XPG_I_2 domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein mkt1 - putative

Species:

Leishmania infantum

UniProt:

A4I633_LEIIN

TriTrypDb:

LINF_300040000

Length:

799

Annotations

Annotations by Jardim et al.

DNA repair, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I633

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I633

Function

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Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0010608	post-transcriptional regulation of gene expression	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0034248	regulation of amide metabolic process	5	12
GO:0050789	regulation of biological process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0017108	5'-flap endonuclease activity	7	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.594
CLV_C14_Caspase3-7	457	461	PF00656	0.366
CLV_NRD_NRD_1	166	168	PF00675	0.354
CLV_NRD_NRD_1	241	243	PF00675	0.330
CLV_NRD_NRD_1	270	272	PF00675	0.386
CLV_NRD_NRD_1	305	307	PF00675	0.348
CLV_NRD_NRD_1	33	35	PF00675	0.300
CLV_NRD_NRD_1	333	335	PF00675	0.334
CLV_NRD_NRD_1	384	386	PF00675	0.503
CLV_NRD_NRD_1	86	88	PF00675	0.380

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P424	Leptomonas seymouri	76%	99%
A0A0S4JHW4	Bodo saltans	30%	100%
A0A1X0P1K6	Trypanosomatidae	37%	100%
A0A3Q8IF24	Leishmania donovani	100%	100%
A0A3R7MIQ4	Trypanosoma rangeli	37%	100%
A4HIT1	Leishmania braziliensis	95%	100%
C9ZRF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q6U6	Leishmania major	98%	100%
Q587E3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	37%	100%

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