LeishMANIAdb
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Reverse transcriptase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Reverse transcriptase domain-containing protein
Gene product:
T-complex protein 11 - putative
Species:
Leishmania infantum
UniProt:
A4I632_LEIIN
TriTrypDb:
LINF_300039900
Length:
875

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, T-complex 11, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I632
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I632

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 1
GO:0009987 cellular process 1 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 5 9 PF00656 0.676
CLV_C14_Caspase3-7 744 748 PF00656 0.491
CLV_NRD_NRD_1 135 137 PF00675 0.594
CLV_NRD_NRD_1 171 173 PF00675 0.803
CLV_NRD_NRD_1 284 286 PF00675 0.539
CLV_NRD_NRD_1 318 320 PF00675 0.544
CLV_NRD_NRD_1 377 379 PF00675 0.736
CLV_NRD_NRD_1 403 405 PF00675 0.554
CLV_NRD_NRD_1 406 408 PF00675 0.524
CLV_NRD_NRD_1 608 610 PF00675 0.420
CLV_NRD_NRD_1 647 649 PF00675 0.415
CLV_NRD_NRD_1 713 715 PF00675 0.449
CLV_NRD_NRD_1 810 812 PF00675 0.475
CLV_NRD_NRD_1 94 96 PF00675 0.460
CLV_PCSK_FUR_1 404 408 PF00082 0.605
CLV_PCSK_KEX2_1 123 125 PF00082 0.664
CLV_PCSK_KEX2_1 135 137 PF00082 0.522
CLV_PCSK_KEX2_1 232 234 PF00082 0.576
CLV_PCSK_KEX2_1 294 296 PF00082 0.596
CLV_PCSK_KEX2_1 317 319 PF00082 0.560
CLV_PCSK_KEX2_1 376 378 PF00082 0.740
CLV_PCSK_KEX2_1 405 407 PF00082 0.531
CLV_PCSK_KEX2_1 465 467 PF00082 0.462
CLV_PCSK_KEX2_1 647 649 PF00082 0.413
CLV_PCSK_KEX2_1 713 715 PF00082 0.449
CLV_PCSK_KEX2_1 810 812 PF00082 0.363
CLV_PCSK_KEX2_1 93 95 PF00082 0.483
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.644
CLV_PCSK_PC1ET2_1 232 234 PF00082 0.498
CLV_PCSK_PC1ET2_1 294 296 PF00082 0.596
CLV_PCSK_PC1ET2_1 317 319 PF00082 0.560
CLV_PCSK_PC1ET2_1 405 407 PF00082 0.616
CLV_PCSK_PC1ET2_1 465 467 PF00082 0.242
CLV_PCSK_SKI1_1 135 139 PF00082 0.592
CLV_PCSK_SKI1_1 191 195 PF00082 0.503
CLV_PCSK_SKI1_1 198 202 PF00082 0.524
CLV_PCSK_SKI1_1 20 24 PF00082 0.476
CLV_PCSK_SKI1_1 229 233 PF00082 0.493
CLV_PCSK_SKI1_1 261 265 PF00082 0.594
CLV_PCSK_SKI1_1 294 298 PF00082 0.542
CLV_PCSK_SKI1_1 413 417 PF00082 0.473
CLV_PCSK_SKI1_1 465 469 PF00082 0.368
CLV_PCSK_SKI1_1 533 537 PF00082 0.470
CLV_PCSK_SKI1_1 626 630 PF00082 0.453
CLV_PCSK_SKI1_1 650 654 PF00082 0.385
CLV_PCSK_SKI1_1 714 718 PF00082 0.413
CLV_PCSK_SKI1_1 810 814 PF00082 0.365
CLV_PCSK_SKI1_1 845 849 PF00082 0.353
CLV_PCSK_SKI1_1 860 864 PF00082 0.294
DEG_APCC_DBOX_1 809 817 PF00400 0.475
DEG_APCC_DBOX_1 859 867 PF00400 0.449
DEG_APCC_DBOX_1 92 100 PF00400 0.455
DEG_Nend_Nbox_1 1 3 PF02207 0.500
DEG_SCF_FBW7_1 54 60 PF00400 0.518
DEG_SPOP_SBC_1 361 365 PF00917 0.783
DOC_CKS1_1 334 339 PF01111 0.779
DOC_CKS1_1 54 59 PF01111 0.594
DOC_CYCLIN_RxL_1 188 195 PF00134 0.508
DOC_MAPK_DCC_7 822 832 PF00069 0.417
DOC_MAPK_DCC_7 860 868 PF00069 0.572
DOC_MAPK_gen_1 123 131 PF00069 0.735
DOC_MAPK_gen_1 465 473 PF00069 0.417
DOC_MAPK_gen_1 609 617 PF00069 0.470
DOC_MAPK_gen_1 647 655 PF00069 0.385
DOC_MAPK_gen_1 90 99 PF00069 0.449
DOC_MAPK_MEF2A_6 860 868 PF00069 0.572
DOC_MAPK_RevD_3 699 714 PF00069 0.417
DOC_PP1_RVXF_1 624 631 PF00149 0.454
DOC_PP1_RVXF_1 682 689 PF00149 0.344
DOC_PP1_RVXF_1 809 816 PF00149 0.344
DOC_PP2B_LxvP_1 55 58 PF13499 0.606
DOC_PP2B_LxvP_1 605 608 PF13499 0.475
DOC_USP7_MATH_1 236 240 PF00917 0.676
DOC_USP7_MATH_1 325 329 PF00917 0.597
DOC_USP7_MATH_1 361 365 PF00917 0.743
DOC_USP7_MATH_1 369 373 PF00917 0.721
DOC_USP7_MATH_1 539 543 PF00917 0.458
DOC_USP7_MATH_1 638 642 PF00917 0.350
DOC_USP7_MATH_1 706 710 PF00917 0.477
DOC_USP7_MATH_1 719 723 PF00917 0.389
DOC_WW_Pin1_4 164 169 PF00397 0.776
DOC_WW_Pin1_4 173 178 PF00397 0.665
DOC_WW_Pin1_4 203 208 PF00397 0.570
DOC_WW_Pin1_4 242 247 PF00397 0.773
DOC_WW_Pin1_4 326 331 PF00397 0.693
DOC_WW_Pin1_4 333 338 PF00397 0.736
DOC_WW_Pin1_4 362 367 PF00397 0.732
DOC_WW_Pin1_4 457 462 PF00397 0.413
DOC_WW_Pin1_4 527 532 PF00397 0.449
DOC_WW_Pin1_4 53 58 PF00397 0.547
DOC_WW_Pin1_4 549 554 PF00397 0.363
LIG_14-3-3_CanoR_1 135 140 PF00244 0.601
LIG_14-3-3_CanoR_1 274 278 PF00244 0.521
LIG_14-3-3_CanoR_1 28 38 PF00244 0.608
LIG_14-3-3_CanoR_1 295 301 PF00244 0.515
LIG_14-3-3_CanoR_1 306 313 PF00244 0.402
LIG_14-3-3_CanoR_1 540 548 PF00244 0.443
LIG_14-3-3_CanoR_1 609 618 PF00244 0.466
LIG_14-3-3_CanoR_1 665 670 PF00244 0.359
LIG_14-3-3_CanoR_1 726 736 PF00244 0.418
LIG_14-3-3_CanoR_1 822 830 PF00244 0.398
LIG_Actin_WH2_2 646 664 PF00022 0.354
LIG_Actin_WH2_2 733 748 PF00022 0.389
LIG_Actin_WH2_2 92 107 PF00022 0.399
LIG_BIR_III_4 8 12 PF00653 0.647
LIG_BRCT_BRCA1_1 613 617 PF00533 0.344
LIG_Clathr_ClatBox_1 700 704 PF01394 0.449
LIG_DCNL_PONY_1 1 4 PF03556 0.445
LIG_EVH1_2 676 680 PF00568 0.449
LIG_FHA_1 141 147 PF00498 0.513
LIG_FHA_1 165 171 PF00498 0.564
LIG_FHA_1 295 301 PF00498 0.531
LIG_FHA_1 327 333 PF00498 0.723
LIG_FHA_1 355 361 PF00498 0.785
LIG_FHA_1 550 556 PF00498 0.430
LIG_FHA_1 610 616 PF00498 0.355
LIG_FHA_1 655 661 PF00498 0.492
LIG_FHA_1 696 702 PF00498 0.395
LIG_FHA_1 822 828 PF00498 0.383
LIG_FHA_1 832 838 PF00498 0.290
LIG_FHA_1 869 875 PF00498 0.657
LIG_FHA_2 274 280 PF00498 0.547
LIG_FHA_2 3 9 PF00498 0.693
LIG_FHA_2 307 313 PF00498 0.482
LIG_FHA_2 345 351 PF00498 0.701
LIG_FHA_2 427 433 PF00498 0.651
LIG_FHA_2 444 450 PF00498 0.432
LIG_FHA_2 641 647 PF00498 0.344
LIG_FHA_2 665 671 PF00498 0.449
LIG_FHA_2 691 697 PF00498 0.385
LIG_FHA_2 742 748 PF00498 0.475
LIG_FHA_2 779 785 PF00498 0.351
LIG_FHA_2 796 802 PF00498 0.307
LIG_LIR_Apic_2 333 337 PF02991 0.741
LIG_LIR_Gen_1 311 320 PF02991 0.561
LIG_LIR_Gen_1 493 502 PF02991 0.420
LIG_LIR_Gen_1 670 680 PF02991 0.415
LIG_LIR_Gen_1 802 813 PF02991 0.365
LIG_LIR_Nem_3 222 227 PF02991 0.381
LIG_LIR_Nem_3 311 316 PF02991 0.556
LIG_LIR_Nem_3 493 497 PF02991 0.351
LIG_LIR_Nem_3 499 503 PF02991 0.302
LIG_LIR_Nem_3 670 675 PF02991 0.343
LIG_LIR_Nem_3 802 808 PF02991 0.365
LIG_MYND_1 381 385 PF01753 0.571
LIG_MYND_1 484 488 PF01753 0.398
LIG_NRBOX 466 472 PF00104 0.449
LIG_NRBOX 698 704 PF00104 0.344
LIG_Pex14_2 144 148 PF04695 0.504
LIG_Pex14_2 563 567 PF04695 0.364
LIG_Pex14_2 617 621 PF04695 0.475
LIG_SH2_CRK 301 305 PF00017 0.493
LIG_SH2_CRK 334 338 PF00017 0.740
LIG_SH2_NCK_1 334 338 PF00017 0.740
LIG_SH2_STAP1 227 231 PF00017 0.494
LIG_SH2_STAP1 421 425 PF00017 0.446
LIG_SH2_STAT3 227 230 PF00017 0.536
LIG_SH2_STAT5 115 118 PF00017 0.651
LIG_SH2_STAT5 149 152 PF00017 0.523
LIG_SH2_STAT5 212 215 PF00017 0.566
LIG_SH2_STAT5 388 391 PF00017 0.557
LIG_SH2_STAT5 410 413 PF00017 0.524
LIG_SH2_STAT5 596 599 PF00017 0.385
LIG_SH2_STAT5 681 684 PF00017 0.363
LIG_SH2_STAT5 805 808 PF00017 0.363
LIG_SH3_1 378 384 PF00018 0.617
LIG_SH3_1 431 437 PF00018 0.667
LIG_SH3_3 13 19 PF00018 0.645
LIG_SH3_3 378 384 PF00018 0.566
LIG_SH3_3 391 397 PF00018 0.553
LIG_SH3_3 431 437 PF00018 0.725
LIG_SH3_3 51 57 PF00018 0.538
LIG_SH3_3 630 636 PF00018 0.398
LIG_SH3_3 670 676 PF00018 0.475
LIG_SH3_3 851 857 PF00018 0.381
LIG_SUMO_SIM_anti_2 657 663 PF11976 0.447
LIG_SUMO_SIM_anti_2 698 704 PF11976 0.347
LIG_SUMO_SIM_anti_2 730 736 PF11976 0.376
LIG_SUMO_SIM_par_1 469 476 PF11976 0.415
LIG_SUMO_SIM_par_1 698 704 PF11976 0.346
LIG_SUMO_SIM_par_1 732 739 PF11976 0.380
LIG_TRAF2_1 643 646 PF00917 0.396
LIG_TRAF2_1 693 696 PF00917 0.344
LIG_TYR_ITIM 299 304 PF00017 0.484
LIG_UBA3_1 106 113 PF00899 0.499
LIG_WRC_WIRS_1 805 810 PF05994 0.364
LIG_WW_3 482 486 PF00397 0.437
MOD_CDC14_SPxK_1 530 533 PF00782 0.449
MOD_CDK_SPK_2 242 247 PF00069 0.695
MOD_CDK_SPK_2 326 331 PF00069 0.693
MOD_CDK_SPxK_1 527 533 PF00069 0.449
MOD_CDK_SPxxK_3 173 180 PF00069 0.663
MOD_CDK_SPxxK_3 242 249 PF00069 0.739
MOD_CK1_1 152 158 PF00069 0.645
MOD_CK1_1 171 177 PF00069 0.771
MOD_CK1_1 179 185 PF00069 0.595
MOD_CK1_1 219 225 PF00069 0.392
MOD_CK1_1 245 251 PF00069 0.725
MOD_CK1_1 59 65 PF00069 0.614
MOD_CK1_1 631 637 PF00069 0.468
MOD_CK1_1 867 873 PF00069 0.648
MOD_CK2_1 236 242 PF00069 0.642
MOD_CK2_1 273 279 PF00069 0.560
MOD_CK2_1 306 312 PF00069 0.484
MOD_CK2_1 31 37 PF00069 0.521
MOD_CK2_1 344 350 PF00069 0.646
MOD_CK2_1 443 449 PF00069 0.441
MOD_CK2_1 640 646 PF00069 0.360
MOD_CK2_1 690 696 PF00069 0.385
MOD_CK2_1 780 786 PF00069 0.303
MOD_CK2_1 795 801 PF00069 0.393
MOD_CK2_1 855 861 PF00069 0.439
MOD_GlcNHglycan 117 120 PF01048 0.574
MOD_GlcNHglycan 173 176 PF01048 0.773
MOD_GlcNHglycan 181 184 PF01048 0.564
MOD_GlcNHglycan 221 224 PF01048 0.455
MOD_GlcNHglycan 238 241 PF01048 0.724
MOD_GlcNHglycan 37 41 PF01048 0.516
MOD_GlcNHglycan 371 374 PF01048 0.664
MOD_GlcNHglycan 541 544 PF01048 0.446
MOD_GlcNHglycan 601 604 PF01048 0.463
MOD_GlcNHglycan 662 665 PF01048 0.338
MOD_GlcNHglycan 721 724 PF01048 0.458
MOD_GSK3_1 115 122 PF00069 0.546
MOD_GSK3_1 149 156 PF00069 0.581
MOD_GSK3_1 164 171 PF00069 0.778
MOD_GSK3_1 179 186 PF00069 0.468
MOD_GSK3_1 212 219 PF00069 0.456
MOD_GSK3_1 238 245 PF00069 0.698
MOD_GSK3_1 248 255 PF00069 0.778
MOD_GSK3_1 268 275 PF00069 0.533
MOD_GSK3_1 302 309 PF00069 0.497
MOD_GSK3_1 452 459 PF00069 0.475
MOD_GSK3_1 53 60 PF00069 0.542
MOD_GSK3_1 66 73 PF00069 0.440
MOD_GSK3_1 660 667 PF00069 0.411
MOD_GSK3_1 741 748 PF00069 0.315
MOD_GSK3_1 778 785 PF00069 0.403
MOD_GSK3_1 786 793 PF00069 0.355
MOD_GSK3_1 864 871 PF00069 0.548
MOD_N-GLC_1 344 349 PF02516 0.642
MOD_N-GLC_1 457 462 PF02516 0.413
MOD_N-GLC_1 512 517 PF02516 0.423
MOD_N-GLC_1 585 590 PF02516 0.475
MOD_NEK2_1 2 7 PF00069 0.439
MOD_NEK2_1 216 221 PF00069 0.394
MOD_NEK2_1 225 230 PF00069 0.416
MOD_NEK2_1 360 365 PF00069 0.782
MOD_NEK2_1 628 633 PF00069 0.475
MOD_NEK2_1 660 665 PF00069 0.348
MOD_NEK2_1 745 750 PF00069 0.348
MOD_NEK2_1 752 757 PF00069 0.351
MOD_NEK2_1 868 873 PF00069 0.599
MOD_PIKK_1 130 136 PF00454 0.647
MOD_PIKK_1 149 155 PF00454 0.556
MOD_PIKK_1 252 258 PF00454 0.727
MOD_PIKK_1 443 449 PF00454 0.480
MOD_PIKK_1 727 733 PF00454 0.463
MOD_PIKK_1 752 758 PF00454 0.421
MOD_PK_1 95 101 PF00069 0.496
MOD_PKA_1 135 141 PF00069 0.557
MOD_PKA_1 294 300 PF00069 0.540
MOD_PKA_1 609 615 PF00069 0.242
MOD_PKA_2 135 141 PF00069 0.557
MOD_PKA_2 171 177 PF00069 0.722
MOD_PKA_2 179 185 PF00069 0.496
MOD_PKA_2 248 254 PF00069 0.782
MOD_PKA_2 273 279 PF00069 0.572
MOD_PKA_2 29 35 PF00069 0.592
MOD_PKA_2 294 300 PF00069 0.488
MOD_PKA_2 302 308 PF00069 0.396
MOD_PKA_2 539 545 PF00069 0.418
MOD_PKA_2 664 670 PF00069 0.385
MOD_PKA_2 790 796 PF00069 0.427
MOD_PKA_2 821 827 PF00069 0.398
MOD_PKB_1 93 101 PF00069 0.561
MOD_Plk_1 533 539 PF00069 0.374
MOD_Plk_1 585 591 PF00069 0.437
MOD_Plk_1 695 701 PF00069 0.356
MOD_Plk_1 769 775 PF00069 0.382
MOD_Plk_2-3 238 244 PF00069 0.658
MOD_Plk_4 140 146 PF00069 0.528
MOD_Plk_4 212 218 PF00069 0.500
MOD_Plk_4 273 279 PF00069 0.553
MOD_Plk_4 533 539 PF00069 0.398
MOD_Plk_4 695 701 PF00069 0.366
MOD_Plk_4 706 712 PF00069 0.309
MOD_Plk_4 745 751 PF00069 0.332
MOD_ProDKin_1 164 170 PF00069 0.778
MOD_ProDKin_1 173 179 PF00069 0.662
MOD_ProDKin_1 203 209 PF00069 0.568
MOD_ProDKin_1 242 248 PF00069 0.775
MOD_ProDKin_1 326 332 PF00069 0.694
MOD_ProDKin_1 333 339 PF00069 0.736
MOD_ProDKin_1 362 368 PF00069 0.733
MOD_ProDKin_1 457 463 PF00069 0.413
MOD_ProDKin_1 527 533 PF00069 0.449
MOD_ProDKin_1 53 59 PF00069 0.546
MOD_ProDKin_1 549 555 PF00069 0.363
MOD_SUMO_for_1 231 234 PF00179 0.574
MOD_SUMO_rev_2 195 202 PF00179 0.523
MOD_SUMO_rev_2 287 296 PF00179 0.610
MOD_SUMO_rev_2 408 417 PF00179 0.576
TRG_DiLeu_BaEn_1 696 701 PF01217 0.344
TRG_DiLeu_BaLyEn_6 102 107 PF01217 0.431
TRG_ENDOCYTIC_2 301 304 PF00928 0.486
TRG_ENDOCYTIC_2 421 424 PF00928 0.477
TRG_ENDOCYTIC_2 805 808 PF00928 0.328
TRG_ENDOCYTIC_2 859 862 PF00928 0.341
TRG_ER_diArg_1 135 137 PF00400 0.632
TRG_ER_diArg_1 28 31 PF00400 0.632
TRG_ER_diArg_1 318 320 PF00400 0.594
TRG_ER_diArg_1 375 378 PF00400 0.684
TRG_ER_diArg_1 404 407 PF00400 0.574
TRG_ER_diArg_1 484 487 PF00400 0.346
TRG_ER_diArg_1 488 491 PF00400 0.344
TRG_ER_diArg_1 647 650 PF00400 0.449
TRG_ER_diArg_1 810 812 PF00400 0.475
TRG_ER_diArg_1 93 95 PF00400 0.540
TRG_NES_CRM1_1 41 53 PF08389 0.573
TRG_Pf-PMV_PEXEL_1 191 195 PF00026 0.503
TRG_Pf-PMV_PEXEL_1 233 238 PF00026 0.614
TRG_Pf-PMV_PEXEL_1 36 41 PF00026 0.570
TRG_Pf-PMV_PEXEL_1 409 414 PF00026 0.603
TRG_Pf-PMV_PEXEL_1 571 575 PF00026 0.328
TRG_Pf-PMV_PEXEL_1 620 624 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 726 731 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ54 Leptomonas seymouri 63% 100%
A0A0S4JLJ6 Bodo saltans 29% 91%
A0A1X0P1B7 Trypanosomatidae 38% 100%
A0A3S7X411 Leishmania donovani 99% 100%
A0A422NMF0 Trypanosoma rangeli 38% 100%
A4HIT0 Leishmania braziliensis 84% 100%
C9ZRF0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9B1B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q6U7 Leishmania major 94% 100%
V5B765 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS