Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5V8_LEIIN

TriTrypDb:

LINF_300033300

Length:

274

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4I5V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5V8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.600
CLV_NRD_NRD_1	124	126	PF00675	0.392
CLV_NRD_NRD_1	2	4	PF00675	0.457
CLV_NRD_NRD_1	267	269	PF00675	0.335
CLV_PCSK_KEX2_1	267	269	PF00082	0.317
CLV_PCSK_SKI1_1	125	129	PF00082	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.680
DOC_MAPK_MEF2A_6	196	203	PF00069	0.540
DOC_PP1_RVXF_1	235	242	PF00149	0.579
DOC_PP1_RVXF_1	35	41	PF00149	0.672
DOC_PP2B_LxvP_1	142	145	PF13499	0.342
DOC_USP7_MATH_1	165	169	PF00917	0.317
DOC_USP7_MATH_1	227	231	PF00917	0.543
DOC_USP7_MATH_1	255	259	PF00917	0.575
DOC_USP7_MATH_1	32	36	PF00917	0.759
DOC_WW_Pin1_4	148	153	PF00397	0.380
LIG_14-3-3_CanoR_1	219	223	PF00244	0.614
LIG_14-3-3_CanoR_1	240	246	PF00244	0.662
LIG_14-3-3_CanoR_1	256	263	PF00244	0.429
LIG_14-3-3_CanoR_1	31	40	PF00244	0.668
LIG_Actin_WH2_2	226	242	PF00022	0.545
LIG_eIF4E_1	133	139	PF01652	0.406
LIG_FHA_1	133	139	PF00498	0.319
LIG_FHA_2	187	193	PF00498	0.620
LIG_LIR_Gen_1	200	211	PF02991	0.599
LIG_LIR_Nem_3	168	174	PF02991	0.374
LIG_LIR_Nem_3	200	206	PF02991	0.531
LIG_LIR_Nem_3	213	218	PF02991	0.513
LIG_LIR_Nem_3	269	273	PF02991	0.523
LIG_LYPXL_yS_3	211	214	PF13949	0.514
LIG_NRBOX	133	139	PF00104	0.406
LIG_Pex14_2	124	128	PF04695	0.547
LIG_Pex14_2	270	274	PF04695	0.569
LIG_PTB_Apo_2	126	133	PF02174	0.533
LIG_SH2_STAT3	154	157	PF00017	0.424
LIG_SH2_STAT3	179	182	PF00017	0.548
LIG_SH2_STAT5	133	136	PF00017	0.363
LIG_SH2_STAT5	154	157	PF00017	0.440
LIG_SH2_STAT5	171	174	PF00017	0.283
LIG_SH3_3	115	121	PF00018	0.717
LIG_SH3_3	4	10	PF00018	0.577
LIG_TRAF2_1	180	183	PF00917	0.473
LIG_TRAF2_1	54	57	PF00917	0.701
MOD_CK2_1	12	18	PF00069	0.628
MOD_CK2_1	177	183	PF00069	0.434
MOD_CK2_1	186	192	PF00069	0.581
MOD_CK2_1	218	224	PF00069	0.571
MOD_CK2_1	50	56	PF00069	0.682
MOD_GlcNHglycan	167	170	PF01048	0.352
MOD_GlcNHglycan	21	24	PF01048	0.477
MOD_GlcNHglycan	229	232	PF01048	0.309
MOD_GlcNHglycan	234	237	PF01048	0.342
MOD_GlcNHglycan	257	260	PF01048	0.283
MOD_GlcNHglycan	44	47	PF01048	0.513
MOD_GlcNHglycan	52	55	PF01048	0.536
MOD_GlcNHglycan	7	10	PF01048	0.489
MOD_GSK3_1	144	151	PF00069	0.453
MOD_GSK3_1	227	234	PF00069	0.565
MOD_GSK3_1	32	39	PF00069	0.686
MOD_GSK3_1	42	49	PF00069	0.692
MOD_GSK3_1	5	12	PF00069	0.595
MOD_N-GLC_1	41	46	PF02516	0.517
MOD_NEK2_1	11	16	PF00069	0.692
MOD_NEK2_1	132	137	PF00069	0.319
MOD_NEK2_1	21	26	PF00069	0.712
MOD_NEK2_1	241	246	PF00069	0.512
MOD_NEK2_1	33	38	PF00069	0.633
MOD_PIKK_1	205	211	PF00454	0.562
MOD_PIKK_1	218	224	PF00454	0.489
MOD_PIKK_1	46	52	PF00454	0.696
MOD_PKA_2	218	224	PF00069	0.598
MOD_PKA_2	255	261	PF00069	0.543
MOD_PKA_2	36	42	PF00069	0.642
MOD_Plk_4	210	216	PF00069	0.578
MOD_Plk_4	241	247	PF00069	0.558
MOD_ProDKin_1	148	154	PF00069	0.382
MOD_SUMO_for_1	187	190	PF00179	0.522
TRG_ENDOCYTIC_2	171	174	PF00928	0.364
TRG_ENDOCYTIC_2	211	214	PF00928	0.544
TRG_ER_diArg_1	266	268	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B3	Leptomonas seymouri	68%	100%
A0A0S4IU47	Bodo saltans	37%	75%
A0A1X0P2M0	Trypanosomatidae	49%	100%
A0A3R7L2S3	Trypanosoma rangeli	47%	100%
A0A3S7X3P3	Leishmania donovani	100%	100%
A4HIL3	Leishmania braziliensis	84%	100%
D0A1H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	86%
E9B153	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q713	Leishmania major	93%	100%