LeishMANIAdb
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TPH domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPH domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I5W1_LEIIN
TriTrypDb:
LINF_300033600
Length:
798

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I5W1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5W1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 3 7 PF00656 0.540
CLV_C14_Caspase3-7 755 759 PF00656 0.484
CLV_NRD_NRD_1 14 16 PF00675 0.565
CLV_NRD_NRD_1 181 183 PF00675 0.434
CLV_NRD_NRD_1 267 269 PF00675 0.437
CLV_NRD_NRD_1 277 279 PF00675 0.448
CLV_NRD_NRD_1 322 324 PF00675 0.408
CLV_NRD_NRD_1 330 332 PF00675 0.422
CLV_NRD_NRD_1 385 387 PF00675 0.451
CLV_NRD_NRD_1 412 414 PF00675 0.440
CLV_NRD_NRD_1 447 449 PF00675 0.454
CLV_NRD_NRD_1 455 457 PF00675 0.510
CLV_NRD_NRD_1 586 588 PF00675 0.519
CLV_NRD_NRD_1 607 609 PF00675 0.534
CLV_NRD_NRD_1 617 619 PF00675 0.394
CLV_NRD_NRD_1 735 737 PF00675 0.448
CLV_PCSK_FUR_1 264 268 PF00082 0.572
CLV_PCSK_FUR_1 320 324 PF00082 0.441
CLV_PCSK_FUR_1 328 332 PF00082 0.424
CLV_PCSK_FUR_1 383 387 PF00082 0.414
CLV_PCSK_KEX2_1 144 146 PF00082 0.484
CLV_PCSK_KEX2_1 180 182 PF00082 0.498
CLV_PCSK_KEX2_1 187 189 PF00082 0.484
CLV_PCSK_KEX2_1 264 266 PF00082 0.463
CLV_PCSK_KEX2_1 267 269 PF00082 0.431
CLV_PCSK_KEX2_1 277 279 PF00082 0.436
CLV_PCSK_KEX2_1 322 324 PF00082 0.424
CLV_PCSK_KEX2_1 330 332 PF00082 0.399
CLV_PCSK_KEX2_1 385 387 PF00082 0.414
CLV_PCSK_KEX2_1 412 414 PF00082 0.440
CLV_PCSK_KEX2_1 447 449 PF00082 0.455
CLV_PCSK_KEX2_1 470 472 PF00082 0.424
CLV_PCSK_KEX2_1 586 588 PF00082 0.516
CLV_PCSK_KEX2_1 607 609 PF00082 0.475
CLV_PCSK_KEX2_1 700 702 PF00082 0.400
CLV_PCSK_KEX2_1 735 737 PF00082 0.459
CLV_PCSK_PC1ET2_1 144 146 PF00082 0.484
CLV_PCSK_PC1ET2_1 187 189 PF00082 0.476
CLV_PCSK_PC1ET2_1 470 472 PF00082 0.424
CLV_PCSK_PC1ET2_1 700 702 PF00082 0.377
CLV_PCSK_SKI1_1 127 131 PF00082 0.618
CLV_PCSK_SKI1_1 164 168 PF00082 0.532
CLV_PCSK_SKI1_1 297 301 PF00082 0.439
CLV_PCSK_SKI1_1 314 318 PF00082 0.393
CLV_PCSK_SKI1_1 342 346 PF00082 0.502
CLV_PCSK_SKI1_1 350 354 PF00082 0.398
CLV_PCSK_SKI1_1 366 370 PF00082 0.337
CLV_PCSK_SKI1_1 412 416 PF00082 0.484
CLV_PCSK_SKI1_1 608 612 PF00082 0.405
CLV_PCSK_SKI1_1 618 622 PF00082 0.381
CLV_PCSK_SKI1_1 710 714 PF00082 0.398
CLV_PCSK_SKI1_1 725 729 PF00082 0.380
CLV_PCSK_SKI1_1 791 795 PF00082 0.412
DEG_APCC_DBOX_1 439 447 PF00400 0.448
DEG_APCC_DBOX_1 607 615 PF00400 0.460
DEG_APCC_DBOX_1 790 798 PF00400 0.429
DEG_SPOP_SBC_1 75 79 PF00917 0.575
DOC_CDC14_PxL_1 4 12 PF14671 0.550
DOC_CYCLIN_RxL_1 615 622 PF00134 0.495
DOC_PP4_FxxP_1 104 107 PF00568 0.552
DOC_USP7_MATH_1 107 111 PF00917 0.704
DOC_USP7_MATH_1 217 221 PF00917 0.678
DOC_USP7_MATH_1 42 46 PF00917 0.599
DOC_USP7_MATH_1 54 58 PF00917 0.559
DOC_USP7_MATH_1 574 578 PF00917 0.553
DOC_USP7_MATH_1 651 655 PF00917 0.642
DOC_USP7_MATH_1 670 674 PF00917 0.314
DOC_USP7_MATH_1 741 745 PF00917 0.478
DOC_USP7_MATH_1 75 79 PF00917 0.625
DOC_USP7_UBL2_3 58 62 PF12436 0.646
DOC_USP7_UBL2_3 696 700 PF12436 0.431
DOC_WW_Pin1_4 117 122 PF00397 0.674
DOC_WW_Pin1_4 8 13 PF00397 0.624
LIG_14-3-3_CanoR_1 145 151 PF00244 0.538
LIG_14-3-3_CanoR_1 15 21 PF00244 0.563
LIG_14-3-3_CanoR_1 272 277 PF00244 0.539
LIG_14-3-3_CanoR_1 525 529 PF00244 0.505
LIG_14-3-3_CanoR_1 586 590 PF00244 0.474
LIG_14-3-3_CanoR_1 689 695 PF00244 0.435
LIG_BIR_II_1 1 5 PF00653 0.600
LIG_FHA_1 28 34 PF00498 0.454
LIG_FHA_1 427 433 PF00498 0.446
LIG_FHA_1 663 669 PF00498 0.523
LIG_FHA_2 147 153 PF00498 0.454
LIG_FHA_2 33 39 PF00498 0.610
LIG_FHA_2 333 339 PF00498 0.366
LIG_FHA_2 365 371 PF00498 0.441
LIG_FHA_2 504 510 PF00498 0.481
LIG_FHA_2 586 592 PF00498 0.601
LIG_LIR_Apic_2 102 107 PF02991 0.706
LIG_LIR_Apic_2 26 32 PF02991 0.628
LIG_LIR_Gen_1 19 25 PF02991 0.554
LIG_LIR_Gen_1 298 308 PF02991 0.438
LIG_LIR_Gen_1 622 633 PF02991 0.386
LIG_LIR_Gen_1 729 738 PF02991 0.441
LIG_LIR_Nem_3 19 23 PF02991 0.509
LIG_LIR_Nem_3 298 303 PF02991 0.440
LIG_LIR_Nem_3 362 368 PF02991 0.443
LIG_LIR_Nem_3 622 628 PF02991 0.385
LIG_LIR_Nem_3 729 734 PF02991 0.434
LIG_MYND_1 8 12 PF01753 0.625
LIG_PCNA_yPIPBox_3 534 547 PF02747 0.410
LIG_SH2_CRK 147 151 PF00017 0.465
LIG_SH2_CRK 29 33 PF00017 0.453
LIG_SH2_CRK 596 600 PF00017 0.546
LIG_SH2_NCK_1 147 151 PF00017 0.535
LIG_SH2_SRC 113 116 PF00017 0.627
LIG_SH2_STAP1 100 104 PF00017 0.574
LIG_SH2_STAP1 25 29 PF00017 0.591
LIG_SH2_STAT3 439 442 PF00017 0.462
LIG_SH2_STAT5 113 116 PF00017 0.657
LIG_SH2_STAT5 29 32 PF00017 0.604
LIG_SH3_3 69 75 PF00018 0.710
LIG_TRAF2_1 149 152 PF00917 0.519
LIG_TRAF2_1 279 282 PF00917 0.538
LIG_TRAF2_1 35 38 PF00917 0.618
LIG_TRAF2_1 416 419 PF00917 0.460
LIG_TRAF2_1 506 509 PF00917 0.522
LIG_TRAF2_1 552 555 PF00917 0.417
LIG_TRAF2_1 673 676 PF00917 0.390
LIG_TRAF2_1 743 746 PF00917 0.481
LIG_WRC_WIRS_1 365 370 PF05994 0.428
LIG_WRC_WIRS_1 575 580 PF05994 0.566
MOD_CDK_SPxxK_3 8 15 PF00069 0.625
MOD_CK1_1 11 17 PF00069 0.561
MOD_CK1_1 116 122 PF00069 0.604
MOD_CK1_1 43 49 PF00069 0.628
MOD_CK1_1 576 582 PF00069 0.553
MOD_CK1_1 684 690 PF00069 0.447
MOD_CK1_1 77 83 PF00069 0.622
MOD_CK2_1 146 152 PF00069 0.531
MOD_CK2_1 255 261 PF00069 0.579
MOD_CK2_1 32 38 PF00069 0.604
MOD_CK2_1 332 338 PF00069 0.363
MOD_CK2_1 364 370 PF00069 0.427
MOD_CK2_1 495 501 PF00069 0.465
MOD_CK2_1 503 509 PF00069 0.460
MOD_CK2_1 585 591 PF00069 0.539
MOD_CK2_1 670 676 PF00069 0.510
MOD_CK2_1 726 732 PF00069 0.549
MOD_CK2_1 740 746 PF00069 0.359
MOD_GlcNHglycan 219 222 PF01048 0.593
MOD_GlcNHglycan 433 438 PF01048 0.395
MOD_GlcNHglycan 84 87 PF01048 0.614
MOD_GSK3_1 113 120 PF00069 0.705
MOD_GSK3_1 227 234 PF00069 0.779
MOD_GSK3_1 40 47 PF00069 0.648
MOD_GSK3_1 503 510 PF00069 0.571
MOD_GSK3_1 6 13 PF00069 0.568
MOD_GSK3_1 684 691 PF00069 0.447
MOD_GSK3_1 77 84 PF00069 0.565
MOD_LATS_1 270 276 PF00433 0.538
MOD_N-GLC_1 303 308 PF02516 0.394
MOD_N-GLC_1 495 500 PF02516 0.464
MOD_NEK2_1 146 151 PF00069 0.467
MOD_NEK2_1 303 308 PF00069 0.394
MOD_NEK2_1 426 431 PF00069 0.523
MOD_NEK2_1 503 508 PF00069 0.466
MOD_NEK2_1 511 516 PF00069 0.453
MOD_NEK2_1 573 578 PF00069 0.573
MOD_PIKK_1 210 216 PF00454 0.578
MOD_PIKK_1 741 747 PF00454 0.539
MOD_PK_1 681 687 PF00069 0.512
MOD_PKA_1 82 88 PF00069 0.613
MOD_PKA_2 202 208 PF00069 0.494
MOD_PKA_2 390 396 PF00069 0.506
MOD_PKA_2 524 530 PF00069 0.506
MOD_PKA_2 54 60 PF00069 0.715
MOD_PKA_2 585 591 PF00069 0.512
MOD_PKA_2 642 648 PF00069 0.355
MOD_PKA_2 688 694 PF00069 0.511
MOD_Plk_1 303 309 PF00069 0.393
MOD_Plk_1 495 501 PF00069 0.555
MOD_Plk_1 651 657 PF00069 0.526
MOD_Plk_2-3 585 591 PF00069 0.473
MOD_Plk_4 303 309 PF00069 0.414
MOD_Plk_4 524 530 PF00069 0.607
MOD_Plk_4 651 657 PF00069 0.526
MOD_ProDKin_1 117 123 PF00069 0.677
MOD_ProDKin_1 8 14 PF00069 0.623
MOD_SUMO_for_1 166 169 PF00179 0.532
MOD_SUMO_for_1 316 319 PF00179 0.412
MOD_SUMO_for_1 414 417 PF00179 0.669
MOD_SUMO_for_1 569 572 PF00179 0.504
MOD_SUMO_for_1 680 683 PF00179 0.419
MOD_SUMO_for_1 695 698 PF00179 0.422
MOD_SUMO_rev_2 138 146 PF00179 0.470
MOD_SUMO_rev_2 346 354 PF00179 0.483
MOD_SUMO_rev_2 359 365 PF00179 0.383
MOD_SUMO_rev_2 544 552 PF00179 0.443
MOD_SUMO_rev_2 613 621 PF00179 0.390
MOD_SUMO_rev_2 673 680 PF00179 0.508
MOD_SUMO_rev_2 697 702 PF00179 0.386
MOD_SUMO_rev_2 718 727 PF00179 0.427
TRG_AP2beta_CARGO_1 362 372 PF09066 0.440
TRG_DiLeu_BaEn_1 311 316 PF01217 0.398
TRG_DiLeu_BaEn_1 723 728 PF01217 0.402
TRG_DiLeu_LyEn_5 311 316 PF01217 0.398
TRG_ENDOCYTIC_2 147 150 PF00928 0.534
TRG_ENDOCYTIC_2 568 571 PF00928 0.426
TRG_ENDOCYTIC_2 596 599 PF00928 0.433
TRG_ER_diArg_1 179 182 PF00400 0.603
TRG_ER_diArg_1 264 267 PF00400 0.459
TRG_ER_diArg_1 276 278 PF00400 0.445
TRG_ER_diArg_1 321 323 PF00400 0.461
TRG_ER_diArg_1 383 386 PF00400 0.509
TRG_ER_diArg_1 446 448 PF00400 0.490
TRG_ER_diArg_1 561 564 PF00400 0.419
TRG_ER_diArg_1 607 609 PF00400 0.475
TRG_ER_diArg_1 671 674 PF00400 0.506
TRG_ER_diArg_1 734 736 PF00400 0.454
TRG_ER_diArg_1 747 750 PF00400 0.621
TRG_NLS_Bipartite_1 50 65 PF00514 0.662
TRG_NLS_MonoCore_2 57 62 PF00514 0.705
TRG_NLS_MonoExtC_3 57 62 PF00514 0.661
TRG_NLS_MonoExtN_4 48 54 PF00514 0.606
TRG_NLS_MonoExtN_4 55 62 PF00514 0.605
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.466
TRG_Pf-PMV_PEXEL_1 314 318 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 325 329 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 342 346 PF00026 0.524
TRG_Pf-PMV_PEXEL_1 386 390 PF00026 0.522
TRG_Pf-PMV_PEXEL_1 399 403 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 520 524 PF00026 0.554
TRG_Pf-PMV_PEXEL_1 534 538 PF00026 0.360
TRG_Pf-PMV_PEXEL_1 618 622 PF00026 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC64 Leptomonas seymouri 71% 100%
A0A1X0P1G0 Trypanosomatidae 42% 98%
A0A3R7M5L7 Trypanosoma rangeli 44% 100%
A0A3S7X3P7 Leishmania donovani 99% 100%
A4HIL6 Leishmania braziliensis 85% 100%
C9ZR81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B156 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q710 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS