3-hydroxy-3-methylglutaryl coenzyme A reductase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxy-3-methylglutaryl-CoA reductase

Species:

Leishmania infantum

UniProt:

A4I602_LEIIN

TriTrypDb:

LINF_300037500

Length:

434

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase HMGR

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0005778	peroxisomal membrane	6	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I602

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I602

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006629	lipid metabolic process	3	12
GO:0006720	isoprenoid metabolic process	4	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008299	isoprenoid biosynthetic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0015936	coenzyme A metabolic process	6	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006644	phospholipid metabolic process	4	1
GO:0006694	steroid biosynthetic process	5	1
GO:0006721	terpenoid metabolic process	5	1
GO:0008202	steroid metabolic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	6	1
GO:0016114	terpenoid biosynthetic process	5	1
GO:0016125	sterol metabolic process	4	1
GO:0016126	sterol biosynthetic process	5	1
GO:0045337	farnesyl diphosphate biosynthetic process	6	1
GO:0045338	farnesyl diphosphate metabolic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1
GO:1902767	isoprenoid biosynthetic process via mevalonate	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.520
CLV_MEL_PAP_1	204	210	PF00089	0.288
CLV_NRD_NRD_1	2	4	PF00675	0.383
CLV_NRD_NRD_1	428	430	PF00675	0.402
CLV_NRD_NRD_1	54	56	PF00675	0.217
CLV_PCSK_KEX2_1	2	4	PF00082	0.399
CLV_PCSK_KEX2_1	274	276	PF00082	0.307
CLV_PCSK_KEX2_1	54	56	PF00082	0.225
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.307
CLV_PCSK_SKI1_1	180	184	PF00082	0.197
CLV_PCSK_SKI1_1	240	244	PF00082	0.316
CLV_PCSK_SKI1_1	3	7	PF00082	0.443
CLV_PCSK_SKI1_1	33	37	PF00082	0.301
CLV_PCSK_SKI1_1	373	377	PF00082	0.279
DEG_APCC_DBOX_1	372	380	PF00400	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.664
DOC_ANK_TNKS_1	274	281	PF00023	0.423
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.469
DOC_MAPK_MEF2A_6	344	353	PF00069	0.408
DOC_PP1_RVXF_1	30	37	PF00149	0.489
DOC_PP2B_LxvP_1	353	356	PF13499	0.507
DOC_PP2B_PxIxI_1	355	361	PF00149	0.402
DOC_SPAK_OSR1_1	175	179	PF12202	0.451
DOC_USP7_MATH_1	182	186	PF00917	0.402
DOC_USP7_UBL2_3	223	227	PF12436	0.402
DOC_USP7_UBL2_3	426	430	PF12436	0.262
LIG_14-3-3_CanoR_1	2	6	PF00244	0.605
LIG_14-3-3_CanoR_1	240	245	PF00244	0.451
LIG_14-3-3_CanoR_1	263	268	PF00244	0.397
LIG_Actin_WH2_2	270	285	PF00022	0.402
LIG_BIR_III_4	214	218	PF00653	0.402
LIG_BRCT_BRCA1_1	244	248	PF00533	0.488
LIG_FHA_1	142	148	PF00498	0.413
LIG_FHA_1	293	299	PF00498	0.468
LIG_FHA_1	67	73	PF00498	0.507
LIG_FHA_2	323	329	PF00498	0.397
LIG_FHA_2	338	344	PF00498	0.402
LIG_LIR_Gen_1	16	25	PF02991	0.536
LIG_LIR_Gen_1	173	183	PF02991	0.428
LIG_LIR_Gen_1	81	86	PF02991	0.386
LIG_LIR_Nem_3	173	179	PF02991	0.412
LIG_LIR_Nem_3	186	192	PF02991	0.379
LIG_LIR_Nem_3	81	85	PF02991	0.418
LIG_PCNA_yPIPBox_3	372	386	PF02747	0.483
LIG_SH2_PTP2	96	99	PF00017	0.413
LIG_SH2_SRC	96	99	PF00017	0.413
LIG_SH2_STAP1	47	51	PF00017	0.522
LIG_SH2_STAT5	322	325	PF00017	0.488
LIG_SH2_STAT5	96	99	PF00017	0.402
LIG_SH3_3	111	117	PF00018	0.402
LIG_SH3_3	94	100	PF00018	0.402
LIG_SUMO_SIM_anti_2	163	170	PF11976	0.507
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.254
LIG_SUMO_SIM_par_1	105	110	PF11976	0.462
LIG_SUMO_SIM_par_1	155	161	PF11976	0.450
LIG_SUMO_SIM_par_1	240	245	PF11976	0.413
LIG_SUMO_SIM_par_1	347	354	PF11976	0.393
LIG_TYR_ITIM	94	99	PF00017	0.402
LIG_UBA3_1	192	196	PF00899	0.479
LIG_WRC_WIRS_1	159	164	PF05994	0.488
MOD_CK1_1	16	22	PF00069	0.485
MOD_CK1_1	209	215	PF00069	0.488
MOD_CK1_1	288	294	PF00069	0.442
MOD_CK1_1	410	416	PF00069	0.231
MOD_CK2_1	158	164	PF00069	0.402
MOD_CK2_1	381	387	PF00069	0.423
MOD_GlcNHglycan	127	130	PF01048	0.250
MOD_GlcNHglycan	138	141	PF01048	0.179
MOD_GlcNHglycan	208	211	PF01048	0.288
MOD_GlcNHglycan	244	247	PF01048	0.202
MOD_GlcNHglycan	254	257	PF01048	0.202
MOD_GlcNHglycan	300	303	PF01048	0.202
MOD_GlcNHglycan	334	337	PF01048	0.288
MOD_GlcNHglycan	412	415	PF01048	0.295
MOD_GlcNHglycan	421	424	PF01048	0.415
MOD_GlcNHglycan	9	12	PF01048	0.387
MOD_GSK3_1	288	295	PF00069	0.474
MOD_GSK3_1	334	341	PF00069	0.396
MOD_GSK3_1	364	371	PF00069	0.482
MOD_GSK3_1	62	69	PF00069	0.479
MOD_N-GLC_1	136	141	PF02516	0.288
MOD_N-GLC_1	292	297	PF02516	0.288
MOD_N-GLC_2	247	249	PF02516	0.202
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	125	130	PF00069	0.398
MOD_NEK2_1	183	188	PF00069	0.402
MOD_NEK2_1	206	211	PF00069	0.418
MOD_NEK2_1	242	247	PF00069	0.420
MOD_NEK2_1	292	297	PF00069	0.426
MOD_NEK2_1	298	303	PF00069	0.381
MOD_NEK2_1	349	354	PF00069	0.395
MOD_NEK2_1	7	12	PF00069	0.543
MOD_PIKK_1	368	374	PF00454	0.488
MOD_PK_1	191	197	PF00069	0.488
MOD_PK_1	263	269	PF00069	0.426
MOD_PKA_1	252	258	PF00069	0.402
MOD_PKA_2	1	7	PF00069	0.600
MOD_PKA_2	206	212	PF00069	0.418
MOD_PKA_2	298	304	PF00069	0.488
MOD_Plk_1	407	413	PF00069	0.254
MOD_Plk_1	80	86	PF00069	0.451
MOD_Plk_2-3	158	164	PF00069	0.413
MOD_Plk_4	263	269	PF00069	0.402
MOD_Plk_4	285	291	PF00069	0.419
MOD_Plk_4	407	413	PF00069	0.254
MOD_Plk_4	81	87	PF00069	0.511
MOD_SUMO_rev_2	24	34	PF00179	0.563
MOD_SUMO_rev_2	245	255	PF00179	0.402
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.507
TRG_ENDOCYTIC_2	96	99	PF00928	0.402
TRG_ER_diArg_1	1	3	PF00400	0.604
TRG_ER_diArg_1	53	55	PF00400	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0A1C3I2	Panax ginseng	54%	76%
A0A0A1C930	Panax ginseng	53%	73%
A0A0N1HYY3	Leptomonas seymouri	84%	100%
A0A0S4JI16	Bodo saltans	67%	100%
A0A1X0P1N0	Trypanosomatidae	64%	100%
A0A3S5ISH8	Trypanosoma rangeli	63%	100%
A0A3S7X3U0	Leishmania donovani	100%	100%
A2X8W3	Oryza sativa subsp. indica	56%	81%
A4HIQ3	Leishmania braziliensis	93%	100%
B0R6J9	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	46%	100%
C8VN86	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	50%	100%
C9ZRC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B193	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O08424	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	42%	100%
O24594	Zea mays	54%	75%
O26662	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	43%	100%
O59469	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	46%	100%
O64966	Gossypium hirsutum	54%	74%
O64967	Gossypium hirsutum	55%	69%
P14891	Arabidopsis thaliana	53%	73%
P29057	Hevea brasiliensis	54%	75%
P34135	Dictyostelium discoideum	50%	79%
P34136	Dictyostelium discoideum	52%	83%
P43256	Arabidopsis thaliana	53%	77%
P48020	Solanum tuberosum	52%	73%
P48021	Camptotheca acuminata	54%	73%
P48022	Solanum lycopersicum	52%	72%
Q00583	Hevea brasiliensis	52%	74%
Q01559	Nicotiana sylvestris	52%	72%
Q03163	Catharanthus roseus	53%	72%
Q0DY59	Oryza sativa subsp. japonica	56%	82%
Q41437	Solanum tuberosum	51%	73%
Q41438	Solanum tuberosum	51%	76%
Q58116	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	40%	100%
Q59468	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	44%	100%
Q9V1R3	Pyrococcus abyssi (strain GE5 / Orsay)	44%	100%
Q9XEL8	Capsicum annuum	52%	72%
Q9XHL5	Oryza sativa subsp. japonica	55%	77%
Q9Y0F3	Leishmania major	97%	100%
Q9YAS4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	51%	100%
U5JCC6	Panax ginseng	53%	74%
V5B780	Trypanosoma cruzi	65%	100%