TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat/TPR repeat - putative

Species:

Leishmania infantum

UniProt:

A4I5Y0_LEIIN

TriTrypDb:

LINF_300035500

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.603
CLV_C14_Caspase3-7	315	319	PF00656	0.630
CLV_NRD_NRD_1	121	123	PF00675	0.490
CLV_NRD_NRD_1	127	129	PF00675	0.452
CLV_NRD_NRD_1	167	169	PF00675	0.536
CLV_NRD_NRD_1	172	174	PF00675	0.521
CLV_NRD_NRD_1	182	184	PF00675	0.565
CLV_NRD_NRD_1	292	294	PF00675	0.664
CLV_NRD_NRD_1	421	423	PF00675	0.278
CLV_NRD_NRD_1	521	523	PF00675	0.289
CLV_NRD_NRD_1	691	693	PF00675	0.323
CLV_PCSK_FUR_1	170	174	PF00082	0.523
CLV_PCSK_KEX2_1	127	129	PF00082	0.406
CLV_PCSK_KEX2_1	167	169	PF00082	0.536
CLV_PCSK_KEX2_1	172	174	PF00082	0.521
CLV_PCSK_KEX2_1	182	184	PF00082	0.565
CLV_PCSK_KEX2_1	292	294	PF00082	0.713
CLV_PCSK_KEX2_1	40	42	PF00082	0.651
CLV_PCSK_KEX2_1	420	422	PF00082	0.366
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.475
CLV_PCSK_PC7_1	168	174	PF00082	0.559
CLV_PCSK_SKI1_1	398	402	PF00082	0.512
CLV_PCSK_SKI1_1	444	448	PF00082	0.289
CLV_PCSK_SKI1_1	517	521	PF00082	0.324
CLV_PCSK_SKI1_1	543	547	PF00082	0.426
CLV_PCSK_SKI1_1	811	815	PF00082	0.389
DEG_APCC_DBOX_1	102	110	PF00400	0.443
DEG_APCC_DBOX_1	189	197	PF00400	0.584
DEG_APCC_DBOX_1	796	804	PF00400	0.483
DEG_APCC_KENBOX_2	162	166	PF00400	0.454
DEG_SCF_FBW7_2	217	223	PF00400	0.621
DEG_SPOP_SBC_1	11	15	PF00917	0.609
DEG_SPOP_SBC_1	309	313	PF00917	0.652
DOC_CKS1_1	217	222	PF01111	0.620
DOC_CYCLIN_RxL_1	430	441	PF00134	0.370
DOC_MAPK_DCC_7	190	198	PF00069	0.604
DOC_MAPK_gen_1	190	198	PF00069	0.617
DOC_MAPK_gen_1	49	59	PF00069	0.388
DOC_MAPK_MEF2A_6	607	614	PF00069	0.432
DOC_MAPK_MEF2A_6	658	667	PF00069	0.349
DOC_MAPK_MEF2A_6	811	818	PF00069	0.448
DOC_MAPK_NFAT4_5	811	819	PF00069	0.454
DOC_PP1_RVXF_1	609	615	PF00149	0.479
DOC_PP1_RVXF_1	754	761	PF00149	0.362
DOC_USP7_MATH_1	11	15	PF00917	0.685
DOC_USP7_MATH_1	197	201	PF00917	0.644
DOC_USP7_MATH_1	234	238	PF00917	0.783
DOC_USP7_MATH_1	248	252	PF00917	0.619
DOC_USP7_MATH_1	261	265	PF00917	0.632
DOC_USP7_MATH_1	267	271	PF00917	0.699
DOC_USP7_MATH_1	88	92	PF00917	0.436
DOC_USP7_UBL2_3	811	815	PF12436	0.417
DOC_WW_Pin1_4	191	196	PF00397	0.517
DOC_WW_Pin1_4	208	213	PF00397	0.573
DOC_WW_Pin1_4	216	221	PF00397	0.567
DOC_WW_Pin1_4	238	243	PF00397	0.646
DOC_WW_Pin1_4	436	441	PF00397	0.383
DOC_WW_Pin1_4	606	611	PF00397	0.311
LIG_14-3-3_CanoR_1	103	113	PF00244	0.404
LIG_14-3-3_CanoR_1	16	26	PF00244	0.657
LIG_14-3-3_CanoR_1	172	181	PF00244	0.590
LIG_14-3-3_CanoR_1	185	193	PF00244	0.507
LIG_14-3-3_CanoR_1	398	407	PF00244	0.495
LIG_14-3-3_CanoR_1	475	485	PF00244	0.362
LIG_14-3-3_CanoR_1	653	658	PF00244	0.323
LIG_14-3-3_CanoR_1	756	761	PF00244	0.323
LIG_Actin_WH2_2	25	42	PF00022	0.377
LIG_Actin_WH2_2	592	609	PF00022	0.290
LIG_Actin_WH2_2	796	813	PF00022	0.462
LIG_APCC_ABBA_1	729	734	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	728	734	PF00400	0.431
LIG_BRCT_BRCA1_1	294	298	PF00533	0.707
LIG_EH_1	475	479	PF12763	0.362
LIG_FHA_1	115	121	PF00498	0.383
LIG_FHA_1	266	272	PF00498	0.632
LIG_FHA_1	3	9	PF00498	0.664
LIG_FHA_1	311	317	PF00498	0.675
LIG_FHA_1	334	340	PF00498	0.629
LIG_FHA_1	34	40	PF00498	0.522
LIG_FHA_1	361	367	PF00498	0.579
LIG_FHA_1	431	437	PF00498	0.383
LIG_FHA_1	458	464	PF00498	0.426
LIG_FHA_1	46	52	PF00498	0.433
LIG_FHA_1	465	471	PF00498	0.395
LIG_FHA_1	499	505	PF00498	0.383
LIG_FHA_1	533	539	PF00498	0.317
LIG_FHA_1	611	617	PF00498	0.358
LIG_FHA_1	635	641	PF00498	0.289
LIG_FHA_1	703	709	PF00498	0.293
LIG_FHA_1	714	720	PF00498	0.371
LIG_FHA_1	738	744	PF00498	0.402
LIG_FHA_1	772	778	PF00498	0.323
LIG_FHA_1	793	799	PF00498	0.454
LIG_FHA_1	91	97	PF00498	0.431
LIG_FHA_2	325	331	PF00498	0.606
LIG_FHA_2	343	349	PF00498	0.555
LIG_LIR_Apic_2	272	277	PF02991	0.643
LIG_LIR_Gen_1	115	124	PF02991	0.466
LIG_LIR_Gen_1	141	152	PF02991	0.318
LIG_LIR_Gen_1	738	747	PF02991	0.366
LIG_LIR_Nem_3	115	119	PF02991	0.399
LIG_LIR_Nem_3	141	147	PF02991	0.318
LIG_LIR_Nem_3	441	446	PF02991	0.396
LIG_LIR_Nem_3	738	742	PF02991	0.347
LIG_LYPXL_SIV_4	723	731	PF13949	0.431
LIG_MYND_1	191	195	PF01753	0.575
LIG_MYND_1	24	28	PF01753	0.522
LIG_NBox_RRM_1	773	783	PF00076	0.237
LIG_NRBOX	46	52	PF00104	0.446
LIG_PCNA_PIPBox_1	404	413	PF02747	0.390
LIG_Pex14_2	443	447	PF04695	0.289
LIG_PTB_Apo_2	405	412	PF02174	0.387
LIG_PTB_Apo_2	445	452	PF02174	0.289
LIG_PTB_Apo_2	513	520	PF02174	0.298
LIG_PTB_Apo_2	649	656	PF02174	0.281
LIG_PTB_Apo_2	683	690	PF02174	0.305
LIG_PTB_Apo_2	718	725	PF02174	0.311
LIG_PTB_Phospho_1	405	411	PF10480	0.397
LIG_PTB_Phospho_1	649	655	PF10480	0.366
LIG_PTB_Phospho_1	718	724	PF10480	0.348
LIG_REV1ctd_RIR_1	511	521	PF16727	0.351
LIG_RPA_C_Fungi	580	592	PF08784	0.292
LIG_RPA_C_Fungi	682	694	PF08784	0.305
LIG_SH2_CRK	274	278	PF00017	0.668
LIG_SH2_CRK	623	627	PF00017	0.383
LIG_SH2_CRK	98	102	PF00017	0.418
LIG_SH2_GRB2like	582	585	PF00017	0.289
LIG_SH2_GRB2like	684	687	PF00017	0.324
LIG_SH2_NCK_1	131	135	PF00017	0.289
LIG_SH2_NCK_1	274	278	PF00017	0.668
LIG_SH2_NCK_1	549	553	PF00017	0.324
LIG_SH2_NCK_1	766	770	PF00017	0.187
LIG_SH2_PTP2	56	59	PF00017	0.452
LIG_SH2_SRC	561	564	PF00017	0.383
LIG_SH2_STAP1	131	135	PF00017	0.289
LIG_SH2_STAP1	150	154	PF00017	0.289
LIG_SH2_STAP1	35	39	PF00017	0.412
LIG_SH2_STAP1	432	436	PF00017	0.289
LIG_SH2_STAP1	459	463	PF00017	0.368
LIG_SH2_STAP1	466	470	PF00017	0.188
LIG_SH2_STAP1	527	531	PF00017	0.325
LIG_SH2_STAP1	534	538	PF00017	0.257
LIG_SH2_STAP1	561	565	PF00017	0.311
LIG_SH2_STAP1	568	572	PF00017	0.266
LIG_SH2_STAP1	629	633	PF00017	0.383
LIG_SH2_STAP1	670	674	PF00017	0.323
LIG_SH2_STAP1	684	688	PF00017	0.323
LIG_SH2_STAP1	697	701	PF00017	0.243
LIG_SH2_STAP1	704	708	PF00017	0.162
LIG_SH2_STAP1	739	743	PF00017	0.373
LIG_SH2_STAP1	829	833	PF00017	0.326
LIG_SH2_STAT3	411	414	PF00017	0.367
LIG_SH2_STAT5	274	277	PF00017	0.667
LIG_SH2_STAT5	35	38	PF00017	0.450
LIG_SH2_STAT5	411	414	PF00017	0.516
LIG_SH2_STAT5	432	435	PF00017	0.340
LIG_SH2_STAT5	459	462	PF00017	0.489
LIG_SH2_STAT5	466	469	PF00017	0.248
LIG_SH2_STAT5	534	537	PF00017	0.317
LIG_SH2_STAT5	553	556	PF00017	0.234
LIG_SH2_STAT5	56	59	PF00017	0.392
LIG_SH2_STAT5	655	658	PF00017	0.366
LIG_SH2_STAT5	684	687	PF00017	0.450
LIG_SH2_STAT5	704	707	PF00017	0.206
LIG_SH2_STAT5	724	727	PF00017	0.194
LIG_SH2_STAT5	739	742	PF00017	0.389
LIG_SH3_1	778	784	PF00018	0.362
LIG_SH3_3	200	206	PF00018	0.715
LIG_SH3_3	21	27	PF00018	0.566
LIG_SH3_3	214	220	PF00018	0.591
LIG_SH3_3	228	234	PF00018	0.514
LIG_SH3_3	236	242	PF00018	0.665
LIG_SH3_3	471	477	PF00018	0.362
LIG_SH3_3	778	784	PF00018	0.362
LIG_SUMO_SIM_par_1	267	273	PF11976	0.586
LIG_TYR_ITIM	621	626	PF00017	0.383
LIG_TYR_ITIM	96	101	PF00017	0.418
MOD_CDC14_SPxK_1	211	214	PF00782	0.622
MOD_CDK_SPK_2	606	611	PF00069	0.311
MOD_CDK_SPxK_1	208	214	PF00069	0.613
MOD_CK1_1	241	247	PF00069	0.630
MOD_CK1_1	272	278	PF00069	0.650
MOD_CK1_1	299	305	PF00069	0.660
MOD_CK1_1	308	314	PF00069	0.581
MOD_CK1_1	342	348	PF00069	0.579
MOD_CK1_1	368	374	PF00069	0.639
MOD_CK1_1	390	396	PF00069	0.598
MOD_CK1_1	4	10	PF00069	0.669
MOD_CK1_1	785	791	PF00069	0.427
MOD_CK1_1	792	798	PF00069	0.369
MOD_CK2_1	267	273	PF00069	0.656
MOD_CK2_1	308	314	PF00069	0.637
MOD_CK2_1	317	323	PF00069	0.681
MOD_CK2_1	342	348	PF00069	0.655
MOD_CK2_1	366	372	PF00069	0.642
MOD_CK2_1	88	94	PF00069	0.574
MOD_Cter_Amidation	290	293	PF01082	0.748
MOD_GlcNHglycan	175	178	PF01048	0.541
MOD_GlcNHglycan	235	239	PF01048	0.681
MOD_GlcNHglycan	263	266	PF01048	0.760
MOD_GlcNHglycan	286	289	PF01048	0.685
MOD_GlcNHglycan	329	334	PF01048	0.640
MOD_GlcNHglycan	575	578	PF01048	0.343
MOD_GlcNHglycan	63	66	PF01048	0.442
MOD_GlcNHglycan	669	673	PF01048	0.433
MOD_GlcNHglycan	83	86	PF01048	0.700
MOD_GSK3_1	2	9	PF00069	0.740
MOD_GSK3_1	204	211	PF00069	0.650
MOD_GSK3_1	234	241	PF00069	0.719
MOD_GSK3_1	261	268	PF00069	0.595
MOD_GSK3_1	292	299	PF00069	0.587
MOD_GSK3_1	304	311	PF00069	0.501
MOD_GSK3_1	329	336	PF00069	0.657
MOD_GSK3_1	360	367	PF00069	0.623
MOD_GSK3_1	383	390	PF00069	0.586
MOD_GSK3_1	532	539	PF00069	0.325
MOD_GSK3_1	606	613	PF00069	0.318
MOD_GSK3_1	782	789	PF00069	0.431
MOD_LATS_1	515	521	PF00433	0.273
MOD_LATS_1	651	657	PF00433	0.323
MOD_N-GLC_1	304	309	PF02516	0.796
MOD_N-GLC_1	457	462	PF02516	0.324
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	186	191	PF00069	0.591
MOD_NEK2_1	249	254	PF00069	0.646
MOD_NEK2_1	317	322	PF00069	0.730
MOD_NEK2_1	366	371	PF00069	0.522
MOD_NEK2_2	670	675	PF00069	0.366
MOD_PIKK_1	104	110	PF00454	0.362
MOD_PIKK_1	292	298	PF00454	0.712
MOD_PIKK_1	517	523	PF00454	0.305
MOD_PKA_1	292	298	PF00069	0.663
MOD_PKA_2	104	110	PF00069	0.411
MOD_PKA_2	292	298	PF00069	0.734
MOD_PKA_2	45	51	PF00069	0.422
MOD_PKA_2	792	798	PF00069	0.351
MOD_PKB_1	183	191	PF00069	0.606
MOD_Plk_1	272	278	PF00069	0.593
MOD_Plk_1	304	310	PF00069	0.629
MOD_Plk_1	324	330	PF00069	0.635
MOD_Plk_4	312	318	PF00069	0.651
MOD_Plk_4	786	792	PF00069	0.395
MOD_ProDKin_1	191	197	PF00069	0.516
MOD_ProDKin_1	208	214	PF00069	0.576
MOD_ProDKin_1	216	222	PF00069	0.567
MOD_ProDKin_1	238	244	PF00069	0.644
MOD_ProDKin_1	436	442	PF00069	0.383
MOD_ProDKin_1	606	612	PF00069	0.305
MOD_SUMO_rev_2	539	545	PF00179	0.324
MOD_SUMO_rev_2	808	813	PF00179	0.376
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.449
TRG_DiLeu_BaLyEn_6	836	841	PF01217	0.401
TRG_ENDOCYTIC_2	35	38	PF00928	0.454
TRG_ENDOCYTIC_2	56	59	PF00928	0.427
TRG_ENDOCYTIC_2	623	626	PF00928	0.383
TRG_ENDOCYTIC_2	657	660	PF00928	0.383
TRG_ENDOCYTIC_2	739	742	PF00928	0.389
TRG_ENDOCYTIC_2	98	101	PF00928	0.457
TRG_ER_diArg_1	103	106	PF00400	0.422
TRG_ER_diArg_1	166	168	PF00400	0.541
TRG_ER_diArg_1	181	183	PF00400	0.558
TRG_ER_diArg_1	190	193	PF00400	0.553
TRG_ER_diArg_1	292	294	PF00400	0.639
TRG_ER_diArg_1	420	422	PF00400	0.366
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	619	624	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	839	843	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB6	Leptomonas seymouri	58%	98%
A0A0S4ITS9	Bodo saltans	29%	100%
A0A3S7X3S0	Leishmania donovani	99%	100%
A4HIN3	Leishmania braziliensis	73%	100%
E9B173	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q6Z1	Leishmania major	91%	100%
V5BSG3	Trypanosoma cruzi	29%	100%