Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5X3_LEIIN

TriTrypDb:

LINF_300034750

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 0
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5X3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	280	282	PF00675	0.495
CLV_NRD_NRD_1	297	299	PF00675	0.507
CLV_NRD_NRD_1	50	52	PF00675	0.487
CLV_PCSK_FUR_1	51	55	PF00082	0.493
CLV_PCSK_KEX2_1	297	299	PF00082	0.481
CLV_PCSK_KEX2_1	53	55	PF00082	0.463
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.500
CLV_PCSK_SKI1_1	222	226	PF00082	0.376
CLV_PCSK_SKI1_1	298	302	PF00082	0.475
CLV_PCSK_SKI1_1	58	62	PF00082	0.407
DEG_APCC_DBOX_1	305	313	PF00400	0.430
DEG_APCC_DBOX_1	53	61	PF00400	0.415
DEG_APCC_KENBOX_2	315	319	PF00400	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DOC_CYCLIN_yClb1_LxF_4	309	315	PF00134	0.580
DOC_CYCLIN_yClb5_NLxxxL_5	53	61	PF00134	0.416
DOC_MAPK_gen_1	281	289	PF00069	0.477
DOC_MAPK_gen_1	51	59	PF00069	0.423
DOC_MAPK_MEF2A_6	281	289	PF00069	0.417
DOC_MAPK_MEF2A_6	51	59	PF00069	0.387
DOC_MAPK_NFAT4_5	52	60	PF00069	0.526
DOC_PP1_RVXF_1	235	241	PF00149	0.513
DOC_USP7_MATH_1	135	139	PF00917	0.563
DOC_USP7_MATH_1	190	194	PF00917	0.596
LIG_14-3-3_CanoR_1	126	131	PF00244	0.443
LIG_14-3-3_CanoR_1	298	308	PF00244	0.584
LIG_BRCT_BRCA1_1	96	100	PF00533	0.415
LIG_FHA_1	114	120	PF00498	0.472
LIG_FHA_1	146	152	PF00498	0.457
LIG_FHA_1	223	229	PF00498	0.383
LIG_FHA_1	284	290	PF00498	0.457
LIG_FHA_1	33	39	PF00498	0.475
LIG_FHA_2	105	111	PF00498	0.455
LIG_FHA_2	249	255	PF00498	0.422
LIG_FHA_2	61	67	PF00498	0.539
LIG_LIR_Gen_1	256	265	PF02991	0.539
LIG_LIR_Gen_1	91	101	PF02991	0.342
LIG_LIR_Nem_3	256	261	PF02991	0.541
LIG_LIR_Nem_3	286	291	PF02991	0.372
LIG_LIR_Nem_3	80	86	PF02991	0.545
LIG_LIR_Nem_3	91	96	PF02991	0.452
LIG_Pex14_1	288	292	PF04695	0.322
LIG_Pex14_2	331	335	PF04695	0.411
LIG_PTB_Apo_2	178	185	PF02174	0.488
LIG_PTB_Apo_2	196	203	PF02174	0.327
LIG_PTB_Phospho_1	196	202	PF10480	0.532
LIG_SH2_CRK	202	206	PF00017	0.417
LIG_SH2_CRK	258	262	PF00017	0.567
LIG_SH2_NCK_1	258	262	PF00017	0.544
LIG_SH2_STAP1	202	206	PF00017	0.341
LIG_SH2_STAT5	105	108	PF00017	0.500
LIG_SH2_STAT5	127	130	PF00017	0.346
LIG_SH2_STAT5	186	189	PF00017	0.383
LIG_SH2_STAT5	219	222	PF00017	0.515
LIG_SH2_STAT5	258	261	PF00017	0.508
LIG_SH2_STAT5	311	314	PF00017	0.618
LIG_SH3_3	1	7	PF00018	0.521
LIG_SH3_3	194	200	PF00018	0.538
LIG_SH3_3	229	235	PF00018	0.525
LIG_SUMO_SIM_par_1	171	176	PF11976	0.358
LIG_WRC_WIRS_1	311	316	PF05994	0.600
LIG_WRC_WIRS_1	90	95	PF05994	0.487
MOD_CK1_1	136	142	PF00069	0.404
MOD_CK1_1	147	153	PF00069	0.354
MOD_CK1_1	193	199	PF00069	0.446
MOD_CK1_1	256	262	PF00069	0.520
MOD_CK1_1	91	97	PF00069	0.511
MOD_CK2_1	104	110	PF00069	0.438
MOD_CK2_1	60	66	PF00069	0.534
MOD_GlcNHglycan	109	114	PF01048	0.458
MOD_GlcNHglycan	302	305	PF01048	0.393
MOD_GlcNHglycan	9	12	PF01048	0.662
MOD_GlcNHglycan	96	99	PF01048	0.345
MOD_GSK3_1	100	107	PF00069	0.374
MOD_GSK3_1	109	116	PF00069	0.375
MOD_GSK3_1	283	290	PF00069	0.380
MOD_N-GLC_1	136	141	PF02516	0.424
MOD_N-GLC_1	155	160	PF02516	0.575
MOD_N-GLC_1	208	213	PF02516	0.584
MOD_N-GLC_1	222	227	PF02516	0.468
MOD_N-GLC_1	333	338	PF02516	0.646
MOD_N-GLC_1	67	72	PF02516	0.542
MOD_N-GLC_2	218	220	PF02516	0.392
MOD_NEK2_1	100	105	PF00069	0.359
MOD_NEK2_1	133	138	PF00069	0.425
MOD_NEK2_1	283	288	PF00069	0.513
MOD_NEK2_1	60	65	PF00069	0.415
MOD_PIKK_1	70	76	PF00454	0.582
MOD_PK_1	126	132	PF00069	0.408
MOD_Plk_1	136	142	PF00069	0.484
MOD_Plk_1	193	199	PF00069	0.470
MOD_Plk_1	222	228	PF00069	0.521
MOD_Plk_1	67	73	PF00069	0.532
MOD_Plk_2-3	117	123	PF00069	0.393
MOD_Plk_2-3	248	254	PF00069	0.366
MOD_Plk_4	126	132	PF00069	0.401
MOD_Plk_4	136	142	PF00069	0.395
MOD_Plk_4	147	153	PF00069	0.402
MOD_Plk_4	168	174	PF00069	0.364
MOD_Plk_4	201	207	PF00069	0.565
MOD_Plk_4	228	234	PF00069	0.549
MOD_Plk_4	253	259	PF00069	0.487
MOD_Plk_4	283	289	PF00069	0.369
MOD_Plk_4	310	316	PF00069	0.549
MOD_Plk_4	326	332	PF00069	0.488
TRG_ENDOCYTIC_2	127	130	PF00928	0.392
TRG_ENDOCYTIC_2	202	205	PF00928	0.608
TRG_ENDOCYTIC_2	258	261	PF00928	0.508
TRG_ENDOCYTIC_2	311	314	PF00928	0.493
TRG_ER_diArg_1	296	298	PF00400	0.589
TRG_NLS_MonoCore_2	50	55	PF00514	0.427
TRG_NLS_MonoExtN_4	51	56	PF00514	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A9	Leptomonas seymouri	47%	94%
A0A0S4IU13	Bodo saltans	25%	100%
A0A1X0P1Q5	Trypanosomatidae	24%	100%
A0A1X0P2Z8	Trypanosomatidae	39%	89%
A0A3R7LKG2	Trypanosoma rangeli	40%	100%
A0A3S7X3Q6	Leishmania donovani	100%	100%
A4HIM8	Leishmania braziliensis	65%	100%
B6DTB5	Bodo saltans	31%	100%
C9ZR97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZR98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B167	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6Z8	Leishmania major	93%	100%