Pentatricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentatricopeptide repeat domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I5W7_LEIIN

TriTrypDb:

LINF_300034200

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.538
CLV_C14_Caspase3-7	493	497	PF00656	0.588
CLV_C14_Caspase3-7	603	607	PF00656	0.525
CLV_NRD_NRD_1	28	30	PF00675	0.426
CLV_NRD_NRD_1	39	41	PF00675	0.501
CLV_NRD_NRD_1	54	56	PF00675	0.683
CLV_NRD_NRD_1	640	642	PF00675	0.533
CLV_PCSK_KEX2_1	28	30	PF00082	0.439
CLV_PCSK_KEX2_1	39	41	PF00082	0.501
CLV_PCSK_KEX2_1	53	55	PF00082	0.679
CLV_PCSK_KEX2_1	640	642	PF00082	0.558
CLV_PCSK_PC7_1	50	56	PF00082	0.703
CLV_PCSK_SKI1_1	28	32	PF00082	0.441
CLV_PCSK_SKI1_1	308	312	PF00082	0.498
CLV_PCSK_SKI1_1	39	43	PF00082	0.507
CLV_PCSK_SKI1_1	652	656	PF00082	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.608
DEG_SPOP_SBC_1	193	197	PF00917	0.529
DEG_SPOP_SBC_1	72	76	PF00917	0.656
DEG_SPOP_SBC_1	81	85	PF00917	0.602
DOC_CYCLIN_RxL_1	305	313	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.445
DOC_MAPK_DCC_7	535	543	PF00069	0.516
DOC_MAPK_MEF2A_6	592	599	PF00069	0.523
DOC_PP4_FxxP_1	131	134	PF00568	0.668
DOC_PP4_FxxP_1	166	169	PF00568	0.610
DOC_USP7_MATH_1	386	390	PF00917	0.475
DOC_USP7_MATH_1	43	47	PF00917	0.594
DOC_USP7_MATH_1	431	435	PF00917	0.473
DOC_USP7_MATH_1	48	52	PF00917	0.702
DOC_USP7_MATH_1	504	508	PF00917	0.465
DOC_USP7_MATH_1	566	570	PF00917	0.536
DOC_USP7_MATH_1	586	590	PF00917	0.221
DOC_USP7_MATH_1	639	643	PF00917	0.560
DOC_USP7_MATH_1	81	85	PF00917	0.712
DOC_WW_Pin1_4	130	135	PF00397	0.619
DOC_WW_Pin1_4	221	226	PF00397	0.439
DOC_WW_Pin1_4	370	375	PF00397	0.427
DOC_WW_Pin1_4	60	65	PF00397	0.777
DOC_WW_Pin1_4	641	646	PF00397	0.490
DOC_WW_Pin1_4	656	661	PF00397	0.476
LIG_14-3-3_CanoR_1	128	132	PF00244	0.571
LIG_14-3-3_CanoR_1	150	157	PF00244	0.603
LIG_14-3-3_CanoR_1	161	169	PF00244	0.594
LIG_14-3-3_CanoR_1	183	193	PF00244	0.591
LIG_14-3-3_CanoR_1	387	393	PF00244	0.538
LIG_14-3-3_CanoR_1	441	449	PF00244	0.525
LIG_14-3-3_CanoR_1	55	64	PF00244	0.718
LIG_14-3-3_CterR_2	668	673	PF00244	0.527
LIG_Actin_WH2_2	13	30	PF00022	0.444
LIG_BRCT_BRCA1_1	162	166	PF00533	0.688
LIG_BRCT_BRCA1_1	630	634	PF00533	0.490
LIG_CaM_IQ_9	343	359	PF13499	0.537
LIG_eIF4E_1	289	295	PF01652	0.391
LIG_FHA_1	127	133	PF00498	0.683
LIG_FHA_1	193	199	PF00498	0.574
LIG_FHA_1	254	260	PF00498	0.426
LIG_FHA_1	331	337	PF00498	0.412
LIG_FHA_1	353	359	PF00498	0.545
LIG_FHA_1	395	401	PF00498	0.537
LIG_FHA_1	470	476	PF00498	0.537
LIG_FHA_1	653	659	PF00498	0.501
LIG_FHA_1	72	78	PF00498	0.637
LIG_FHA_2	32	38	PF00498	0.486
LIG_FHA_2	401	407	PF00498	0.519
LIG_FHA_2	474	480	PF00498	0.489
LIG_FHA_2	491	497	PF00498	0.402
LIG_FHA_2	601	607	PF00498	0.515
LIG_FHA_2	642	648	PF00498	0.420
LIG_LIR_Apic_2	129	134	PF02991	0.653
LIG_LIR_Apic_2	163	169	PF02991	0.615
LIG_LIR_Gen_1	364	374	PF02991	0.503
LIG_LIR_Gen_1	434	443	PF02991	0.413
LIG_LIR_LC3C_4	270	275	PF02991	0.453
LIG_LIR_Nem_3	364	369	PF02991	0.444
LIG_LIR_Nem_3	434	439	PF02991	0.402
LIG_LIR_Nem_3	442	446	PF02991	0.398
LIG_NRBOX	229	235	PF00104	0.455
LIG_NRBOX	6	12	PF00104	0.435
LIG_Rb_LxCxE_1	278	290	PF01857	0.563
LIG_REV1ctd_RIR_1	363	372	PF16727	0.399
LIG_SH2_CRK	436	440	PF00017	0.368
LIG_SH2_STAP1	418	422	PF00017	0.435
LIG_SH2_STAP1	613	617	PF00017	0.474
LIG_SH2_STAT3	220	223	PF00017	0.474
LIG_SH2_STAT3	350	353	PF00017	0.557
LIG_SH2_STAT5	220	223	PF00017	0.528
LIG_SH2_STAT5	297	300	PF00017	0.479
LIG_SH3_3	219	225	PF00018	0.429
LIG_SH3_3	290	296	PF00018	0.378
LIG_SH3_3	571	577	PF00018	0.437
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.477
LIG_SUMO_SIM_par_1	472	479	PF11976	0.380
LIG_SxIP_EBH_1	165	177	PF03271	0.543
LIG_TRAF2_1	34	37	PF00917	0.550
LIG_UBA3_1	510	516	PF00899	0.452
LIG_WRC_WIRS_1	440	445	PF05994	0.383
MOD_CDK_SPxxK_3	641	648	PF00069	0.487
MOD_CK1_1	117	123	PF00069	0.392
MOD_CK1_1	130	136	PF00069	0.510
MOD_CK1_1	184	190	PF00069	0.553
MOD_CK1_1	301	307	PF00069	0.598
MOD_CK1_1	457	463	PF00069	0.493
MOD_CK1_1	489	495	PF00069	0.436
MOD_CK1_1	503	509	PF00069	0.518
MOD_CK1_1	59	65	PF00069	0.740
MOD_CK1_1	79	85	PF00069	0.718
MOD_CK1_1	87	93	PF00069	0.690
MOD_CK2_1	31	37	PF00069	0.507
MOD_CK2_1	473	479	PF00069	0.498
MOD_DYRK1A_RPxSP_1	641	645	PF00069	0.551
MOD_DYRK1A_RPxSP_1	656	660	PF00069	0.577
MOD_GlcNHglycan	119	122	PF01048	0.377
MOD_GlcNHglycan	189	192	PF01048	0.648
MOD_GlcNHglycan	269	272	PF01048	0.407
MOD_GlcNHglycan	300	303	PF01048	0.416
MOD_GlcNHglycan	312	315	PF01048	0.403
MOD_GlcNHglycan	443	446	PF01048	0.497
MOD_GlcNHglycan	479	483	PF01048	0.427
MOD_GlcNHglycan	496	499	PF01048	0.449
MOD_GlcNHglycan	502	505	PF01048	0.450
MOD_GlcNHglycan	58	61	PF01048	0.707
MOD_GlcNHglycan	588	591	PF01048	0.423
MOD_GlcNHglycan	79	82	PF01048	0.745
MOD_GlcNHglycan	89	92	PF01048	0.773
MOD_GlcNHglycan	94	97	PF01048	0.685
MOD_GSK3_1	126	133	PF00069	0.638
MOD_GSK3_1	156	163	PF00069	0.782
MOD_GSK3_1	181	188	PF00069	0.477
MOD_GSK3_1	201	208	PF00069	0.334
MOD_GSK3_1	39	46	PF00069	0.609
MOD_GSK3_1	431	438	PF00069	0.460
MOD_GSK3_1	465	472	PF00069	0.434
MOD_GSK3_1	486	493	PF00069	0.501
MOD_GSK3_1	500	507	PF00069	0.559
MOD_GSK3_1	56	63	PF00069	0.584
MOD_GSK3_1	652	659	PF00069	0.493
MOD_GSK3_1	71	78	PF00069	0.715
MOD_GSK3_1	80	87	PF00069	0.659
MOD_N-GLC_1	611	616	PF02516	0.375
MOD_N-GLC_2	21	23	PF02516	0.405
MOD_NEK2_1	11	16	PF00069	0.528
MOD_NEK2_1	127	132	PF00069	0.626
MOD_NEK2_1	181	186	PF00069	0.521
MOD_NEK2_1	192	197	PF00069	0.543
MOD_NEK2_1	201	206	PF00069	0.318
MOD_NEK2_1	228	233	PF00069	0.416
MOD_NEK2_1	253	258	PF00069	0.474
MOD_NEK2_1	298	303	PF00069	0.440
MOD_NEK2_1	31	36	PF00069	0.289
MOD_NEK2_1	310	315	PF00069	0.357
MOD_NEK2_1	426	431	PF00069	0.482
MOD_NEK2_1	439	444	PF00069	0.306
MOD_NEK2_1	494	499	PF00069	0.477
MOD_NEK2_1	600	605	PF00069	0.494
MOD_NEK2_1	77	82	PF00069	0.769
MOD_NEK2_1	86	91	PF00069	0.713
MOD_NEK2_1	92	97	PF00069	0.615
MOD_NEK2_2	48	53	PF00069	0.650
MOD_PIKK_1	349	355	PF00454	0.532
MOD_PIKK_1	400	406	PF00454	0.476
MOD_PIKK_1	566	572	PF00454	0.539
MOD_PIKK_1	611	617	PF00454	0.381
MOD_PKA_1	39	45	PF00069	0.547
MOD_PKA_2	127	133	PF00069	0.677
MOD_PKA_2	149	155	PF00069	0.786
MOD_PKA_2	160	166	PF00069	0.606
MOD_PKA_2	182	188	PF00069	0.575
MOD_PKA_2	386	392	PF00069	0.536
MOD_PKA_2	39	45	PF00069	0.610
MOD_PKA_2	639	645	PF00069	0.510
MOD_Plk_1	394	400	PF00069	0.446
MOD_Plk_1	463	469	PF00069	0.535
MOD_Plk_1	628	634	PF00069	0.499
MOD_Plk_2-3	473	479	PF00069	0.517
MOD_Plk_4	11	17	PF00069	0.554
MOD_Plk_4	127	133	PF00069	0.565
MOD_Plk_4	229	235	PF00069	0.403
MOD_Plk_4	435	441	PF00069	0.424
MOD_Plk_4	454	460	PF00069	0.297
MOD_Plk_4	490	496	PF00069	0.447
MOD_ProDKin_1	130	136	PF00069	0.625
MOD_ProDKin_1	221	227	PF00069	0.440
MOD_ProDKin_1	370	376	PF00069	0.425
MOD_ProDKin_1	60	66	PF00069	0.777
MOD_ProDKin_1	641	647	PF00069	0.484
MOD_ProDKin_1	656	662	PF00069	0.467
MOD_SUMO_rev_2	389	393	PF00179	0.556
TRG_DiLeu_BaEn_1	354	359	PF01217	0.587
TRG_ENDOCYTIC_2	436	439	PF00928	0.378
TRG_ER_diArg_1	27	29	PF00400	0.423
TRG_ER_diArg_1	39	41	PF00400	0.501
TRG_ER_diArg_1	52	55	PF00400	0.677
TRG_ER_diArg_1	639	641	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I481	Leptomonas seymouri	70%	98%
A0A0S4IPG5	Bodo saltans	34%	100%
A0A1X0P1H7	Trypanosomatidae	49%	100%
A0A3Q8IG13	Leishmania donovani	100%	100%
A0A3R7JPV2	Trypanosoma rangeli	49%	100%
A4HIM2	Leishmania braziliensis	85%	100%
C9ZR90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B161	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q704	Leishmania major	96%	100%
V5B7A2	Trypanosoma cruzi	49%	100%