LeishMANIAdb
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Eukaryotic translation initiation factor 3 subunit 7-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Eukaryotic translation initiation factor 3 subunit 7-like protein
Gene product:
eukaryotic translation initiation factor 3 subunit 7-like protein
Species:
Leishmania infantum
UniProt:
A4I5Y5_LEIIN
TriTrypDb:
LINF_300036000
Length:
531

Annotations

Annotations by Jardim et al.

Translation, Eukaryotic translation initiation factor 3 subunit 7-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005852 eukaryotic translation initiation factor 3 complex 2 12
GO:0032991 protein-containing complex 1 12
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote/Amastigote: 55, 57, 59

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I5Y5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Y5

Function

Biological processes
Term Name Level Count
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 282 286 PF00656 0.481
CLV_C14_Caspase3-7 378 382 PF00656 0.525
CLV_C14_Caspase3-7 53 57 PF00656 0.462
CLV_NRD_NRD_1 122 124 PF00675 0.278
CLV_NRD_NRD_1 125 127 PF00675 0.285
CLV_NRD_NRD_1 211 213 PF00675 0.306
CLV_NRD_NRD_1 325 327 PF00675 0.261
CLV_NRD_NRD_1 335 337 PF00675 0.183
CLV_NRD_NRD_1 385 387 PF00675 0.234
CLV_NRD_NRD_1 68 70 PF00675 0.306
CLV_PCSK_FUR_1 123 127 PF00082 0.325
CLV_PCSK_KEX2_1 122 124 PF00082 0.270
CLV_PCSK_KEX2_1 125 127 PF00082 0.274
CLV_PCSK_KEX2_1 335 337 PF00082 0.220
CLV_PCSK_KEX2_1 385 387 PF00082 0.290
CLV_PCSK_KEX2_1 68 70 PF00082 0.298
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.298
CLV_PCSK_SKI1_1 102 106 PF00082 0.233
CLV_PCSK_SKI1_1 126 130 PF00082 0.240
CLV_PCSK_SKI1_1 202 206 PF00082 0.256
CLV_PCSK_SKI1_1 421 425 PF00082 0.284
CLV_PCSK_SKI1_1 69 73 PF00082 0.247
DEG_APCC_DBOX_1 219 227 PF00400 0.506
DOC_CKS1_1 169 174 PF01111 0.506
DOC_CYCLIN_RxL_1 183 193 PF00134 0.506
DOC_MAPK_gen_1 407 416 PF00069 0.506
DOC_MAPK_gen_1 85 94 PF00069 0.531
DOC_PP1_RVXF_1 422 428 PF00149 0.410
DOC_PP1_RVXF_1 88 95 PF00149 0.525
DOC_PP4_FxxP_1 3 6 PF00568 0.422
DOC_USP7_MATH_1 306 310 PF00917 0.472
DOC_USP7_MATH_1 52 56 PF00917 0.525
DOC_USP7_MATH_2 30 36 PF00917 0.525
DOC_USP7_UBL2_3 110 114 PF12436 0.483
DOC_USP7_UBL2_3 494 498 PF12436 0.506
DOC_WW_Pin1_4 168 173 PF00397 0.493
DOC_WW_Pin1_4 319 324 PF00397 0.481
DOC_WW_Pin1_4 340 345 PF00397 0.506
DOC_WW_Pin1_4 452 457 PF00397 0.483
LIG_14-3-3_CanoR_1 125 135 PF00244 0.434
LIG_14-3-3_CanoR_1 156 164 PF00244 0.500
LIG_14-3-3_CanoR_1 202 211 PF00244 0.461
LIG_14-3-3_CanoR_1 239 243 PF00244 0.461
LIG_14-3-3_CanoR_1 290 295 PF00244 0.435
LIG_14-3-3_CanoR_1 307 314 PF00244 0.410
LIG_14-3-3_CanoR_1 330 335 PF00244 0.506
LIG_14-3-3_CanoR_1 410 417 PF00244 0.458
LIG_Actin_WH2_2 140 158 PF00022 0.504
LIG_Actin_WH2_2 197 214 PF00022 0.482
LIG_APCC_ABBA_1 478 483 PF00400 0.506
LIG_BIR_II_1 1 5 PF00653 0.342
LIG_CaM_IQ_9 140 156 PF13499 0.506
LIG_Clathr_ClatBox_1 501 505 PF01394 0.580
LIG_FHA_1 169 175 PF00498 0.506
LIG_FHA_1 225 231 PF00498 0.441
LIG_FHA_2 175 181 PF00498 0.482
LIG_FHA_2 203 209 PF00498 0.434
LIG_FHA_2 427 433 PF00498 0.497
LIG_FHA_2 84 90 PF00498 0.483
LIG_LIR_Apic_2 15 19 PF02991 0.376
LIG_LIR_Apic_2 2 6 PF02991 0.302
LIG_LIR_Apic_2 7 12 PF02991 0.421
LIG_LIR_Gen_1 299 308 PF02991 0.481
LIG_LIR_Gen_1 345 355 PF02991 0.421
LIG_LIR_Gen_1 468 478 PF02991 0.506
LIG_LIR_Nem_3 299 305 PF02991 0.481
LIG_LIR_Nem_3 313 317 PF02991 0.481
LIG_LIR_Nem_3 333 337 PF02991 0.458
LIG_LIR_Nem_3 345 350 PF02991 0.372
LIG_LIR_Nem_3 395 399 PF02991 0.493
LIG_LIR_Nem_3 44 48 PF02991 0.438
LIG_LIR_Nem_3 468 474 PF02991 0.494
LIG_LYPXL_yS_3 221 224 PF13949 0.497
LIG_PTB_Apo_2 8 15 PF02174 0.445
LIG_SH2_CRK 169 173 PF00017 0.506
LIG_SH2_CRK 347 351 PF00017 0.422
LIG_SH2_GRB2like 9 12 PF00017 0.481
LIG_SH2_NCK_1 34 38 PF00017 0.525
LIG_SH2_NCK_1 454 458 PF00017 0.506
LIG_SH2_PTP2 9 12 PF00017 0.506
LIG_SH2_SRC 347 350 PF00017 0.481
LIG_SH2_SRC 9 12 PF00017 0.481
LIG_SH2_STAP1 195 199 PF00017 0.506
LIG_SH2_STAP1 302 306 PF00017 0.497
LIG_SH2_STAP1 347 351 PF00017 0.431
LIG_SH2_STAT5 199 202 PF00017 0.506
LIG_SH2_STAT5 337 340 PF00017 0.470
LIG_SH2_STAT5 9 12 PF00017 0.481
LIG_SH3_4 494 501 PF00018 0.506
LIG_SUMO_SIM_anti_2 227 235 PF11976 0.432
LIG_SUMO_SIM_anti_2 412 419 PF11976 0.506
LIG_SUMO_SIM_anti_2 499 510 PF11976 0.546
LIG_SUMO_SIM_par_1 221 229 PF11976 0.422
LIG_SUMO_SIM_par_1 232 238 PF11976 0.426
LIG_SUMO_SIM_par_1 447 453 PF11976 0.525
LIG_SUMO_SIM_par_1 499 515 PF11976 0.590
LIG_TRAF2_1 429 432 PF00917 0.506
LIG_TYR_ITIM 249 254 PF00017 0.506
LIG_WW_1 172 175 PF00397 0.461
MOD_CDK_SPxK_1 340 346 PF00069 0.506
MOD_CDK_SPxxK_3 319 326 PF00069 0.506
MOD_CK1_1 322 328 PF00069 0.488
MOD_CK1_1 415 421 PF00069 0.504
MOD_CK1_1 450 456 PF00069 0.494
MOD_CK1_1 458 464 PF00069 0.495
MOD_CK2_1 174 180 PF00069 0.476
MOD_CK2_1 190 196 PF00069 0.395
MOD_CK2_1 260 266 PF00069 0.454
MOD_CK2_1 290 296 PF00069 0.495
MOD_CK2_1 426 432 PF00069 0.506
MOD_CK2_1 56 62 PF00069 0.498
MOD_CK2_1 83 89 PF00069 0.515
MOD_Cter_Amidation 108 111 PF01082 0.321
MOD_GlcNHglycan 137 140 PF01048 0.289
MOD_GlcNHglycan 157 160 PF01048 0.336
MOD_GSK3_1 131 138 PF00069 0.520
MOD_GSK3_1 306 313 PF00069 0.518
MOD_GSK3_1 375 382 PF00069 0.490
MOD_GSK3_1 483 490 PF00069 0.490
MOD_GSK3_1 52 59 PF00069 0.502
MOD_N-GLC_1 135 140 PF02516 0.276
MOD_N-GLC_1 319 324 PF02516 0.291
MOD_N-GLC_2 404 406 PF02516 0.306
MOD_NEK2_1 155 160 PF00069 0.500
MOD_NEK2_1 190 195 PF00069 0.463
MOD_NEK2_1 235 240 PF00069 0.425
MOD_OFUCOSY 304 310 PF10250 0.269
MOD_PIKK_1 458 464 PF00454 0.470
MOD_PKA_1 126 132 PF00069 0.507
MOD_PKA_2 155 161 PF00069 0.500
MOD_PKA_2 238 244 PF00069 0.494
MOD_PKA_2 278 284 PF00069 0.445
MOD_PKA_2 289 295 PF00069 0.375
MOD_PKA_2 306 312 PF00069 0.395
MOD_PKA_2 409 415 PF00069 0.502
MOD_Plk_1 135 141 PF00069 0.453
MOD_Plk_1 380 386 PF00069 0.506
MOD_Plk_1 88 94 PF00069 0.535
MOD_Plk_2-3 510 516 PF00069 0.690
MOD_Plk_2-3 56 62 PF00069 0.505
MOD_Plk_4 229 235 PF00069 0.482
MOD_Plk_4 392 398 PF00069 0.481
MOD_Plk_4 412 418 PF00069 0.289
MOD_Plk_4 487 493 PF00069 0.465
MOD_Plk_4 88 94 PF00069 0.525
MOD_ProDKin_1 168 174 PF00069 0.493
MOD_ProDKin_1 319 325 PF00069 0.481
MOD_ProDKin_1 340 346 PF00069 0.506
MOD_ProDKin_1 452 458 PF00069 0.483
MOD_SUMO_for_1 258 261 PF00179 0.506
MOD_SUMO_rev_2 20 25 PF00179 0.469
MOD_SUMO_rev_2 415 423 PF00179 0.506
TRG_DiLeu_BaEn_1 229 234 PF01217 0.431
TRG_DiLeu_BaEn_1 354 359 PF01217 0.517
TRG_DiLeu_BaEn_2 195 201 PF01217 0.455
TRG_ENDOCYTIC_2 221 224 PF00928 0.497
TRG_ENDOCYTIC_2 251 254 PF00928 0.445
TRG_ENDOCYTIC_2 302 305 PF00928 0.506
TRG_ENDOCYTIC_2 347 350 PF00928 0.434
TRG_ER_diArg_1 122 125 PF00400 0.485
TRG_ER_diArg_1 334 336 PF00400 0.418
TRG_ER_diArg_1 384 386 PF00400 0.490
TRG_Pf-PMV_PEXEL_1 186 191 PF00026 0.304
TRG_Pf-PMV_PEXEL_1 202 207 PF00026 0.199

