LeishMANIAdb
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Putative V-type ATPase, C subunit

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative V-type ATPase, C subunit
Gene product:
V-type ATPase - C subunit - putative
Species:
Leishmania infantum
UniProt:
A4I657_LEIIN
TriTrypDb:
LINF_300042400
Length:
224

Annotations

Annotations by Jardim et al.

Acidocalcisome, V-type ATPase, C subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0032991 protein-containing complex 1 11
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 11
GO:0033179 proton-transporting V-type ATPase, V0 domain 4 11
GO:0098796 membrane protein complex 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A4I657
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I657

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0005215 transporter activity 1 11
GO:0008324 monoatomic cation transmembrane transporter activity 4 11
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 11
GO:0015075 monoatomic ion transmembrane transporter activity 3 11
GO:0015078 proton transmembrane transporter activity 5 11
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 11
GO:0015399 primary active transmembrane transporter activity 4 11
GO:0016787 hydrolase activity 2 8
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 11
GO:0022804 active transmembrane transporter activity 3 11
GO:0022853 active monoatomic ion transmembrane transporter activity 4 11
GO:0022857 transmembrane transporter activity 2 11
GO:0022890 inorganic cation transmembrane transporter activity 4 11
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 11
GO:0042626 ATPase-coupled transmembrane transporter activity 2 11
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 11
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 11
GO:0140657 ATP-dependent activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 28 32 PF00082 0.357
DEG_APCC_DBOX_1 27 35 PF00400 0.378
DEG_MDM2_SWIB_1 52 59 PF02201 0.402
DEG_SPOP_SBC_1 135 139 PF00917 0.458
DEG_SPOP_SBC_1 187 191 PF00917 0.487
DOC_CDC14_PxL_1 38 46 PF14671 0.335
DOC_CKS1_1 8 13 PF01111 0.703
DOC_MAPK_gen_1 105 114 PF00069 0.470
DOC_MAPK_MEF2A_6 105 114 PF00069 0.482
DOC_MAPK_MEF2A_6 28 37 PF00069 0.360
DOC_PP1_SILK_1 56 61 PF00149 0.414
DOC_USP7_MATH_1 135 139 PF00917 0.414
DOC_USP7_MATH_1 187 191 PF00917 0.482
DOC_USP7_MATH_1 66 70 PF00917 0.295
DOC_USP7_UBL2_3 220 224 PF12436 0.403
DOC_WW_Pin1_4 60 65 PF00397 0.346
DOC_WW_Pin1_4 7 12 PF00397 0.704
LIG_BRCT_BRCA1_1 110 114 PF00533 0.335
LIG_BRCT_BRCA1_1 189 193 PF00533 0.482
LIG_BRCT_BRCA1_2 189 195 PF00533 0.482
LIG_EH1_1 20 28 PF00400 0.632
LIG_FHA_1 211 217 PF00498 0.429
LIG_LIR_Gen_1 190 201 PF02991 0.481
LIG_LIR_Gen_1 53 64 PF02991 0.391
LIG_LIR_Nem_3 190 196 PF02991 0.481
LIG_LIR_Nem_3 47 52 PF02991 0.378
LIG_LIR_Nem_3 53 59 PF02991 0.362
LIG_Pex14_2 52 56 PF04695 0.378
LIG_SH2_CRK 121 125 PF00017 0.335
LIG_SH2_PTP2 29 32 PF00017 0.378
LIG_SH2_STAP1 148 152 PF00017 0.366
LIG_SH2_STAP1 155 159 PF00017 0.303
LIG_SH2_STAT5 155 158 PF00017 0.340
LIG_SH2_STAT5 29 32 PF00017 0.354
LIG_SH3_3 45 51 PF00018 0.494
LIG_SUMO_SIM_par_1 195 200 PF11976 0.335
LIG_TYR_ITIM 27 32 PF00017 0.354
LIG_UBA3_1 124 132 PF00899 0.335
MOD_CDK_SPxK_1 7 13 PF00069 0.711
MOD_CK1_1 136 142 PF00069 0.471
MOD_CK1_1 69 75 PF00069 0.420
MOD_CK1_1 90 96 PF00069 0.516
MOD_GlcNHglycan 141 144 PF01048 0.653
MOD_GlcNHglycan 203 206 PF01048 0.325
MOD_GlcNHglycan 52 55 PF01048 0.585
MOD_GlcNHglycan 89 92 PF01048 0.293
MOD_GlcNHglycan 94 97 PF01048 0.269
MOD_GSK3_1 135 142 PF00069 0.472
MOD_GSK3_1 50 57 PF00069 0.457
MOD_GSK3_1 86 93 PF00069 0.354
MOD_NEK2_1 44 49 PF00069 0.528
MOD_NEK2_2 153 158 PF00069 0.310
MOD_Plk_4 123 129 PF00069 0.329
MOD_Plk_4 147 153 PF00069 0.408
MOD_Plk_4 188 194 PF00069 0.495
MOD_Plk_4 22 28 PF00069 0.541
MOD_Plk_4 44 50 PF00069 0.527
MOD_Plk_4 76 82 PF00069 0.378
MOD_ProDKin_1 60 66 PF00069 0.344
MOD_ProDKin_1 7 13 PF00069 0.703
TRG_ENDOCYTIC_2 121 124 PF00928 0.335
TRG_ENDOCYTIC_2 148 151 PF00928 0.398
TRG_ENDOCYTIC_2 155 158 PF00928 0.334
TRG_ENDOCYTIC_2 29 32 PF00928 0.378

