Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I617_LEIIN

TriTrypDb:

LINF_300039000

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I617

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I617

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.722
CLV_NRD_NRD_1	282	284	PF00675	0.537
CLV_NRD_NRD_1	382	384	PF00675	0.608
CLV_NRD_NRD_1	385	387	PF00675	0.570
CLV_NRD_NRD_1	8	10	PF00675	0.663
CLV_PCSK_FUR_1	380	384	PF00082	0.627
CLV_PCSK_KEX2_1	128	130	PF00082	0.765
CLV_PCSK_KEX2_1	179	181	PF00082	0.782
CLV_PCSK_KEX2_1	202	204	PF00082	0.667
CLV_PCSK_KEX2_1	220	222	PF00082	0.443
CLV_PCSK_KEX2_1	245	247	PF00082	0.695
CLV_PCSK_KEX2_1	282	284	PF00082	0.512
CLV_PCSK_KEX2_1	382	384	PF00082	0.608
CLV_PCSK_KEX2_1	385	387	PF00082	0.570
CLV_PCSK_KEX2_1	8	10	PF00082	0.635
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.707
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.674
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.443
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.695
CLV_PCSK_SKI1_1	3	7	PF00082	0.591
CLV_PCSK_SKI1_1	302	306	PF00082	0.731
DEG_Nend_UBRbox_3	1	3	PF02207	0.668
DOC_CKS1_1	197	202	PF01111	0.670
DOC_PP1_RVXF_1	249	256	PF00149	0.603
DOC_PP2B_LxvP_1	305	308	PF13499	0.721
DOC_PP2B_PxIxI_1	17	23	PF00149	0.580
DOC_PP4_FxxP_1	357	360	PF00568	0.587
DOC_PP4_FxxP_1	65	68	PF00568	0.654
DOC_USP7_MATH_1	141	145	PF00917	0.665
DOC_USP7_MATH_1	219	223	PF00917	0.696
DOC_USP7_MATH_1	230	234	PF00917	0.687
DOC_USP7_MATH_1	257	261	PF00917	0.662
DOC_USP7_MATH_1	66	70	PF00917	0.616
DOC_USP7_MATH_1	92	96	PF00917	0.652
DOC_USP7_UBL2_3	302	306	PF12436	0.733
DOC_WW_Pin1_4	131	136	PF00397	0.666
DOC_WW_Pin1_4	14	19	PF00397	0.509
DOC_WW_Pin1_4	196	201	PF00397	0.582
DOC_WW_Pin1_4	267	272	PF00397	0.532
DOC_WW_Pin1_4	338	343	PF00397	0.672
DOC_WW_Pin1_4	70	75	PF00397	0.745
LIG_14-3-3_CanoR_1	203	208	PF00244	0.769
LIG_14-3-3_CanoR_1	276	285	PF00244	0.578
LIG_14-3-3_CanoR_1	324	328	PF00244	0.692
LIG_BRCT_BRCA1_1	259	263	PF00533	0.586
LIG_BRCT_BRCA1_1	353	357	PF00533	0.608
LIG_FHA_1	15	21	PF00498	0.623
LIG_FHA_1	341	347	PF00498	0.663
LIG_FHA_1	43	49	PF00498	0.659
LIG_FHA_2	100	106	PF00498	0.658
LIG_FHA_2	164	170	PF00498	0.667
LIG_FHA_2	360	366	PF00498	0.515
LIG_LIR_Apic_2	354	360	PF02991	0.550
LIG_LIR_Apic_2	63	68	PF02991	0.637
LIG_LIR_Gen_1	53	64	PF02991	0.542
LIG_LIR_Nem_3	53	59	PF02991	0.532
LIG_PCNA_yPIPBox_3	35	48	PF02747	0.535
LIG_PTB_Apo_2	372	379	PF02174	0.711
LIG_PTB_Phospho_1	372	378	PF10480	0.711
LIG_SH2_CRK	56	60	PF00017	0.539
LIG_SH2_STAT5	26	29	PF00017	0.533
LIG_SH2_STAT5	267	270	PF00017	0.529
LIG_SH2_STAT5	363	366	PF00017	0.567
LIG_SH3_3	132	138	PF00018	0.787
LIG_SH3_3	167	173	PF00018	0.765
LIG_SH3_3	265	271	PF00018	0.564
LIG_SH3_3	341	347	PF00018	0.580
LIG_SH3_3	71	77	PF00018	0.725
LIG_SH3_5	374	378	PF00018	0.713
LIG_TYR_ITIM	54	59	PF00017	0.545
MOD_CDC14_SPxK_1	270	273	PF00782	0.527
MOD_CDK_SPxK_1	196	202	PF00069	0.621
MOD_CDK_SPxK_1	267	273	PF00069	0.531
MOD_CDK_SPxxK_3	196	203	PF00069	0.689
MOD_CK1_1	144	150	PF00069	0.742
MOD_CK1_1	288	294	PF00069	0.709
MOD_CK1_1	84	90	PF00069	0.690
MOD_CK2_1	163	169	PF00069	0.777
MOD_CK2_1	219	225	PF00069	0.719
MOD_CK2_1	266	272	PF00069	0.574
MOD_CK2_1	99	105	PF00069	0.560
MOD_Cter_Amidation	200	203	PF01082	0.735
MOD_GlcNHglycan	113	116	PF01048	0.683
MOD_GlcNHglycan	129	132	PF01048	0.791
MOD_GlcNHglycan	143	146	PF01048	0.684
MOD_GlcNHglycan	287	290	PF01048	0.664
MOD_GlcNHglycan	302	305	PF01048	0.691
MOD_GlcNHglycan	62	65	PF01048	0.654
MOD_GSK3_1	127	134	PF00069	0.677
MOD_GSK3_1	144	151	PF00069	0.763
MOD_GSK3_1	206	213	PF00069	0.726
MOD_GSK3_1	219	226	PF00069	0.606
MOD_GSK3_1	66	73	PF00069	0.650
MOD_GSK3_1	78	85	PF00069	0.558
MOD_GSK3_1	99	106	PF00069	0.667
MOD_N-GLC_1	285	290	PF02516	0.507
MOD_N-GLC_1	81	86	PF02516	0.776
MOD_NEK2_1	111	116	PF00069	0.720
MOD_NEK2_1	277	282	PF00069	0.497
MOD_NEK2_1	300	305	PF00069	0.520
MOD_NEK2_1	376	381	PF00069	0.647
MOD_NEK2_1	4	9	PF00069	0.685
MOD_NEK2_2	230	235	PF00069	0.566
MOD_NEK2_2	351	356	PF00069	0.607
MOD_PIKK_1	277	283	PF00454	0.658
MOD_PIKK_1	42	48	PF00454	0.598
MOD_PKA_1	211	217	PF00069	0.677
MOD_PKA_2	323	329	PF00069	0.762
MOD_PKA_2	351	357	PF00069	0.620
MOD_Plk_2-3	359	365	PF00069	0.512
MOD_Plk_4	106	112	PF00069	0.705
MOD_ProDKin_1	131	137	PF00069	0.664
MOD_ProDKin_1	14	20	PF00069	0.508
MOD_ProDKin_1	196	202	PF00069	0.581
MOD_ProDKin_1	267	273	PF00069	0.531
MOD_ProDKin_1	338	344	PF00069	0.665
MOD_ProDKin_1	70	76	PF00069	0.741
MOD_SUMO_for_1	117	120	PF00179	0.539
MOD_SUMO_for_1	34	37	PF00179	0.627
MOD_SUMO_for_1	50	53	PF00179	0.432
MOD_SUMO_rev_2	120	130	PF00179	0.696
MOD_SUMO_rev_2	209	214	PF00179	0.762
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.703
TRG_ENDOCYTIC_2	56	59	PF00928	0.536
TRG_ER_diArg_1	178	181	PF00400	0.689
TRG_ER_diArg_1	282	284	PF00400	0.579
TRG_ER_diArg_1	380	383	PF00400	0.607
TRG_ER_diArg_1	385	387	PF00400	0.570
TRG_NLS_Bipartite_1	202	224	PF00514	0.749
TRG_NLS_MonoCore_2	201	206	PF00514	0.698
TRG_NLS_MonoExtC_3	219	225	PF00514	0.694
TRG_NLS_MonoExtN_4	200	206	PF00514	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU67	Leptomonas seymouri	46%	86%
A0A0S4JF36	Bodo saltans	25%	95%
A0A3Q8IFV3	Leishmania donovani	99%	100%
A0A422P3G4	Trypanosoma rangeli	32%	74%
A4HIS1	Leishmania braziliensis	67%	98%
C9ZQY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	79%
E9B1A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6V6	Leishmania major	88%	100%
V5BPG9	Trypanosoma cruzi	32%	71%