RRM domain-containing protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 42 (RNA-binding motif protein 42) - putative

Species:

Leishmania infantum

UniProt:

A4I5Z0_LEIIN

TriTrypDb:

LINF_300036500

Length:

332

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding 42 (RNA-binding motif 42) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Phosphorylation

Promastigote: 149

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I5Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Z0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	248	250	PF00675	0.701
CLV_PCSK_KEX2_1	242	244	PF00082	0.713
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.713
CLV_PCSK_SKI1_1	18	22	PF00082	0.458
CLV_PCSK_SKI1_1	258	262	PF00082	0.414
CLV_PCSK_SKI1_1	273	277	PF00082	0.432
CLV_PCSK_SKI1_1	32	36	PF00082	0.446
DEG_APCC_DBOX_1	272	280	PF00400	0.511
DEG_SCF_FBW7_2	150	155	PF00400	0.742
DOC_MAPK_MEF2A_6	311	318	PF00069	0.345
DOC_PP1_RVXF_1	256	262	PF00149	0.424
DOC_PP2B_PxIxI_1	313	319	PF00149	0.347
DOC_USP7_MATH_1	144	148	PF00917	0.731
DOC_USP7_MATH_1	191	195	PF00917	0.630
DOC_WW_Pin1_4	128	133	PF00397	0.548
DOC_WW_Pin1_4	137	142	PF00397	0.542
DOC_WW_Pin1_4	146	151	PF00397	0.713
LIG_14-3-3_CanoR_1	287	296	PF00244	0.415
LIG_14-3-3_CanoR_1	32	37	PF00244	0.467
LIG_APCC_ABBA_1	303	308	PF00400	0.545
LIG_APCC_ABBAyCdc20_2	292	298	PF00400	0.477
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BIR_III_3	1	5	PF00653	0.491
LIG_FHA_1	262	268	PF00498	0.591
LIG_FHA_1	33	39	PF00498	0.389
LIG_FHA_2	101	107	PF00498	0.451
LIG_FHA_2	266	272	PF00498	0.477
LIG_FHA_2	35	41	PF00498	0.363
LIG_IRF3_LxIS_1	41	46	PF10401	0.488
LIG_LIR_Gen_1	198	207	PF02991	0.551
LIG_LIR_Nem_3	198	202	PF02991	0.524
LIG_LIR_Nem_3	50	55	PF02991	0.457
LIG_Pex14_2	11	15	PF04695	0.348
LIG_SH2_CRK	80	84	PF00017	0.373
LIG_SH2_CRK	99	103	PF00017	0.172
LIG_SH2_PTP2	52	55	PF00017	0.515
LIG_SH2_SRC	52	55	PF00017	0.515
LIG_SH2_STAT5	118	121	PF00017	0.379
LIG_SH2_STAT5	52	55	PF00017	0.515
LIG_SH3_3	129	135	PF00018	0.591
LIG_SH3_3	155	161	PF00018	0.707
LIG_SUMO_SIM_par_1	34	40	PF11976	0.430
LIG_TRAF2_1	167	170	PF00917	0.760
LIG_WRC_WIRS_1	105	110	PF05994	0.534
LIG_WW_3	244	248	PF00397	0.713
MOD_CK1_1	198	204	PF00069	0.570
MOD_CK2_1	100	106	PF00069	0.453
MOD_CK2_1	265	271	PF00069	0.448
MOD_Cter_Amidation	223	226	PF01082	0.768
MOD_GlcNHglycan	172	175	PF01048	0.722
MOD_GlcNHglycan	279	282	PF01048	0.478
MOD_GlcNHglycan	289	292	PF01048	0.341
MOD_GSK3_1	100	107	PF00069	0.455
MOD_GSK3_1	144	151	PF00069	0.682
MOD_GSK3_1	191	198	PF00069	0.578
MOD_GSK3_1	261	268	PF00069	0.536
MOD_GSK3_1	60	67	PF00069	0.469
MOD_N-GLC_1	261	266	PF02516	0.536
MOD_N-GLC_1	287	292	PF02516	0.434
MOD_NEK2_1	108	113	PF00069	0.580
MOD_NEK2_1	260	265	PF00069	0.571
MOD_NEK2_1	64	69	PF00069	0.480
MOD_PK_1	70	76	PF00069	0.477
MOD_PKA_1	225	231	PF00069	0.713
MOD_PKA_1	249	255	PF00069	0.718
MOD_PKB_1	247	255	PF00069	0.726
MOD_PKB_1	68	76	PF00069	0.530
MOD_Plk_4	198	204	PF00069	0.612
MOD_Plk_4	321	327	PF00069	0.461
MOD_Plk_4	48	54	PF00069	0.440
MOD_ProDKin_1	128	134	PF00069	0.558
MOD_ProDKin_1	137	143	PF00069	0.545
MOD_ProDKin_1	146	152	PF00069	0.713
MOD_SUMO_for_1	163	166	PF00179	0.780
MOD_SUMO_rev_2	179	188	PF00179	0.728
TRG_ENDOCYTIC_2	52	55	PF00928	0.515
TRG_ENDOCYTIC_2	80	83	PF00928	0.379
TRG_ENDOCYTIC_2	98	101	PF00928	0.345
TRG_ER_diArg_1	326	329	PF00400	0.485
TRG_ER_diArg_1	68	71	PF00400	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL25	Leptomonas seymouri	65%	96%
A0A3R7N1J6	Trypanosoma rangeli	38%	86%
A0A3S5H7N8	Leishmania donovani	100%	100%
A4HIP3	Leishmania braziliensis	86%	100%
E9B183	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6Y1	Leishmania major	93%	100%
V5BX42	Trypanosoma cruzi	38%	80%