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3G9 Leptomonas seymouri 86% 100%
A0A0N1HSG6 Leptomonas seymouri 27% 100%
A0A0N1I3H6 Leptomonas seymouri 31% 100%
A0A0S4IU71 Bodo saltans 27% 100%
A0A0S4JFM4 Bodo saltans 30% 100%
A0A0S4JKG0 Bodo saltans 68% 86%
A0A1X0NGC8 Trypanosomatidae 29% 100%
A0A1X0NHL5 Trypanosomatidae 27% 100%
A0A1X0NZ73 Trypanosomatidae 22% 100%
A0A1X0P179 Trypanosomatidae 75% 100%
A0A3Q8II19 Leishmania donovani 25% 100%
A0A3Q8II88 Leishmania donovani 100% 100%
A0A3Q8ILV9 Leishmania donovani 32% 100%
A0A3R7MQK8 Trypanosoma rangeli 77% 100%
A0A3R7RFU6 Trypanosoma rangeli 28% 100%
A0A3S7WX01 Leishmania donovani 27% 100%
A0A422N304 Trypanosoma rangeli 22% 100%
A0A422NW00 Trypanosoma rangeli 28% 100%
A4HCM7 Leishmania braziliensis 31% 100%
A4HGG2 Leishmania braziliensis 26% 100%
A4HIV2 Leishmania braziliensis 92% 100%
A4HLC1 Leishmania braziliensis 27% 100%
A4HZI5 Leishmania infantum 27% 100%
A4I051 Leishmania infantum 31% 100%
A4I3J4 Leishmania infantum 24% 100%
C0HLB3 Caenorhabditis elegans 28% 100%
C0HLB4 Caenorhabditis elegans 28% 100%
C0HLB5 Caenorhabditis briggsae 29% 100%
C0HLB6 Caenorhabditis briggsae 29% 100%
C9ZRH7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
D0A0Y8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0A7U7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 89%
E9AVH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AW14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AZT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1E0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
G5EDB8 Caenorhabditis elegans 49% 100%
O14046 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 50% 100%
O16110 Aedes aegypti 31% 100%
O18882 Ovis aries 30% 100%
O22552 Vigna radiata var. radiata 28% 100%
O24011 Solanum lycopersicum 28% 100%
P0DH92 Arabidopsis thaliana 28% 100%
P0DH93 Arabidopsis thaliana 28% 100%
P0DH94 Arabidopsis thaliana 28% 100%
P23380 Drosophila melanogaster 32% 100%
P23956 Bos taurus 30% 100%
P23957 Avena sativa 28% 100%
P23968 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 100%
P25515 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P27449 Homo sapiens 29% 100%
P31403 Manduca sexta 32% 100%
P31413 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%
P32842 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P50515 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
P54642 Dictyostelium discoideum 31% 100%
P55277 Heliothis virescens 32% 100%
P59228 Arabidopsis thaliana 28% 100%
P59229 Arabidopsis thaliana 28% 100%
P63081 Rattus norvegicus 26% 100%
P63082 Mus musculus 26% 100%
P68161 Mesembryanthemum crystallinum 28% 100%
P68162 Beta vulgaris 28% 100%
Q00607 Candida tropicalis 27% 100%
Q03105 Torpedo marmorata 27% 100%
Q17046 Ascaris suum 29% 100%
Q24808 Entamoeba dispar 27% 100%
Q24810 Entamoeba histolytica 25% 100%
Q26250 Nephrops norvegicus 31% 100%
Q2TA24 Bos taurus 46% 100%
Q40585 Nicotiana tabacum 28% 100%
Q43362 Chrysotila carterae 32% 100%
Q43434 Gossypium hirsutum 28% 100%
Q4Q6S2 Leishmania major 99% 100%
Q4Q8F0 Leishmania major 25% 100%
Q4QBG2 Leishmania major 31% 100%
Q4QC03 Leishmania major 27% 100%
Q6CT28 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 29% 100%
Q6FUY5 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 29% 100%
Q755G4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 30% 100%
Q91V37 Mus musculus 46% 100%
Q96473 Kalanchoe daigremontiana 28% 100%
Q99437 Homo sapiens 47% 100%
Q9SLA2 Arabidopsis thaliana 57% 100%
Q9SZY7 Arabidopsis thaliana 57% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS