PTB domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5W4_LEIIN

TriTrypDb:

LINF_300033900

Length:

115

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	yes	yes: 14
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 30

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 39
NetGPI	no	yes: 0, no: 39

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I5W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	109	113	PF00082	0.363
CLV_PCSK_SKI1_1	50	54	PF00082	0.385
DEG_APCC_KENBOX_2	100	104	PF00400	0.311
DOC_MAPK_MEF2A_6	105	112	PF00069	0.234
DOC_MAPK_MEF2A_6	74	81	PF00069	0.329
DOC_PP1_RVXF_1	107	113	PF00149	0.341
DOC_PP4_FxxP_1	10	13	PF00568	0.315
DOC_USP7_UBL2_3	46	50	PF12436	0.406
LIG_Actin_WH2_2	78	95	PF00022	0.373
LIG_BRCT_BRCA1_1	6	10	PF00533	0.292
LIG_BRCT_BRCA1_1	74	78	PF00533	0.334
LIG_FHA_1	105	111	PF00498	0.335
LIG_FHA_1	12	18	PF00498	0.344
LIG_FHA_2	19	25	PF00498	0.452
LIG_LIR_Apic_2	7	13	PF02991	0.310
LIG_LIR_Gen_1	75	85	PF02991	0.332
LIG_LIR_Nem_3	75	81	PF02991	0.329
LIG_PDZ_Class_1	110	115	PF00595	0.424
LIG_REV1ctd_RIR_1	109	115	PF16727	0.364
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.399
LIG_SUMO_SIM_par_1	78	84	PF11976	0.387
LIG_TRAF2_1	84	87	PF00917	0.405
MOD_CK2_1	18	24	PF00069	0.464
MOD_CK2_1	81	87	PF00069	0.412
MOD_GSK3_1	13	20	PF00069	0.333
MOD_N-GLC_2	3	5	PF02516	0.342
MOD_NEK2_1	110	115	PF00069	0.416
MOD_NEK2_1	17	22	PF00069	0.343
MOD_NEK2_1	36	41	PF00069	0.392
MOD_NEK2_1	4	9	PF00069	0.282
MOD_NEK2_1	72	77	PF00069	0.350
MOD_NEK2_1	92	97	PF00069	0.427
MOD_PKA_2	104	110	PF00069	0.406
MOD_PKA_2	92	98	PF00069	0.455
MOD_Plk_1	23	29	PF00069	0.378
MOD_Plk_4	73	79	PF00069	0.395
TRG_DiLeu_BaEn_4	87	93	PF01217	0.486
TRG_ER_diArg_1	90	93	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D0	Leptomonas seymouri	36%	77%
A0A0N0P3C7	Leptomonas seymouri	35%	91%
A0A0N1HW96	Leptomonas seymouri	83%	100%
A0A0N1IHI7	Leptomonas seymouri	38%	97%
A0A0S4IPF2	Bodo saltans	54%	100%
A0A0S4IRP9	Bodo saltans	38%	97%
A0A0S4JBB4	Bodo saltans	36%	97%
A0A0S4JFI1	Bodo saltans	46%	100%
A0A1X0NKC2	Trypanosomatidae	36%	97%
A0A1X0P0Q8	Trypanosomatidae	39%	91%
A0A1X0P259	Trypanosomatidae	61%	99%
A0A1X0P760	Trypanosomatidae	36%	100%
A0A3Q8IB96	Leishmania donovani	37%	97%
A0A3R7K0R9	Trypanosoma rangeli	60%	99%
A0A3S5H506	Leishmania donovani	29%	71%
A0A3S7X3W3	Leishmania donovani	100%	100%
A0A3S7X6I1	Leishmania donovani	40%	68%
A0A422N867	Trypanosoma rangeli	38%	92%
A0A422NFX4	Trypanosoma rangeli	36%	96%
A0A422NPM1	Trypanosoma rangeli	37%	100%
A4H3E5	Leishmania braziliensis	33%	98%
A4H9R6	Leishmania braziliensis	37%	100%
A4HIL9	Leishmania braziliensis	89%	100%
A4HLA1	Leishmania braziliensis	36%	100%
A4HRQ0	Leishmania infantum	29%	99%
A4HY35	Leishmania infantum	37%	100%
A4I8S7	Leishmania infantum	40%	91%
C9ZJ38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	92%
C9ZR85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A4S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	91%
E9ACC9	Leishmania major	29%	99%
E9AJL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9ARU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B159	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B3P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4Q707	Leishmania major	96%	100%
Q4QDM4	Leishmania major	36%	100%
V5BMX8	Trypanosoma cruzi	63%	99%