 0.406
CLV_PCSK_SKI1_1 115 119 PF00082 0.556
CLV_PCSK_SKI1_1 133 137 PF00082 0.472
CLV_PCSK_SKI1_1 2 6 PF00082 0.596
CLV_PCSK_SKI1_1 274 278 PF00082 0.436
CLV_PCSK_SKI1_1 288 292 PF00082 0.409
CLV_PCSK_SKI1_1 295 299 PF00082 0.450
CLV_PCSK_SKI1_1 423 427 PF00082 0.492
CLV_PCSK_SKI1_1 431 435 PF00082 0.495
DEG_Nend_UBRbox_1 1 4 PF02207 0.623
DOC_CYCLIN_RxL_1 426 436 PF00134 0.502
DOC_MAPK_gen_1 178 186 PF00069 0.495
DOC_MAPK_gen_1 353 362 PF00069 0.445
DOC_USP7_MATH_1 241 245 PF00917 0.553
DOC_USP7_UBL2_3 188 192 PF12436 0.522
DOC_USP7_UBL2_3 291 295 PF12436 0.542
LIG_14-3-3_CanoR_1 193 200 PF00244 0.571
LIG_EH1_1 328 336 PF00400 0.518
LIG_FHA_1 160 166 PF00498 0.497
LIG_FHA_1 185 191 PF00498 0.561
LIG_FHA_1 354 360 PF00498 0.507
LIG_FHA_1 376 382 PF00498 0.504
LIG_FHA_1 387 393 PF00498 0.457
LIG_FHA_2 194 200 PF00498 0.515
LIG_FHA_2 254 260 PF00498 0.554
LIG_FHA_2 262 268 PF00498 0.548
LIG_FHA_2 349 355 PF00498 0.478
LIG_FHA_2 364 370 PF00498 0.409
LIG_FHA_2 377 383 PF00498 0.493
LIG_LIR_Gen_1 201 210 PF02991 0.547
LIG_LIR_Nem_3 201 207 PF02991 0.522
LIG_LIR_Nem_3 52 56 PF02991 0.476
LIG_LIR_Nem_3 73 78 PF02991 0.546
LIG_SH2_CRK 346 350 PF00017 0.460
LIG_SH2_CRK 75 79 PF00017 0.575
LIG_SH2_STAT5 134 137 PF00017 0.441
LIG_SH2_STAT5 58 61 PF00017 0.473
LIG_SH3_3 316 322 PF00018 0.545
LIG_SUMO_SIM_par_1 182 187 PF11976 0.547
LIG_SUMO_SIM_par_1 358 364 PF11976 0.518
LIG_TRAF2_1 217 220 PF00917 0.562
LIG_TRAF2_1 249 252 PF00917 0.520
LIG_TRAF2_1 336 339 PF00917 0.446
LIG_TRAF2_1 391 394 PF00917 0.438
LIG_TRAF2_1 437 440 PF00917 0.398
LIG_UBA3_1 143 150 PF00899 0.641
LIG_UBA3_1 183 188 PF00899 0.489
LIG_UBA3_1 362 370 PF00899 0.444
LIG_UBA3_1 78 87 PF00899 0.521
LIG_WRC_WIRS_1 33 38 PF05994 0.614
MOD_CK1_1 35 41 PF00069 0.651
MOD_CK1_1 361 367 PF00069 0.533
MOD_CK2_1 151 157 PF00069 0.517
MOD_CK2_1 253 259 PF00069 0.529
MOD_CK2_1 261 267 PF00069 0.527
MOD_CK2_1 312 318 PF00069 0.574
MOD_CK2_1 348 354 PF00069 0.506
MOD_CK2_1 363 369 PF00069 0.497
MOD_CK2_1 376 382 PF00069 0.499
MOD_CK2_1 429 435 PF00069 0.517
MOD_Cter_Amidation 59 62 PF01082 0.598
MOD_GlcNHglycan 251 256 PF01048 0.548
MOD_GlcNHglycan 399 402 PF01048 0.462
MOD_GlcNHglycan 435 438 PF01048 0.535
MOD_GSK3_1 211 218 PF00069 0.496
MOD_GSK3_1 28 35 PF00069 0.585
MOD_GSK3_1 429 436 PF00069 0.495
MOD_N-GLC_1 68 73 PF02516 0.524
MOD_N-GLC_2 57 59 PF02516 0.345
MOD_NEK2_1 184 189 PF00069 0.478
MOD_NEK2_1 363 368 PF00069 0.487
MOD_NEK2_1 433 438 PF00069 0.466
MOD_NEK2_1 49 54 PF00069 0.564
MOD_PIKK_1 115 121 PF00454 0.600
MOD_PIKK_1 312 318 PF00454 0.560
MOD_PK_1 358 364 PF00069 0.544
MOD_PKA_1 192 198 PF00069 0.548
MOD_PKA_2 192 198 PF00069 0.532
MOD_PKA_2 211 217 PF00069 0.292
MOD_PKA_2 63 69 PF00069 0.541
MOD_Plk_1 101 107 PF00069 0.490
MOD_Plk_1 151 157 PF00069 0.564
MOD_Plk_1 212 218 PF00069 0.486
MOD_Plk_1 261 267 PF00069 0.557
MOD_Plk_1 68 74 PF00069 0.588
MOD_Plk_2-3 253 259 PF00069 0.522
MOD_Plk_4 199 205 PF00069 0.534
MOD_Plk_4 32 38 PF00069 0.640
MOD_Plk_4 358 364 PF00069 0.507
MOD_Plk_4 429 435 PF00069 0.445
MOD_SUMO_rev_2 126 135 PF00179 0.602
MOD_SUMO_rev_2 166 172 PF00179 0.531
TRG_DiLeu_BaEn_1 102 107 PF01217 0.568
TRG_DiLeu_BaEn_1 369 374 PF01217 0.379
TRG_DiLeu_BaEn_2 31 37 PF01217 0.593
TRG_DiLeu_BaLyEn_6 170 175 PF01217 0.356
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.604
TRG_DiLeu_LyEn_5 102 107 PF01217 0.562
TRG_ENDOCYTIC_2 204 207 PF00928 0.478
TRG_ENDOCYTIC_2 346 349 PF00928 0.414
TRG_ENDOCYTIC_2 75 78 PF00928 0.555
TRG_ER_diArg_1 122 124 PF00400 0.606
TRG_ER_diArg_1 138 140 PF00400 0.560
TRG_ER_diArg_1 161 164 PF00400 0.567
TRG_ER_diArg_1 421 423 PF00400 0.443
TRG_NLS_MonoCore_2 60 65 PF00514 0.561
TRG_Pf-PMV_PEXEL_1 105 109 PF00026 0.528
TRG_Pf-PMV_PEXEL_1 122 126 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 173 177 PF00026 0.548
TRG_Pf-PMV_PEXEL_1 431 435 PF00026 0.532

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1II28 Leptomonas seymouri 68% 100%
A0A0S4JDF0 Bodo saltans 25% 100%
A0A0S4JHV1 Bodo saltans 26% 72%
A0A1X0P1A4 Trypanosomatidae 39% 99%
A0A3Q8ISB1 Leishmania donovani 100% 100%
A0A422NMD4 Trypanosoma rangeli 38% 98%
A4HIV4 Leishmania braziliensis 71% 100%
C9ZRH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 97%
C9ZYW3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9B1E2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q6S0 Leishmania major 92% 100%
V5B747 Trypanosoma cruzi 38% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS