Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5Z1_LEIIN

TriTrypDb:

LINF_300036600

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.644
CLV_C14_Caspase3-7	606	610	PF00656	0.594
CLV_C14_Caspase3-7	73	77	PF00656	0.656
CLV_NRD_NRD_1	15	17	PF00675	0.678
CLV_NRD_NRD_1	414	416	PF00675	0.522
CLV_NRD_NRD_1	595	597	PF00675	0.440
CLV_PCSK_KEX2_1	15	17	PF00082	0.663
CLV_PCSK_KEX2_1	414	416	PF00082	0.565
CLV_PCSK_KEX2_1	484	486	PF00082	0.472
CLV_PCSK_KEX2_1	595	597	PF00082	0.446
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.472
CLV_PCSK_SKI1_1	121	125	PF00082	0.398
CLV_PCSK_SKI1_1	16	20	PF00082	0.577
CLV_PCSK_SKI1_1	2	6	PF00082	0.661
CLV_PCSK_SKI1_1	280	284	PF00082	0.517
CLV_PCSK_SKI1_1	33	37	PF00082	0.424
CLV_PCSK_SKI1_1	337	341	PF00082	0.397
CLV_PCSK_SKI1_1	386	390	PF00082	0.423
CLV_PCSK_SKI1_1	408	412	PF00082	0.512
CLV_PCSK_SKI1_1	595	599	PF00082	0.483
CLV_PCSK_SKI1_1	88	92	PF00082	0.501
DEG_APCC_DBOX_1	214	222	PF00400	0.529
DEG_APCC_DBOX_1	385	393	PF00400	0.521
DEG_APCC_DBOX_1	594	602	PF00400	0.475
DEG_APCC_KENBOX_2	364	368	PF00400	0.605
DEG_Nend_UBRbox_1	1	4	PF02207	0.712
DEG_SPOP_SBC_1	305	309	PF00917	0.780
DEG_SPOP_SBC_1	499	503	PF00917	0.575
DEG_SPOP_SBC_1	62	66	PF00917	0.757
DEG_SPOP_SBC_1	67	71	PF00917	0.784
DOC_CKS1_1	271	276	PF01111	0.569
DOC_CYCLIN_RxL_1	277	287	PF00134	0.369
DOC_CYCLIN_RxL_1	408	422	PF00134	0.612
DOC_CYCLIN_RxL_1	593	604	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.501
DOC_MAPK_DCC_7	215	223	PF00069	0.516
DOC_MAPK_gen_1	381	391	PF00069	0.527
DOC_MAPK_gen_1	484	492	PF00069	0.537
DOC_MAPK_MEF2A_6	201	208	PF00069	0.466
DOC_MAPK_MEF2A_6	215	223	PF00069	0.337
DOC_MAPK_MEF2A_6	254	261	PF00069	0.500
DOC_MAPK_MEF2A_6	402	411	PF00069	0.652
DOC_PP2B_LxvP_1	522	525	PF13499	0.582
DOC_PP2B_LxvP_1	623	626	PF13499	0.546
DOC_USP7_MATH_1	305	309	PF00917	0.724
DOC_USP7_MATH_1	446	450	PF00917	0.591
DOC_USP7_MATH_1	464	468	PF00917	0.585
DOC_USP7_MATH_1	568	572	PF00917	0.566
DOC_USP7_MATH_1	63	67	PF00917	0.769
DOC_WW_Pin1_4	16	21	PF00397	0.575
DOC_WW_Pin1_4	253	258	PF00397	0.510
DOC_WW_Pin1_4	270	275	PF00397	0.467
DOC_WW_Pin1_4	292	297	PF00397	0.666
DOC_WW_Pin1_4	306	311	PF00397	0.683
DOC_WW_Pin1_4	429	434	PF00397	0.508
LIG_14-3-3_CanoR_1	121	131	PF00244	0.508
LIG_14-3-3_CanoR_1	15	19	PF00244	0.351
LIG_14-3-3_CanoR_1	2	7	PF00244	0.625
LIG_14-3-3_CanoR_1	290	296	PF00244	0.722
LIG_14-3-3_CanoR_1	384	392	PF00244	0.551
LIG_14-3-3_CanoR_1	414	419	PF00244	0.497
LIG_14-3-3_CanoR_1	47	53	PF00244	0.525
LIG_Actin_WH2_2	172	189	PF00022	0.457
LIG_APCC_ABBA_1	231	236	PF00400	0.438
LIG_Clathr_ClatBox_1	128	132	PF01394	0.515
LIG_Clathr_ClatBox_1	373	377	PF01394	0.390
LIG_CSL_BTD_1	195	198	PF09270	0.434
LIG_EH1_1	156	164	PF00400	0.537
LIG_eIF4E_1	157	163	PF01652	0.533
LIG_FHA_1	102	108	PF00498	0.493
LIG_FHA_1	123	129	PF00498	0.507
LIG_FHA_1	208	214	PF00498	0.553
LIG_FHA_1	235	241	PF00498	0.518
LIG_FHA_1	254	260	PF00498	0.525
LIG_FHA_1	3	9	PF00498	0.706
LIG_FHA_1	419	425	PF00498	0.530
LIG_FHA_1	430	436	PF00498	0.503
LIG_FHA_1	467	473	PF00498	0.454
LIG_FHA_1	502	508	PF00498	0.385
LIG_FHA_1	513	519	PF00498	0.414
LIG_FHA_1	615	621	PF00498	0.520
LIG_FHA_2	453	459	PF00498	0.693
LIG_FHA_2	63	69	PF00498	0.756
LIG_FHA_2	71	77	PF00498	0.689
LIG_GBD_Chelix_1	175	183	PF00786	0.476
LIG_IRF3_LxIS_1	143	149	PF10401	0.371
LIG_LIR_Gen_1	139	148	PF02991	0.486
LIG_LIR_Gen_1	19	28	PF02991	0.503
LIG_LIR_Gen_1	242	252	PF02991	0.433
LIG_LIR_Gen_1	502	513	PF02991	0.420
LIG_LIR_Nem_3	139	144	PF02991	0.361
LIG_LIR_Nem_3	151	157	PF02991	0.425
LIG_LIR_Nem_3	17	21	PF02991	0.503
LIG_LIR_Nem_3	180	185	PF02991	0.364
LIG_LIR_Nem_3	242	247	PF02991	0.418
LIG_LIR_Nem_3	330	335	PF02991	0.464
LIG_LIR_Nem_3	40	45	PF02991	0.412
LIG_LIR_Nem_3	491	496	PF02991	0.442
LIG_LIR_Nem_3	502	508	PF02991	0.413
LIG_LYPXL_yS_3	216	219	PF13949	0.454
LIG_NRBOX	469	475	PF00104	0.481
LIG_PCNA_yPIPBox_3	156	169	PF02747	0.424
LIG_PCNA_yPIPBox_3	365	374	PF02747	0.539
LIG_SH2_CRK	21	25	PF00017	0.476
LIG_SH2_CRK	400	404	PF00017	0.592
LIG_SH2_CRK	505	509	PF00017	0.489
LIG_SH2_NCK_1	400	404	PF00017	0.592
LIG_SH2_NCK_1	496	500	PF00017	0.586
LIG_SH2_SRC	375	378	PF00017	0.458
LIG_SH2_STAP1	235	239	PF00017	0.515
LIG_SH2_STAP1	505	509	PF00017	0.489
LIG_SH2_STAP1	512	516	PF00017	0.508
LIG_SH2_STAT5	185	188	PF00017	0.411
LIG_SH2_STAT5	263	266	PF00017	0.519
LIG_SH2_STAT5	353	356	PF00017	0.425
LIG_SH2_STAT5	375	378	PF00017	0.443
LIG_SH3_1	83	89	PF00018	0.474
LIG_SH3_2	217	222	PF14604	0.510
LIG_SH3_3	214	220	PF00018	0.536
LIG_SH3_3	307	313	PF00018	0.628
LIG_SH3_3	393	399	PF00018	0.594
LIG_SH3_3	440	446	PF00018	0.551
LIG_SH3_3	629	635	PF00018	0.615
LIG_SH3_3	83	89	PF00018	0.603
LIG_SH3_4	88	95	PF00018	0.526
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.529
LIG_SUMO_SIM_anti_2	202	211	PF11976	0.557
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.513
LIG_SUMO_SIM_par_1	144	149	PF11976	0.430
LIG_TRAF2_1	319	322	PF00917	0.659
LIG_TRFH_1	216	220	PF08558	0.517
LIG_TYR_ITIM	183	188	PF00017	0.381
LIG_TYR_ITIM	261	266	PF00017	0.420
LIG_TYR_ITSM	17	24	PF00017	0.581
LIG_UBA3_1	107	116	PF00899	0.411
MOD_CDC14_SPxK_1	295	298	PF00782	0.696
MOD_CDK_SPxK_1	292	298	PF00069	0.672
MOD_CK1_1	292	298	PF00069	0.665
MOD_CK1_1	308	314	PF00069	0.674
MOD_CK1_1	327	333	PF00069	0.357
MOD_CK1_1	417	423	PF00069	0.568
MOD_CK1_1	449	455	PF00069	0.661
MOD_CK1_1	603	609	PF00069	0.564
MOD_CK1_1	66	72	PF00069	0.741
MOD_CK2_1	452	458	PF00069	0.686
MOD_CK2_1	62	68	PF00069	0.704
MOD_Cter_Amidation	13	16	PF01082	0.665
MOD_DYRK1A_RPxSP_1	16	20	PF00069	0.571
MOD_GlcNHglycan	266	269	PF01048	0.437
MOD_GlcNHglycan	275	278	PF01048	0.425
MOD_GlcNHglycan	386	389	PF01048	0.522
MOD_GlcNHglycan	452	455	PF01048	0.656
MOD_GlcNHglycan	481	484	PF01048	0.539
MOD_GlcNHglycan	65	68	PF01048	0.728
MOD_GSK3_1	146	153	PF00069	0.409
MOD_GSK3_1	2	9	PF00069	0.688
MOD_GSK3_1	269	276	PF00069	0.539
MOD_GSK3_1	304	311	PF00069	0.720
MOD_GSK3_1	313	320	PF00069	0.706
MOD_GSK3_1	323	330	PF00069	0.383
MOD_GSK3_1	349	356	PF00069	0.535
MOD_GSK3_1	410	417	PF00069	0.515
MOD_GSK3_1	446	453	PF00069	0.643
MOD_GSK3_1	495	502	PF00069	0.524
MOD_GSK3_1	57	64	PF00069	0.622
MOD_GSK3_1	600	607	PF00069	0.526
MOD_GSK3_1	66	73	PF00069	0.702
MOD_N-GLC_1	269	274	PF02516	0.575
MOD_N-GLC_1	604	609	PF02516	0.594
MOD_N-GLC_1	76	81	PF02516	0.799
MOD_NEK2_1	122	127	PF00069	0.464
MOD_NEK2_1	146	151	PF00069	0.393
MOD_NEK2_1	165	170	PF00069	0.436
MOD_NEK2_1	264	269	PF00069	0.416
MOD_NEK2_1	410	415	PF00069	0.529
MOD_NEK2_1	479	484	PF00069	0.453
MOD_NEK2_1	48	53	PF00069	0.583
MOD_NEK2_1	6	11	PF00069	0.680
MOD_NEK2_1	600	605	PF00069	0.489
MOD_PIKK_1	122	128	PF00454	0.502
MOD_PIKK_1	317	323	PF00454	0.591
MOD_PIKK_1	57	63	PF00454	0.603
MOD_PIKK_1	7	13	PF00454	0.720
MOD_PIKK_1	88	94	PF00454	0.518
MOD_PK_1	134	140	PF00069	0.522
MOD_PKA_1	414	420	PF00069	0.498
MOD_PKA_2	14	20	PF00069	0.598
MOD_PKA_2	289	295	PF00069	0.628
MOD_PKA_2	414	420	PF00069	0.540
MOD_PKA_2	6	12	PF00069	0.625
MOD_PKA_2	601	607	PF00069	0.477
MOD_PKB_1	288	296	PF00069	0.706
MOD_Plk_1	327	333	PF00069	0.428
MOD_Plk_1	563	569	PF00069	0.540
MOD_Plk_1	604	610	PF00069	0.597
MOD_Plk_4	101	107	PF00069	0.495
MOD_Plk_4	177	183	PF00069	0.378
MOD_Plk_4	226	232	PF00069	0.399
MOD_Plk_4	255	261	PF00069	0.518
MOD_Plk_4	414	420	PF00069	0.517
MOD_Plk_4	488	494	PF00069	0.394
MOD_ProDKin_1	16	22	PF00069	0.572
MOD_ProDKin_1	253	259	PF00069	0.502
MOD_ProDKin_1	270	276	PF00069	0.468
MOD_ProDKin_1	292	298	PF00069	0.671
MOD_ProDKin_1	306	312	PF00069	0.683
MOD_ProDKin_1	429	435	PF00069	0.503
TRG_DiLeu_BaEn_1	158	163	PF01217	0.526
TRG_DiLeu_BaEn_1	242	247	PF01217	0.398
TRG_DiLeu_BaEn_2	117	123	PF01217	0.402
TRG_DiLeu_BaEn_3	202	208	PF01217	0.463
TRG_DiLeu_BaEn_4	487	493	PF01217	0.485
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.431
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.524
TRG_DiLeu_BaLyEn_6	577	582	PF01217	0.446
TRG_ENDOCYTIC_2	185	188	PF00928	0.392
TRG_ENDOCYTIC_2	21	24	PF00928	0.455
TRG_ENDOCYTIC_2	216	219	PF00928	0.454
TRG_ENDOCYTIC_2	263	266	PF00928	0.407
TRG_ENDOCYTIC_2	505	508	PF00928	0.483
TRG_ER_diArg_1	414	416	PF00400	0.565
TRG_ER_diArg_1	594	596	PF00400	0.442
TRG_NES_CRM1_1	139	152	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D3	Leptomonas seymouri	67%	100%
A0A1X0P1N4	Trypanosomatidae	40%	100%
A0A3S7X3S8	Leishmania donovani	100%	92%
A0A422P0R1	Trypanosoma rangeli	39%	100%
A4HIP4	Leishmania braziliensis	85%	100%
C9ZRB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B184	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q6Y0	Leishmania major	95%	100%
V5BSF5	Trypanosoma cruzi	39%	100%