LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
tRNA (Guanine-1)-methyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4I5Y8_LEIIN
TriTrypDb:
LINF_300036300
Length:
387

Annotations

Annotations by Jardim et al.

RNA Processing, tRNA (Guanine-1)-methyltransferase, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I5Y8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Y8

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 1
GO:0002939 tRNA N1-guanine methylation 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006399 tRNA metabolic process 7 1
GO:0006400 tRNA modification 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008033 tRNA processing 8 1
GO:0008152 metabolic process 1 7
GO:0009451 RNA modification 5 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0030488 tRNA methylation 5 1
GO:0032259 methylation 2 7
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043414 macromolecule methylation 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000049 tRNA binding 5 1
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0003824 catalytic activity 1 9
GO:0005488 binding 1 1
GO:0008168 methyltransferase activity 4 9
GO:0008173 RNA methyltransferase activity 4 3
GO:0008175 tRNA methyltransferase activity 5 3
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 3
GO:0009019 tRNA (guanine-N1-)-methyltransferase activity 7 3
GO:0016423 tRNA (guanine) methyltransferase activity 6 3
GO:0016740 transferase activity 2 9
GO:0016741 transferase activity, transferring one-carbon groups 3 9
GO:0097159 organic cyclic compound binding 2 1
GO:0140098 catalytic activity, acting on RNA 3 3
GO:0140101 catalytic activity, acting on a tRNA 4 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:1901363 heterocyclic compound binding 2 1
GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity 8 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 104 106 PF00675 0.508
CLV_NRD_NRD_1 115 117 PF00675 0.404
CLV_NRD_NRD_1 210 212 PF00675 0.225
CLV_NRD_NRD_1 329 331 PF00675 0.482
CLV_NRD_NRD_1 338 340 PF00675 0.558
CLV_NRD_NRD_1 52 54 PF00675 0.632
CLV_NRD_NRD_1 55 57 PF00675 0.565
CLV_NRD_NRD_1 77 79 PF00675 0.448
CLV_PCSK_FUR_1 338 342 PF00082 0.530
CLV_PCSK_FUR_1 53 57 PF00082 0.556
CLV_PCSK_FUR_1 75 79 PF00082 0.450
CLV_PCSK_KEX2_1 104 106 PF00082 0.508
CLV_PCSK_KEX2_1 114 116 PF00082 0.411
CLV_PCSK_KEX2_1 210 212 PF00082 0.225
CLV_PCSK_KEX2_1 329 331 PF00082 0.482
CLV_PCSK_KEX2_1 338 340 PF00082 0.510
CLV_PCSK_KEX2_1 52 54 PF00082 0.602
CLV_PCSK_KEX2_1 55 57 PF00082 0.524
CLV_PCSK_KEX2_1 63 65 PF00082 0.414
CLV_PCSK_KEX2_1 74 76 PF00082 0.355
CLV_PCSK_KEX2_1 77 79 PF00082 0.398
CLV_PCSK_PC1ET2_1 340 342 PF00082 0.520
CLV_PCSK_PC1ET2_1 63 65 PF00082 0.470
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.518
CLV_PCSK_SKI1_1 293 297 PF00082 0.212
CLV_PCSK_SKI1_1 63 67 PF00082 0.469
DEG_SCF_FBW7_1 13 19 PF00400 0.529
DOC_CKS1_1 13 18 PF01111 0.528
DOC_MAPK_gen_1 101 111 PF00069 0.439
DOC_MAPK_gen_1 336 346 PF00069 0.677
DOC_PP2B_LxvP_1 225 228 PF13499 0.427
DOC_USP7_MATH_1 16 20 PF00917 0.621
DOC_USP7_MATH_1 31 35 PF00917 0.478
DOC_USP7_MATH_1 41 45 PF00917 0.565
DOC_USP7_UBL2_3 336 340 PF12436 0.516
DOC_USP7_UBL2_3 70 74 PF12436 0.448
DOC_WW_Pin1_4 235 240 PF00397 0.427
DOC_WW_Pin1_4 312 317 PF00397 0.507
DOC_WW_Pin1_4 44 49 PF00397 0.593
DOC_WW_Pin1_4 9 14 PF00397 0.575
LIG_14-3-3_CanoR_1 341 347 PF00244 0.624
LIG_14-3-3_CanoR_1 53 59 PF00244 0.537
LIG_Actin_WH2_2 153 170 PF00022 0.507
LIG_Actin_WH2_2 296 313 PF00022 0.507
LIG_BRCT_BRCA1_1 222 226 PF00533 0.507
LIG_CaM_NSCaTE_8 318 325 PF13499 0.427
LIG_EH1_1 298 306 PF00400 0.507
LIG_FHA_1 118 124 PF00498 0.413
LIG_FHA_1 247 253 PF00498 0.447
LIG_FHA_1 275 281 PF00498 0.468
LIG_FHA_2 13 19 PF00498 0.463
LIG_FHA_2 187 193 PF00498 0.453
LIG_FHA_2 241 247 PF00498 0.473
LIG_FHA_2 57 63 PF00498 0.460
LIG_FHA_2 95 101 PF00498 0.458
LIG_LIR_Gen_1 163 172 PF02991 0.425
LIG_LIR_Nem_3 163 167 PF02991 0.425
LIG_LIR_Nem_3 207 212 PF02991 0.420
LIG_Pex14_1 222 226 PF04695 0.425
LIG_Pex14_2 140 144 PF04695 0.274
LIG_RPA_C_Fungi 110 122 PF08784 0.441
LIG_SH2_CRK 164 168 PF00017 0.295
LIG_SH2_NCK_1 267 271 PF00017 0.380
LIG_SH2_STAT5 251 254 PF00017 0.271
LIG_SH3_3 10 16 PF00018 0.593
LIG_SH3_3 130 136 PF00018 0.494
LIG_SH3_3 170 176 PF00018 0.265
LIG_TRAF2_1 377 380 PF00917 0.475
LIG_TRAF2_1 59 62 PF00917 0.424
LIG_TYR_ITIM 162 167 PF00017 0.268
LIG_TYR_ITIM 305 310 PF00017 0.380
LIG_ULM_U2AF65_1 338 343 PF00076 0.421
MOD_CK1_1 12 18 PF00069 0.592
MOD_CK1_1 155 161 PF00069 0.247
MOD_CK1_1 20 26 PF00069 0.572
MOD_CK1_1 238 244 PF00069 0.268
MOD_CK1_1 266 272 PF00069 0.312
MOD_CK1_1 44 50 PF00069 0.613
MOD_CK2_1 12 18 PF00069 0.460
MOD_CK2_1 184 190 PF00069 0.380
MOD_CK2_1 240 246 PF00069 0.271
MOD_CK2_1 346 352 PF00069 0.596
MOD_CK2_1 56 62 PF00069 0.469
MOD_CK2_1 94 100 PF00069 0.509
MOD_Cter_Amidation 336 339 PF01082 0.517
MOD_Cter_Amidation 75 78 PF01082 0.333
MOD_GlcNHglycan 164 167 PF01048 0.296
MOD_GlcNHglycan 23 26 PF01048 0.572
MOD_GlcNHglycan 268 271 PF01048 0.416
MOD_GlcNHglycan 348 351 PF01048 0.636
MOD_GlcNHglycan 374 377 PF01048 0.638
MOD_GSK3_1 12 19 PF00069 0.587
MOD_GSK3_1 146 153 PF00069 0.384
MOD_GSK3_1 162 169 PF00069 0.367
MOD_GSK3_1 342 349 PF00069 0.651
MOD_GSK3_1 368 375 PF00069 0.552
MOD_N-GLC_1 31 36 PF02516 0.497
MOD_N-GLC_1 372 377 PF02516 0.654
MOD_N-GLC_2 124 126 PF02516 0.359
MOD_N-GLC_2 290 292 PF02516 0.247
MOD_NEK2_1 140 145 PF00069 0.302
MOD_NEK2_1 162 167 PF00069 0.260
MOD_NEK2_1 21 26 PF00069 0.539
MOD_NEK2_2 17 22 PF00069 0.477
MOD_PIKK_1 155 161 PF00454 0.247
MOD_PIKK_1 214 220 PF00454 0.312
MOD_PIKK_1 226 232 PF00454 0.268
MOD_PIKK_1 56 62 PF00454 0.374
MOD_PKA_2 21 27 PF00069 0.513
MOD_PKA_2 342 348 PF00069 0.618
MOD_PKA_2 54 60 PF00069 0.571
MOD_PKA_2 94 100 PF00069 0.614
MOD_Plk_1 140 146 PF00069 0.307
MOD_Plk_1 17 23 PF00069 0.477
MOD_Plk_2-3 357 363 PF00069 0.693
MOD_Plk_4 134 140 PF00069 0.318
MOD_Plk_4 177 183 PF00069 0.366
MOD_Plk_4 282 288 PF00069 0.390
MOD_ProDKin_1 235 241 PF00069 0.268
MOD_ProDKin_1 312 318 PF00069 0.380
MOD_ProDKin_1 44 50 PF00069 0.592
MOD_ProDKin_1 9 15 PF00069 0.574
MOD_SUMO_rev_2 57 65 PF00179 0.468
TRG_ENDOCYTIC_2 164 167 PF00928 0.295
TRG_ENDOCYTIC_2 206 209 PF00928 0.360
TRG_ENDOCYTIC_2 307 310 PF00928 0.382
TRG_ER_diArg_1 114 116 PF00400 0.408
TRG_ER_diArg_1 209 211 PF00400 0.265
TRG_ER_diArg_1 338 341 PF00400 0.618
TRG_ER_diArg_1 52 55 PF00400 0.659
TRG_ER_diArg_1 75 78 PF00400 0.400
TRG_NLS_Bipartite_1 329 344 PF00514 0.613
TRG_NLS_MonoExtC_3 338 343 PF00514 0.547
TRG_NLS_MonoExtN_4 336 343 PF00514 0.565

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I770 Leptomonas seymouri 69% 100%
A0A0S4JPX3 Bodo saltans 43% 100%
A0A1X0P1F8 Trypanosomatidae 47% 100%
A0A3S5ISH7 Trypanosoma rangeli 49% 100%
A0A3S7X3S5 Leishmania donovani 100% 100%
A4HIP1 Leishmania braziliensis 74% 100%
E9B181 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
O14214 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
Q4I8X0 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 28% 95%
Q4Q6Y3 Leishmania major 89% 100%
Q59Q39 Candida albicans (strain SC5314 / ATCC MYA-2876) 26% 100%
Q5B8X0 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 27% 93%
Q6C1W9 Yarrowia lipolytica (strain CLIB 122 / E 150) 24% 100%
Q6CUM6 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 28% 100%
Q6FQB2 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 27% 100%
Q6PF06 Homo sapiens 25% 100%
Q9D075 Mus musculus 25% 100%
V5DNZ8 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS