LeishMANIAdb
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AarF/ABC1/UbiB kinase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
AarF/ABC1/UbiB kinase family protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I5X2_LEIIN
TriTrypDb:
LINF_300034700
Length:
191

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4I5X2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5X2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 128 132 PF00656 0.438
CLV_NRD_NRD_1 166 168 PF00675 0.661
CLV_PCSK_KEX2_1 166 168 PF00082 0.654
CLV_PCSK_SKI1_1 101 105 PF00082 0.667
CLV_PCSK_SKI1_1 87 91 PF00082 0.635
DEG_APCC_DBOX_1 9 17 PF00400 0.415
DOC_CYCLIN_yCln2_LP_2 77 83 PF00134 0.383
DOC_MAPK_gen_1 166 177 PF00069 0.483
DOC_PP4_FxxP_1 177 180 PF00568 0.408
DOC_PP4_FxxP_1 187 190 PF00568 0.428
DOC_WW_Pin1_4 176 181 PF00397 0.450
DOC_WW_Pin1_4 95 100 PF00397 0.462
LIG_14-3-3_CanoR_1 10 14 PF00244 0.449
LIG_14-3-3_CanoR_1 166 174 PF00244 0.419
LIG_FHA_1 69 75 PF00498 0.462
LIG_FHA_1 76 82 PF00498 0.376
LIG_LIR_Apic_2 184 190 PF02991 0.466
LIG_LIR_Nem_3 159 165 PF02991 0.341
LIG_LIR_Nem_3 26 32 PF02991 0.609
LIG_MYND_1 137 141 PF01753 0.423
LIG_Pex14_2 187 191 PF04695 0.497
LIG_SH2_STAT3 32 35 PF00017 0.420
LIG_SH2_STAT5 27 30 PF00017 0.620
LIG_SH2_STAT5 32 35 PF00017 0.489
LIG_WRC_WIRS_1 69 74 PF05994 0.451
MOD_CDK_SPxK_1 95 101 PF00069 0.462
MOD_CK1_1 4 10 PF00069 0.562
MOD_CK2_1 148 154 PF00069 0.444
MOD_GlcNHglycan 150 153 PF01048 0.668
MOD_GlcNHglycan 18 21 PF01048 0.427
MOD_GlcNHglycan 3 6 PF01048 0.489
MOD_GlcNHglycan 51 54 PF01048 0.678
MOD_GSK3_1 64 71 PF00069 0.488
MOD_NEK2_1 129 134 PF00069 0.470
MOD_NEK2_1 23 28 PF00069 0.318
MOD_PIKK_1 64 70 PF00454 0.455
MOD_PKA_1 166 172 PF00069 0.458
MOD_PKA_2 165 171 PF00069 0.452
MOD_PKA_2 9 15 PF00069 0.364
MOD_Plk_1 183 189 PF00069 0.407
MOD_Plk_1 56 62 PF00069 0.463
MOD_Plk_4 23 29 PF00069 0.355
MOD_Plk_4 4 10 PF00069 0.550
MOD_ProDKin_1 176 182 PF00069 0.449
MOD_ProDKin_1 95 101 PF00069 0.462
TRG_ER_diArg_1 165 167 PF00400 0.454
TRG_NES_CRM1_1 64 75 PF08389 0.381
TRG_Pf-PMV_PEXEL_1 143 147 PF00026 0.657

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCB6 Leptomonas seymouri 61% 100%
A0A0S4ITI4 Bodo saltans 32% 83%
A0A1X0P1H2 Trypanosomatidae 36% 97%
A0A3Q8IJN4 Leishmania donovani 99% 100%
A0A3R7M429 Trypanosoma rangeli 39% 100%
A4HIM7 Leishmania braziliensis 83% 100%
C9ZR96 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9B166 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q6Z9 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS