Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5X1_LEIIN

TriTrypDb:

LINF_300034600

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5X1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.593
CLV_NRD_NRD_1	100	102	PF00675	0.694
CLV_NRD_NRD_1	149	151	PF00675	0.523
CLV_NRD_NRD_1	152	154	PF00675	0.505
CLV_NRD_NRD_1	228	230	PF00675	0.589
CLV_NRD_NRD_1	313	315	PF00675	0.546
CLV_NRD_NRD_1	387	389	PF00675	0.580
CLV_NRD_NRD_1	54	56	PF00675	0.540
CLV_NRD_NRD_1	9	11	PF00675	0.553
CLV_PCSK_FUR_1	384	388	PF00082	0.551
CLV_PCSK_FUR_1	52	56	PF00082	0.525
CLV_PCSK_KEX2_1	100	102	PF00082	0.665
CLV_PCSK_KEX2_1	149	151	PF00082	0.575
CLV_PCSK_KEX2_1	386	388	PF00082	0.581
CLV_PCSK_KEX2_1	54	56	PF00082	0.540
CLV_PCSK_KEX2_1	9	11	PF00082	0.553
CLV_PCSK_SKI1_1	10	14	PF00082	0.502
CLV_PCSK_SKI1_1	154	158	PF00082	0.559
CLV_PCSK_SKI1_1	370	374	PF00082	0.643
CLV_PCSK_SKI1_1	426	430	PF00082	0.735
DOC_CKS1_1	42	47	PF01111	0.521
DOC_CKS1_1	427	432	PF01111	0.723
DOC_CYCLIN_RxL_1	237	247	PF00134	0.571
DOC_MAPK_gen_1	149	159	PF00069	0.591
DOC_MAPK_MEF2A_6	9	16	PF00069	0.558
DOC_PP4_FxxP_1	42	45	PF00568	0.589
DOC_USP7_MATH_1	166	170	PF00917	0.533
DOC_USP7_MATH_1	179	183	PF00917	0.646
DOC_USP7_MATH_1	212	216	PF00917	0.668
DOC_USP7_MATH_1	269	273	PF00917	0.747
DOC_USP7_MATH_1	88	92	PF00917	0.595
DOC_WW_Pin1_4	265	270	PF00397	0.720
DOC_WW_Pin1_4	284	289	PF00397	0.700
DOC_WW_Pin1_4	41	46	PF00397	0.519
DOC_WW_Pin1_4	412	417	PF00397	0.762
DOC_WW_Pin1_4	426	431	PF00397	0.664
DOC_WW_Pin1_4	434	439	PF00397	0.731
DOC_WW_Pin1_4	448	453	PF00397	0.636
DOC_WW_Pin1_4	62	67	PF00397	0.585
LIG_14-3-3_CanoR_1	100	106	PF00244	0.614
LIG_14-3-3_CanoR_1	245	249	PF00244	0.732
LIG_14-3-3_CanoR_1	279	286	PF00244	0.779
LIG_14-3-3_CanoR_1	337	341	PF00244	0.628
LIG_14-3-3_CanoR_1	439	449	PF00244	0.782
LIG_14-3-3_CanoR_1	52	58	PF00244	0.727
LIG_APCC_ABBA_1	12	17	PF00400	0.558
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_BIR_III_4	261	265	PF00653	0.745
LIG_BRCT_BRCA1_1	189	193	PF00533	0.588
LIG_CaM_IQ_9	309	324	PF13499	0.551
LIG_FHA_1	101	107	PF00498	0.480
LIG_FHA_1	341	347	PF00498	0.572
LIG_FHA_1	441	447	PF00498	0.708
LIG_FHA_2	26	32	PF00498	0.503
LIG_FHA_2	77	83	PF00498	0.681
LIG_GBD_Chelix_1	217	225	PF00786	0.603
LIG_Integrin_isoDGR_2	185	187	PF01839	0.728
LIG_LIR_Apic_2	41	45	PF02991	0.667
LIG_LIR_Gen_1	80	90	PF02991	0.574
LIG_LIR_Nem_3	80	86	PF02991	0.578
LIG_SH2_STAP1	83	87	PF00017	0.563
LIG_SH3_3	118	124	PF00018	0.717
LIG_SH3_3	263	269	PF00018	0.724
LIG_SH3_3	410	416	PF00018	0.780
LIG_SH3_3	432	438	PF00018	0.753
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.590
LIG_SUMO_SIM_par_1	43	49	PF11976	0.523
LIG_TRAF2_1	21	24	PF00917	0.559
LIG_WRC_WIRS_1	39	44	PF05994	0.663
MOD_CDC14_SPxK_1	451	454	PF00782	0.686
MOD_CDK_SPK_2	265	270	PF00069	0.720
MOD_CDK_SPK_2	434	439	PF00069	0.744
MOD_CDK_SPxK_1	448	454	PF00069	0.699
MOD_CDK_SPxxK_3	412	419	PF00069	0.668
MOD_CDK_SPxxK_3	434	441	PF00069	0.741
MOD_CK1_1	247	253	PF00069	0.774
MOD_CK1_1	278	284	PF00069	0.751
MOD_CK1_1	38	44	PF00069	0.661
MOD_CK1_1	380	386	PF00069	0.590
