Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF872) - putative

Species:

Leishmania infantum

UniProt:

A4I5V7_LEIIN

TriTrypDb:

LINF_300033200

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I5V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5V7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.470
CLV_PCSK_FUR_1	60	64	PF00082	0.428
CLV_PCSK_KEX2_1	62	64	PF00082	0.499
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.438
CLV_PCSK_SKI1_1	115	119	PF00082	0.275
CLV_PCSK_SKI1_1	88	92	PF00082	0.356
DEG_Nend_UBRbox_1	1	4	PF02207	0.704
DOC_MAPK_gen_1	145	153	PF00069	0.275
DOC_MAPK_MEF2A_6	83	91	PF00069	0.573
DOC_PP1_RVXF_1	106	112	PF00149	0.552
DOC_PP1_RVXF_1	86	92	PF00149	0.567
DOC_PP2B_LxvP_1	158	161	PF13499	0.312
DOC_PP2B_LxvP_1	182	185	PF13499	0.582
DOC_PP4_FxxP_1	93	96	PF00568	0.516
DOC_USP7_MATH_1	8	12	PF00917	0.714
DOC_WW_Pin1_4	10	15	PF00397	0.670
LIG_14-3-3_CanoR_1	176	182	PF00244	0.588
LIG_14-3-3_CanoR_1	44	53	PF00244	0.664
LIG_14-3-3_CanoR_1	60	66	PF00244	0.663
LIG_FHA_1	11	17	PF00498	0.649
LIG_FHA_2	43	49	PF00498	0.599
LIG_LIR_Apic_2	92	96	PF02991	0.532
LIG_LIR_Gen_1	180	187	PF02991	0.590
LIG_LIR_Nem_3	165	170	PF02991	0.482
LIG_LIR_Nem_3	180	184	PF02991	0.497
LIG_LIR_Nem_3	33	37	PF02991	0.642
LIG_LIR_Nem_3	72	78	PF02991	0.669
LIG_MAD2	88	96	PF02301	0.541
LIG_Pex14_2	117	121	PF04695	0.312
LIG_SH2_CRK	170	174	PF00017	0.581
LIG_SH2_CRK	179	183	PF00017	0.535
LIG_SH2_STAP1	164	168	PF00017	0.388
LIG_SH2_STAP1	85	89	PF00017	0.624
LIG_SH2_STAT5	141	144	PF00017	0.367
LIG_SH2_STAT5	172	175	PF00017	0.556
LIG_SH2_STAT5	179	182	PF00017	0.674
LIG_SH3_2	96	101	PF14604	0.529
LIG_SH3_3	93	99	PF00018	0.546
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.312
LIG_SUMO_SIM_par_1	13	18	PF11976	0.659
LIG_TYR_ITIM	168	173	PF00017	0.451
LIG_WW_3	41	45	PF00397	0.613
MOD_CK1_1	61	67	PF00069	0.652
MOD_CK2_1	42	48	PF00069	0.606
MOD_CK2_1	64	70	PF00069	0.623
MOD_CMANNOS	111	114	PF00535	0.336
MOD_GlcNHglycan	123	126	PF01048	0.388
MOD_GlcNHglycan	9	13	PF01048	0.498
MOD_GSK3_1	121	128	PF00069	0.388
MOD_NEK2_1	121	126	PF00069	0.414
MOD_NEK2_1	171	176	PF00069	0.532
MOD_NEK2_2	162	167	PF00069	0.388
MOD_Plk_4	125	131	PF00069	0.388
MOD_Plk_4	162	168	PF00069	0.482
MOD_Plk_4	177	183	PF00069	0.507
MOD_ProDKin_1	10	16	PF00069	0.670
TRG_ENDOCYTIC_2	119	122	PF00928	0.312
TRG_ENDOCYTIC_2	163	166	PF00928	0.312
TRG_ENDOCYTIC_2	170	173	PF00928	0.525
TRG_ENDOCYTIC_2	179	182	PF00928	0.580
TRG_ENDOCYTIC_2	75	78	PF00928	0.671
TRG_ER_diArg_1	1	4	PF00400	0.717
TRG_ER_diArg_1	103	106	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q7	Leptomonas seymouri	65%	100%
A0A3Q8IF42	Leishmania donovani	98%	100%
A4HIL2	Leishmania braziliensis	80%	100%
E9B152	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q714	Leishmania major	95%	100%