LeishMANIAdb
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Putative CAS/CSE/importin domain protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative CAS/CSE/importin domain protein
Gene product:
CAS/CSE/importin domain protein - putative
Species:
Leishmania infantum
UniProt:
A4I629_LEIIN
TriTrypDb:
LINF_300039600
Length:
975

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, CAS/CSE/importin domain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005635 nuclear envelope 4 1
GO:0005643 nuclear pore 3 1
GO:0005829 cytosol 2 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 2
GO:0140513 nuclear protein-containing complex 2 1
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I629
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I629

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0006606 protein import into nucleus 5 1
GO:0006611 protein export from nucleus 5 1
GO:0006913 nucleocytoplasmic transport 5 1
GO:0033365 protein localization to organelle 5 1
GO:0034504 protein localization to nucleus 6 1
GO:0051168 nuclear export 6 1
GO:0051169 nuclear transport 4 1
GO:0051170 import into nucleus 6 1
GO:0072594 establishment of protein localization to organelle 4 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0019899 enzyme binding 3 12
GO:0031267 small GTPase binding 5 12
GO:0051020 GTPase binding 4 12
GO:0005049 nuclear export signal receptor activity 3 1
GO:0140104 molecular carrier activity 1 1
GO:0140142 nucleocytoplasmic carrier activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 163 165 PF00675 0.535
CLV_NRD_NRD_1 386 388 PF00675 0.264
CLV_NRD_NRD_1 806 808 PF00675 0.283
CLV_NRD_NRD_1 844 846 PF00675 0.264
CLV_PCSK_KEX2_1 385 387 PF00082 0.256
CLV_PCSK_KEX2_1 806 808 PF00082 0.283
CLV_PCSK_SKI1_1 141 145 PF00082 0.448
CLV_PCSK_SKI1_1 153 157 PF00082 0.301
CLV_PCSK_SKI1_1 214 218 PF00082 0.288
CLV_PCSK_SKI1_1 224 228 PF00082 0.236
CLV_PCSK_SKI1_1 35 39 PF00082 0.562
CLV_PCSK_SKI1_1 394 398 PF00082 0.331
CLV_PCSK_SKI1_1 405 409 PF00082 0.318
CLV_PCSK_SKI1_1 447 451 PF00082 0.290
CLV_PCSK_SKI1_1 531 535 PF00082 0.350
CLV_Separin_Metazoa 391 395 PF03568 0.474
DEG_APCC_DBOX_1 339 347 PF00400 0.566
DEG_APCC_DBOX_1 34 42 PF00400 0.477
DEG_APCC_DBOX_1 393 401 PF00400 0.518
DEG_APCC_DBOX_1 404 412 PF00400 0.518
DEG_Nend_UBRbox_3 1 3 PF02207 0.690
DEG_SPOP_SBC_1 155 159 PF00917 0.413
DOC_CDC14_PxL_1 349 357 PF14671 0.518
DOC_CKS1_1 29 34 PF01111 0.468
DOC_CKS1_1 600 605 PF01111 0.518
DOC_CKS1_1 968 973 PF01111 0.618
DOC_CYCLIN_RxL_1 30 42 PF00134 0.480
DOC_CYCLIN_RxL_1 391 402 PF00134 0.506
DOC_CYCLIN_RxL_1 790 800 PF00134 0.608
DOC_CYCLIN_yCln2_LP_2 186 192 PF00134 0.530
DOC_CYCLIN_yCln2_LP_2 761 767 PF00134 0.518
DOC_MAPK_DCC_7 705 714 PF00069 0.518
DOC_MAPK_FxFP_2 583 586 PF00069 0.566
DOC_MAPK_gen_1 340 349 PF00069 0.518
DOC_MAPK_gen_1 385 392 PF00069 0.518
DOC_MAPK_gen_1 424 432 PF00069 0.474
DOC_MAPK_gen_1 790 799 PF00069 0.474
DOC_MAPK_gen_1 845 852 PF00069 0.464
DOC_MAPK_MEF2A_6 238 245 PF00069 0.483
DOC_MAPK_MEF2A_6 426 434 PF00069 0.495
DOC_MAPK_MEF2A_6 790 799 PF00069 0.473
DOC_MAPK_RevD_3 792 807 PF00069 0.483
DOC_PP2B_LxvP_1 398 401 PF13499 0.518
DOC_PP2B_LxvP_1 588 591 PF13499 0.518
DOC_PP4_FxxP_1 506 509 PF00568 0.518
DOC_PP4_FxxP_1 583 586 PF00568 0.558
DOC_USP7_MATH_1 241 245 PF00917 0.487
DOC_USP7_MATH_1 82 86 PF00917 0.610
DOC_USP7_MATH_1 861 865 PF00917 0.522
DOC_USP7_MATH_1 909 913 PF00917 0.538
DOC_USP7_UBL2_3 73 77 PF12436 0.394
DOC_WW_Pin1_4 21 26 PF00397 0.495
DOC_WW_Pin1_4 28 33 PF00397 0.430
DOC_WW_Pin1_4 477 482 PF00397 0.496
DOC_WW_Pin1_4 59 64 PF00397 0.492
DOC_WW_Pin1_4 599 604 PF00397 0.611
DOC_WW_Pin1_4 783 788 PF00397 0.502
DOC_WW_Pin1_4 890 895 PF00397 0.474
DOC_WW_Pin1_4 967 972 PF00397 0.622
LIG_14-3-3_CanoR_1 153 163 PF00244 0.497
LIG_14-3-3_CanoR_1 181 187 PF00244 0.507
LIG_14-3-3_CanoR_1 252 256 PF00244 0.483
LIG_14-3-3_CanoR_1 447 454 PF00244 0.492
LIG_14-3-3_CanoR_1 782 787 PF00244 0.510
LIG_14-3-3_CanoR_1 845 852 PF00244 0.492
LIG_14-3-3_CanoR_1 9 16 PF00244 0.493
LIG_Actin_WH2_2 209 226 PF00022 0.518
LIG_Actin_WH2_2 94 109 PF00022 0.436
LIG_APCC_ABBA_1 768 773 PF00400 0.566
LIG_BRCT_BRCA1_1 579 583 PF00533 0.584
LIG_CSL_BTD_1 831 834 PF09270 0.474
LIG_eIF4E_1 431 437 PF01652 0.518
LIG_eIF4E_1 573 579 PF01652 0.474
LIG_FHA_1 131 137 PF00498 0.445
LIG_FHA_1 171 177 PF00498 0.425
LIG_FHA_1 215 221 PF00498 0.474
LIG_FHA_1 277 283 PF00498 0.481
LIG_FHA_1 410 416 PF00498 0.543
LIG_FHA_1 510 516 PF00498 0.506
LIG_FHA_1 755 761 PF00498 0.464
LIG_FHA_1 838 844 PF00498 0.499
LIG_FHA_1 845 851 PF00498 0.489
LIG_FHA_2 225 231 PF00498 0.468
LIG_FHA_2 29 35 PF00498 0.598
LIG_FHA_2 500 506 PF00498 0.483
LIG_FHA_2 56 62 PF00498 0.478
LIG_FHA_2 98 104 PF00498 0.459
LIG_GBD_Chelix_1 392 400 PF00786 0.366
LIG_HP1_1 241 245 PF01393 0.483
LIG_IBAR_NPY_1 571 573 PF08397 0.566
LIG_LIR_Apic_2 505 509 PF02991 0.518
LIG_LIR_Apic_2 580 586 PF02991 0.614
LIG_LIR_Gen_1 286 297 PF02991 0.526
LIG_LIR_Gen_1 428 438 PF02991 0.518
LIG_LIR_Gen_1 501 511 PF02991 0.568
LIG_LIR_Gen_1 687 696 PF02991 0.560
LIG_LIR_Gen_1 788 799 PF02991 0.528
LIG_LIR_LC3C_4 315 319 PF02991 0.483
LIG_LIR_LC3C_4 487 492 PF02991 0.518
LIG_LIR_Nem_3 210 216 PF02991 0.593
LIG_LIR_Nem_3 286 292 PF02991 0.474
LIG_LIR_Nem_3 428 434 PF02991 0.518
LIG_LIR_Nem_3 501 507 PF02991 0.568
LIG_LIR_Nem_3 602 608 PF02991 0.518
LIG_LIR_Nem_3 65 70 PF02991 0.389
LIG_LIR_Nem_3 656 660 PF02991 0.464
LIG_LIR_Nem_3 687 692 PF02991 0.566
LIG_LIR_Nem_3 720 725 PF02991 0.474
LIG_LIR_Nem_3 773 779 PF02991 0.478
LIG_LIR_Nem_3 788 794 PF02991 0.499
LIG_LIR_Nem_3 916 922 PF02991 0.485
LIG_MAD2 826 834 PF02301 0.518
LIG_NRBOX 851 857 PF00104 0.474
LIG_PCNA_PIPBox_1 944 953 PF02747 0.518
LIG_PCNA_yPIPBox_3 944 954 PF02747 0.518
LIG_Pex14_1 281 285 PF04695 0.518
LIG_Pex14_2 128 132 PF04695 0.353
LIG_Pex14_2 285 289 PF04695 0.474
LIG_Pex14_2 292 296 PF04695 0.481
LIG_Pex14_2 68 72 PF04695 0.417
LIG_RPA_C_Fungi 381 393 PF08784 0.301
LIG_SH2_CRK 184 188 PF00017 0.389
LIG_SH2_CRK 213 217 PF00017 0.482
LIG_SH2_CRK 605 609 PF00017 0.377
LIG_SH2_CRK 689 693 PF00017 0.335
LIG_SH2_GRB2like 748 751 PF00017 0.377
LIG_SH2_PTP2 791 794 PF00017 0.335
LIG_SH2_SRC 40 43 PF00017 0.502
LIG_SH2_STAP1 504 508 PF00017 0.444
LIG_SH2_STAP1 616 620 PF00017 0.377
LIG_SH2_STAT3 166 169 PF00017 0.421
LIG_SH2_STAT3 260 263 PF00017 0.328
LIG_SH2_STAT3 345 348 PF00017 0.377
LIG_SH2_STAT3 573 576 PF00017 0.335
LIG_SH2_STAT3 660 663 PF00017 0.301
LIG_SH2_STAT5 345 348 PF00017 0.474
LIG_SH2_STAT5 365 368 PF00017 0.272
LIG_SH2_STAT5 372 375 PF00017 0.338
LIG_SH2_STAT5 399 402 PF00017 0.377
LIG_SH2_STAT5 40 43 PF00017 0.397
LIG_SH2_STAT5 431 434 PF00017 0.316
LIG_SH2_STAT5 573 576 PF00017 0.390
LIG_SH2_STAT5 577 580 PF00017 0.388
LIG_SH2_STAT5 657 660 PF00017 0.309
LIG_SH2_STAT5 791 794 PF00017 0.375
LIG_SH2_STAT5 811 814 PF00017 0.474
LIG_SH3_3 123 129 PF00018 0.404
LIG_SH3_3 250 256 PF00018 0.328
LIG_SH3_3 26 32 PF00018 0.487
LIG_SH3_3 400 406 PF00018 0.460
LIG_SH3_3 605 611 PF00018 0.351
LIG_SH3_3 828 834 PF00018 0.294
LIG_SH3_3 965 971 PF00018 0.498
LIG_SUMO_SIM_anti_2 118 124 PF11976 0.409
LIG_SUMO_SIM_anti_2 133 140 PF11976 0.448
LIG_SUMO_SIM_anti_2 321 327 PF11976 0.374
LIG_SUMO_SIM_anti_2 800 805 PF11976 0.360
LIG_SUMO_SIM_par_1 434 439 PF11976 0.377
LIG_SUMO_SIM_par_1 53 58 PF11976 0.442
LIG_SxIP_EBH_1 705 714 PF03271 0.328
LIG_TRFH_1 349 353 PF08558 0.244
LIG_UBA3_1 620 626 PF00899 0.305
LIG_UBA3_1 741 746 PF00899 0.349
LIG_WRC_WIRS_1 282 287 PF05994 0.377
LIG_WRC_WIRS_1 947 952 PF05994 0.352
MOD_CDK_SPK_2 785 790 PF00069 0.301
MOD_CDK_SPxxK_3 28 35 PF00069 0.500
MOD_CDK_SPxxK_3 599 606 PF00069 0.377
MOD_CDK_SPxxK_3 783 790 PF00069 0.195
MOD_CK1_1 194 200 PF00069 0.440
MOD_CK1_1 251 257 PF00069 0.446
MOD_CK1_1 310 316 PF00069 0.330
MOD_CK1_1 477 483 PF00069 0.337
MOD_CK1_1 599 605 PF00069 0.455
MOD_CK1_1 785 791 PF00069 0.379
MOD_CK1_1 872 878 PF00069 0.438
MOD_CK2_1 28 34 PF00069 0.583
MOD_CK2_1 281 287 PF00069 0.503
MOD_CK2_1 499 505 PF00069 0.377
MOD_CK2_1 532 538 PF00069 0.558
MOD_CK2_1 55 61 PF00069 0.475
MOD_CK2_1 552 558 PF00069 0.377
MOD_CK2_1 80 86 PF00069 0.484
MOD_CK2_1 97 103 PF00069 0.451
MOD_DYRK1A_RPxSP_1 21 25 PF00069 0.492
MOD_GlcNHglycan 108 111 PF01048 0.548
MOD_GlcNHglycan 144 147 PF01048 0.518
MOD_GlcNHglycan 253 256 PF01048 0.407
MOD_GlcNHglycan 264 267 PF01048 0.332
MOD_GlcNHglycan 271 274 PF01048 0.249
MOD_GlcNHglycan 326 329 PF01048 0.340
MOD_GlcNHglycan 47 50 PF01048 0.398
MOD_GlcNHglycan 475 479 PF01048 0.403
MOD_GlcNHglycan 538 542 PF01048 0.447
MOD_GlcNHglycan 871 874 PF01048 0.377
MOD_GlcNHglycan 907 910 PF01048 0.323
MOD_GlcNHglycan 958 961 PF01048 0.391
MOD_GSK3_1 130 137 PF00069 0.406
MOD_GSK3_1 154 161 PF00069 0.414
MOD_GSK3_1 194 201 PF00069 0.371
MOD_GSK3_1 21 28 PF00069 0.462
MOD_GSK3_1 306 313 PF00069 0.338
MOD_GSK3_1 332 339 PF00069 0.316
MOD_GSK3_1 377 384 PF00069 0.340
MOD_GSK3_1 55 62 PF00069 0.464
MOD_GSK3_1 668 675 PF00069 0.377
MOD_GSK3_1 857 864 PF00069 0.380
MOD_GSK3_1 868 875 PF00069 0.274
MOD_GSK3_1 901 908 PF00069 0.402
MOD_GSK3_1 909 916 PF00069 0.413
MOD_GSK3_1 97 104 PF00069 0.352
MOD_N-GLC_1 207 212 PF02516 0.443
MOD_N-GLC_2 247 249 PF02516 0.377
MOD_NEK2_1 105 110 PF00069 0.577
MOD_NEK2_1 156 161 PF00069 0.557
MOD_NEK2_1 324 329 PF00069 0.467
MOD_NEK2_1 392 397 PF00069 0.303
MOD_NEK2_1 415 420 PF00069 0.363
MOD_NEK2_1 442 447 PF00069 0.451
MOD_NEK2_1 498 503 PF00069 0.349
MOD_NEK2_1 55 60 PF00069 0.529
MOD_NEK2_1 668 673 PF00069 0.335
MOD_NEK2_1 68 73 PF00069 0.269
MOD_NEK2_1 797 802 PF00069 0.362
MOD_NEK2_1 856 861 PF00069 0.377
MOD_NEK2_1 905 910 PF00069 0.347
MOD_NEK2_1 915 920 PF00069 0.282
MOD_NEK2_1 958 963 PF00069 0.388
MOD_NEK2_2 241 246 PF00069 0.328
MOD_NEK2_2 526 531 PF00069 0.473
MOD_NEK2_2 63 68 PF00069 0.512
MOD_NEK2_2 771 776 PF00069 0.426
MOD_PIKK_1 201 207 PF00454 0.482
MOD_PIKK_1 442 448 PF00454 0.311
MOD_PIKK_1 591 597 PF00454 0.473
MOD_PIKK_1 614 620 PF00454 0.459
MOD_PIKK_1 694 700 PF00454 0.444
MOD_PIKK_1 703 709 PF00454 0.444
MOD_PIKK_1 8 14 PF00454 0.503
MOD_PKA_2 106 112 PF00069 0.451
MOD_PKA_2 251 257 PF00069 0.328
MOD_PKA_2 329 335 PF00069 0.360
MOD_PKA_2 8 14 PF00069 0.503
MOD_PKA_2 844 850 PF00069 0.340
MOD_PKA_2 97 103 PF00069 0.417
MOD_Plk_1 224 230 PF00069 0.334
MOD_Plk_1 857 863 PF00069 0.474
MOD_Plk_1 945 951 PF00069 0.352
MOD_Plk_2-3 225 231 PF00069 0.335
MOD_Plk_4 134 140 PF00069 0.426
MOD_Plk_4 158 164 PF00069 0.441
MOD_Plk_4 182 188 PF00069 0.416
MOD_Plk_4 194 200 PF00069 0.309
MOD_Plk_4 241 247 PF00069 0.394
MOD_Plk_4 552 558 PF00069 0.430
MOD_Plk_4 63 69 PF00069 0.366
MOD_Plk_4 755 761 PF00069 0.366
MOD_Plk_4 771 777 PF00069 0.204
MOD_Plk_4 797 803 PF00069 0.360
MOD_Plk_4 901 907 PF00069 0.420
MOD_Plk_4 946 952 PF00069 0.436
MOD_Plk_4 97 103 PF00069 0.487
MOD_ProDKin_1 21 27 PF00069 0.499
MOD_ProDKin_1 28 34 PF00069 0.430
MOD_ProDKin_1 477 483 PF00069 0.346
MOD_ProDKin_1 59 65 PF00069 0.484
MOD_ProDKin_1 599 605 PF00069 0.507
MOD_ProDKin_1 783 789 PF00069 0.354
MOD_ProDKin_1 890 896 PF00069 0.316
MOD_ProDKin_1 967 973 PF00069 0.518
MOD_SUMO_rev_2 842 847 PF00179 0.384
TRG_DiLeu_BaEn_1 118 123 PF01217 0.401
TRG_DiLeu_BaEn_2 819 825 PF01217 0.377
TRG_DiLeu_BaEn_2 945 951 PF01217 0.377
TRG_DiLeu_BaLyEn_6 403 408 PF01217 0.377
TRG_DiLeu_BaLyEn_6 851 856 PF01217 0.377
TRG_ENDOCYTIC_2 184 187 PF00928 0.309
TRG_ENDOCYTIC_2 213 216 PF00928 0.482
TRG_ENDOCYTIC_2 431 434 PF00928 0.450
TRG_ENDOCYTIC_2 504 507 PF00928 0.444
TRG_ENDOCYTIC_2 605 608 PF00928 0.377
TRG_ENDOCYTIC_2 689 692 PF00928 0.316
TRG_ENDOCYTIC_2 791 794 PF00928 0.457
TRG_ER_diArg_1 385 387 PF00400 0.301
TRG_NES_CRM1_1 221 234 PF08389 0.301
TRG_NES_CRM1_1 766 781 PF08389 0.444
TRG_Pf-PMV_PEXEL_1 114 118 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 405 410 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 854 858 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 878 882 PF00026 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVU8 Leptomonas seymouri 52% 100%
A0A0S4JLP3 Bodo saltans 36% 100%
A0A1X0P1D2 Trypanosomatidae 43% 100%
A0A3R7KF83 Trypanosoma rangeli 44% 100%
A0A3S7X3V7 Leishmania donovani 99% 100%
A4HIS7 Leishmania braziliensis 89% 100%
A5D785 Bos taurus 26% 100%
C9ZRE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B1B4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O13671 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
P33307 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P55060 Homo sapiens 26% 100%
Q4Q6V0 Leishmania major 96% 100%
Q54E36 Dictyostelium discoideum 25% 100%
Q5R9J2 Pongo abelii 26% 100%
Q6GMY9 Xenopus laevis 27% 100%
Q7SZC2 Danio rerio 26% 100%
Q8AY73 Oreochromis niloticus 27% 100%
Q9ERK4 Mus musculus 26% 100%
Q9PTU3 Pagrus major 26% 100%
Q9XZU1 Drosophila melanogaster 26% 100%
Q9ZPY7 Arabidopsis thaliana 25% 100%
V5BSD2 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS