DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA ligase

Gene product:

DNA ligase I - putative

Species:

Leishmania infantum

UniProt:

A4I634_LEIIN

TriTrypDb:

LINF_300040100

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I634

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I634

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006281	DNA repair	5	12
GO:0006310	DNA recombination	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0071897	DNA biosynthetic process	5	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006266	DNA ligation	5	1
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006273	lagging strand elongation	7	1
GO:0022616	DNA strand elongation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003909	DNA ligase activity	4	12
GO:0003910	DNA ligase (ATP) activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016886	ligase activity, forming phosphoric ester bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.349
CLV_C14_Caspase3-7	452	456	PF00656	0.253
CLV_C14_Caspase3-7	469	473	PF00656	0.303
CLV_C14_Caspase3-7	503	507	PF00656	0.440
CLV_NRD_NRD_1	173	175	PF00675	0.243
CLV_NRD_NRD_1	397	399	PF00675	0.243
CLV_NRD_NRD_1	433	435	PF00675	0.244
CLV_PCSK_KEX2_1	172	174	PF00082	0.243
CLV_PCSK_KEX2_1	280	282	PF00082	0.435
CLV_PCSK_KEX2_1	433	435	PF00082	0.243
CLV_PCSK_KEX2_1	492	494	PF00082	0.243
CLV_PCSK_KEX2_1	525	527	PF00082	0.243
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.435
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.243
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.243
CLV_PCSK_PC7_1	168	174	PF00082	0.264
CLV_PCSK_SKI1_1	153	157	PF00082	0.338
CLV_PCSK_SKI1_1	179	183	PF00082	0.301
CLV_PCSK_SKI1_1	281	285	PF00082	0.448
CLV_PCSK_SKI1_1	315	319	PF00082	0.272
CLV_PCSK_SKI1_1	434	438	PF00082	0.256
CLV_PCSK_SKI1_1	61	65	PF00082	0.258
DOC_ANK_TNKS_1	467	474	PF00023	0.264
DOC_CDC14_PxL_1	251	259	PF14671	0.286
DOC_CYCLIN_RxL_1	173	184	PF00134	0.277
DOC_CYCLIN_yClb1_LxF_4	445	450	PF00134	0.308
DOC_MAPK_DCC_7	249	259	PF00069	0.290
DOC_MAPK_gen_1	280	288	PF00069	0.362
DOC_MAPK_gen_1	492	500	PF00069	0.243
DOC_MAPK_MEF2A_6	183	192	PF00069	0.258
DOC_MAPK_MEF2A_6	61	70	PF00069	0.277
DOC_PP1_RVXF_1	432	439	PF00149	0.419
DOC_PP1_RVXF_1	445	451	PF00149	0.419
DOC_PP1_RVXF_1	59	66	PF00149	0.345
DOC_USP7_MATH_1	163	167	PF00917	0.271
DOC_USP7_MATH_1	206	210	PF00917	0.258
DOC_USP7_MATH_1	274	278	PF00917	0.452
DOC_USP7_MATH_1	301	305	PF00917	0.417
DOC_USP7_MATH_1	32	36	PF00917	0.590
DOC_USP7_MATH_1	491	495	PF00917	0.258
DOC_USP7_MATH_1	52	56	PF00917	0.167
DOC_USP7_MATH_2	365	371	PF00917	0.264
DOC_USP7_UBL2_3	280	284	PF12436	0.427
DOC_WW_Pin1_4	486	491	PF00397	0.258
DOC_WW_Pin1_4	603	608	PF00397	0.243
LIG_14-3-3_CanoR_1	172	181	PF00244	0.382
LIG_Actin_WH2_2	411	429	PF00022	0.308
LIG_AP_GAE_1	7	13	PF02883	0.451
LIG_APCC_ABBA_1	378	383	PF00400	0.308
LIG_APCC_ABBAyCdc20_2	327	333	PF00400	0.370
LIG_BIR_II_1	1	5	PF00653	0.213
LIG_BIR_III_4	184	188	PF00653	0.243
LIG_CSL_BTD_1	19	22	PF09270	0.400
LIG_CtBP_PxDLS_1	75	79	PF00389	0.388
LIG_deltaCOP1_diTrp_1	587	596	PF00928	0.243
LIG_FHA_1	300	306	PF00498	0.243
LIG_FHA_1	382	388	PF00498	0.287
LIG_FHA_1	507	513	PF00498	0.349
LIG_FHA_1	562	568	PF00498	0.243
LIG_FHA_1	62	68	PF00498	0.345
LIG_FHA_2	12	18	PF00498	0.500
LIG_FHA_2	156	162	PF00498	0.370
LIG_FHA_2	240	246	PF00498	0.482
LIG_FHA_2	450	456	PF00498	0.314
LIG_FHA_2	462	468	PF00498	0.256
LIG_FHA_2	479	485	PF00498	0.185
LIG_GBD_Chelix_1	193	201	PF00786	0.258
LIG_LIR_Apic_2	17	23	PF02991	0.356
LIG_LIR_Gen_1	14	23	PF02991	0.492
LIG_LIR_Gen_1	494	505	PF02991	0.243
LIG_LIR_Gen_1	543	551	PF02991	0.246
LIG_LIR_Gen_1	64	71	PF02991	0.291
LIG_LIR_Nem_3	14	19	PF02991	0.345
LIG_LIR_Nem_3	154	159	PF02991	0.321
LIG_LIR_Nem_3	335	341	PF02991	0.278
LIG_LIR_Nem_3	349	355	PF02991	0.272
LIG_LIR_Nem_3	435	441	PF02991	0.295
LIG_LIR_Nem_3	449	453	PF02991	0.323
LIG_LIR_Nem_3	494	500	PF02991	0.243
LIG_LIR_Nem_3	527	533	PF02991	0.248
LIG_LIR_Nem_3	543	548	PF02991	0.288
LIG_LIR_Nem_3	64	68	PF02991	0.295
LIG_LIR_Nem_3	7	13	PF02991	0.386
LIG_LYPXL_yS_3	352	355	PF13949	0.243
LIG_NRBOX	235	241	PF00104	0.384
LIG_NRBOX	62	68	PF00104	0.388
LIG_Pex14_2	16	20	PF04695	0.388
LIG_Pex14_2	218	222	PF04695	0.426
LIG_SH2_CRK	545	549	PF00017	0.277
LIG_SH2_GRB2like	419	422	PF00017	0.243
LIG_SH2_NCK_1	252	256	PF00017	0.361
LIG_SH2_SRC	453	456	PF00017	0.307
LIG_SH2_STAP1	216	220	PF00017	0.256
LIG_SH2_STAP1	282	286	PF00017	0.361
LIG_SH2_STAT3	629	632	PF00017	0.308
LIG_SH2_STAT3	651	654	PF00017	0.394
LIG_SH2_STAT5	419	422	PF00017	0.290
LIG_SH2_STAT5	453	456	PF00017	0.272
LIG_SH2_STAT5	488	491	PF00017	0.243
LIG_SH2_STAT5	629	632	PF00017	0.388
LIG_SH2_STAT5	83	86	PF00017	0.243
LIG_SH3_2	290	295	PF14604	0.294
LIG_SH3_3	16	22	PF00018	0.449
LIG_SH3_3	23	29	PF00018	0.548
LIG_SH3_3	287	293	PF00018	0.421
LIG_SH3_3	359	365	PF00018	0.264
LIG_SH3_3	403	409	PF00018	0.240
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.370
LIG_SUMO_SIM_anti_2	302	310	PF11976	0.337
LIG_SUMO_SIM_anti_2	509	516	PF11976	0.303
LIG_SUMO_SIM_par_1	302	310	PF11976	0.396
LIG_SUMO_SIM_par_1	364	370	PF11976	0.242
LIG_SUMO_SIM_par_1	66	72	PF11976	0.308
LIG_TYR_ITIM	81	86	PF00017	0.258
LIG_UBA3_1	308	316	PF00899	0.388
LIG_WRC_WIRS_1	13	18	PF05994	0.483
LIG_WRC_WIRS_1	368	373	PF05994	0.258
LIG_WRC_WIRS_1	462	467	PF05994	0.279
LIG_WW_3	21	25	PF00397	0.463
MOD_CDK_SPxK_1	486	492	PF00069	0.258
MOD_CDK_SPxxK_3	486	493	PF00069	0.258
MOD_CK1_1	151	157	PF00069	0.308
MOD_CK1_1	303	309	PF00069	0.338
MOD_CK1_1	342	348	PF00069	0.258
MOD_CK1_1	449	455	PF00069	0.338
MOD_CK2_1	11	17	PF00069	0.387
MOD_CK2_1	155	161	PF00069	0.329
MOD_CK2_1	461	467	PF00069	0.332
MOD_CK2_1	478	484	PF00069	0.185
MOD_CK2_1	52	58	PF00069	0.243
MOD_Cter_Amidation	313	316	PF01082	0.388
MOD_Cter_Amidation	396	399	PF01082	0.243
MOD_Cter_Amidation	523	526	PF01082	0.365
MOD_GlcNHglycan	126	129	PF01048	0.308
MOD_GlcNHglycan	150	153	PF01048	0.272
MOD_GlcNHglycan	165	168	PF01048	0.221
MOD_GlcNHglycan	207	211	PF01048	0.277
MOD_GlcNHglycan	261	264	PF01048	0.474
MOD_GlcNHglycan	49	53	PF01048	0.243
MOD_GSK3_1	151	158	PF00069	0.308
MOD_GSK3_1	235	242	PF00069	0.463
MOD_GSK3_1	28	35	PF00069	0.602
MOD_GSK3_1	299	306	PF00069	0.277
MOD_GSK3_1	342	349	PF00069	0.281
MOD_GSK3_1	449	456	PF00069	0.394
MOD_GSK3_1	48	55	PF00069	0.243
MOD_N-GLC_1	426	431	PF02516	0.308
MOD_N-GLC_1	486	491	PF02516	0.264
MOD_NEK2_1	239	244	PF00069	0.419
MOD_NEK2_1	426	431	PF00069	0.288
MOD_NEK2_1	466	471	PF00069	0.261
MOD_NEK2_1	5	10	PF00069	0.425
MOD_NEK2_1	563	568	PF00069	0.345
MOD_PIKK_1	561	567	PF00454	0.302
MOD_PK_1	284	290	PF00069	0.408
MOD_PKA_1	172	178	PF00069	0.388
MOD_PKA_1	315	321	PF00069	0.337
MOD_PKA_2	124	130	PF00069	0.277
MOD_PKA_2	172	178	PF00069	0.388
MOD_PKA_2	342	348	PF00069	0.272
MOD_Plk_1	284	290	PF00069	0.363
MOD_Plk_1	404	410	PF00069	0.307
MOD_Plk_1	426	432	PF00069	0.308
MOD_Plk_1	466	472	PF00069	0.258
MOD_Plk_1	6	12	PF00069	0.467
MOD_Plk_1	601	607	PF00069	0.251
MOD_Plk_2-3	253	259	PF00069	0.342
MOD_Plk_2-3	461	467	PF00069	0.279
MOD_Plk_4	140	146	PF00069	0.243
MOD_Plk_4	235	241	PF00069	0.464
MOD_Plk_4	268	274	PF00069	0.474
MOD_Plk_4	367	373	PF00069	0.243
MOD_Plk_4	449	455	PF00069	0.273
MOD_Plk_4	461	467	PF00069	0.216
MOD_Plk_4	61	67	PF00069	0.357
MOD_ProDKin_1	486	492	PF00069	0.258
MOD_ProDKin_1	603	609	PF00069	0.243
MOD_SUMO_rev_2	592	601	PF00179	0.262
MOD_SUMO_rev_2	634	639	PF00179	0.408
TRG_DiLeu_BaEn_2	366	372	PF01217	0.308
TRG_DiLeu_BaEn_4	558	564	PF01217	0.388
TRG_ENDOCYTIC_2	159	162	PF00928	0.388
TRG_ENDOCYTIC_2	352	355	PF00928	0.271
TRG_ENDOCYTIC_2	545	548	PF00928	0.277
TRG_ENDOCYTIC_2	83	86	PF00928	0.243
TRG_ER_diArg_1	171	174	PF00400	0.246
TRG_ER_diArg_1	630	633	PF00400	0.258
TRG_NES_CRM1_1	58	72	PF08389	0.275
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	628	632	PF00026	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB08	Leptomonas seymouri	81%	87%
A0A0S4JHN9	Bodo saltans	63%	95%
A0A1X0P2U4	Trypanosomatidae	65%	94%
A0A3Q8II77	Leishmania donovani	100%	87%
A0A422NMG1	Trypanosoma rangeli	65%	96%
A0B7F9	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	100%
A0PTC0	Mycobacterium ulcerans (strain Agy99)	28%	100%
A0RWD6	Cenarchaeum symbiosum (strain A)	34%	100%
A1RTK4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	34%	100%
A1RXA6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	29%	100%
A1RY72	Thermofilum pendens (strain DSM 2475 / Hrk 5)	32%	100%
A2BJX6	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	34%	100%
A2SR38	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	28%	100%
A3CWP1	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	29%	100%
A3DP49	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	34%	100%
A3MS62	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	33%	100%
A4F870	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	25%	100%
A4FY19	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	26%	100%
A4HIT2	Leishmania braziliensis	91%	100%
A4TDS2	Mycolicibacterium gilvum (strain PYR-GCK)	27%	100%
A4WH24	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	33%	100%
A4YD25	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	32%	100%
A5UKX2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	28%	100%
A6UNY0	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	26%	100%
A6UVC4	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	26%	100%
A6VFQ9	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	26%	100%
A7IAA9	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	28%	100%
A8AB20	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	35%	100%
A8MDU6	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	32%	100%
A9A3K1	Nitrosopumilus maritimus (strain SCM1)	33%	100%
A9AAX4	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	25%	100%
B0R4C9	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	27%	100%
B1L3K8	Korarchaeum cryptofilum (strain OPF8)	27%	100%
B1L3V2	Korarchaeum cryptofilum (strain OPF8)	33%	100%
B1YA52	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	34%	100%
B2HHE1	Mycobacterium marinum (strain ATCC BAA-535 / M)	29%	100%
B5YD88	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	30%	100%
B6YTR4	Thermococcus onnurineus (strain NA1)	31%	100%
B8DZX8	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	29%	100%
B8GGB8	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	29%	100%
B9LUZ9	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	26%	100%
C0QSL7	Persephonella marina (strain DSM 14350 / EX-H1)	32%	100%
C3MJ14	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	33%	100%
C3MYD2	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	33%	100%
C3MZR1	Sulfolobus islandicus (strain M.16.27)	33%	100%
C3N834	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	33%	100%
C3NF77	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	33%	100%
C4KIZ2	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	33%	100%
C9ZRF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	89%
D2CJS7	Sulfophobococcus zilligii	34%	100%
D4GYZ4	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	27%	100%
E9B1B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
G3GTP0	Cricetulus griseus	24%	73%
O29632	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O59288	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O67398	Aquifex aeolicus (strain VF5)	33%	100%
O93723	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	100%
P04819	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	88%
P0CL74	Pyrococcus abyssi	30%	100%
P0CL75	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
P12000	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	87%
P18858	Homo sapiens	44%	73%
P37913	Mus musculus	44%	73%
P49917	Homo sapiens	25%	73%
P54875	Methanothermobacter thermautotrophicus	27%	100%
P56709	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q02093	Acidianus ambivalens	33%	100%
Q0W0X1	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	29%	100%
Q12X08	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	28%	100%
Q18GX5	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	27%	100%
Q18HT7	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	26%	100%
Q1II25	Koribacter versatilis (strain Ellin345)	27%	100%
Q27474	Caenorhabditis elegans	43%	86%
Q2FTH4	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	28%	100%
Q2NHF9	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	26%	100%
Q3IPX0	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	28%	100%
Q42572	Arabidopsis thaliana	45%	84%
Q46BA3	Methanosarcina barkeri (strain Fusaro / DSM 804)	27%	100%
Q46C04	Methanosarcina barkeri (strain Fusaro / DSM 804)	30%	100%
Q4JAM1	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	32%	100%
Q4Q6U5	Leishmania major	97%	100%
Q50566	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
Q57635	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q5R6L3	Pongo abelii	24%	73%
Q5V4R0	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	26%	100%
Q6L195	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	32%	100%
Q6LYM1	Methanococcus maripaludis (strain S2 / LL)	26%	100%
Q74M64	Nanoarchaeum equitans (strain Kin4-M)	27%	100%
Q75CA4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	68%
Q8BTF7	Mus musculus	24%	73%
Q8PTK1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	28%	100%
Q8PVR7	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	30%	100%
Q8TMT1	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	28%	100%
Q8TSR7	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	31%	100%
Q8TWN3	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	30%	100%
Q976G4	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	32%	100%
Q979A1	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	32%	100%
Q980T8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	33%	100%
Q9C1W9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	86%
Q9HH07	Thermococcus fumicolans	30%	100%
Q9HHC4	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	100%
Q9HJ26	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	32%	100%
Q9HR35	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	27%	100%
Q9JHY8	Rattus norvegicus	43%	73%
Q9P9K9	Saccharolobus shibatae	33%	100%
Q9W1H4	Drosophila melanogaster	42%	89%
Q9YD18	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
V5BSC7	Trypanosoma cruzi	66%	95%