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDH4 Leptomonas seymouri 81% 100%
A0A0S4IWX5 Bodo saltans 31% 88%
A0A1X0P1D0 Trypanosomatidae 38% 100%
A0A3R7P1P7 Trypanosoma rangeli 39% 100%
A0A3S7X3V2 Leishmania donovani 100% 100%
A1C777 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 28% 91%
A1DI25 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 24% 91%
A4HIN8 Leishmania braziliensis 94% 100%
A4RFH6 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 25% 93%
A7SMR1 Nematostella vectensis 25% 94%
B0X6P7 Culex quinquefasciatus 23% 87%
B0XU47 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 25% 91%
B3LY71 Drosophila ananassae 23% 95%
B3LZN3 Drosophila ananassae 24% 97%
B3P1F9 Drosophila erecta 24% 96%
B3P8G6 Drosophila erecta 23% 95%
B4GFS1 Drosophila persimilis 24% 97%
B4GP93 Drosophila persimilis 22% 98%
B4HFV9 Drosophila sechellia 22% 95%
B4HHG8 Drosophila sechellia 23% 97%
B4JTN0 Drosophila grimshawi 23% 94%
B4JUM0 Drosophila grimshawi 22% 95%
B4K892 Drosophila mojavensis 23% 94%
B4KDI2 Drosophila mojavensis 22% 96%
B4LYI3 Drosophila virilis 23% 94%
B4M5A7 Drosophila virilis 22% 96%
B4N8Z4 Drosophila willistoni 24% 97%
B4NLG2 Drosophila willistoni 23% 95%
B4PNN4 Drosophila yakuba 24% 96%
B4PNV2 Drosophila yakuba 22% 95%
B4QT07 Drosophila simulans 23% 96%
B4R222 Drosophila simulans 22% 95%
B5DY99 Drosophila pseudoobscura pseudoobscura 22% 94%
C9ZRB0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 95%
E9B178 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
K7IM66 Nasonia vitripennis 24% 95%
O15371 Homo sapiens 24% 97%
O70194 Mus musculus 25% 97%
P0CN48 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 23% 97%
P0CN49 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 23% 97%
P30642 Caenorhabditis elegans 24% 93%
Q0ZB77 Bombyx mori 24% 97%
Q16UF8 Aedes aegypti 23% 86%
Q295S1 Drosophila pseudoobscura pseudoobscura 23% 97%
Q3T122 Bos taurus 24% 97%
Q4Q6Y6 Leishmania major 98% 100%
Q4R8R4 Macaca fascicularis 24% 97%
Q4X054 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 25% 91%
Q554U9 Dictyostelium discoideum 23% 100%
Q5R925 Pongo abelii 24% 97%
Q6AYK8 Rattus norvegicus 25% 97%
Q6C1N1 Yarrowia lipolytica (strain CLIB 122 / E 150) 25% 100%
Q6TH15 Danio rerio 25% 96%
Q7QBW3 Anopheles gambiae 24% 91%
Q9VCK0 Drosophila melanogaster 22% 95%
Q9VGC7 Drosophila melanogaster 24% 96%
V5B793 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS