Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I653_LEIIN

TriTrypDb:

LINF_300042000

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I653

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I653

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.644
CLV_PCSK_SKI1_1	55	59	PF00082	0.756
CLV_PCSK_SKI1_1	72	76	PF00082	0.762
DEG_APCC_DBOX_1	225	233	PF00400	0.750
DEG_COP1_1	264	273	PF00400	0.546
DEG_Nend_UBRbox_2	1	3	PF02207	0.611
DOC_CKS1_1	288	293	PF01111	0.749
DOC_CKS1_1	294	299	PF01111	0.641
DOC_CYCLIN_yCln2_LP_2	294	300	PF00134	0.741
DOC_MAPK_gen_1	22	30	PF00069	0.635
DOC_PP2B_LxvP_1	66	69	PF13499	0.729
DOC_PP4_FxxP_1	156	159	PF00568	0.702
DOC_PP4_FxxP_1	199	202	PF00568	0.606
DOC_PP4_FxxP_1	211	214	PF00568	0.633
DOC_PP4_FxxP_1	244	247	PF00568	0.792
DOC_USP7_MATH_1	109	113	PF00917	0.726
DOC_USP7_MATH_1	119	123	PF00917	0.740
DOC_USP7_MATH_1	124	128	PF00917	0.640
DOC_USP7_MATH_1	149	153	PF00917	0.755
DOC_USP7_MATH_1	159	163	PF00917	0.743
DOC_USP7_MATH_1	273	277	PF00917	0.567
DOC_USP7_MATH_1	280	284	PF00917	0.605
DOC_USP7_MATH_2	159	165	PF00917	0.783
DOC_USP7_UBL2_3	218	222	PF12436	0.796
DOC_WW_Pin1_4	140	145	PF00397	0.703
DOC_WW_Pin1_4	217	222	PF00397	0.748
DOC_WW_Pin1_4	243	248	PF00397	0.803
DOC_WW_Pin1_4	256	261	PF00397	0.662
DOC_WW_Pin1_4	287	292	PF00397	0.711
DOC_WW_Pin1_4	293	298	PF00397	0.704
DOC_WW_Pin1_4	58	63	PF00397	0.760
LIG_14-3-3_CanoR_1	134	144	PF00244	0.569
LIG_14-3-3_CanoR_1	226	230	PF00244	0.750
LIG_14-3-3_CanoR_1	24	31	PF00244	0.665
LIG_14-3-3_CanoR_1	55	64	PF00244	0.747
LIG_APCC_ABBA_1	196	201	PF00400	0.614
LIG_BRCT_BRCA1_1	166	170	PF00533	0.772
LIG_deltaCOP1_diTrp_1	201	211	PF00928	0.737
LIG_FHA_1	130	136	PF00498	0.714
LIG_FHA_1	185	191	PF00498	0.719
LIG_FHA_1	23	29	PF00498	0.663
LIG_FHA_1	300	306	PF00498	0.680
LIG_FHA_1	35	41	PF00498	0.659
LIG_LIR_Apic_2	153	159	PF02991	0.706
LIG_LIR_Apic_2	209	214	PF02991	0.726
LIG_LIR_Apic_2	241	247	PF02991	0.779
LIG_LIR_Gen_1	167	178	PF02991	0.732
LIG_LIR_Nem_3	167	173	PF02991	0.757
LIG_LIR_Nem_3	296	301	PF02991	0.691
LIG_MYND_1	64	68	PF01753	0.631
LIG_NRBOX	80	86	PF00104	0.584
LIG_PCNA_yPIPBox_3	72	85	PF02747	0.660
LIG_SH2_CRK	301	305	PF00017	0.683
LIG_SH2_CRK	320	324	PF00017	0.613
LIG_SH2_CRK	345	349	PF00017	0.751
LIG_SH2_NCK_1	233	237	PF00017	0.712
LIG_SH2_NCK_1	320	324	PF00017	0.634
LIG_SH2_NCK_1	345	349	PF00017	0.742
LIG_SH2_NCK_1	7	11	PF00017	0.647
LIG_SH2_SRC	345	348	PF00017	0.729
LIG_SH2_SRC	7	10	PF00017	0.648
LIG_SH2_STAP1	233	237	PF00017	0.754
LIG_SH2_STAT3	307	310	PF00017	0.687
LIG_SH2_STAT5	301	304	PF00017	0.684
LIG_SH3_1	360	366	PF00018	0.693
LIG_SH3_2	62	67	PF14604	0.806
LIG_SH3_3	115	121	PF00018	0.770
LIG_SH3_3	148	154	PF00018	0.651
LIG_SH3_3	244	250	PF00018	0.746
LIG_SH3_3	254	260	PF00018	0.719
LIG_SH3_3	283	289	PF00018	0.705
LIG_SH3_3	309	315	PF00018	0.596
LIG_SH3_3	360	366	PF00018	0.616
LIG_SH3_3	59	65	PF00018	0.761
LIG_SH3_4	106	113	PF00018	0.727
LIG_SH3_4	218	225	PF00018	0.787
LIG_SUMO_SIM_anti_2	25	32	PF11976	0.659
LIG_TRAF2_1	93	96	PF00917	0.795
LIG_TRFH_1	211	215	PF08558	0.601
MOD_CDK_SPK_2	217	222	PF00069	0.789
MOD_CK1_1	152	158	PF00069	0.775
MOD_CK1_1	164	170	PF00069	0.615
MOD_CK1_1	217	223	PF00069	0.727
MOD_CK1_1	23	29	PF00069	0.663
MOD_CK1_1	235	241	PF00069	0.738
MOD_CK1_1	99	105	PF00069	0.770
MOD_CK2_1	225	231	PF00069	0.709
MOD_GlcNHglycan	101	104	PF01048	0.786
MOD_GlcNHglycan	111	114	PF01048	0.707
MOD_GlcNHglycan	121	124	PF01048	0.733
MOD_GlcNHglycan	126	129	PF01048	0.638
MOD_GlcNHglycan	163	166	PF01048	0.742
MOD_GlcNHglycan	234	237	PF01048	0.723
MOD_GlcNHglycan	241	244	PF01048	0.716
MOD_GlcNHglycan	267	270	PF01048	0.775
MOD_GlcNHglycan	282	285	PF01048	0.607
MOD_GSK3_1	129	136	PF00069	0.684
MOD_GSK3_1	160	167	PF00069	0.705
MOD_GSK3_1	213	220	PF00069	0.683
MOD_GSK3_1	22	29	PF00069	0.679
MOD_GSK3_1	235	242	PF00069	0.663
MOD_GSK3_1	261	268	PF00069	0.652
MOD_GSK3_1	269	276	PF00069	0.602
MOD_GSK3_1	51	58	PF00069	0.726
MOD_GSK3_1	95	102	PF00069	0.731
MOD_N-GLC_1	238	243	PF02516	0.706
MOD_NEK2_1	1	6	PF00069	0.592
MOD_NEK2_1	225	230	PF00069	0.732
MOD_NEK2_1	232	237	PF00069	0.671
MOD_NEK2_1	274	279	PF00069	0.705
MOD_PIKK_1	249	255	PF00454	0.714
MOD_PKA_2	133	139	PF00069	0.573
MOD_PKA_2	225	231	PF00069	0.756
MOD_PKA_2	23	29	PF00069	0.663
MOD_Plk_1	191	197	PF00069	0.712
MOD_Plk_1	239	245	PF00069	0.701
MOD_Plk_1	26	32	PF00069	0.565
MOD_Plk_1	8	14	PF00069	0.681
MOD_Plk_4	26	32	PF00069	0.660
MOD_ProDKin_1	140	146	PF00069	0.702
MOD_ProDKin_1	217	223	PF00069	0.747
MOD_ProDKin_1	243	249	PF00069	0.805
MOD_ProDKin_1	256	262	PF00069	0.660
MOD_ProDKin_1	287	293	PF00069	0.712
MOD_ProDKin_1	58	64	PF00069	0.758
MOD_SUMO_rev_2	152	162	PF00179	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGN6	Leptomonas seymouri	55%	98%
A0A3Q8IEJ9	Leishmania donovani	100%	100%
A0A422NME0	Trypanosoma rangeli	29%	99%
A4HIU8	Leishmania braziliensis	75%	98%
C9ZRH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	96%
E9B1D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6S6	Leishmania major	94%	100%
V5BX10	Trypanosoma cruzi	26%	99%