LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I5T8_LEIIN
TriTrypDb:
LINF_300031300
Length:
719

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5T8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5T8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 585 589 PF00656 0.592
CLV_NRD_NRD_1 284 286 PF00675 0.614
CLV_NRD_NRD_1 389 391 PF00675 0.600
CLV_NRD_NRD_1 638 640 PF00675 0.672
CLV_NRD_NRD_1 644 646 PF00675 0.617
CLV_NRD_NRD_1 665 667 PF00675 0.636
CLV_NRD_NRD_1 701 703 PF00675 0.526
CLV_PCSK_FUR_1 663 667 PF00082 0.638
CLV_PCSK_KEX2_1 130 132 PF00082 0.629
CLV_PCSK_KEX2_1 389 391 PF00082 0.460
CLV_PCSK_KEX2_1 601 603 PF00082 0.582
CLV_PCSK_KEX2_1 644 646 PF00082 0.652
CLV_PCSK_KEX2_1 665 667 PF00082 0.636
CLV_PCSK_KEX2_1 701 703 PF00082 0.526
CLV_PCSK_PC1ET2_1 130 132 PF00082 0.629
CLV_PCSK_PC1ET2_1 601 603 PF00082 0.582
CLV_PCSK_SKI1_1 360 364 PF00082 0.445
CLV_PCSK_SKI1_1 389 393 PF00082 0.455
CLV_PCSK_SKI1_1 441 445 PF00082 0.436
DEG_APCC_DBOX_1 488 496 PF00400 0.480
DEG_Nend_UBRbox_2 1 3 PF02207 0.635
DEG_SPOP_SBC_1 149 153 PF00917 0.642
DEG_SPOP_SBC_1 221 225 PF00917 0.647
DOC_CDC14_PxL_1 559 567 PF14671 0.677
DOC_CKS1_1 413 418 PF01111 0.425
DOC_CYCLIN_RxL_1 506 516 PF00134 0.446
DOC_MAPK_DCC_7 557 567 PF00069 0.655
DOC_MAPK_gen_1 198 207 PF00069 0.613
DOC_MAPK_gen_1 397 404 PF00069 0.457
DOC_MAPK_gen_1 509 519 PF00069 0.443
DOC_PP1_RVXF_1 363 369 PF00149 0.426
DOC_PP2B_LxvP_1 565 568 PF13499 0.673
DOC_PP4_MxPP_1 264 267 PF00568 0.561
DOC_SPAK_OSR1_1 673 677 PF12202 0.634
DOC_USP7_MATH_1 149 153 PF00917 0.700
DOC_USP7_MATH_1 154 158 PF00917 0.656
DOC_USP7_MATH_1 161 165 PF00917 0.588
DOC_USP7_MATH_1 221 225 PF00917 0.650
DOC_USP7_MATH_1 305 309 PF00917 0.649
DOC_USP7_MATH_1 34 38 PF00917 0.606
DOC_USP7_MATH_1 649 653 PF00917 0.686
DOC_USP7_MATH_1 90 94 PF00917 0.638
DOC_USP7_MATH_1 95 99 PF00917 0.622
DOC_USP7_MATH_2 23 29 PF00917 0.660
DOC_USP7_UBL2_3 626 630 PF12436 0.694
DOC_WW_Pin1_4 227 232 PF00397 0.698
DOC_WW_Pin1_4 237 242 PF00397 0.622
DOC_WW_Pin1_4 412 417 PF00397 0.456
DOC_WW_Pin1_4 66 71 PF00397 0.675
LIG_14-3-3_CanoR_1 285 291 PF00244 0.681
LIG_14-3-3_CanoR_1 333 343 PF00244 0.506
LIG_14-3-3_CanoR_1 352 356 PF00244 0.475
LIG_14-3-3_CanoR_1 506 512 PF00244 0.356
LIG_14-3-3_CanoR_1 577 583 PF00244 0.603
LIG_Actin_WH2_2 406 424 PF00022 0.419
LIG_APCC_ABBA_1 511 516 PF00400 0.439
LIG_BRCT_BRCA1_1 353 357 PF00533 0.510
LIG_BRCT_BRCA1_1 436 440 PF00533 0.443
LIG_BRCT_BRCA1_1 670 674 PF00533 0.632
LIG_Clathr_ClatBox_1 517 521 PF01394 0.404
LIG_eIF4E_1 514 520 PF01652 0.440
LIG_FHA_1 485 491 PF00498 0.439
LIG_FHA_1 506 512 PF00498 0.484
LIG_FHA_1 577 583 PF00498 0.592
LIG_FHA_1 86 92 PF00498 0.638
LIG_FHA_2 437 443 PF00498 0.430
LIG_FHA_2 55 61 PF00498 0.658
LIG_FHA_2 583 589 PF00498 0.602
LIG_FHA_2 657 663 PF00498 0.694
LIG_LIR_Gen_1 367 375 PF02991 0.434
LIG_LIR_Gen_1 400 407 PF02991 0.311
LIG_LIR_Gen_1 456 463 PF02991 0.470
LIG_LIR_Nem_3 331 335 PF02991 0.492
LIG_LIR_Nem_3 367 371 PF02991 0.426
LIG_LIR_Nem_3 400 404 PF02991 0.315
LIG_LIR_Nem_3 437 443 PF02991 0.563
LIG_LIR_Nem_3 456 460 PF02991 0.284
LIG_LIR_Nem_3 609 615 PF02991 0.633
LIG_LYPXL_yS_3 612 615 PF13949 0.634
LIG_MYND_1 560 564 PF01753 0.550
LIG_NRBOX 406 412 PF00104 0.430
LIG_PCNA_yPIPBox_3 680 694 PF02747 0.639
LIG_SH2_CRK 332 336 PF00017 0.493
LIG_SH2_NCK_1 109 113 PF00017 0.711
LIG_SH2_SRC 109 112 PF00017 0.711
LIG_SH2_STAP1 216 220 PF00017 0.567
LIG_SH2_STAP1 514 518 PF00017 0.439
LIG_SH2_STAP1 546 550 PF00017 0.632
LIG_SH2_STAT3 716 719 PF00017 0.567
LIG_SH2_STAT5 212 215 PF00017 0.603
LIG_SH3_1 475 481 PF00018 0.453
LIG_SH3_1 557 563 PF00018 0.652
LIG_SH3_3 164 170 PF00018 0.675
LIG_SH3_3 17 23 PF00018 0.668
LIG_SH3_3 475 481 PF00018 0.453
LIG_SH3_3 557 563 PF00018 0.652
LIG_SH3_3 679 685 PF00018 0.667
LIG_SUMO_SIM_anti_2 409 415 PF11976 0.477
LIG_SUMO_SIM_par_1 266 272 PF11976 0.644
LIG_SUMO_SIM_par_1 409 415 PF11976 0.375
LIG_UBA3_1 264 273 PF00899 0.564
LIG_UBA3_1 391 399 PF00899 0.448
LIG_UBA3_1 459 468 PF00899 0.416
LIG_UBA3_1 708 717 PF00899 0.507
MOD_CDK_SPxK_1 237 243 PF00069 0.668
MOD_CDK_SPxxK_3 241 248 PF00069 0.669
MOD_CK1_1 150 156 PF00069 0.653
MOD_CK1_1 174 180 PF00069 0.692
MOD_CK1_1 219 225 PF00069 0.581
MOD_CK1_1 244 250 PF00069 0.667
MOD_CK1_1 252 258 PF00069 0.603
MOD_CK1_1 269 275 PF00069 0.551
MOD_CK1_1 280 286 PF00069 0.687
MOD_CK1_1 308 314 PF00069 0.649
MOD_CK1_1 331 337 PF00069 0.581
MOD_CK1_1 41 47 PF00069 0.698
MOD_CK1_1 584 590 PF00069 0.640
MOD_CK1_1 661 667 PF00069 0.680
MOD_CK2_1 154 160 PF00069 0.688
MOD_CK2_1 32 38 PF00069 0.691
MOD_CK2_1 417 423 PF00069 0.451
MOD_CK2_1 54 60 PF00069 0.712
MOD_CK2_1 95 101 PF00069 0.649
MOD_GlcNHglycan 152 155 PF01048 0.679
MOD_GlcNHglycan 163 166 PF01048 0.595
MOD_GlcNHglycan 173 176 PF01048 0.595
MOD_GlcNHglycan 318 321 PF01048 0.610
MOD_GlcNHglycan 381 384 PF01048 0.600
MOD_GlcNHglycan 64 67 PF01048 0.693
MOD_GSK3_1 14 21 PF00069 0.616
MOD_GSK3_1 144 151 PF00069 0.692
MOD_GSK3_1 170 177 PF00069 0.624
MOD_GSK3_1 216 223 PF00069 0.577
MOD_GSK3_1 237 244 PF00069 0.654
MOD_GSK3_1 249 256 PF00069 0.636
MOD_GSK3_1 277 284 PF00069 0.672
MOD_GSK3_1 308 315 PF00069 0.593
MOD_GSK3_1 331 338 PF00069 0.572
MOD_GSK3_1 34 41 PF00069 0.623
MOD_GSK3_1 607 614 PF00069 0.611
MOD_GSK3_1 62 69 PF00069 0.720
MOD_GSK3_1 664 671 PF00069 0.598
MOD_GSK3_1 707 714 PF00069 0.530
MOD_GSK3_1 71 78 PF00069 0.626
MOD_GSK3_1 81 88 PF00069 0.593
MOD_N-GLC_1 249 254 PF02516 0.648
MOD_N-GLC_1 281 286 PF02516 0.593
MOD_N-GLC_1 607 612 PF02516 0.615
MOD_NEK2_1 220 225 PF00069 0.585
MOD_NEK2_1 335 340 PF00069 0.511
MOD_NEK2_1 40 45 PF00069 0.680
MOD_NEK2_1 436 441 PF00069 0.404
MOD_NEK2_1 615 620 PF00069 0.633
MOD_NEK2_2 417 422 PF00069 0.457
MOD_PIKK_1 14 20 PF00454 0.600
MOD_PIKK_1 174 180 PF00454 0.682
MOD_PIKK_1 707 713 PF00454 0.527
MOD_PIKK_1 75 81 PF00454 0.643
MOD_PKA_1 130 136 PF00069 0.631
MOD_PKA_2 130 136 PF00069 0.680
MOD_PKA_2 144 150 PF00069 0.589
MOD_PKA_2 252 258 PF00069 0.683
MOD_PKA_2 278 284 PF00069 0.697
MOD_PKA_2 351 357 PF00069 0.519
MOD_PKA_2 505 511 PF00069 0.416
MOD_PKA_2 576 582 PF00069 0.624
MOD_PKA_2 664 670 PF00069 0.619
MOD_Plk_1 249 255 PF00069 0.645
MOD_Plk_1 70 76 PF00069 0.655
MOD_Plk_2-3 400 406 PF00069 0.444
MOD_Plk_4 711 717 PF00069 0.552
MOD_ProDKin_1 227 233 PF00069 0.701
MOD_ProDKin_1 237 243 PF00069 0.624
MOD_ProDKin_1 412 418 PF00069 0.451
MOD_ProDKin_1 66 72 PF00069 0.674
MOD_SUMO_rev_2 47 57 PF00179 0.704
TRG_DiLeu_BaEn_1 515 520 PF01217 0.443
TRG_DiLeu_BaEn_2 422 428 PF01217 0.434
TRG_ENDOCYTIC_2 332 335 PF00928 0.499
TRG_ENDOCYTIC_2 457 460 PF00928 0.467
TRG_ENDOCYTIC_2 514 517 PF00928 0.444
TRG_ENDOCYTIC_2 612 615 PF00928 0.634
TRG_ER_diArg_1 276 279 PF00400 0.611
TRG_ER_diArg_1 389 391 PF00400 0.458
TRG_ER_diArg_1 450 453 PF00400 0.431
TRG_ER_diArg_1 644 646 PF00400 0.680
TRG_ER_diArg_1 663 666 PF00400 0.639
TRG_ER_diArg_1 701 703 PF00400 0.526
TRG_Pf-PMV_PEXEL_1 475 480 PF00026 0.428
TRG_Pf-PMV_PEXEL_1 701 705 PF00026 0.505

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IEY6 Leishmania donovani 99% 100%
A4HIJ3 Leishmania braziliensis 58% 100%
E9B132 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 99%
Q4Q733 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS