Cytochrome c oxidase subunit 1

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5W3_LEIIN

TriTrypDb:

LINF_300033800

Length:

104

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase subunit 3 (SDH3) Complex II Electron transport Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005749	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	4	1
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045257	succinate dehydrogenase complex (ubiquinone)	5	1
GO:0045281	succinate dehydrogenase complex	4	1
GO:0045283	fumarate reductase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	7
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I5W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.377
CLV_NRD_NRD_1	65	67	PF00675	0.578
CLV_PCSK_KEX2_1	6	8	PF00082	0.352
CLV_PCSK_KEX2_1	65	67	PF00082	0.578
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.352
CLV_PCSK_SKI1_1	75	79	PF00082	0.559
DOC_MAPK_gen_1	6	14	PF00069	0.636
DOC_MAPK_gen_1	62	71	PF00069	0.377
DOC_PP2B_LxvP_1	12	15	PF13499	0.647
DOC_PP4_FxxP_1	27	30	PF00568	0.382
DOC_USP7_MATH_1	40	44	PF00917	0.527
LIG_14-3-3_CanoR_1	49	53	PF00244	0.383
LIG_14-3-3_CanoR_1	7	13	PF00244	0.560
LIG_14-3-3_CanoR_1	91	97	PF00244	0.348
LIG_EH_1	100	104	PF12763	0.453
LIG_FHA_1	17	23	PF00498	0.550
LIG_FHA_1	88	94	PF00498	0.360
LIG_LIR_Gen_1	59	68	PF02991	0.417
LIG_LIR_Nem_3	59	63	PF02991	0.418
LIG_LYPXL_S_1	79	83	PF13949	0.581
LIG_LYPXL_yS_3	80	83	PF13949	0.387
LIG_SH2_NCK_1	60	64	PF00017	0.495
LIG_SH2_PTP2	68	71	PF00017	0.367
LIG_SH2_STAP1	18	22	PF00017	0.547
LIG_SH2_STAT5	18	21	PF00017	0.549
LIG_SH2_STAT5	68	71	PF00017	0.367
LIG_SH3_3	2	8	PF00018	0.572
LIG_SH3_3	66	72	PF00018	0.379
LIG_TYR_ITIM	78	83	PF00017	0.379
LIG_WRC_WIRS_1	93	98	PF05994	0.385
MOD_CK1_1	43	49	PF00069	0.409
MOD_GSK3_1	43	50	PF00069	0.361
MOD_GSK3_1	85	92	PF00069	0.426
MOD_NEK2_1	89	94	PF00069	0.388
MOD_PIKK_1	82	88	PF00454	0.395
MOD_PKA_2	48	54	PF00069	0.371
MOD_Plk_2-3	56	62	PF00069	0.446
MOD_Plk_4	28	34	PF00069	0.322
MOD_Plk_4	43	49	PF00069	0.359
MOD_SUMO_rev_2	50	59	PF00179	0.459
TRG_ENDOCYTIC_2	60	63	PF00928	0.419
TRG_ENDOCYTIC_2	68	71	PF00928	0.335
TRG_ENDOCYTIC_2	80	83	PF00928	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD88	Leptomonas seymouri	87%	100%
A0A0S4ITZ5	Bodo saltans	58%	100%
A0A1X0P1F7	Trypanosomatidae	75%	98%
A0A3S7X3P6	Leishmania donovani	100%	100%
A0A422N2Z8	Trypanosoma rangeli	69%	94%
A4HIL8	Leishmania braziliensis	92%	100%
C9ZR84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B158	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q708	Leishmania major	99%	100%
V5BSK5	Trypanosoma cruzi	67%	98%