Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5W8_LEIIN

TriTrypDb:

LINF_300034300

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I5W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5W8

PDB structure(s): 7aih_BM , 7am2_BM , 7ane_BM

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.431
CLV_NRD_NRD_1	212	214	PF00675	0.544
CLV_NRD_NRD_1	270	272	PF00675	0.365
CLV_NRD_NRD_1	45	47	PF00675	0.413
CLV_NRD_NRD_1	79	81	PF00675	0.381
CLV_PCSK_KEX2_1	140	142	PF00082	0.490
CLV_PCSK_KEX2_1	411	413	PF00082	0.427
CLV_PCSK_KEX2_1	79	81	PF00082	0.381
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.409
CLV_PCSK_PC7_1	137	143	PF00082	0.579
CLV_PCSK_SKI1_1	17	21	PF00082	0.373
CLV_PCSK_SKI1_1	182	186	PF00082	0.431
CLV_PCSK_SKI1_1	389	393	PF00082	0.524
CLV_PCSK_SKI1_1	47	51	PF00082	0.410
CLV_PCSK_SKI1_1	89	93	PF00082	0.479
CLV_PCSK_SKI1_1	98	102	PF00082	0.465
DEG_APCC_DBOX_1	16	24	PF00400	0.405
DEG_COP1_1	163	172	PF00400	0.463
DOC_CDC14_PxL_1	20	28	PF14671	0.408
DOC_MAPK_DCC_7	339	349	PF00069	0.462
DOC_MAPK_gen_1	188	197	PF00069	0.517
DOC_PP2B_LxvP_1	353	356	PF13499	0.479
DOC_USP7_MATH_1	288	292	PF00917	0.432
DOC_WW_Pin1_4	116	121	PF00397	0.515
DOC_WW_Pin1_4	327	332	PF00397	0.384
LIG_14-3-3_CanoR_1	282	286	PF00244	0.459
LIG_14-3-3_CanoR_1	71	78	PF00244	0.371
LIG_14-3-3_CanoR_1	89	94	PF00244	0.481
LIG_APCC_ABBAyCdc20_2	79	85	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_FHA_1	117	123	PF00498	0.496
LIG_FHA_1	338	344	PF00498	0.510
LIG_FHA_1	378	384	PF00498	0.567
LIG_FHA_2	25	31	PF00498	0.285
LIG_FHA_2	327	333	PF00498	0.427
LIG_FHA_2	437	443	PF00498	0.591
LIG_FHA_2	90	96	PF00498	0.426
LIG_LIR_Gen_1	154	162	PF02991	0.344
LIG_LIR_Gen_1	226	233	PF02991	0.437
LIG_LIR_Gen_1	368	378	PF02991	0.390
LIG_LIR_Gen_1	54	62	PF02991	0.365
LIG_LIR_Nem_3	13	19	PF02991	0.449
LIG_LIR_Nem_3	2	7	PF02991	0.492
LIG_LIR_Nem_3	226	230	PF02991	0.446
LIG_LIR_Nem_3	315	320	PF02991	0.381
LIG_LIR_Nem_3	368	374	PF02991	0.398
LIG_LIR_Nem_3	54	59	PF02991	0.361
LIG_PCNA_yPIPBox_3	213	223	PF02747	0.540
LIG_Pex14_1	266	270	PF04695	0.352
LIG_SH2_CRK	227	231	PF00017	0.492
LIG_SH2_NCK_1	227	231	PF00017	0.493
LIG_SH2_NCK_1	328	332	PF00017	0.373
LIG_SH2_NCK_1	72	76	PF00017	0.353
LIG_SH2_STAP1	124	128	PF00017	0.521
LIG_SH2_STAP1	402	406	PF00017	0.501
LIG_SH2_STAP1	72	76	PF00017	0.368
LIG_SH2_STAP1	83	87	PF00017	0.387
LIG_SH2_STAT3	322	325	PF00017	0.493
LIG_SH2_STAT5	155	158	PF00017	0.418
LIG_SH2_STAT5	179	182	PF00017	0.410
LIG_SH2_STAT5	279	282	PF00017	0.455
LIG_SH2_STAT5	326	329	PF00017	0.403
LIG_SH2_STAT5	72	75	PF00017	0.377
LIG_SH2_STAT5	77	80	PF00017	0.363
LIG_SH3_3	35	41	PF00018	0.493
LIG_SH3_3	416	422	PF00018	0.509
LIG_SUMO_SIM_par_1	237	242	PF11976	0.477
LIG_TRAF2_1	27	30	PF00917	0.398
LIG_TYR_ITIM	70	75	PF00017	0.343
LIG_UBA3_1	316	321	PF00899	0.428
MOD_CDK_SPK_2	116	121	PF00069	0.515
MOD_CK1_1	297	303	PF00069	0.486
MOD_CK2_1	24	30	PF00069	0.292
MOD_CK2_1	420	426	PF00069	0.496
MOD_CK2_1	436	442	PF00069	0.485
MOD_CK2_1	89	95	PF00069	0.491
MOD_GlcNHglycan	104	107	PF01048	0.543
MOD_GlcNHglycan	201	204	PF01048	0.685
MOD_GlcNHglycan	290	293	PF01048	0.444
MOD_GlcNHglycan	296	299	PF01048	0.494
MOD_GlcNHglycan	398	401	PF01048	0.549
MOD_GlcNHglycan	442	446	PF01048	0.648
MOD_GSK3_1	102	109	PF00069	0.403
MOD_GSK3_1	294	301	PF00069	0.429
MOD_GSK3_1	422	429	PF00069	0.523
MOD_GSK3_1	437	444	PF00069	0.565
MOD_GSK3_1	89	96	PF00069	0.423
MOD_N-GLC_1	24	29	PF02516	0.531
MOD_NEK2_1	19	24	PF00069	0.401
MOD_NEK2_1	383	388	PF00069	0.446
MOD_NEK2_1	70	75	PF00069	0.344
MOD_NEK2_1	93	98	PF00069	0.456
MOD_PKA_2	245	251	PF00069	0.426
MOD_PKA_2	281	287	PF00069	0.433
MOD_PKA_2	288	294	PF00069	0.404
MOD_PKA_2	426	432	PF00069	0.620
MOD_PKA_2	70	76	PF00069	0.366
MOD_Plk_1	239	245	PF00069	0.367
MOD_Plk_1	24	30	PF00069	0.534
MOD_Plk_4	281	287	PF00069	0.399
MOD_Plk_4	312	318	PF00069	0.459
MOD_Plk_4	383	389	PF00069	0.440
MOD_Plk_4	89	95	PF00069	0.421
MOD_ProDKin_1	116	122	PF00069	0.510
MOD_ProDKin_1	327	333	PF00069	0.386
MOD_SUMO_rev_2	183	189	PF00179	0.405
MOD_SUMO_rev_2	212	219	PF00179	0.453
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.443
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.456
TRG_ENDOCYTIC_2	155	158	PF00928	0.357
TRG_ENDOCYTIC_2	16	19	PF00928	0.530
TRG_ENDOCYTIC_2	227	230	PF00928	0.460
TRG_ENDOCYTIC_2	72	75	PF00928	0.337
TRG_ENDOCYTIC_2	83	86	PF00928	0.375
TRG_ER_diArg_1	139	142	PF00400	0.635
TRG_ER_diArg_1	78	80	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJE9	Leptomonas seymouri	76%	100%
A0A0S4IPF0	Bodo saltans	44%	100%
A0A1X0P1F2	Trypanosomatidae	56%	100%
A0A3Q8IFT4	Leishmania donovani	100%	100%
A0A422N0P2	Trypanosoma rangeli	59%	100%
A4HIM3	Leishmania braziliensis	85%	100%
C9ZR91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	83%
E9B162	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q703	Leishmania major	98%	100%
V5BMU7	Trypanosoma cruzi	59%	100%