LeishMANIAdb
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Small glutamine-rich tetratricopeptide repeat protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Small glutamine-rich tetratricopeptide repeat protein
Gene product:
small glutamine-rich tetratricopeptide repeat protein - putative
Species:
Leishmania infantum
UniProt:
A4I5V1_LEIIN
TriTrypDb:
LINF_300032600
Length:
408

Annotations

Annotations by Jardim et al.

Metal Binding, Small glutamine-rich tetratricopeptide repeat SGT

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 3
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1
GO:0032991 protein-containing complex 1 1
GO:0072379 ER membrane insertion complex 2 1
GO:0072380 TRC complex 3 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 407

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I5V1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5V1

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006605 protein targeting 5 1
GO:0006612 protein targeting to membrane 5 1
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane 6 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006950 response to stress 2 1
GO:0008104 protein localization 4 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0015031 protein transport 4 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0030433 ubiquitin-dependent ERAD pathway 6 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0045047 protein targeting to ER 6 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0050896 response to stimulus 1 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0051716 cellular response to stimulus 2 1
GO:0070727 cellular macromolecule localization 3 1
GO:0070972 protein localization to endoplasmic reticulum 6 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072599 establishment of protein localization to endoplasmic reticulum 5 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901698 response to nitrogen compound 3 1
Molecular functions
Term Name Level Count
GO:0060090 molecular adaptor activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.418
CLV_NRD_NRD_1 24 26 PF00675 0.422
CLV_NRD_NRD_1 359 361 PF00675 0.481
CLV_NRD_NRD_1 75 77 PF00675 0.576
CLV_PCSK_KEX2_1 24 26 PF00082 0.507
CLV_PCSK_KEX2_1 240 242 PF00082 0.504
CLV_PCSK_KEX2_1 75 77 PF00082 0.585
CLV_PCSK_PC1ET2_1 240 242 PF00082 0.504
CLV_PCSK_PC7_1 71 77 PF00082 0.564
CLV_PCSK_SKI1_1 14 18 PF00082 0.306
CLV_PCSK_SKI1_1 67 71 PF00082 0.497
DEG_Nend_UBRbox_2 1 3 PF02207 0.642
DOC_CKS1_1 339 344 PF01111 0.418
DOC_PP1_RVXF_1 11 18 PF00149 0.321
DOC_PP1_RVXF_1 82 89 PF00149 0.465
DOC_PP4_FxxP_1 401 404 PF00568 0.579
DOC_USP7_MATH_1 273 277 PF00917 0.500
DOC_USP7_MATH_1 49 53 PF00917 0.512
DOC_USP7_UBL2_3 114 118 PF12436 0.258
DOC_USP7_UBL2_3 236 240 PF12436 0.390
DOC_USP7_UBL2_3 95 99 PF12436 0.439
DOC_WW_Pin1_4 338 343 PF00397 0.418
LIG_14-3-3_CanoR_1 24 31 PF00244 0.392
LIG_FHA_1 153 159 PF00498 0.258
LIG_FHA_2 232 238 PF00498 0.509
LIG_FHA_2 56 62 PF00498 0.449
LIG_IBAR_NPY_1 124 126 PF08397 0.366
LIG_LIR_Gen_1 18 23 PF02991 0.333
LIG_LIR_Gen_1 199 210 PF02991 0.265
LIG_LIR_Gen_1 276 285 PF02991 0.507
LIG_LIR_Gen_1 299 308 PF02991 0.521
LIG_LIR_Gen_1 82 92 PF02991 0.372
LIG_LIR_Nem_3 199 205 PF02991 0.265
LIG_LIR_Nem_3 299 303 PF02991 0.498
LIG_LIR_Nem_3 341 346 PF02991 0.405
LIG_LIR_Nem_3 82 88 PF02991 0.357
LIG_PTB_Apo_2 192 199 PF02174 0.290
LIG_PTB_Apo_2 281 288 PF02174 0.416
LIG_PTB_Apo_2 294 301 PF02174 0.406
LIG_PTB_Apo_2 395 402 PF02174 0.509
LIG_PTB_Phospho_1 192 198 PF10480 0.290
LIG_REV1ctd_RIR_1 165 175 PF16727 0.231
LIG_SH2_CRK 202 206 PF00017 0.246
LIG_SH2_STAP1 108 112 PF00017 0.411
LIG_SH2_STAP1 154 158 PF00017 0.231
LIG_SH2_STAP1 198 202 PF00017 0.240
LIG_SH2_STAP1 215 219 PF00017 0.183
LIG_SH2_STAT5 154 157 PF00017 0.238
LIG_SH2_STAT5 383 386 PF00017 0.435
LIG_SH2_STAT5 97 100 PF00017 0.353
LIG_SH3_3 25 31 PF00018 0.458
LIG_SH3_3 336 342 PF00018 0.494
LIG_SUMO_SIM_anti_2 57 64 PF11976 0.419
LIG_WRC_WIRS_1 16 21 PF05994 0.322
MOD_CDK_SPxxK_3 338 345 PF00069 0.493
MOD_CK1_1 309 315 PF00069 0.584
MOD_CK2_1 23 29 PF00069 0.467
MOD_CK2_1 231 237 PF00069 0.484
MOD_CK2_1 74 80 PF00069 0.535
MOD_GlcNHglycan 51 54 PF01048 0.651
MOD_GlcNHglycan 76 79 PF01048 0.582
MOD_GSK3_1 196 203 PF00069 0.238
MOD_GSK3_1 246 253 PF00069 0.425
MOD_N-GLC_1 213 218 PF02516 0.394
MOD_N-GLC_1 231 236 PF02516 0.414
MOD_NEK2_1 15 20 PF00069 0.344
MOD_NEK2_1 287 292 PF00069 0.510
MOD_NEK2_1 399 404 PF00069 0.531
MOD_PIKK_1 140 146 PF00454 0.374
MOD_PIKK_1 23 29 PF00454 0.396
MOD_PIKK_1 273 279 PF00454 0.454
MOD_PIKK_1 309 315 PF00454 0.592
MOD_PKA_2 23 29 PF00069 0.457
MOD_PKA_2 74 80 PF00069 0.502
MOD_Plk_1 273 279 PF00069 0.488
MOD_Plk_2-3 102 108 PF00069 0.364
MOD_ProDKin_1 338 344 PF00069 0.419
MOD_SUMO_rev_2 237 246 PF00179 0.413
MOD_SUMO_rev_2 77 86 PF00179 0.433
TRG_DiLeu_BaEn_1 299 304 PF01217 0.469
TRG_ENDOCYTIC_2 126 129 PF00928 0.393
TRG_ENDOCYTIC_2 202 205 PF00928 0.246
TRG_ENDOCYTIC_2 377 380 PF00928 0.529
TRG_ER_diArg_1 23 25 PF00400 0.489
TRG_NES_CRM1_1 320 334 PF08389 0.595

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5L1 Leptomonas seymouri 84% 100%
A0A0S4ITV7 Bodo saltans 59% 100%
A0A1X0P1H3 Trypanosomatidae 61% 100%
A0A3R7KEN1 Trypanosoma rangeli 60% 98%
A0A3S7X3N8 Leishmania donovani 100% 100%
A4HIK6 Leishmania braziliensis 92% 100%
C9ZR70 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 98%
E9B146 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 99%
Q4Q720 Leishmania major 98% 100%
Q54VG4 Dictyostelium discoideum 27% 100%
V5BX66 Trypanosoma cruzi 61% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS