LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I5T2_LEIIN
TriTrypDb:
LINF_300030800
Length:
408

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 1
GO:0030863 cortical cytoskeleton 6 1
GO:0030864 cortical actin cytoskeleton 7 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I5T2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5T2

Function

Biological processes
Term Name Level Count
GO:0008064 regulation of actin polymerization or depolymerization 6 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0030832 regulation of actin filament length 5 1
GO:0030833 regulation of actin filament polymerization 7 1
GO:0032271 regulation of protein polymerization 6 1
GO:0032535 regulation of cellular component size 4 1
GO:0032956 regulation of actin cytoskeleton organization 5 1
GO:0032970 regulation of actin filament-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0043254 regulation of protein-containing complex assembly 5 1
GO:0044087 regulation of cellular component biogenesis 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051493 regulation of cytoskeleton organization 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090066 regulation of anatomical structure size 3 1
GO:0110053 regulation of actin filament organization 6 1
GO:1902903 regulation of supramolecular fiber organization 5 1
Molecular functions
Term Name Level Count
GO:0003779 actin binding 4 10
GO:0005488 binding 1 10
GO:0005515 protein binding 2 10
GO:0008092 cytoskeletal protein binding 3 10
GO:0044877 protein-containing complex binding 2 1
GO:0051015 actin filament binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 12 16 PF00656 0.302
CLV_NRD_NRD_1 147 149 PF00675 0.577
CLV_NRD_NRD_1 245 247 PF00675 0.261
CLV_NRD_NRD_1 310 312 PF00675 0.496
CLV_PCSK_FUR_1 145 149 PF00082 0.565
CLV_PCSK_KEX2_1 144 146 PF00082 0.540
CLV_PCSK_KEX2_1 147 149 PF00082 0.580
CLV_PCSK_KEX2_1 245 247 PF00082 0.262
CLV_PCSK_KEX2_1 310 312 PF00082 0.618
CLV_PCSK_KEX2_1 41 43 PF00082 0.340
CLV_PCSK_KEX2_1 59 61 PF00082 0.307
CLV_PCSK_PC1ET2_1 144 146 PF00082 0.515
CLV_PCSK_PC1ET2_1 41 43 PF00082 0.366
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.295
CLV_PCSK_SKI1_1 182 186 PF00082 0.478
CLV_PCSK_SKI1_1 246 250 PF00082 0.278
CLV_PCSK_SKI1_1 301 305 PF00082 0.369
DEG_Kelch_Keap1_1 236 241 PF01344 0.476
DEG_SCF_TRCP1_1 105 110 PF00400 0.426
DOC_CKS1_1 304 309 PF01111 0.424
DOC_CYCLIN_yCln2_LP_2 354 360 PF00134 0.515
DOC_MAPK_gen_1 166 176 PF00069 0.483
DOC_MAPK_gen_1 349 358 PF00069 0.585
DOC_MAPK_gen_1 41 48 PF00069 0.313
DOC_MAPK_MEF2A_6 147 156 PF00069 0.604
DOC_MAPK_RevD_3 230 246 PF00069 0.435
DOC_PP1_RVXF_1 232 238 PF00149 0.458
DOC_PP1_RVXF_1 244 251 PF00149 0.398
DOC_PP2B_LxvP_1 354 357 PF13499 0.522
DOC_PP4_FxxP_1 304 307 PF00568 0.404
DOC_USP7_MATH_1 34 38 PF00917 0.452
DOC_USP7_MATH_1 380 384 PF00917 0.609
DOC_USP7_MATH_1 53 57 PF00917 0.268
DOC_WW_Pin1_4 169 174 PF00397 0.509
DOC_WW_Pin1_4 274 279 PF00397 0.524
DOC_WW_Pin1_4 303 308 PF00397 0.404
DOC_WW_Pin1_4 375 380 PF00397 0.620
LIG_14-3-3_CanoR_1 147 152 PF00244 0.579
LIG_14-3-3_CanoR_1 182 188 PF00244 0.265
LIG_14-3-3_CanoR_1 234 238 PF00244 0.415
LIG_14-3-3_CanoR_1 331 335 PF00244 0.368
LIG_14-3-3_CanoR_1 347 357 PF00244 0.441
LIG_APCC_ABBA_1 127 132 PF00400 0.394
LIG_BRCT_BRCA1_1 105 109 PF00533 0.459
LIG_BRCT_BRCA1_1 321 325 PF00533 0.460
LIG_BRCT_BRCA1_1 36 40 PF00533 0.447
LIG_BRCT_BRCA1_1 87 91 PF00533 0.388
LIG_deltaCOP1_diTrp_1 225 233 PF00928 0.451
LIG_FHA_1 178 184 PF00498 0.419
LIG_FHA_1 338 344 PF00498 0.635
LIG_FHA_1 349 355 PF00498 0.690
LIG_FHA_1 387 393 PF00498 0.331
LIG_FHA_1 70 76 PF00498 0.379
LIG_FHA_2 163 169 PF00498 0.586
LIG_FHA_2 304 310 PF00498 0.534
LIG_GBD_Chelix_1 400 408 PF00786 0.271
LIG_LIR_Apic_2 302 307 PF02991 0.380
LIG_LIR_Gen_1 193 200 PF02991 0.444
LIG_LIR_Gen_1 88 98 PF02991 0.440
LIG_LIR_Nem_3 193 199 PF02991 0.444
LIG_LIR_Nem_3 227 233 PF02991 0.428
LIG_LIR_Nem_3 88 94 PF02991 0.432
LIG_LYPXL_S_1 268 272 PF13949 0.294
LIG_LYPXL_yS_3 269 272 PF13949 0.494
LIG_PCNA_yPIPBox_3 209 220 PF02747 0.413
LIG_PDZ_Class_3 403 408 PF00595 0.276
LIG_Pex14_2 233 237 PF04695 0.494
LIG_SH2_PTP2 50 53 PF00017 0.387
LIG_SH2_STAP1 281 285 PF00017 0.431
LIG_SH2_STAT5 284 287 PF00017 0.415
LIG_SH2_STAT5 47 50 PF00017 0.311
LIG_SH3_3 157 163 PF00018 0.622
LIG_SH3_3 167 173 PF00018 0.537
LIG_SH3_3 354 360 PF00018 0.627
LIG_SUMO_SIM_anti_2 387 394 PF11976 0.380
LIG_SUMO_SIM_par_1 171 177 PF11976 0.461
LIG_TRAF2_1 165 168 PF00917 0.533
LIG_TRAF2_1 224 227 PF00917 0.518
LIG_TRAF2_1 385 388 PF00917 0.381
LIG_UBA3_1 216 221 PF00899 0.438
MOD_CDK_SPxxK_3 303 310 PF00069 0.419
MOD_CK1_1 177 183 PF00069 0.569
MOD_CK1_1 366 372 PF00069 0.601
MOD_CK1_1 90 96 PF00069 0.313
MOD_CK2_1 162 168 PF00069 0.684
MOD_CK2_1 169 175 PF00069 0.659
MOD_CK2_1 198 204 PF00069 0.433
MOD_CK2_1 235 241 PF00069 0.476
MOD_CK2_1 330 336 PF00069 0.458
MOD_CK2_1 382 388 PF00069 0.452
MOD_Cter_Amidation 145 148 PF01082 0.534
MOD_DYRK1A_RPxSP_1 169 173 PF00069 0.528
MOD_GlcNHglycan 105 108 PF01048 0.611
MOD_GlcNHglycan 175 179 PF01048 0.351
MOD_GlcNHglycan 301 304 PF01048 0.502
MOD_GlcNHglycan 36 39 PF01048 0.484
MOD_GlcNHglycan 366 369 PF01048 0.669
MOD_GSK3_1 103 110 PF00069 0.440
MOD_GSK3_1 200 207 PF00069 0.511
MOD_GSK3_1 299 306 PF00069 0.474
MOD_GSK3_1 319 326 PF00069 0.458
MOD_GSK3_1 348 355 PF00069 0.691
MOD_GSK3_1 366 373 PF00069 0.561
MOD_GSK3_1 382 389 PF00069 0.577
MOD_GSK3_1 65 72 PF00069 0.474
MOD_GSK3_1 81 88 PF00069 0.313
MOD_N-GLC_1 107 112 PF02516 0.417
MOD_N-GLC_1 190 195 PF02516 0.224
MOD_N-GLC_1 68 73 PF02516 0.439
MOD_NEK2_1 233 238 PF00069 0.403
MOD_NEK2_1 28 33 PF00069 0.370
MOD_NEK2_1 319 324 PF00069 0.481
MOD_NEK2_1 98 103 PF00069 0.571
MOD_NEK2_2 36 41 PF00069 0.387
MOD_PKA_1 147 153 PF00069 0.599
MOD_PKA_2 147 153 PF00069 0.552
MOD_PKA_2 168 174 PF00069 0.495
MOD_PKA_2 233 239 PF00069 0.409
MOD_PKA_2 330 336 PF00069 0.361
MOD_PKA_2 352 358 PF00069 0.547
MOD_PKA_2 8 14 PF00069 0.356
MOD_PKA_2 98 104 PF00069 0.620
MOD_PKB_1 145 153 PF00069 0.586
MOD_Plk_1 107 113 PF00069 0.416
MOD_Plk_1 320 326 PF00069 0.468
MOD_Plk_1 386 392 PF00069 0.379
MOD_Plk_4 320 326 PF00069 0.344
MOD_Plk_4 330 336 PF00069 0.559
MOD_Plk_4 53 59 PF00069 0.460
MOD_Plk_4 90 96 PF00069 0.365
MOD_Plk_4 98 104 PF00069 0.449
MOD_ProDKin_1 169 175 PF00069 0.502
MOD_ProDKin_1 274 280 PF00069 0.524
MOD_ProDKin_1 303 309 PF00069 0.412
MOD_ProDKin_1 375 381 PF00069 0.616
MOD_SUMO_rev_2 19 26 PF00179 0.362
TRG_DiLeu_BaEn_1 388 393 PF01217 0.316
TRG_ENDOCYTIC_2 269 272 PF00928 0.458
TRG_ENDOCYTIC_2 30 33 PF00928 0.292
TRG_ER_diArg_1 145 148 PF00400 0.559
TRG_ER_diArg_1 245 247 PF00400 0.473
TRG_ER_diArg_1 310 312 PF00400 0.481
TRG_NES_CRM1_1 92 105 PF08389 0.364
TRG_NLS_MonoExtC_3 143 148 PF00514 0.524

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5G8 Leptomonas seymouri 66% 100%
A0A1X0P342 Trypanosomatidae 40% 100%
A0A3Q8IFZ1 Leishmania donovani 100% 100%
A4HII8 Leishmania braziliensis 84% 100%
C9ZR53 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 91%
E9B127 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q738 Leishmania major 96% 100%
V5BMX2 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS