LeishMANIAdb
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S-adenosylmethionine decarboxylase proenzyme

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
S-adenosylmethionine decarboxylase proenzyme
Gene product:
S-adenosylmethionine decarboxylase
Species:
Leishmania infantum
UniProt:
A4I5Z2_LEIIN
TriTrypDb:
LINF_300036700
Length:
382

Annotations

Annotations by Jardim et al.

Polyamine metabolism, S-adenosylmethionine decarboxylase proenzyme ADOMETC

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I5Z2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Z2

Function

Biological processes
Term Name Level Count
GO:0006576 biogenic amine metabolic process 5 12
GO:0006595 polyamine metabolic process 6 12
GO:0006596 polyamine biosynthetic process 7 12
GO:0006597 spermine biosynthetic process 8 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0008215 spermine metabolic process 7 12
GO:0008216 spermidine metabolic process 7 12
GO:0008295 spermidine biosynthetic process 8 12
GO:0009058 biosynthetic process 2 12
GO:0009308 amine metabolic process 4 12
GO:0009309 amine biosynthetic process 5 12
GO:0009987 cellular process 1 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0042401 biogenic amine biosynthetic process 6 12
GO:0044237 cellular metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004014 adenosylmethionine decarboxylase activity 5 12
GO:0016829 lyase activity 2 12
GO:0016830 carbon-carbon lyase activity 3 12
GO:0016831 carboxy-lyase activity 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.255
CLV_PCSK_KEX2_1 37 39 PF00082 0.206
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.206
CLV_PCSK_SKI1_1 228 232 PF00082 0.247
CLV_PCSK_SKI1_1 293 297 PF00082 0.354
CLV_PCSK_SKI1_1 98 102 PF00082 0.223
DEG_APCC_DBOX_1 123 131 PF00400 0.370
DEG_Nend_UBRbox_3 1 3 PF02207 0.553
DOC_MAPK_gen_1 291 298 PF00069 0.294
DOC_MAPK_gen_1 300 310 PF00069 0.259
DOC_MAPK_gen_1 37 43 PF00069 0.237
DOC_MAPK_MEF2A_6 303 310 PF00069 0.237
DOC_PP4_FxxP_1 309 312 PF00568 0.255
DOC_PP4_FxxP_1 32 35 PF00568 0.223
DOC_SPAK_OSR1_1 303 307 PF12202 0.223
DOC_USP7_MATH_1 146 150 PF00917 0.315
DOC_USP7_MATH_1 171 175 PF00917 0.237
DOC_USP7_MATH_1 188 192 PF00917 0.237
DOC_USP7_UBL2_3 206 210 PF12436 0.361
DOC_WW_Pin1_4 266 271 PF00397 0.223
DOC_WW_Pin1_4 311 316 PF00397 0.350
LIG_14-3-3_CanoR_1 187 197 PF00244 0.280
LIG_14-3-3_CanoR_1 228 237 PF00244 0.336
LIG_14-3-3_CanoR_1 303 307 PF00244 0.298
LIG_14-3-3_CanoR_1 44 48 PF00244 0.433
LIG_AP2alpha_1 213 217 PF02296 0.257
LIG_APCC_ABBA_1 306 311 PF00400 0.255
LIG_BRCT_BRCA1_1 213 217 PF00533 0.188
LIG_BRCT_BRCA1_1 89 93 PF00533 0.243
LIG_deltaCOP1_diTrp_1 126 132 PF00928 0.223
LIG_deltaCOP1_diTrp_1 238 248 PF00928 0.238
LIG_eIF4E_1 333 339 PF01652 0.245
LIG_FHA_1 104 110 PF00498 0.257
LIG_FHA_1 222 228 PF00498 0.223
LIG_FHA_1 238 244 PF00498 0.223
LIG_FHA_1 263 269 PF00498 0.223
LIG_FHA_1 303 309 PF00498 0.293
LIG_FHA_1 358 364 PF00498 0.423
LIG_FHA_2 218 224 PF00498 0.237
LIG_FHA_2 229 235 PF00498 0.237
LIG_FHA_2 240 246 PF00498 0.255
LIG_FHA_2 267 273 PF00498 0.223
LIG_FHA_2 340 346 PF00498 0.236
LIG_FHA_2 47 53 PF00498 0.237
LIG_FHA_2 5 11 PF00498 0.559
LIG_HOMEOBOX 139 142 PF00046 0.233
LIG_LIR_Apic_2 31 35 PF02991 0.239
LIG_LIR_Gen_1 126 137 PF02991 0.223
LIG_LIR_Gen_1 152 162 PF02991 0.257
LIG_LIR_Gen_1 260 270 PF02991 0.228
LIG_LIR_Nem_3 126 132 PF02991 0.252
LIG_LIR_Nem_3 152 157 PF02991 0.230
LIG_LIR_Nem_3 174 180 PF02991 0.224
LIG_LIR_Nem_3 275 279 PF02991 0.255
LIG_LIR_Nem_3 331 336 PF02991 0.288
LIG_LIR_Nem_3 59 65 PF02991 0.237
LIG_Pex14_2 213 217 PF04695 0.238
LIG_SH2_CRK 336 340 PF00017 0.315
LIG_SH2_GRB2like 81 84 PF00017 0.251
LIG_SH2_SRC 182 185 PF00017 0.255
LIG_SH2_SRC 81 84 PF00017 0.251
LIG_SH2_STAP1 182 186 PF00017 0.255
LIG_SH2_STAP1 253 257 PF00017 0.255
LIG_SH2_STAP1 288 292 PF00017 0.237
LIG_SH2_STAT5 167 170 PF00017 0.315
LIG_SH2_STAT5 177 180 PF00017 0.184
LIG_SH2_STAT5 350 353 PF00017 0.245
LIG_SH2_STAT5 357 360 PF00017 0.282
LIG_SH2_STAT5 81 84 PF00017 0.260
LIG_SH2_STAT5 85 88 PF00017 0.270
LIG_SH3_3 295 301 PF00018 0.223
LIG_SH3_3 309 315 PF00018 0.223
LIG_SUMO_SIM_anti_2 10 16 PF11976 0.379
LIG_SUMO_SIM_par_1 98 103 PF11976 0.225
LIG_TRAF2_1 362 365 PF00917 0.580
LIG_UBA3_1 14 22 PF00899 0.420
LIG_UBA3_1 92 96 PF00899 0.315
MOD_CDK_SPxxK_3 311 318 PF00069 0.370
MOD_CK1_1 221 227 PF00069 0.311
MOD_CK1_1 275 281 PF00069 0.223
MOD_CK1_1 5 11 PF00069 0.542
MOD_CK1_1 60 66 PF00069 0.401
MOD_CK1_1 75 81 PF00069 0.164
MOD_CK2_1 217 223 PF00069 0.237
MOD_CK2_1 339 345 PF00069 0.223
MOD_GlcNHglycan 120 123 PF01048 0.315
MOD_GlcNHglycan 220 223 PF01048 0.237
MOD_GlcNHglycan 62 65 PF01048 0.403
MOD_GSK3_1 100 107 PF00069 0.246
MOD_GSK3_1 188 195 PF00069 0.255
MOD_GSK3_1 217 224 PF00069 0.253
MOD_GSK3_1 262 269 PF00069 0.225
MOD_GSK3_1 53 60 PF00069 0.300
MOD_GSK3_1 81 88 PF00069 0.223
MOD_N-GLC_1 135 140 PF02516 0.223
MOD_N-GLC_1 286 291 PF02516 0.274
MOD_N-GLC_1 5 10 PF02516 0.439
MOD_N-GLC_2 2 4 PF02516 0.505
MOD_NEK2_1 109 114 PF00069 0.280
MOD_NEK2_1 17 22 PF00069 0.377
MOD_NEK2_1 197 202 PF00069 0.255
MOD_NEK2_1 217 222 PF00069 0.210
MOD_NEK2_1 339 344 PF00069 0.317
MOD_NEK2_1 57 62 PF00069 0.298
MOD_NEK2_1 87 92 PF00069 0.227
MOD_NEK2_2 239 244 PF00069 0.233
MOD_PIKK_1 192 198 PF00454 0.255
MOD_PKA_2 302 308 PF00069 0.250
MOD_PKA_2 340 346 PF00069 0.307
MOD_PKA_2 43 49 PF00069 0.433
MOD_PKA_2 75 81 PF00069 0.233
MOD_Plk_1 135 141 PF00069 0.223
MOD_Plk_1 192 198 PF00069 0.275
MOD_Plk_1 57 63 PF00069 0.283
MOD_Plk_1 88 94 PF00069 0.223
MOD_Plk_4 10 16 PF00069 0.394
MOD_Plk_4 105 111 PF00069 0.117
MOD_Plk_4 128 134 PF00069 0.223
MOD_Plk_4 197 203 PF00069 0.223
MOD_Plk_4 57 63 PF00069 0.315
MOD_Plk_4 81 87 PF00069 0.244
MOD_Plk_4 88 94 PF00069 0.202
MOD_ProDKin_1 266 272 PF00069 0.223
MOD_ProDKin_1 311 317 PF00069 0.350
TRG_DiLeu_BaEn_2 127 133 PF01217 0.223
TRG_DiLeu_BaEn_2 88 94 PF01217 0.231
TRG_ENDOCYTIC_2 177 180 PF00928 0.241
TRG_ENDOCYTIC_2 182 185 PF00928 0.232
TRG_ENDOCYTIC_2 263 266 PF00928 0.223
TRG_ENDOCYTIC_2 336 339 PF00928 0.311
TRG_ENDOCYTIC_2 350 353 PF00928 0.246
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Z0 Leptomonas seymouri 92% 98%
A0A0N1PCH0 Leptomonas seymouri 26% 100%
A0A0S4JHX8 Bodo saltans 70% 100%
A0A0S4JRG8 Bodo saltans 28% 100%
A0A1X0P1C0 Trypanosomatidae 27% 100%
A0A1X0P1E2 Trypanosomatidae 71% 100%
A0A3Q8IEH8 Leishmania donovani 100% 100%
A0A3S7X3S7 Leishmania donovani 25% 100%
A0A422P0Q5 Trypanosoma rangeli 25% 100%
A0A422P0V0 Trypanosoma rangeli 72% 100%
A2XV58 Oryza sativa subsp. indica 35% 96%
A4HIP5 Leishmania braziliensis 92% 100%
A4HIP6 Leishmania braziliensis 26% 85%
A4I5Z3 Leishmania infantum 25% 100%
A5HNV6 Trypanosoma brucei brucei 28% 100%
C9ZRB5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
C9ZRB7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D3Z6H8 Mus musculus 33% 100%
E9B185 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9B186 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 85%
O02655 Caenorhabditis elegans 33% 100%
O04009 Nicotiana tabacum 33% 100%
O24575 Zea mays 35% 96%
O49972 Brassica juncea 32% 100%
O65354 Helianthus annuus 32% 100%
O76240 Trypanosoma cruzi 74% 100%
O80402 Nicotiana sylvestris 33% 100%
P0DMN7 Mus musculus 33% 100%
P17707 Homo sapiens 33% 100%
P17708 Rattus norvegicus 33% 100%
P21182 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 96%
P28918 Mesocricetus auratus 33% 100%
P46255 Spinacia oleracea 32% 100%
P50243 Bos taurus 33% 100%
P50244 Trypanosoma brucei brucei 64% 100%
P79888 Xenopus laevis 32% 100%
P82185 Mus spretus 33% 100%
P91931 Drosophila melanogaster 33% 100%
Q04694 Solanum tuberosum 33% 100%
Q0JC10 Oryza sativa subsp. japonica 35% 96%
Q25264 Leishmania donovani 100% 100%
Q27883 Onchocerca volvulus 33% 100%
Q38IY3 Solanum chilense 30% 100%
Q39676 Dianthus caryophyllus 34% 100%
Q39677 Dianthus caryophyllus 34% 100%
Q3E9D5 Arabidopsis thaliana 28% 100%
Q42613 Brassica juncea 32% 100%
Q42679 Catharanthus roseus 33% 100%
Q42829 Hordeum chilense 34% 97%
Q43820 Pisum sativum 34% 100%
Q4Q6X8 Leishmania major 25% 85%
Q4Q6X9 Leishmania major 98% 100%
Q8T1E3 Dictyostelium discoideum 35% 100%
Q96286 Arabidopsis thaliana 31% 100%
Q96471 Ipomoea nil 34% 100%
Q96555 Datura stramonium 33% 100%
Q9AXE3 Daucus carota 31% 100%
Q9LSU6 Arabidopsis thaliana 35% 100%
Q9M4D8 Vicia faba 34% 100%
Q9M6K1 Ipomoea batatas 33% 100%
Q9NGA0 Leishmania infantum 99% 97%
Q9P7E3 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
Q9S7T9 Arabidopsis thaliana 31% 100%
Q9SDM8 Brassica juncea 31% 100%
V5B784 Trypanosoma cruzi 28% 100%
V5DNV4 Trypanosoma cruzi 74% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS