A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.
Phosphatase, serine/threonine phosphatase
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 6, no: 10 |
| NetGPI | no | yes: 0, no: 16 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 13 |
| GO:0110165 | cellular anatomical entity | 1 | 13 |
Related structures:
AlphaFold database: A4I612
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 17 |
| GO:0016787 | hydrolase activity | 2 | 17 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 152 | 154 | PF00675 | 0.220 |
| CLV_NRD_NRD_1 | 31 | 33 | PF00675 | 0.204 |
| CLV_PCSK_KEX2_1 | 31 | 33 | PF00082 | 0.239 |
| CLV_PCSK_SKI1_1 | 136 | 140 | PF00082 | 0.233 |
| CLV_PCSK_SKI1_1 | 154 | 158 | PF00082 | 0.142 |
| CLV_PCSK_SKI1_1 | 224 | 228 | PF00082 | 0.401 |
| DOC_MAPK_gen_1 | 6 | 13 | PF00069 | 0.401 |
| DOC_MAPK_MEF2A_6 | 6 | 13 | PF00069 | 0.396 |
| DOC_MAPK_NFAT4_5 | 6 | 14 | PF00069 | 0.254 |
| DOC_USP7_MATH_1 | 308 | 312 | PF00917 | 0.317 |
| DOC_USP7_MATH_1 | 350 | 354 | PF00917 | 0.605 |
| DOC_USP7_UBL2_3 | 120 | 124 | PF12436 | 0.386 |
| DOC_USP7_UBL2_3 | 236 | 240 | PF12436 | 0.232 |
| DOC_WW_Pin1_4 | 197 | 202 | PF00397 | 0.216 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.268 |
| LIG_FHA_1 | 189 | 195 | PF00498 | 0.348 |
| LIG_FHA_1 | 295 | 301 | PF00498 | 0.263 |
| LIG_FHA_1 | 323 | 329 | PF00498 | 0.214 |
| LIG_FHA_1 | 330 | 336 | PF00498 | 0.299 |
| LIG_FHA_2 | 208 | 214 | PF00498 | 0.282 |
| LIG_Integrin_RGD_1 | 116 | 118 | PF01839 | 0.271 |
| LIG_LIR_Gen_1 | 330 | 339 | PF02991 | 0.343 |
| LIG_LIR_Nem_3 | 118 | 122 | PF02991 | 0.434 |
| LIG_LIR_Nem_3 | 239 | 245 | PF02991 | 0.229 |
| LIG_LIR_Nem_3 | 325 | 329 | PF02991 | 0.216 |
| LIG_LIR_Nem_3 | 330 | 334 | PF02991 | 0.343 |
| LIG_LIR_Nem_3 | 365 | 371 | PF02991 | 0.594 |
| LIG_NRBOX | 8 | 14 | PF00104 | 0.285 |
| LIG_PCNA_PIPBox_1 | 320 | 329 | PF02747 | 0.233 |
| LIG_SH2_STAP1 | 43 | 47 | PF00017 | 0.495 |
| LIG_SH2_STAT5 | 149 | 152 | PF00017 | 0.400 |
| LIG_SH2_STAT5 | 327 | 330 | PF00017 | 0.363 |
| LIG_SH2_STAT5 | 348 | 351 | PF00017 | 0.593 |
| LIG_SH3_3 | 214 | 220 | PF00018 | 0.196 |
| LIG_SH3_3 | 251 | 257 | PF00018 | 0.271 |
| LIG_SUMO_SIM_anti_2 | 332 | 338 | PF11976 | 0.349 |
| LIG_SUMO_SIM_anti_2 | 46 | 51 | PF11976 | 0.415 |
| LIG_SUMO_SIM_anti_2 | 8 | 14 | PF11976 | 0.304 |
| LIG_SUMO_SIM_anti_2 | 81 | 87 | PF11976 | 0.416 |
| LIG_SUMO_SIM_par_1 | 219 | 225 | PF11976 | 0.204 |
| LIG_SUMO_SIM_par_1 | 269 | 274 | PF11976 | 0.224 |
| LIG_SUMO_SIM_par_1 | 32 | 38 | PF11976 | 0.440 |
| LIG_UBA3_1 | 176 | 182 | PF00899 | 0.273 |
| LIG_WRC_WIRS_1 | 328 | 333 | PF05994 | 0.199 |
| MOD_CDK_SPxxK_3 | 197 | 204 | PF00069 | 0.333 |
| MOD_CK1_1 | 141 | 147 | PF00069 | 0.252 |
| MOD_CK1_1 | 170 | 176 | PF00069 | 0.240 |
| MOD_CK1_1 | 188 | 194 | PF00069 | 0.256 |
| MOD_CK1_1 | 306 | 312 | PF00069 | 0.462 |
| MOD_CK1_1 | 322 | 328 | PF00069 | 0.251 |
| MOD_CK2_1 | 178 | 184 | PF00069 | 0.213 |
| MOD_GlcNHglycan | 129 | 132 | PF01048 | 0.354 |
| MOD_GlcNHglycan | 13 | 16 | PF01048 | 0.243 |
| MOD_GlcNHglycan | 26 | 29 | PF01048 | 0.329 |
| MOD_GlcNHglycan | 312 | 315 | PF01048 | 0.603 |
| MOD_GlcNHglycan | 352 | 355 | PF01048 | 0.438 |
| MOD_GSK3_1 | 123 | 130 | PF00069 | 0.263 |
| MOD_GSK3_1 | 302 | 309 | PF00069 | 0.576 |
| MOD_GSK3_1 | 7 | 14 | PF00069 | 0.552 |
| MOD_N-GLC_1 | 141 | 146 | PF02516 | 0.273 |
| MOD_N-GLC_1 | 195 | 200 | PF02516 | 0.290 |
| MOD_NEK2_1 | 11 | 16 | PF00069 | 0.317 |
| MOD_NEK2_1 | 127 | 132 | PF00069 | 0.288 |
| MOD_NEK2_1 | 176 | 181 | PF00069 | 0.300 |
| MOD_NEK2_1 | 195 | 200 | PF00069 | 0.229 |
| MOD_NEK2_1 | 222 | 227 | PF00069 | 0.269 |
| MOD_NEK2_1 | 275 | 280 | PF00069 | 0.287 |
| MOD_NEK2_1 | 302 | 307 | PF00069 | 0.389 |
| MOD_NEK2_1 | 319 | 324 | PF00069 | 0.300 |
| MOD_Plk_1 | 294 | 300 | PF00069 | 0.345 |
| MOD_Plk_1 | 43 | 49 | PF00069 | 0.294 |
| MOD_Plk_4 | 244 | 250 | PF00069 | 0.217 |
| MOD_Plk_4 | 322 | 328 | PF00069 | 0.251 |
| MOD_Plk_4 | 338 | 344 | PF00069 | 0.253 |
| MOD_Plk_4 | 45 | 51 | PF00069 | 0.255 |
| MOD_Plk_4 | 7 | 13 | PF00069 | 0.479 |
| MOD_ProDKin_1 | 197 | 203 | PF00069 | 0.256 |
| MOD_SUMO_rev_2 | 235 | 243 | PF00179 | 0.336 |
| TRG_DiLeu_BaEn_1 | 29 | 34 | PF01217 | 0.296 |
| TRG_DiLeu_BaEn_1 | 65 | 70 | PF01217 | 0.384 |
| TRG_DiLeu_BaLyEn_6 | 356 | 361 | PF01217 | 0.458 |
| TRG_DiLeu_BaLyEn_6 | 51 | 56 | PF01217 | 0.408 |
| TRG_DiLeu_BaLyEn_6 | 84 | 89 | PF01217 | 0.348 |
| TRG_ENDOCYTIC_2 | 119 | 122 | PF00928 | 0.300 |
| TRG_ENDOCYTIC_2 | 159 | 162 | PF00928 | 0.397 |
| TRG_ENDOCYTIC_2 | 326 | 329 | PF00928 | 0.322 |
| TRG_ENDOCYTIC_2 | 348 | 351 | PF00928 | 0.548 |
| TRG_ENDOCYTIC_2 | 368 | 371 | PF00928 | 0.469 |
| TRG_ER_diArg_1 | 150 | 153 | PF00400 | 0.240 |
| TRG_ER_diArg_1 | 31 | 33 | PF00400 | 0.236 |
| TRG_NES_CRM1_1 | 66 | 82 | PF08389 | 0.361 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I3V2 | Leptomonas seymouri | 74% | 99% |
| A0A0N1P9R1 | Leptomonas seymouri | 26% | 100% |
| A0A0S4JBT9 | Bodo saltans | 33% | 95% |
| A0A0S4JMN0 | Bodo saltans | 29% | 92% |
| A0A0S4KJG1 | Bodo saltans | 58% | 100% |
| A0A1X0NU01 | Trypanosomatidae | 24% | 99% |
| A0A1X0NZX7 | Trypanosomatidae | 30% | 83% |
| A0A1X0P2G6 | Trypanosomatidae | 65% | 100% |
| A0A3Q8IBB4 | Leishmania donovani | 28% | 100% |
| A0A3Q8IIK0 | Leishmania donovani | 29% | 98% |
| A0A3R7NTC0 | Trypanosoma rangeli | 64% | 100% |
| A0A3S5IRW3 | Trypanosoma rangeli | 27% | 90% |
| A0A3S7X3U9 | Leishmania donovani | 99% | 100% |
| A4HCJ2 | Leishmania braziliensis | 28% | 100% |
| A4HH45 | Leishmania braziliensis | 29% | 100% |
| A4HIR7 | Leishmania braziliensis | 82% | 100% |
| A4I008 | Leishmania infantum | 28% | 100% |
| A4I498 | Leishmania infantum | 29% | 100% |
| C9ZQ86 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 27% | 99% |
| C9ZRD7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 61% | 84% |
| E9ADP5 | Leishmania major | 28% | 100% |
| E9AM35 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |
| E9AVY1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 27% | 100% |
| E9B1A3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 92% | 100% |
| O74480 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 29% | 100% |
| Q4Q6W1 | Leishmania major | 93% | 100% |
| Q4QBJ8 | Leishmania major | 27% | 100% |
| Q944L7 | Arabidopsis thaliana | 27% | 95% |
| V5ARZ9 | Trypanosoma cruzi | 25% | 99% |
| V5BPY7 | Trypanosoma cruzi | 30% | 85% |
| V5BX32 | Trypanosoma cruzi | 57% | 100% |