ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeats (many copies)/Ankyrin repeat - putative

Species:

Leishmania infantum

UniProt:

A4I610_LEIIN

TriTrypDb:

LINF_300038300

Length:

411

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I610

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I610

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.390
CLV_C14_Caspase3-7	266	270	PF00656	0.602
CLV_C14_Caspase3-7	325	329	PF00656	0.514
CLV_NRD_NRD_1	318	320	PF00675	0.400
CLV_NRD_NRD_1	32	34	PF00675	0.357
CLV_NRD_NRD_1	352	354	PF00675	0.479
CLV_NRD_NRD_1	396	398	PF00675	0.474
CLV_PCSK_FUR_1	316	320	PF00082	0.406
CLV_PCSK_KEX2_1	318	320	PF00082	0.404
CLV_PCSK_KEX2_1	32	34	PF00082	0.335
CLV_PCSK_KEX2_1	352	354	PF00082	0.400
CLV_PCSK_SKI1_1	13	17	PF00082	0.365
CLV_PCSK_SKI1_1	162	166	PF00082	0.364
CLV_PCSK_SKI1_1	302	306	PF00082	0.387
CLV_PCSK_SKI1_1	36	40	PF00082	0.298
CLV_PCSK_SKI1_1	399	403	PF00082	0.525
CLV_PCSK_SKI1_1	404	408	PF00082	0.589
DEG_Nend_UBRbox_3	1	3	PF02207	0.547
DOC_CKS1_1	119	124	PF01111	0.318
DOC_CKS1_1	255	260	PF01111	0.330
DOC_MAPK_gen_1	32	41	PF00069	0.263
DOC_MAPK_HePTP_8	137	149	PF00069	0.243
DOC_MAPK_MEF2A_6	140	149	PF00069	0.287
DOC_USP7_MATH_1	128	132	PF00917	0.259
DOC_USP7_MATH_1	184	188	PF00917	0.329
DOC_USP7_MATH_1	263	267	PF00917	0.441
DOC_USP7_UBL2_3	306	310	PF12436	0.416
DOC_USP7_UBL2_3	404	408	PF12436	0.554
DOC_WW_Pin1_4	118	123	PF00397	0.336
DOC_WW_Pin1_4	188	193	PF00397	0.244
DOC_WW_Pin1_4	254	259	PF00397	0.363
DOC_WW_Pin1_4	85	90	PF00397	0.244
LIG_14-3-3_CanoR_1	140	147	PF00244	0.237
LIG_14-3-3_CanoR_1	378	382	PF00244	0.433
LIG_BIR_III_2	189	193	PF00653	0.309
LIG_BRCT_BRCA1_1	119	123	PF00533	0.326
LIG_BRCT_BRCA1_1	34	38	PF00533	0.390
LIG_FHA_1	189	195	PF00498	0.291
LIG_FHA_1	341	347	PF00498	0.470
LIG_FHA_1	63	69	PF00498	0.313
LIG_FHA_2	307	313	PF00498	0.457
LIG_FHA_2	378	384	PF00498	0.532
LIG_FHA_2	64	70	PF00498	0.315
LIG_Integrin_RGD_1	232	234	PF01839	0.346
LIG_LIR_Apic_2	253	258	PF02991	0.412
LIG_LIR_Gen_1	270	281	PF02991	0.306
LIG_LIR_Gen_1	35	45	PF02991	0.266
LIG_LIR_Nem_3	270	276	PF02991	0.313
LIG_LIR_Nem_3	35	41	PF02991	0.266
LIG_NRP_CendR_1	408	411	PF00754	0.640
LIG_PCNA_PIPBox_1	201	210	PF02747	0.371
LIG_PCNA_yPIPBox_3	198	208	PF02747	0.371
LIG_PTB_Apo_2	249	256	PF02174	0.457
LIG_PTB_Phospho_1	249	255	PF10480	0.392
LIG_SH2_CRK	255	259	PF00017	0.361
LIG_SH2_SRC	381	384	PF00017	0.447
LIG_SH2_STAP1	381	385	PF00017	0.501
LIG_SH2_STAT5	207	210	PF00017	0.238
LIG_SH2_STAT5	299	302	PF00017	0.434
LIG_SH2_STAT5	70	73	PF00017	0.278
LIG_SH2_STAT5	98	101	PF00017	0.249
LIG_TRAF2_1	309	312	PF00917	0.435
MOD_CK2_1	306	312	PF00069	0.417
MOD_CK2_1	324	330	PF00069	0.453
MOD_CK2_1	377	383	PF00069	0.534
MOD_CK2_1	63	69	PF00069	0.371
MOD_GlcNHglycan	157	160	PF01048	0.247
MOD_GlcNHglycan	223	226	PF01048	0.400
MOD_GlcNHglycan	269	272	PF01048	0.511
MOD_GlcNHglycan	408	411	PF01048	0.600
MOD_GSK3_1	110	117	PF00069	0.309
MOD_GSK3_1	118	125	PF00069	0.339
MOD_GSK3_1	184	191	PF00069	0.309
MOD_GSK3_1	263	270	PF00069	0.587
MOD_GSK3_1	294	301	PF00069	0.534
MOD_GSK3_1	402	409	PF00069	0.510
MOD_N-GLC_1	289	294	PF02516	0.370
MOD_N-GLC_1	347	352	PF02516	0.420
MOD_N-GLC_1	63	68	PF02516	0.257
MOD_N-GLC_1	79	84	PF02516	0.284
MOD_NEK2_1	402	407	PF00069	0.460
MOD_PIKK_1	115	121	PF00454	0.529
MOD_PKA_1	294	300	PF00069	0.433
MOD_PKA_1	32	38	PF00069	0.309
MOD_PKA_2	139	145	PF00069	0.452
MOD_PKA_2	155	161	PF00069	0.194
MOD_PKA_2	169	175	PF00069	0.176
MOD_PKA_2	263	269	PF00069	0.504
MOD_PKA_2	32	38	PF00069	0.390
MOD_PKA_2	377	383	PF00069	0.431
MOD_Plk_1	110	116	PF00069	0.259
MOD_Plk_1	402	408	PF00069	0.475
MOD_Plk_1	63	69	PF00069	0.256
MOD_Plk_4	52	58	PF00069	0.238
MOD_ProDKin_1	118	124	PF00069	0.331
MOD_ProDKin_1	188	194	PF00069	0.244
MOD_ProDKin_1	254	260	PF00069	0.361
MOD_ProDKin_1	85	91	PF00069	0.244
MOD_SUMO_rev_2	142	149	PF00179	0.328
TRG_DiLeu_BaEn_1	274	279	PF01217	0.320
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.244
TRG_ER_diArg_1	31	33	PF00400	0.309
TRG_ER_diArg_1	316	319	PF00400	0.382
TRG_ER_diArg_1	352	354	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX1	Leptomonas seymouri	75%	100%
A0A0S4IZB7	Bodo saltans	24%	74%
A0A0S4J2H9	Bodo saltans	27%	72%
A0A0S4KFJ4	Bodo saltans	51%	100%
A0A1X0P1M7	Trypanosomatidae	52%	100%
A0A3R7KWY8	Trypanosoma rangeli	54%	100%
A0A3S7X3U4	Leishmania donovani	100%	100%
A4H9M0	Leishmania braziliensis	24%	100%
A4HIR5	Leishmania braziliensis	85%	100%
A6NK59	Homo sapiens	26%	70%
A6QPE7	Bos taurus	30%	100%
C9ZRD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3J162	Medicago truncatula	27%	76%
E5RJM6	Homo sapiens	32%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0C927	Rattus norvegicus	25%	69%
Q1RHT6	Rickettsia bellii (strain RML369-C)	23%	67%
Q3KP44	Homo sapiens	28%	67%
Q3V096	Mus musculus	23%	78%
Q4Q6W3	Leishmania major	97%	100%
Q4ULZ2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	23%	100%
Q502M6	Danio rerio	26%	100%
Q63369	Rattus norvegicus	28%	79%
Q6AWW5	Arabidopsis thaliana	24%	78%
Q6P6B7	Homo sapiens	25%	100%
Q96NS5	Homo sapiens	26%	91%
Q9J569	Fowlpox virus (strain NVSL)	27%	68%
Q9J5H9	Fowlpox virus (strain NVSL)	25%	71%
Q9J5I7	Fowlpox virus (strain NVSL)	22%	94%
V5BMS1	Trypanosoma cruzi	54%	100%