Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5W5_LEIIN

TriTrypDb:

LINF_300034000

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.613
CLV_NRD_NRD_1	144	146	PF00675	0.372
CLV_NRD_NRD_1	276	278	PF00675	0.522
CLV_PCSK_KEX2_1	143	145	PF00082	0.369
CLV_PCSK_KEX2_1	182	184	PF00082	0.515
CLV_PCSK_KEX2_1	276	278	PF00082	0.522
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.515
CLV_PCSK_PC7_1	140	146	PF00082	0.382
CLV_PCSK_SKI1_1	115	119	PF00082	0.613
CLV_PCSK_SKI1_1	132	136	PF00082	0.442
CLV_PCSK_SKI1_1	6	10	PF00082	0.503
CLV_Separin_Metazoa	81	85	PF03568	0.503
DEG_APCC_DBOX_1	5	13	PF00400	0.519
DEG_Nend_Nbox_1	1	3	PF02207	0.444
DEG_ODPH_VHL_1	241	253	PF01847	0.409
DEG_SCF_FBW7_1	125	130	PF00400	0.554
DOC_CYCLIN_RxL_1	3	10	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.520
DOC_MAPK_HePTP_8	205	217	PF00069	0.490
DOC_MAPK_MEF2A_6	208	217	PF00069	0.363
DOC_PP2B_LxvP_1	224	227	PF13499	0.537
DOC_PP2B_LxvP_1	41	44	PF13499	0.386
DOC_PP2B_LxvP_1	89	92	PF13499	0.480
DOC_USP7_MATH_1	11	15	PF00917	0.496
DOC_USP7_MATH_1	125	129	PF00917	0.714
DOC_USP7_MATH_1	265	269	PF00917	0.490
DOC_USP7_MATH_1	302	306	PF00917	0.414
DOC_WW_Pin1_4	121	126	PF00397	0.602
DOC_WW_Pin1_4	127	132	PF00397	0.522
DOC_WW_Pin1_4	7	12	PF00397	0.509
DOC_WW_Pin1_4	97	102	PF00397	0.588
LIG_14-3-3_CanoR_1	144	150	PF00244	0.396
LIG_14-3-3_CanoR_1	220	225	PF00244	0.530
LIG_CSL_BTD_1	230	233	PF09270	0.551
LIG_FHA_1	112	118	PF00498	0.452
LIG_FHA_1	186	192	PF00498	0.477
LIG_FHA_1	201	207	PF00498	0.304
LIG_FHA_1	253	259	PF00498	0.462
LIG_FHA_1	292	298	PF00498	0.397
LIG_FHA_1	344	350	PF00498	0.407
LIG_FHA_1	40	46	PF00498	0.548
LIG_FHA_1	66	72	PF00498	0.542
LIG_FHA_2	268	274	PF00498	0.481
LIG_FHA_2	319	325	PF00498	0.397
LIG_LIR_Apic_2	259	263	PF02991	0.471
LIG_LIR_Apic_2	305	309	PF02991	0.477
LIG_LIR_Gen_1	181	192	PF02991	0.529
LIG_LIR_Gen_1	321	330	PF02991	0.540
LIG_LIR_LC3C_4	62	66	PF02991	0.390
LIG_LIR_Nem_3	136	141	PF02991	0.424
LIG_LIR_Nem_3	181	187	PF02991	0.510
LIG_LIR_Nem_3	321	326	PF02991	0.554
LIG_MYND_1	91	95	PF01753	0.527
LIG_SH2_CRK	260	264	PF00017	0.472
LIG_SH2_CRK	278	282	PF00017	0.394
LIG_SH2_GRB2like	278	281	PF00017	0.397
LIG_SH2_GRB2like	287	290	PF00017	0.354
LIG_SH2_NCK_1	323	327	PF00017	0.393
LIG_SH2_NCK_1	330	334	PF00017	0.405
LIG_SH2_SRC	184	187	PF00017	0.525
LIG_SH2_SRC	287	290	PF00017	0.347
LIG_SH2_SRC	330	333	PF00017	0.455
LIG_SH2_STAP1	287	291	PF00017	0.397
LIG_SH2_STAP1	330	334	PF00017	0.462
LIG_SH2_STAT5	184	187	PF00017	0.465
LIG_SH3_1	88	94	PF00018	0.448
LIG_SH3_3	246	252	PF00018	0.504
LIG_SH3_3	88	94	PF00018	0.576
LIG_SH3_CIN85_PxpxPR_1	127	132	PF14604	0.523
LIG_SUMO_SIM_par_1	254	259	PF11976	0.548
LIG_TRAF2_1	333	336	PF00917	0.465
LIG_TRAF2_1	78	81	PF00917	0.458
LIG_TYR_ITSM	319	326	PF00017	0.361
LIG_WW_2	91	94	PF00397	0.473
MOD_CDC14_SPxK_1	10	13	PF00782	0.377
MOD_CDK_SPK_2	127	132	PF00069	0.577
MOD_CDK_SPxK_1	7	13	PF00069	0.379
MOD_CK1_1	103	109	PF00069	0.497
MOD_CK1_1	121	127	PF00069	0.727
MOD_CK1_1	267	273	PF00069	0.491
MOD_CK2_1	267	273	PF00069	0.570
MOD_CK2_1	318	324	PF00069	0.579
MOD_CK2_1	75	81	PF00069	0.369
MOD_GlcNHglycan	127	130	PF01048	0.699
MOD_GlcNHglycan	176	179	PF01048	0.557
MOD_GlcNHglycan	233	236	PF01048	0.535
MOD_GSK3_1	121	128	PF00069	0.708
MOD_GSK3_1	174	181	PF00069	0.653
MOD_GSK3_1	200	207	PF00069	0.498
MOD_GSK3_1	287	294	PF00069	0.400
MOD_GSK3_1	39	46	PF00069	0.383
MOD_GSK3_1	7	14	PF00069	0.399
MOD_GSK3_1	99	106	PF00069	0.636
MOD_N-GLC_1	121	126	PF02516	0.749
MOD_NEK2_1	118	123	PF00069	0.512
MOD_PIKK_1	11	17	PF00454	0.402
MOD_PIKK_1	291	297	PF00454	0.521
MOD_PKA_2	219	225	PF00069	0.529
MOD_PKB_1	143	151	PF00069	0.392
MOD_Plk_1	287	293	PF00069	0.359
MOD_Plk_1	39	45	PF00069	0.456
MOD_Plk_4	287	293	PF00069	0.349
MOD_Plk_4	43	49	PF00069	0.337
MOD_ProDKin_1	121	127	PF00069	0.606
MOD_ProDKin_1	7	13	PF00069	0.508
MOD_ProDKin_1	97	103	PF00069	0.574
MOD_SUMO_rev_2	53	62	PF00179	0.516
TRG_AP2beta_CARGO_1	136	145	PF09066	0.427
TRG_DiLeu_BaEn_1	335	340	PF01217	0.427
TRG_ENDOCYTIC_2	184	187	PF00928	0.475
TRG_ENDOCYTIC_2	278	281	PF00928	0.511
TRG_ENDOCYTIC_2	323	326	PF00928	0.417
TRG_ER_diArg_1	143	145	PF00400	0.371
TRG_ER_diArg_1	275	277	PF00400	0.523
TRG_ER_diArg_1	83	86	PF00400	0.481
TRG_ER_diArg_1	88	91	PF00400	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X8	Leptomonas seymouri	58%	93%
A0A1X0P300	Trypanosomatidae	43%	100%
A0A3S5IQF3	Trypanosoma rangeli	40%	100%
A0A3S7X3T3	Leishmania donovani	100%	100%
A4HIM0	Leishmania braziliensis	80%	100%
C9ZR87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	81%
Q4Q706	Leishmania major	96%	100%
V5BSH3	Trypanosoma cruzi	41%	100%