Meiosis-specific nuclear structural protein 1

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor - Mitostatin - putative

Species:

Leishmania infantum

UniProt:

A4I5Z6_LEIIN

TriTrypDb:

LINF_300037300

Length:

411

Annotations

Annotations by Jardim et al.

Flagella, Tumour suppressor, Mitostatin, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4I5Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Z6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.465
CLV_NRD_NRD_1	106	108	PF00675	0.308
CLV_NRD_NRD_1	155	157	PF00675	0.282
CLV_NRD_NRD_1	160	162	PF00675	0.275
CLV_NRD_NRD_1	200	202	PF00675	0.255
CLV_NRD_NRD_1	225	227	PF00675	0.313
CLV_NRD_NRD_1	231	233	PF00675	0.296
CLV_NRD_NRD_1	282	284	PF00675	0.334
CLV_NRD_NRD_1	337	339	PF00675	0.279
CLV_NRD_NRD_1	347	349	PF00675	0.274
CLV_NRD_NRD_1	354	356	PF00675	0.184
CLV_NRD_NRD_1	366	368	PF00675	0.262
CLV_NRD_NRD_1	54	56	PF00675	0.284
CLV_NRD_NRD_1	77	79	PF00675	0.317
CLV_PCSK_FUR_1	104	108	PF00082	0.322
CLV_PCSK_FUR_1	158	162	PF00082	0.350
CLV_PCSK_FUR_1	232	236	PF00082	0.295
CLV_PCSK_KEX2_1	106	108	PF00082	0.296
CLV_PCSK_KEX2_1	155	157	PF00082	0.280
CLV_PCSK_KEX2_1	160	162	PF00082	0.273
CLV_PCSK_KEX2_1	200	202	PF00082	0.254
CLV_PCSK_KEX2_1	225	227	PF00082	0.271
CLV_PCSK_KEX2_1	234	236	PF00082	0.231
CLV_PCSK_KEX2_1	282	284	PF00082	0.326
CLV_PCSK_KEX2_1	322	324	PF00082	0.276
CLV_PCSK_KEX2_1	336	338	PF00082	0.213
CLV_PCSK_KEX2_1	366	368	PF00082	0.336
CLV_PCSK_KEX2_1	77	79	PF00082	0.308
CLV_PCSK_KEX2_1	96	98	PF00082	0.140
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.262
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.287
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.251
CLV_PCSK_PC7_1	156	162	PF00082	0.324
CLV_PCSK_PC7_1	332	338	PF00082	0.316
CLV_PCSK_SKI1_1	183	187	PF00082	0.317
CLV_PCSK_SKI1_1	2	6	PF00082	0.670
CLV_PCSK_SKI1_1	28	32	PF00082	0.486
CLV_PCSK_SKI1_1	283	287	PF00082	0.357
CLV_PCSK_SKI1_1	337	341	PF00082	0.306
CLV_PCSK_SKI1_1	78	82	PF00082	0.301
CLV_PCSK_SKI1_1	88	92	PF00082	0.287
DEG_Nend_UBRbox_1	1	4	PF02207	0.607
DOC_MAPK_gen_1	128	137	PF00069	0.511
DOC_MAPK_gen_1	232	241	PF00069	0.468
DOC_MAPK_gen_1	249	257	PF00069	0.541
DOC_MAPK_MEF2A_6	232	241	PF00069	0.404
DOC_PP1_RVXF_1	392	398	PF00149	0.577
DOC_USP7_MATH_1	44	48	PF00917	0.474
DOC_USP7_UBL2_3	340	344	PF12436	0.534
LIG_Actin_WH2_2	12	30	PF00022	0.454
LIG_Actin_WH2_2	42	57	PF00022	0.534
LIG_LIR_Gen_1	167	176	PF02991	0.505
LIG_LIR_Nem_3	167	172	PF02991	0.467
LIG_LIR_Nem_3	38	42	PF02991	0.478
LIG_LIR_Nem_3	382	386	PF02991	0.534
LIG_LYPXL_yS_3	39	42	PF13949	0.557
LIG_NRBOX	236	242	PF00104	0.468
LIG_SH2_CRK	383	387	PF00017	0.530
LIG_SH2_NCK_1	383	387	PF00017	0.502
LIG_SH2_SRC	383	386	PF00017	0.534
LIG_SH2_STAT5	194	197	PF00017	0.468
LIG_SH2_STAT5	364	367	PF00017	0.454
LIG_SH2_STAT5	53	56	PF00017	0.513
LIG_SH2_STAT5	82	85	PF00017	0.458
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.404
LIG_TRAF2_1	123	126	PF00917	0.516
LIG_TRAF2_1	185	188	PF00917	0.506
LIG_TRAF2_1	228	231	PF00917	0.432
LIG_TRAF2_1	285	288	PF00917	0.534
LIG_TRAF2_1	92	95	PF00917	0.465
MOD_CK2_1	54	60	PF00069	0.465
MOD_Cter_Amidation	223	226	PF01082	0.419
MOD_GlcNHglycan	64	68	PF01048	0.357
MOD_NEK2_1	149	154	PF00069	0.380
MOD_NEK2_1	54	59	PF00069	0.465
MOD_PIKK_1	44	50	PF00454	0.400
MOD_PKA_2	248	254	PF00069	0.413
MOD_PKA_2	54	60	PF00069	0.451
MOD_SUMO_for_1	185	188	PF00179	0.394
MOD_SUMO_for_1	285	288	PF00179	0.372
MOD_SUMO_for_1	90	93	PF00179	0.386
MOD_SUMO_rev_2	203	209	PF00179	0.307
MOD_SUMO_rev_2	21	30	PF00179	0.486
MOD_SUMO_rev_2	302	310	PF00179	0.408
MOD_SUMO_rev_2	341	350	PF00179	0.430
MOD_SUMO_rev_2	391	395	PF00179	0.577
TRG_DiLeu_BaEn_1	236	241	PF01217	0.307
TRG_DiLeu_BaEn_1	274	279	PF01217	0.326
TRG_DiLeu_BaEn_3	392	398	PF01217	0.582
TRG_DiLeu_BaEn_4	334	340	PF01217	0.419
TRG_ENDOCYTIC_2	383	386	PF00928	0.414
TRG_ENDOCYTIC_2	39	42	PF00928	0.462
TRG_ER_diArg_1	105	107	PF00400	0.407
TRG_ER_diArg_1	158	161	PF00400	0.341
TRG_ER_diArg_1	225	227	PF00400	0.419
TRG_ER_diArg_1	282	284	PF00400	0.390
TRG_ER_diArg_1	336	338	PF00400	0.370
TRG_ER_diArg_1	365	367	PF00400	0.320
TRG_NLS_MonoExtC_3	54	60	PF00514	0.380
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF3	Leptomonas seymouri	76%	93%
A0A0S4JLP4	Bodo saltans	38%	94%
A0A1X0P1N3	Trypanosomatidae	51%	94%
A0A3Q8IF15	Leishmania donovani	100%	100%
A0A422P0U0	Trypanosoma rangeli	52%	94%
A4HIQ1	Leishmania braziliensis	87%	100%
C9ZRC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	94%
E9B191	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q2KIQ2	Bos taurus	29%	83%
Q4Q6X3	Leishmania major	96%	100%
Q61884	Mus musculus	28%	84%
Q8NEH6	Homo sapiens	30%	83%