MOD_CK1_1	393	399	PF00069	0.690
MOD_CK2_1	18	24	PF00069	0.512
MOD_CK2_1	207	213	PF00069	0.718
MOD_CK2_1	25	31	PF00069	0.493
MOD_CK2_1	76	82	PF00069	0.576
MOD_GlcNHglycan	164	167	PF01048	0.628
MOD_GlcNHglycan	168	171	PF01048	0.655
MOD_GlcNHglycan	20	23	PF01048	0.549
MOD_GlcNHglycan	213	217	PF01048	0.656
MOD_GlcNHglycan	249	252	PF01048	0.693
MOD_GlcNHglycan	261	265	PF01048	0.799
MOD_GlcNHglycan	288	291	PF01048	0.768
MOD_GlcNHglycan	326	329	PF01048	0.515
MOD_GlcNHglycan	392	395	PF01048	0.677
MOD_GSK3_1	162	169	PF00069	0.639
MOD_GSK3_1	187	194	PF00069	0.757
MOD_GSK3_1	207	214	PF00069	0.748
MOD_GSK3_1	260	267	PF00069	0.728
MOD_GSK3_1	275	282	PF00069	0.663
MOD_GSK3_1	336	343	PF00069	0.633
MOD_GSK3_1	382	389	PF00069	0.642
MOD_GSK3_1	414	421	PF00069	0.743
MOD_GSK3_1	426	433	PF00069	0.661
MOD_GSK3_1	53	60	PF00069	0.621
MOD_N-GLC_1	179	184	PF02516	0.676
MOD_NEK2_1	16	21	PF00069	0.460
MOD_NEK2_1	193	198	PF00069	0.725
MOD_NEK2_1	244	249	PF00069	0.627
MOD_NEK2_1	25	30	PF00069	0.345
MOD_NEK2_1	340	345	PF00069	0.554
MOD_NEK2_1	358	363	PF00069	0.566
MOD_NEK2_1	40	45	PF00069	0.483
MOD_NEK2_1	5	10	PF00069	0.536
MOD_NEK2_1	67	72	PF00069	0.614
MOD_PIKK_1	100	106	PF00454	0.587
MOD_PIKK_1	187	193	PF00454	0.666
MOD_PIKK_1	216	222	PF00454	0.710
MOD_PIKK_1	345	351	PF00454	0.547
MOD_PIKK_1	377	383	PF00454	0.612
MOD_PIKK_1	386	392	PF00454	0.754
MOD_PK_1	279	285	PF00069	0.712
MOD_PKA_1	100	106	PF00069	0.621
MOD_PKA_1	386	392	PF00069	0.530
MOD_PKA_2	244	250	PF00069	0.632
MOD_PKA_2	269	275	PF00069	0.715
MOD_PKA_2	278	284	PF00069	0.700
MOD_PKA_2	336	342	PF00069	0.555
MOD_PKA_2	35	41	PF00069	0.567
MOD_PKA_2	386	392	PF00069	0.576
MOD_PKA_2	399	405	PF00069	0.655
MOD_PKA_2	418	424	PF00069	0.725
MOD_PKA_2	53	59	PF00069	0.653
MOD_PKA_2	99	105	PF00069	0.618
MOD_PKB_1	375	383	PF00069	0.571
MOD_PKB_1	384	392	PF00069	0.640
MOD_Plk_1	16	22	PF00069	0.555
MOD_Plk_1	170	176	PF00069	0.789
MOD_Plk_1	212	218	PF00069	0.627
MOD_Plk_4	170	176	PF00069	0.726
MOD_Plk_4	35	41	PF00069	0.513
MOD_ProDKin_1	265	271	PF00069	0.719
MOD_ProDKin_1	284	290	PF00069	0.698
MOD_ProDKin_1	41	47	PF00069	0.519
MOD_ProDKin_1	412	418	PF00069	0.762
MOD_ProDKin_1	426	432	PF00069	0.663
MOD_ProDKin_1	434	440	PF00069	0.729
MOD_ProDKin_1	448	454	PF00069	0.637
MOD_ProDKin_1	62	68	PF00069	0.587
MOD_SUMO_for_1	301	304	PF00179	0.581
MOD_SUMO_for_1	333	336	PF00179	0.585
MOD_SUMO_rev_2	366	372	PF00179	0.572
TRG_DiLeu_BaEn_1	237	242	PF01217	0.584
TRG_DiLeu_BaEn_1	304	309	PF01217	0.556
TRG_DiLeu_BaEn_1	368	373	PF01217	0.664
TRG_DiLeu_BaEn_1	82	87	PF01217	0.567
TRG_DiLeu_LyEn_5	237	242	PF01217	0.558
TRG_ENDOCYTIC_2	83	86	PF00928	0.569
TRG_ER_diArg_1	375	378	PF00400	0.604
TRG_ER_diArg_1	384	387	PF00400	0.556
TRG_ER_diArg_1	52	55	PF00400	0.521
TRG_NES_CRM1_1	367	382	PF08389	0.660
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	422	427	PF00026	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUI5	Leptomonas seymouri	47%	71%
A0A3Q8IEH0	Leishmania donovani	100%	100%
A4HIM6	Leishmania braziliensis	70%	100%
E9B165	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q700	Leishmania major	88%	100%