LeishMANIAdb
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Putative serine/threonine-protein kinase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine-protein kinase
Gene product:
serine/threonine-protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4I649_LEIIN
TriTrypDb:
LINF_300041600
Length:
748

Annotations

Annotations by Jardim et al.

Protein kinase, serine/threonine- kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I649
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I649

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0000245 spliceosomal complex assembly 7 1
GO:0007165 signal transduction 2 1
GO:0016043 cellular component organization 3 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0035556 intracellular signal transduction 3 1
GO:0043933 protein-containing complex organization 4 1
GO:0050684 regulation of mRNA processing 7 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0065007 biological regulation 1 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903311 regulation of mRNA metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0004674 protein serine/threonine kinase activity 4 4
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 371 375 PF00656 0.714
CLV_C14_Caspase3-7 587 591 PF00656 0.613
CLV_C14_Caspase3-7 695 699 PF00656 0.623
CLV_NRD_NRD_1 143 145 PF00675 0.359
CLV_NRD_NRD_1 25 27 PF00675 0.595
CLV_NRD_NRD_1 338 340 PF00675 0.389
CLV_NRD_NRD_1 348 350 PF00675 0.405
CLV_PCSK_KEX2_1 25 27 PF00082 0.546
CLV_PCSK_KEX2_1 337 339 PF00082 0.408
CLV_PCSK_KEX2_1 609 611 PF00082 0.689
CLV_PCSK_PC1ET2_1 25 27 PF00082 0.546
CLV_PCSK_PC1ET2_1 609 611 PF00082 0.718
CLV_PCSK_SKI1_1 162 166 PF00082 0.248
CLV_PCSK_SKI1_1 26 30 PF00082 0.615
CLV_PCSK_SKI1_1 273 277 PF00082 0.229
CLV_PCSK_SKI1_1 330 334 PF00082 0.458
CLV_PCSK_SKI1_1 343 347 PF00082 0.472
CLV_PCSK_SKI1_1 350 354 PF00082 0.533
CLV_PCSK_SKI1_1 407 411 PF00082 0.215
CLV_PCSK_SKI1_1 500 504 PF00082 0.232
CLV_PCSK_SKI1_1 523 527 PF00082 0.304
CLV_PCSK_SKI1_1 641 645 PF00082 0.368
CLV_PCSK_SKI1_1 9 13 PF00082 0.704
DEG_APCC_DBOX_1 272 280 PF00400 0.229
DEG_SCF_FBW7_1 298 305 PF00400 0.308
DOC_ANK_TNKS_1 107 114 PF00023 0.617
DOC_CKS1_1 299 304 PF01111 0.308
DOC_CKS1_1 429 434 PF01111 0.207
DOC_MAPK_gen_1 183 191 PF00069 0.276
DOC_MAPK_gen_1 416 425 PF00069 0.215
DOC_MAPK_HePTP_8 413 425 PF00069 0.215
DOC_MAPK_MEF2A_6 416 425 PF00069 0.215
DOC_PP1_RVXF_1 163 170 PF00149 0.215
DOC_PP4_FxxP_1 30 33 PF00568 0.621
DOC_PP4_FxxP_1 313 316 PF00568 0.431
DOC_PP4_FxxP_1 531 534 PF00568 0.215
DOC_USP7_MATH_1 302 306 PF00917 0.385
DOC_USP7_MATH_1 33 37 PF00917 0.572
DOC_USP7_MATH_1 468 472 PF00917 0.364
DOC_USP7_MATH_1 608 612 PF00917 0.718
DOC_USP7_MATH_1 618 622 PF00917 0.564
DOC_USP7_UBL2_3 12 16 PF12436 0.584
DOC_USP7_UBL2_3 23 27 PF12436 0.622
DOC_USP7_UBL2_3 330 334 PF12436 0.421
DOC_USP7_UBL2_3 342 346 PF12436 0.378
DOC_USP7_UBL2_3 5 9 PF12436 0.592
DOC_USP7_UBL2_3 519 523 PF12436 0.228
DOC_USP7_UBL2_3 67 71 PF12436 0.468
DOC_WW_Pin1_4 298 303 PF00397 0.274
DOC_WW_Pin1_4 428 433 PF00397 0.217
DOC_WW_Pin1_4 542 547 PF00397 0.377
LIG_14-3-3_CanoR_1 321 329 PF00244 0.630
LIG_14-3-3_CanoR_1 349 353 PF00244 0.616
LIG_14-3-3_CanoR_1 671 680 PF00244 0.482
LIG_APCC_ABBA_1 244 249 PF00400 0.229
LIG_BRCT_BRCA1_1 620 624 PF00533 0.623
LIG_Clathr_ClatBox_1 276 280 PF01394 0.229
LIG_CtBP_PxDLS_1 478 482 PF00389 0.229
LIG_deltaCOP1_diTrp_1 383 391 PF00928 0.516
LIG_deltaCOP1_diTrp_1 434 443 PF00928 0.265
LIG_EH1_1 303 311 PF00400 0.354
LIG_eIF4E_1 203 209 PF01652 0.215
LIG_FHA_1 172 178 PF00498 0.215
LIG_FHA_1 32 38 PF00498 0.469
LIG_FHA_1 408 414 PF00498 0.215
LIG_FHA_1 675 681 PF00498 0.541
LIG_FHA_2 126 132 PF00498 0.567
LIG_FHA_2 133 139 PF00498 0.423
LIG_FHA_2 323 329 PF00498 0.609
LIG_FHA_2 380 386 PF00498 0.479
LIG_FHA_2 429 435 PF00498 0.217
LIG_FHA_2 587 593 PF00498 0.648
LIG_FHA_2 634 640 PF00498 0.458
LIG_FHA_2 642 648 PF00498 0.351
LIG_FHA_2 733 739 PF00498 0.608
LIG_Integrin_RGD_1 363 365 PF01839 0.612
LIG_LIR_Apic_2 415 421 PF02991 0.215
LIG_LIR_Apic_2 427 432 PF02991 0.215
LIG_LIR_Apic_2 530 534 PF02991 0.229
LIG_LIR_Gen_1 184 191 PF02991 0.229
LIG_LIR_Gen_1 200 209 PF02991 0.185
LIG_LIR_Gen_1 389 399 PF02991 0.308
LIG_LIR_Nem_3 159 164 PF02991 0.224
LIG_LIR_Nem_3 200 206 PF02991 0.242
LIG_LIR_Nem_3 259 263 PF02991 0.296
LIG_LIR_Nem_3 389 394 PF02991 0.419
LIG_LIR_Nem_3 485 491 PF02991 0.328
LIG_LIR_Nem_3 504 510 PF02991 0.159
LIG_LIR_Nem_3 554 559 PF02991 0.332
LIG_LIR_Nem_3 561 567 PF02991 0.354
LIG_MAD2 716 724 PF02301 0.508
LIG_MYND_3 533 537 PF01753 0.207
LIG_Pex14_2 172 176 PF04695 0.215
LIG_PTB_Apo_2 155 162 PF02174 0.369
LIG_PTB_Apo_2 631 638 PF02174 0.487
LIG_PTB_Phospho_1 155 161 PF10480 0.374
LIG_PTB_Phospho_1 631 637 PF10480 0.493
LIG_Rb_pABgroove_1 238 246 PF01858 0.276
LIG_SH2_CRK 161 165 PF00017 0.281
LIG_SH2_CRK 260 264 PF00017 0.215
LIG_SH2_CRK 341 345 PF00017 0.371
LIG_SH2_CRK 429 433 PF00017 0.207
LIG_SH2_CRK 564 568 PF00017 0.462
LIG_SH2_GRB2like 492 495 PF00017 0.298
LIG_SH2_NCK_1 198 202 PF00017 0.229
LIG_SH2_NCK_1 598 602 PF00017 0.662
LIG_SH2_SRC 203 206 PF00017 0.215
LIG_SH2_STAP1 132 136 PF00017 0.487
LIG_SH2_STAP1 198 202 PF00017 0.239
LIG_SH2_STAT5 171 174 PF00017 0.215
LIG_SH2_STAT5 229 232 PF00017 0.248
LIG_SH2_STAT5 637 640 PF00017 0.468
LIG_SUMO_SIM_anti_2 284 291 PF11976 0.229
LIG_SUMO_SIM_anti_2 305 311 PF11976 0.411
LIG_SUMO_SIM_anti_2 463 472 PF11976 0.215
LIG_SUMO_SIM_par_1 249 256 PF11976 0.215
LIG_SUMO_SIM_par_1 430 437 PF11976 0.207
LIG_TRAF2_1 345 348 PF00917 0.518
LIG_TRAF2_1 582 585 PF00917 0.616
LIG_TRAF2_1 736 739 PF00917 0.580
LIG_TYR_ITIM 505 510 PF00017 0.360
LIG_UBA3_1 306 311 PF00899 0.329
MOD_CDK_SPK_2 298 303 PF00069 0.229
MOD_CK1_1 194 200 PF00069 0.360
MOD_CK1_1 305 311 PF00069 0.447
MOD_CK1_1 35 41 PF00069 0.514
MOD_CK1_1 377 383 PF00069 0.638
MOD_CK1_1 402 408 PF00069 0.215
MOD_CK1_1 591 597 PF00069 0.612
MOD_CK1_1 600 606 PF00069 0.683
MOD_CK1_1 674 680 PF00069 0.508
MOD_CK2_1 106 112 PF00069 0.662
MOD_CK2_1 132 138 PF00069 0.474
MOD_CK2_1 194 200 PF00069 0.360
MOD_CK2_1 250 256 PF00069 0.232
MOD_CK2_1 379 385 PF00069 0.514
MOD_CK2_1 458 464 PF00069 0.253
MOD_CK2_1 571 577 PF00069 0.510
MOD_CK2_1 579 585 PF00069 0.594
MOD_CK2_1 633 639 PF00069 0.489
MOD_CK2_1 732 738 PF00069 0.605
MOD_CMANNOS 176 179 PF00535 0.215
MOD_Cter_Amidation 68 71 PF01082 0.495
MOD_GlcNHglycan 193 196 PF01048 0.215
MOD_GlcNHglycan 571 576 PF01048 0.558
MOD_GlcNHglycan 577 582 PF01048 0.603
MOD_GlcNHglycan 599 602 PF01048 0.638
MOD_GSK3_1 102 109 PF00069 0.669
MOD_GSK3_1 12 19 PF00069 0.693
MOD_GSK3_1 298 305 PF00069 0.343
MOD_GSK3_1 31 38 PF00069 0.558
MOD_GSK3_1 328 335 PF00069 0.469
MOD_GSK3_1 588 595 PF00069 0.630
MOD_GSK3_1 596 603 PF00069 0.628
MOD_GSK3_1 604 611 PF00069 0.601
MOD_GSK3_1 674 681 PF00069 0.514
MOD_GSK3_1 704 711 PF00069 0.673
MOD_N-GLC_1 235 240 PF02516 0.278
MOD_N-GLC_1 633 638 PF02516 0.484
MOD_N-GLC_2 220 222 PF02516 0.340
MOD_N-GLC_2 401 403 PF02516 0.215
MOD_NEK2_1 1 6 PF00069 0.690
MOD_NEK2_1 230 235 PF00069 0.253
MOD_NEK2_1 332 337 PF00069 0.394
MOD_NEK2_1 399 404 PF00069 0.215
MOD_NEK2_1 633 638 PF00069 0.484
MOD_NEK2_1 82 87 PF00069 0.536
MOD_PIKK_1 332 338 PF00454 0.409
MOD_PIKK_1 592 598 PF00454 0.567
MOD_PIKK_1 705 711 PF00454 0.715
MOD_PKA_1 16 22 PF00069 0.724
MOD_PKA_2 348 354 PF00069 0.623
MOD_PKA_2 41 47 PF00069 0.522
MOD_PKA_2 678 684 PF00069 0.630
MOD_Plk_1 633 639 PF00069 0.439
MOD_Plk_2-3 586 592 PF00069 0.766
MOD_Plk_2-3 733 739 PF00069 0.706
MOD_Plk_4 171 177 PF00069 0.215
MOD_Plk_4 250 256 PF00069 0.231
MOD_Plk_4 302 308 PF00069 0.376
MOD_Plk_4 348 354 PF00069 0.460
MOD_Plk_4 647 653 PF00069 0.514
MOD_ProDKin_1 298 304 PF00069 0.274
MOD_ProDKin_1 428 434 PF00069 0.217
MOD_ProDKin_1 542 548 PF00069 0.377
MOD_SUMO_for_1 292 295 PF00179 0.215
MOD_SUMO_for_1 345 348 PF00179 0.458
MOD_SUMO_rev_2 199 209 PF00179 0.233
MOD_SUMO_rev_2 286 294 PF00179 0.229
MOD_SUMO_rev_2 326 332 PF00179 0.440
MOD_SUMO_rev_2 347 352 PF00179 0.453
MOD_SUMO_rev_2 355 362 PF00179 0.501
MOD_SUMO_rev_2 55 63 PF00179 0.598
TRG_DiLeu_BaEn_1 348 353 PF01217 0.512
TRG_DiLeu_BaEn_1 668 673 PF01217 0.379
TRG_DiLeu_BaEn_2 526 532 PF01217 0.229
TRG_DiLeu_BaEn_4 628 634 PF01217 0.497
TRG_DiLeu_BaEn_4 675 681 PF01217 0.593
TRG_DiLeu_LyEn_5 668 673 PF01217 0.423
TRG_ENDOCYTIC_2 148 151 PF00928 0.297
TRG_ENDOCYTIC_2 161 164 PF00928 0.215
TRG_ENDOCYTIC_2 186 189 PF00928 0.242
TRG_ENDOCYTIC_2 203 206 PF00928 0.148
TRG_ENDOCYTIC_2 260 263 PF00928 0.265
TRG_ENDOCYTIC_2 341 344 PF00928 0.423
TRG_ENDOCYTIC_2 507 510 PF00928 0.360
TRG_ENDOCYTIC_2 564 567 PF00928 0.396
TRG_ER_diArg_1 337 339 PF00400 0.443
TRG_NLS_Bipartite_1 16 30 PF00514 0.636
TRG_NLS_MonoExtC_3 24 29 PF00514 0.619
TRG_NLS_MonoExtC_3 521 526 PF00514 0.273
TRG_NLS_MonoExtC_3 66 71 PF00514 0.613
TRG_NLS_MonoExtN_4 23 30 PF00514 0.621
TRG_NLS_MonoExtN_4 519 526 PF00514 0.273
TRG_NLS_MonoExtN_4 65 71 PF00514 0.693
TRG_Pf-PMV_PEXEL_1 207 211 PF00026 0.229
TRG_Pf-PMV_PEXEL_1 500 504 PF00026 0.229
TRG_Pf-PMV_PEXEL_1 671 675 PF00026 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1H8 Leptomonas seymouri 82% 100%
A0A0S4JMD1 Bodo saltans 55% 97%
A0A1X0P1B0 Trypanosomatidae 60% 100%
A0A3R7KF70 Trypanosoma rangeli 58% 100%
A0A3S7X404 Leishmania donovani 99% 100%
A4HIU4 Leishmania braziliensis 83% 100%
C9ZRG9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9B1D2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q6T0 Leishmania major 94% 100%
V5B752 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS