Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I630_LEIIN

TriTrypDb:

LINF_300039700

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I630

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I630

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.374
CLV_NRD_NRD_1	59	61	PF00675	0.373
CLV_NRD_NRD_1	63	65	PF00675	0.403
CLV_PCSK_KEX2_1	193	195	PF00082	0.374
CLV_PCSK_KEX2_1	59	61	PF00082	0.349
CLV_PCSK_KEX2_1	63	65	PF00082	0.385
CLV_PCSK_PC7_1	189	195	PF00082	0.363
CLV_PCSK_PC7_1	59	65	PF00082	0.355
CLV_PCSK_SKI1_1	110	114	PF00082	0.447
CLV_PCSK_SKI1_1	59	63	PF00082	0.401
CLV_Separin_Metazoa	56	60	PF03568	0.382
DEG_Nend_UBRbox_1	1	4	PF02207	0.362
DEG_SPOP_SBC_1	230	234	PF00917	0.483
DOC_CYCLIN_RxL_1	105	114	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.434
DOC_MAPK_gen_1	105	113	PF00069	0.363
DOC_MAPK_gen_1	59	68	PF00069	0.461
DOC_MAPK_MEF2A_6	105	113	PF00069	0.368
DOC_PP1_RVXF_1	62	69	PF00149	0.410
DOC_PP2B_LxvP_1	88	91	PF13499	0.552
DOC_PP4_FxxP_1	68	71	PF00568	0.398
DOC_USP7_MATH_1	142	146	PF00917	0.590
DOC_USP7_MATH_1	168	172	PF00917	0.291
DOC_WW_Pin1_4	16	21	PF00397	0.412
DOC_WW_Pin1_4	31	36	PF00397	0.325
LIG_14-3-3_CanoR_1	25	29	PF00244	0.451
LIG_Actin_WH2_2	175	191	PF00022	0.361
LIG_APCC_ABBA_1	1	6	PF00400	0.417
LIG_APCC_ABBA_1	51	56	PF00400	0.326
LIG_FHA_1	153	159	PF00498	0.548
LIG_FHA_1	16	22	PF00498	0.458
LIG_LIR_Apic_2	31	35	PF02991	0.398
LIG_LIR_Gen_1	49	58	PF02991	0.326
LIG_LIR_Gen_1	6	16	PF02991	0.373
LIG_LIR_Nem_3	225	230	PF02991	0.483
LIG_LIR_Nem_3	49	54	PF02991	0.336
LIG_LIR_Nem_3	6	12	PF02991	0.366
LIG_MAD2	133	141	PF02301	0.465
LIG_NRBOX	57	63	PF00104	0.341
LIG_PTB_Apo_2	173	180	PF02174	0.382
LIG_SH2_CRK	100	104	PF00017	0.412
LIG_SH2_NCK_1	100	104	PF00017	0.412
LIG_SH2_NCK_1	32	36	PF00017	0.391
LIG_SH2_SRC	45	48	PF00017	0.399
LIG_SH2_STAT5	197	200	PF00017	0.337
LIG_SH2_STAT5	45	48	PF00017	0.464
LIG_SH3_3	135	141	PF00018	0.450
LIG_SH3_3	177	183	PF00018	0.432
LIG_TRAF2_1	8	11	PF00917	0.387
LIG_TRAF2_1	90	93	PF00917	0.496
LIG_UBA3_1	106	110	PF00899	0.337
LIG_WRC_WIRS_1	21	26	PF05994	0.412
LIG_WW_3	102	106	PF00397	0.398
MOD_CK1_1	145	151	PF00069	0.717
MOD_CK2_1	159	165	PF00069	0.441
MOD_CK2_1	41	47	PF00069	0.358
MOD_GSK3_1	140	147	PF00069	0.571
MOD_GSK3_1	148	155	PF00069	0.553
MOD_GSK3_1	16	23	PF00069	0.457
MOD_GSK3_1	24	31	PF00069	0.395
MOD_N-GLC_1	145	150	PF02516	0.593
MOD_N-GLC_1	16	21	PF02516	0.412
MOD_NEK2_1	111	116	PF00069	0.399
MOD_NEK2_1	229	234	PF00069	0.617
MOD_NEK2_1	24	29	PF00069	0.404
MOD_NEK2_1	41	46	PF00069	0.336
MOD_NEK2_1	83	88	PF00069	0.748
MOD_NEK2_2	20	25	PF00069	0.405
MOD_PKA_2	217	223	PF00069	0.494
MOD_PKA_2	24	30	PF00069	0.448
MOD_Plk_1	41	47	PF00069	0.348
MOD_Plk_1	83	89	PF00069	0.571
MOD_Plk_4	41	47	PF00069	0.394
MOD_Plk_4	69	75	PF00069	0.449
MOD_Plk_4	83	89	PF00069	0.635
MOD_ProDKin_1	16	22	PF00069	0.415
MOD_ProDKin_1	31	37	PF00069	0.321
TRG_DiLeu_BaEn_1	225	230	PF01217	0.483
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.386
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.537
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.340
TRG_ENDOCYTIC_2	9	12	PF00928	0.407
TRG_ENDOCYTIC_2	99	102	PF00928	0.506
TRG_ER_diArg_1	58	60	PF00400	0.358
TRG_ER_diArg_1	62	64	PF00400	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I1	Leptomonas seymouri	60%	100%
A0A3Q8IJQ2	Leishmania donovani	99%	100%
A4HIS8	Leishmania braziliensis	76%	100%
E9B1B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6U9	Leishmania major	91%	100%