LeishMANIAdb
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XPG_I_2 domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
XPG_I_2 domain-containing protein
Gene product:
protein mkt1 - putative
Species:
Leishmania infantum
UniProt:
A4I633_LEIIN
TriTrypDb:
LINF_300040000
Length:
799

Annotations

Annotations by Jardim et al.

DNA repair, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I633
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I633

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 12
GO:0009889 regulation of biosynthetic process 4 12
GO:0010468 regulation of gene expression 5 12
GO:0010556 regulation of macromolecule biosynthetic process 5 12
GO:0010608 post-transcriptional regulation of gene expression 6 12
GO:0019222 regulation of metabolic process 3 12
GO:0031323 regulation of cellular metabolic process 4 12
GO:0031326 regulation of cellular biosynthetic process 5 12
GO:0034248 regulation of amide metabolic process 5 12
GO:0050789 regulation of biological process 2 12
GO:0050794 regulation of cellular process 3 12
GO:0051171 regulation of nitrogen compound metabolic process 4 12
GO:0051246 regulation of protein metabolic process 5 12
GO:0060255 regulation of macromolecule metabolic process 4 12
GO:0065007 biological regulation 1 12
GO:0080090 regulation of primary metabolic process 4 12
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004518 nuclease activity 4 1
GO:0004519 endonuclease activity 5 1
GO:0004520 DNA endonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0017108 5'-flap endonuclease activity 7 1
GO:0048256 flap endonuclease activity 6 1
GO:0140097 catalytic activity, acting on DNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 285 289 PF00656 0.594
CLV_C14_Caspase3-7 457 461 PF00656 0.366
CLV_NRD_NRD_1 166 168 PF00675 0.354
CLV_NRD_NRD_1 241 243 PF00675 0.330
CLV_NRD_NRD_1 270 272 PF00675 0.386
CLV_NRD_NRD_1 305 307 PF00675 0.348
CLV_NRD_NRD_1 33 35 PF00675 0.300
CLV_NRD_NRD_1 333 335 PF00675 0.334
CLV_NRD_NRD_1 384 386 PF00675 0.503
CLV_NRD_NRD_1 86 88 PF00675 0.380
CLV_PCSK_FUR_1 331 335 PF00082 0.424
CLV_PCSK_KEX2_1 240 242 PF00082 0.362
CLV_PCSK_KEX2_1 270 272 PF00082 0.386
CLV_PCSK_KEX2_1 305 307 PF00082 0.351
CLV_PCSK_KEX2_1 33 35 PF00082 0.300
CLV_PCSK_KEX2_1 333 335 PF00082 0.334
CLV_PCSK_KEX2_1 384 386 PF00082 0.503
CLV_PCSK_PC7_1 266 272 PF00082 0.389
CLV_PCSK_SKI1_1 101 105 PF00082 0.323
CLV_PCSK_SKI1_1 215 219 PF00082 0.273
CLV_PCSK_SKI1_1 25 29 PF00082 0.415
CLV_PCSK_SKI1_1 301 305 PF00082 0.360
CLV_PCSK_SKI1_1 338 342 PF00082 0.309
CLV_Separin_Metazoa 540 544 PF03568 0.323
CLV_Separin_Metazoa 84 88 PF03568 0.579
DEG_APCC_DBOX_1 304 312 PF00400 0.540
DOC_CYCLIN_yCln2_LP_2 359 365 PF00134 0.450
DOC_MAPK_DCC_7 385 395 PF00069 0.323
DOC_MAPK_DCC_7 435 444 PF00069 0.313
DOC_MAPK_FxFP_2 640 643 PF00069 0.323
DOC_MAPK_MEF2A_6 435 444 PF00069 0.313
DOC_MAPK_MEF2A_6 724 731 PF00069 0.389
DOC_PP1_RVXF_1 494 501 PF00149 0.313
DOC_PP2B_LxvP_1 311 314 PF13499 0.493
DOC_PP2B_LxvP_1 359 362 PF13499 0.445
DOC_PP4_FxxP_1 190 193 PF00568 0.503
DOC_PP4_FxxP_1 341 344 PF00568 0.497
DOC_PP4_FxxP_1 526 529 PF00568 0.323
DOC_PP4_FxxP_1 640 643 PF00568 0.237
DOC_SPAK_OSR1_1 154 158 PF12202 0.495
DOC_USP7_MATH_1 364 368 PF00917 0.297
DOC_USP7_MATH_1 386 390 PF00917 0.323
DOC_USP7_MATH_1 406 410 PF00917 0.342
DOC_USP7_MATH_1 511 515 PF00917 0.342
DOC_USP7_MATH_2 125 131 PF00917 0.594
DOC_USP7_UBL2_3 21 25 PF12436 0.506
DOC_WW_Pin1_4 118 123 PF00397 0.637
DOC_WW_Pin1_4 340 345 PF00397 0.481
DOC_WW_Pin1_4 68 73 PF00397 0.478
LIG_14-3-3_CanoR_1 295 303 PF00244 0.516
LIG_14-3-3_CanoR_1 622 627 PF00244 0.350
LIG_AP_GAE_1 249 255 PF02883 0.554
LIG_BRCT_BRCA1_1 187 191 PF00533 0.516
LIG_BRCT_BRCA1_1 198 202 PF00533 0.538
LIG_BRCT_BRCA1_1 41 45 PF00533 0.573
LIG_BRCT_BRCA1_1 496 500 PF00533 0.321
LIG_BRCT_BRCA1_1 585 589 PF00533 0.345
LIG_BRCT_BRCA1_1 599 603 PF00533 0.272
LIG_BRCT_BRCA1_1 646 650 PF00533 0.309
LIG_deltaCOP1_diTrp_1 410 420 PF00928 0.303
LIG_EH1_1 610 618 PF00400 0.342
LIG_FHA_1 439 445 PF00498 0.362
LIG_FHA_1 465 471 PF00498 0.324
LIG_FHA_1 542 548 PF00498 0.240
LIG_FHA_1 59 65 PF00498 0.543
LIG_FHA_1 604 610 PF00498 0.304
LIG_FHA_1 651 657 PF00498 0.323
LIG_FHA_1 734 740 PF00498 0.394
LIG_FHA_1 81 87 PF00498 0.553
LIG_FHA_2 216 222 PF00498 0.528
LIG_FHA_2 271 277 PF00498 0.608
LIG_FHA_2 283 289 PF00498 0.441
LIG_FHA_2 528 534 PF00498 0.245
LIG_FHA_2 544 550 PF00498 0.205
LIG_FHA_2 660 666 PF00498 0.323
LIG_FHA_2 667 673 PF00498 0.261
LIG_LIR_Apic_2 188 193 PF02991 0.493
LIG_LIR_Apic_2 524 529 PF02991 0.323
LIG_LIR_Gen_1 226 235 PF02991 0.482
LIG_LIR_Gen_1 249 258 PF02991 0.550
LIG_LIR_Gen_1 272 281 PF02991 0.517
LIG_LIR_Gen_1 625 635 PF02991 0.329
LIG_LIR_Gen_1 688 699 PF02991 0.323
LIG_LIR_Gen_1 704 713 PF02991 0.248
LIG_LIR_Gen_1 74 82 PF02991 0.479
LIG_LIR_LC3C_4 549 554 PF02991 0.323
LIG_LIR_Nem_3 130 134 PF02991 0.577
LIG_LIR_Nem_3 199 205 PF02991 0.477
LIG_LIR_Nem_3 226 230 PF02991 0.474
LIG_LIR_Nem_3 249 255 PF02991 0.554
LIG_LIR_Nem_3 272 277 PF02991 0.546
LIG_LIR_Nem_3 373 378 PF02991 0.258
LIG_LIR_Nem_3 408 414 PF02991 0.258
LIG_LIR_Nem_3 443 449 PF02991 0.367
LIG_LIR_Nem_3 497 503 PF02991 0.321
LIG_LIR_Nem_3 532 537 PF02991 0.227
LIG_LIR_Nem_3 625 631 PF02991 0.304
LIG_LIR_Nem_3 682 687 PF02991 0.283
LIG_LIR_Nem_3 688 694 PF02991 0.270
LIG_LIR_Nem_3 70 76 PF02991 0.481
LIG_LIR_Nem_3 704 708 PF02991 0.237
LIG_MLH1_MIPbox_1 187 191 PF16413 0.541
LIG_PCNA_yPIPBox_3 484 494 PF02747 0.361
LIG_Pex14_1 413 417 PF04695 0.237
LIG_Pex14_1 585 589 PF04695 0.323
LIG_Pex14_2 100 104 PF04695 0.541
LIG_Pex14_2 151 155 PF04695 0.578
LIG_Pex14_2 349 353 PF04695 0.436
LIG_Pex14_2 500 504 PF04695 0.323
LIG_Pex14_2 642 646 PF04695 0.323
LIG_Pex14_2 687 691 PF04695 0.323
LIG_Pex14_2 730 734 PF04695 0.351
LIG_SH2_CRK 483 487 PF00017 0.350
LIG_SH2_CRK 534 538 PF00017 0.261
LIG_SH2_CRK 705 709 PF00017 0.342
LIG_SH2_CRK 76 80 PF00017 0.505
LIG_SH2_CRK 793 797 PF00017 0.526
LIG_SH2_NCK_1 705 709 PF00017 0.342
LIG_SH2_NCK_1 76 80 PF00017 0.514
LIG_SH2_SRC 699 702 PF00017 0.323
LIG_SH2_SRC 793 796 PF00017 0.520
LIG_SH2_STAP1 243 247 PF00017 0.579
LIG_SH2_STAP1 82 86 PF00017 0.554
LIG_SH2_STAT5 181 184 PF00017 0.456
LIG_SH2_STAT5 351 354 PF00017 0.346
LIG_SH2_STAT5 417 420 PF00017 0.390
LIG_SH2_STAT5 465 468 PF00017 0.343
LIG_SH2_STAT5 494 497 PF00017 0.292
LIG_SH2_STAT5 503 506 PF00017 0.194
LIG_SH2_STAT5 519 522 PF00017 0.106
LIG_SH2_STAT5 654 657 PF00017 0.248
LIG_SH2_STAT5 76 79 PF00017 0.501
LIG_SH2_STAT5 82 85 PF00017 0.509
LIG_SH2_STAT5 92 95 PF00017 0.565
LIG_SH3_2 281 286 PF14604 0.607
LIG_SH3_3 119 125 PF00018 0.617
LIG_SH3_3 278 284 PF00018 0.593
LIG_SH3_3 354 360 PF00018 0.367
LIG_SH3_3 400 406 PF00018 0.342
LIG_SH3_3 474 480 PF00018 0.396
LIG_SH3_3 57 63 PF00018 0.563
LIG_SH3_3 578 584 PF00018 0.252
LIG_SH3_3 585 591 PF00018 0.243
LIG_SH3_3 749 755 PF00018 0.539
LIG_SH3_3 756 762 PF00018 0.529
LIG_SUMO_SIM_anti_2 204 209 PF11976 0.550
LIG_SUMO_SIM_anti_2 549 556 PF11976 0.323
LIG_SUMO_SIM_par_1 535 540 PF11976 0.233
LIG_SUMO_SIM_par_1 61 68 PF11976 0.564
LIG_SxIP_EBH_1 572 583 PF03271 0.248
LIG_TRAF2_1 156 159 PF00917 0.571
LIG_TRAF2_1 662 665 PF00917 0.323
LIG_TRFH_1 399 403 PF08558 0.436
LIG_TYR_ITIM 481 486 PF00017 0.414
LIG_TYR_ITIM 703 708 PF00017 0.436
LIG_UBA3_1 401 407 PF00899 0.409
LIG_WRC_WIRS_1 13 18 PF05994 0.526
LIG_WRC_WIRS_1 446 451 PF05994 0.499
LIG_WRC_WIRS_1 469 474 PF05994 0.483
LIG_WW_3 794 798 PF00397 0.711
MOD_CK1_1 15 21 PF00069 0.536
MOD_CK1_1 185 191 PF00069 0.409
MOD_CK1_1 231 237 PF00069 0.509
MOD_CK1_1 5 11 PF00069 0.646
MOD_CK1_1 514 520 PF00069 0.288
MOD_CK1_1 74 80 PF00069 0.473
MOD_CK2_1 445 451 PF00069 0.439
MOD_CK2_1 527 533 PF00069 0.289
MOD_CK2_1 659 665 PF00069 0.409
MOD_CK2_1 666 672 PF00069 0.369
MOD_GlcNHglycan 131 134 PF01048 0.483
MOD_GlcNHglycan 187 190 PF01048 0.339
MOD_GlcNHglycan 249 255 PF01048 0.487
MOD_GlcNHglycan 354 357 PF01048 0.349
MOD_GlcNHglycan 379 383 PF01048 0.409
MOD_GlcNHglycan 512 516 PF01048 0.345
MOD_GlcNHglycan 585 588 PF01048 0.303
MOD_GlcNHglycan 645 649 PF01048 0.349
MOD_GlcNHglycan 73 76 PF01048 0.469
MOD_GSK3_1 191 198 PF00069 0.505
MOD_GSK3_1 35 42 PF00069 0.530
MOD_GSK3_1 434 441 PF00069 0.492
MOD_GSK3_1 464 471 PF00069 0.450
MOD_GSK3_1 482 489 PF00069 0.168
MOD_GSK3_1 5 12 PF00069 0.637
MOD_GSK3_1 510 517 PF00069 0.334
MOD_GSK3_1 568 575 PF00069 0.299
MOD_GSK3_1 58 65 PF00069 0.451
MOD_GSK3_1 597 604 PF00069 0.346
MOD_GSK3_1 67 74 PF00069 0.156
MOD_GSK3_1 675 682 PF00069 0.409
MOD_GSK3_1 781 788 PF00069 0.497
MOD_N-GLC_1 136 141 PF02516 0.456
MOD_N-GLC_2 107 109 PF02516 0.457
MOD_N-GLC_2 580 582 PF02516 0.436
MOD_NEK2_1 182 187 PF00069 0.362
MOD_NEK2_1 257 262 PF00069 0.418
MOD_NEK2_1 352 357 PF00069 0.409
MOD_NEK2_1 377 382 PF00069 0.305
MOD_NEK2_1 454 459 PF00069 0.533
MOD_NEK2_1 541 546 PF00069 0.279
MOD_NEK2_1 603 608 PF00069 0.353
MOD_NEK2_1 650 655 PF00069 0.382
MOD_NEK2_1 666 671 PF00069 0.409
MOD_NEK2_1 67 72 PF00069 0.452
MOD_NEK2_1 9 14 PF00069 0.494
MOD_NEK2_2 173 178 PF00069 0.499
MOD_NEK2_2 324 329 PF00069 0.474
MOD_PIKK_1 182 188 PF00454 0.410
MOD_PIKK_1 364 370 PF00454 0.346
MOD_PIKK_1 426 432 PF00454 0.620
MOD_PK_1 572 578 PF00069 0.289
MOD_PKA_1 270 276 PF00069 0.498
MOD_PKA_2 270 276 PF00069 0.534
MOD_PKA_2 294 300 PF00069 0.472
MOD_PKA_2 621 627 PF00069 0.414
MOD_Plk_1 136 142 PF00069 0.420
MOD_Plk_1 173 179 PF00069 0.493
MOD_Plk_1 250 256 PF00069 0.446
MOD_Plk_1 378 384 PF00069 0.409
MOD_Plk_1 559 565 PF00069 0.429
MOD_Plk_2-3 223 229 PF00069 0.469
MOD_Plk_2-3 527 533 PF00069 0.409
MOD_Plk_2-3 701 707 PF00069 0.409
MOD_Plk_4 12 18 PF00069 0.429
MOD_Plk_4 231 237 PF00069 0.483
MOD_Plk_4 386 392 PF00069 0.312
MOD_Plk_4 39 45 PF00069 0.495
MOD_Plk_4 514 520 PF00069 0.361
MOD_Plk_4 572 578 PF00069 0.289
MOD_Plk_4 62 68 PF00069 0.442
MOD_Plk_4 650 656 PF00069 0.386
MOD_Plk_4 679 685 PF00069 0.322
MOD_Plk_4 74 80 PF00069 0.399
MOD_ProDKin_1 118 124 PF00069 0.567
MOD_ProDKin_1 340 346 PF00069 0.351
MOD_ProDKin_1 68 74 PF00069 0.343
MOD_SUMO_rev_2 15 22 PF00179 0.417
MOD_SUMO_rev_2 297 303 PF00179 0.498
MOD_SUMO_rev_2 97 103 PF00179 0.466
TRG_DiLeu_BaEn_1 298 303 PF01217 0.518
TRG_DiLeu_BaEn_1 533 538 PF01217 0.289
TRG_DiLeu_BaLyEn_6 354 359 PF01217 0.436
TRG_DiLeu_BaLyEn_6 373 378 PF01217 0.409
TRG_ENDOCYTIC_2 351 354 PF00928 0.294
TRG_ENDOCYTIC_2 417 420 PF00928 0.417
TRG_ENDOCYTIC_2 446 449 PF00928 0.461
TRG_ENDOCYTIC_2 483 486 PF00928 0.383
TRG_ENDOCYTIC_2 534 537 PF00928 0.289
TRG_ENDOCYTIC_2 705 708 PF00928 0.418
TRG_ENDOCYTIC_2 76 79 PF00928 0.338
TRG_ENDOCYTIC_2 82 85 PF00928 0.333
TRG_ER_diArg_1 239 242 PF00400 0.493
TRG_ER_diArg_1 304 306 PF00400 0.472
TRG_ER_diArg_1 32 34 PF00400 0.397
TRG_ER_diArg_1 331 334 PF00400 0.505
TRG_ER_diArg_1 383 385 PF00400 0.382
TRG_NES_CRM1_1 679 692 PF08389 0.409
TRG_Pf-PMV_PEXEL_1 167 171 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 49 53 PF00026 0.477
TRG_Pf-PMV_PEXEL_1 608 612 PF00026 0.291
TRG_Pf-PMV_PEXEL_1 715 720 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 87 91 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P424 Leptomonas seymouri 76% 99%
A0A0S4JHW4 Bodo saltans 30% 100%
A0A1X0P1K6 Trypanosomatidae 37% 100%
A0A3Q8IF24 Leishmania donovani 100% 100%
A0A3R7MIQ4 Trypanosoma rangeli 37% 100%
A4HIT1 Leishmania braziliensis 95% 100%
C9ZRF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9B1B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q4Q6U6 Leishmania major 98% 100%
Q587E3 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 37% 100%
V5BX20 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS