LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I607_LEIIN
TriTrypDb:
LINF_300038000
Length:
95

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I607
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I607

PDB structure(s): 7ane_ba

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.520
CLV_PCSK_KEX2_1 3 5 PF00082 0.498
DEG_Nend_Nbox_1 1 3 PF02207 0.560
DOC_USP7_UBL2_3 34 38 PF12436 0.603
LIG_14-3-3_CanoR_1 3 10 PF00244 0.519
LIG_FHA_2 17 23 PF00498 0.468
LIG_LIR_Apic_2 49 54 PF02991 0.473
LIG_LIR_Gen_1 58 66 PF02991 0.461
LIG_LIR_Nem_3 58 63 PF02991 0.464
LIG_LIR_Nem_3 77 83 PF02991 0.309
LIG_SH2_GRB2like 12 15 PF00017 0.520
LIG_SH2_STAP1 76 80 PF00017 0.396
LIG_SH2_STAT5 43 46 PF00017 0.435
LIG_SH2_STAT5 76 79 PF00017 0.401
LIG_SH2_STAT5 8 11 PF00017 0.425
MOD_CK2_1 16 22 PF00069 0.472
MOD_GSK3_1 42 49 PF00069 0.462
MOD_NEK2_1 15 20 PF00069 0.389
MOD_NEK2_1 2 7 PF00069 0.556
MOD_NEK2_1 74 79 PF00069 0.415
MOD_PKA_1 3 9 PF00069 0.498
MOD_PKA_2 2 8 PF00069 0.561
TRG_ENDOCYTIC_2 12 15 PF00928 0.444
TRG_ENDOCYTIC_2 47 50 PF00928 0.441
TRG_ENDOCYTIC_2 75 78 PF00928 0.455
TRG_ER_diArg_1 2 4 PF00400 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB19 Leptomonas seymouri 91% 100%
A0A0S4JPT8 Bodo saltans 83% 100%
A0A3S7X3X0 Leishmania donovani 100% 100%
A0A422P0T6 Trypanosoma rangeli 85% 78%
A4HIR2 Leishmania braziliensis 94% 100%
C9ZRC9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 100%
E9B198 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4Q6W6 Leishmania major 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS