AAA family ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA family ATPase-like protein

Species:

Leishmania infantum

UniProt:

A4I5S8_LEIIN

TriTrypDb:

LINF_300030500

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5S8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.631
CLV_C14_Caspase3-7	880	884	PF00656	0.335
CLV_C14_Caspase3-7	904	908	PF00656	0.335
CLV_C14_Caspase3-7	930	934	PF00656	0.416
CLV_C14_Caspase3-7	980	984	PF00656	0.458
CLV_NRD_NRD_1	420	422	PF00675	0.467
CLV_NRD_NRD_1	645	647	PF00675	0.543
CLV_NRD_NRD_1	944	946	PF00675	0.338
CLV_PCSK_KEX2_1	110	112	PF00082	0.616
CLV_PCSK_KEX2_1	221	223	PF00082	0.614
CLV_PCSK_KEX2_1	420	422	PF00082	0.466
CLV_PCSK_KEX2_1	645	647	PF00082	0.498
CLV_PCSK_KEX2_1	767	769	PF00082	0.606
CLV_PCSK_KEX2_1	944	946	PF00082	0.414
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.669
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.614
CLV_PCSK_PC1ET2_1	767	769	PF00082	0.606
CLV_PCSK_SKI1_1	26	30	PF00082	0.418
CLV_PCSK_SKI1_1	384	388	PF00082	0.574
CLV_PCSK_SKI1_1	437	441	PF00082	0.513
CLV_PCSK_SKI1_1	815	819	PF00082	0.358
CLV_PCSK_SKI1_1	827	831	PF00082	0.250
CLV_PCSK_SKI1_1	863	867	PF00082	0.319
CLV_PCSK_SKI1_1	917	921	PF00082	0.447
DEG_APCC_DBOX_1	441	449	PF00400	0.587
DEG_APCC_DBOX_1	58	66	PF00400	0.405
DEG_APCC_DBOX_1	691	699	PF00400	0.513
DEG_COP1_1	400	409	PF00400	0.634
DEG_SPOP_SBC_1	146	150	PF00917	0.736
DEG_SPOP_SBC_1	160	164	PF00917	0.717
DOC_ANK_TNKS_1	116	123	PF00023	0.602
DOC_CDC14_PxL_1	377	385	PF14671	0.379
DOC_CDC14_PxL_1	947	955	PF14671	0.524
DOC_CYCLIN_yClb1_LxF_4	917	923	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	112	115	PF00134	0.691
DOC_CYCLIN_yCln2_LP_2	195	198	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.400
DOC_MAPK_gen_1	645	651	PF00069	0.416
DOC_MAPK_gen_1	767	773	PF00069	0.602
DOC_MAPK_gen_1	916	923	PF00069	0.447
DOC_MAPK_gen_1	938	948	PF00069	0.335
DOC_MAPK_MEF2A_6	426	434	PF00069	0.554
DOC_MAPK_MEF2A_6	870	878	PF00069	0.335
DOC_MAPK_MEF2A_6	94	102	PF00069	0.426
DOC_MAPK_MEF2A_6	941	950	PF00069	0.335
DOC_PP1_RVXF_1	565	572	PF00149	0.564
DOC_PP2B_LxvP_1	112	115	PF13499	0.691
DOC_PP2B_LxvP_1	195	198	PF13499	0.633
DOC_PP2B_LxvP_1	678	681	PF13499	0.500
DOC_PP2B_PxIxI_1	92	98	PF00149	0.426
DOC_PP4_FxxP_1	104	107	PF00568	0.549
DOC_PP4_FxxP_1	139	142	PF00568	0.603
DOC_SPAK_OSR1_1	768	772	PF12202	0.602
DOC_USP7_MATH_1	1006	1010	PF00917	0.458
DOC_USP7_MATH_1	160	164	PF00917	0.757
DOC_USP7_MATH_1	171	175	PF00917	0.635
DOC_USP7_MATH_1	242	246	PF00917	0.775
DOC_USP7_MATH_1	271	275	PF00917	0.736
DOC_USP7_MATH_1	556	560	PF00917	0.687
DOC_USP7_MATH_1	598	602	PF00917	0.463
DOC_USP7_MATH_1	657	661	PF00917	0.487
DOC_USP7_MATH_1	707	711	PF00917	0.515
DOC_USP7_MATH_1	743	747	PF00917	0.540
DOC_USP7_MATH_1	823	827	PF00917	0.335
DOC_USP7_MATH_1	835	839	PF00917	0.335
DOC_USP7_UBL2_3	257	261	PF12436	0.747
DOC_WW_Pin1_4	229	234	PF00397	0.674
DOC_WW_Pin1_4	247	252	PF00397	0.636
DOC_WW_Pin1_4	497	502	PF00397	0.766
DOC_WW_Pin1_4	64	69	PF00397	0.399
DOC_WW_Pin1_4	809	814	PF00397	0.467
DOC_WW_Pin1_4	870	875	PF00397	0.447
DOC_WW_Pin1_4	89	94	PF00397	0.422
LIG_14-3-3_CanoR_1	203	211	PF00244	0.588
LIG_14-3-3_CanoR_1	384	389	PF00244	0.560
LIG_14-3-3_CanoR_1	40	45	PF00244	0.414
LIG_14-3-3_CanoR_1	420	424	PF00244	0.584
LIG_14-3-3_CanoR_1	433	439	PF00244	0.406
LIG_14-3-3_CanoR_1	442	446	PF00244	0.429
LIG_14-3-3_CanoR_1	497	501	PF00244	0.644
LIG_14-3-3_CanoR_1	52	57	PF00244	0.400
LIG_14-3-3_CanoR_1	597	603	PF00244	0.555
LIG_14-3-3_CanoR_1	625	631	PF00244	0.580
LIG_14-3-3_CanoR_1	73	80	PF00244	0.407
LIG_14-3-3_CanoR_1	744	749	PF00244	0.557
LIG_14-3-3_CanoR_1	755	763	PF00244	0.549
LIG_14-3-3_CanoR_1	891	899	PF00244	0.352
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BRCT_BRCA1_1	516	520	PF00533	0.467
LIG_BRCT_BRCA1_1	66	70	PF00533	0.399
LIG_BRCT_BRCA1_1	75	79	PF00533	0.397
LIG_BRCT_BRCA1_1	802	806	PF00533	0.506
LIG_deltaCOP1_diTrp_1	1030	1038	PF00928	0.456
LIG_deltaCOP1_diTrp_1	414	419	PF00928	0.561
LIG_deltaCOP1_diTrp_1	796	804	PF00928	0.546
LIG_FHA_1	121	127	PF00498	0.577
LIG_FHA_1	433	439	PF00498	0.571
LIG_FHA_1	442	448	PF00498	0.546
LIG_FHA_1	521	527	PF00498	0.479
LIG_FHA_1	532	538	PF00498	0.462
LIG_FHA_1	564	570	PF00498	0.554
LIG_FHA_1	733	739	PF00498	0.464
LIG_FHA_2	1010	1016	PF00498	0.354
LIG_FHA_2	204	210	PF00498	0.722
LIG_FHA_2	284	290	PF00498	0.681
LIG_FHA_2	504	510	PF00498	0.675
LIG_FHA_2	723	729	PF00498	0.412
LIG_FHA_2	748	754	PF00498	0.566
LIG_FHA_2	775	781	PF00498	0.448
LIG_FHA_2	788	794	PF00498	0.373
LIG_FHA_2	902	908	PF00498	0.335
LIG_FHA_2	950	956	PF00498	0.571
LIG_FHA_2	984	990	PF00498	0.399
LIG_HCF-1_HBM_1	509	512	PF13415	0.533
LIG_LIR_Gen_1	412	423	PF02991	0.512
LIG_LIR_Gen_1	43	50	PF02991	0.409
LIG_LIR_Gen_1	570	578	PF02991	0.597
LIG_LIR_Gen_1	777	785	PF02991	0.443
LIG_LIR_Gen_1	803	814	PF02991	0.550
LIG_LIR_Gen_1	996	1006	PF02991	0.335
LIG_LIR_LC3C_4	523	526	PF02991	0.493
LIG_LIR_Nem_3	330	335	PF02991	0.627
LIG_LIR_Nem_3	412	418	PF02991	0.528
LIG_LIR_Nem_3	43	48	PF02991	0.411
LIG_LIR_Nem_3	516	521	PF02991	0.643
LIG_LIR_Nem_3	570	574	PF02991	0.575
LIG_LIR_Nem_3	777	781	PF02991	0.425
LIG_LIR_Nem_3	803	809	PF02991	0.516
LIG_LIR_Nem_3	996	1002	PF02991	0.335
LIG_MYND_1	114	118	PF01753	0.662
LIG_MYND_1	372	376	PF01753	0.698
LIG_PCNA_yPIPBox_3	720	733	PF02747	0.555
LIG_Pex14_1	415	419	PF04695	0.554
LIG_Pex14_2	28	32	PF04695	0.420
LIG_PTB_Apo_2	958	965	PF02174	0.311
LIG_SH2_CRK	336	340	PF00017	0.671
LIG_SH2_CRK	820	824	PF00017	0.335
LIG_SH2_PTP2	429	432	PF00017	0.542
LIG_SH2_PTP2	947	950	PF00017	0.335
LIG_SH2_STAT5	429	432	PF00017	0.518
LIG_SH2_STAT5	568	571	PF00017	0.568
LIG_SH2_STAT5	947	950	PF00017	0.335
LIG_SH2_STAT5	977	980	PF00017	0.335
LIG_SH2_STAT5	985	988	PF00017	0.335
LIG_SH3_2	951	956	PF14604	0.552
LIG_SH3_3	112	118	PF00018	0.595
LIG_SH3_3	167	173	PF00018	0.595
LIG_SH3_3	370	376	PF00018	0.546
LIG_SH3_3	768	774	PF00018	0.486
LIG_SH3_3	808	814	PF00018	0.353
LIG_SH3_3	842	848	PF00018	0.335
LIG_SH3_3	933	939	PF00018	0.335
LIG_SH3_3	945	951	PF00018	0.335
LIG_SUMO_SIM_anti_2	444	449	PF11976	0.449
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.432
LIG_SUMO_SIM_anti_2	989	996	PF11976	0.335
LIG_SUMO_SIM_par_1	361	367	PF11976	0.600
LIG_SUMO_SIM_par_1	443	449	PF11976	0.540
LIG_SUMO_SIM_par_1	522	528	PF11976	0.384
LIG_SUMO_SIM_par_1	638	644	PF11976	0.547
LIG_SUMO_SIM_par_1	674	679	PF11976	0.491
LIG_SUMO_SIM_par_1	710	719	PF11976	0.532
LIG_TRAF2_1	506	509	PF00917	0.714
LIG_TRFH_1	103	107	PF08558	0.424
LIG_TYR_ITIM	427	432	PF00017	0.555
LIG_TYR_ITSM	328	335	PF00017	0.635
MOD_CDK_SPK_2	252	257	PF00069	0.736
MOD_CDK_SPK_2	89	94	PF00069	0.422
MOD_CDK_SPxK_1	809	815	PF00069	0.488
MOD_CDK_SPxxK_3	252	259	PF00069	0.642
MOD_CK1_1	1009	1015	PF00069	0.477
MOD_CK1_1	148	154	PF00069	0.725
MOD_CK1_1	155	161	PF00069	0.735
MOD_CK1_1	245	251	PF00069	0.733
MOD_CK1_1	31	37	PF00069	0.409
MOD_CK1_1	408	414	PF00069	0.629
MOD_CK1_1	43	49	PF00069	0.396
MOD_CK1_1	513	519	PF00069	0.631
MOD_CK1_1	542	548	PF00069	0.461
MOD_CK1_1	583	589	PF00069	0.477
MOD_CK1_1	621	627	PF00069	0.566
MOD_CK1_1	674	680	PF00069	0.348
MOD_CK2_1	408	414	PF00069	0.644
MOD_CK2_1	503	509	PF00069	0.721
MOD_CK2_1	542	548	PF00069	0.536
MOD_CK2_1	949	955	PF00069	0.526
MOD_CK2_1	983	989	PF00069	0.340
MOD_DYRK1A_RPxSP_1	497	501	PF00069	0.644
MOD_DYRK1A_RPxSP_1	870	874	PF00069	0.447
MOD_GlcNHglycan	158	161	PF01048	0.576
MOD_GlcNHglycan	188	191	PF01048	0.742
MOD_GlcNHglycan	247	250	PF01048	0.730
MOD_GlcNHglycan	283	286	PF01048	0.614
MOD_GlcNHglycan	321	324	PF01048	0.512
MOD_GlcNHglycan	344	347	PF01048	0.694
MOD_GlcNHglycan	483	486	PF01048	0.705
MOD_GlcNHglycan	491	494	PF01048	0.742
MOD_GlcNHglycan	512	515	PF01048	0.705
MOD_GlcNHglycan	52	55	PF01048	0.413
MOD_GlcNHglycan	541	544	PF01048	0.514
MOD_GlcNHglycan	558	561	PF01048	0.624
MOD_GlcNHglycan	600	603	PF01048	0.563
MOD_GlcNHglycan	620	623	PF01048	0.342
MOD_GlcNHglycan	653	656	PF01048	0.385
MOD_GlcNHglycan	666	669	PF01048	0.439
MOD_GlcNHglycan	681	684	PF01048	0.463
MOD_GlcNHglycan	757	760	PF01048	0.509
MOD_GlcNHglycan	783	786	PF01048	0.515
MOD_GSK3_1	145	152	PF00069	0.728
MOD_GSK3_1	154	161	PF00069	0.735
MOD_GSK3_1	210	217	PF00069	0.817
MOD_GSK3_1	229	236	PF00069	0.587
MOD_GSK3_1	277	284	PF00069	0.688
MOD_GSK3_1	28	35	PF00069	0.416
MOD_GSK3_1	405	412	PF00069	0.671
MOD_GSK3_1	437	444	PF00069	0.501
MOD_GSK3_1	48	55	PF00069	0.384
MOD_GSK3_1	496	503	PF00069	0.704
MOD_GSK3_1	510	517	PF00069	0.726
MOD_GSK3_1	556	563	PF00069	0.763
MOD_GSK3_1	580	587	PF00069	0.503
MOD_GSK3_1	598	605	PF00069	0.442
MOD_GSK3_1	617	624	PF00069	0.341
MOD_GSK3_1	743	750	PF00069	0.552
MOD_GSK3_1	800	807	PF00069	0.550
MOD_GSK3_1	897	904	PF00069	0.343
MOD_GSK3_1	979	986	PF00069	0.335
MOD_LATS_1	1040	1046	PF00433	0.636
MOD_LATS_1	38	44	PF00433	0.410
MOD_N-GLC_1	203	208	PF02516	0.634
MOD_N-GLC_1	40	45	PF02516	0.414
MOD_N-GLC_1	774	779	PF02516	0.405
MOD_N-GLC_1	809	814	PF02516	0.560
MOD_N-GLC_1	835	840	PF02516	0.335
MOD_NEK2_1	145	150	PF00069	0.602
MOD_NEK2_1	28	33	PF00069	0.420
MOD_NEK2_1	309	314	PF00069	0.623
MOD_NEK2_1	328	333	PF00069	0.406
MOD_NEK2_1	342	347	PF00069	0.484
MOD_NEK2_1	419	424	PF00069	0.576
MOD_NEK2_1	432	437	PF00069	0.497
MOD_NEK2_1	448	453	PF00069	0.568
MOD_NEK2_1	48	53	PF00069	0.383
MOD_NEK2_1	481	486	PF00069	0.652
MOD_NEK2_1	520	525	PF00069	0.411
MOD_NEK2_1	671	676	PF00069	0.532
MOD_NEK2_1	732	737	PF00069	0.429
MOD_NEK2_1	769	774	PF00069	0.470
MOD_PIKK_1	432	438	PF00454	0.504
MOD_PIKK_1	722	728	PF00454	0.425
MOD_PIKK_1	897	903	PF00454	0.335
MOD_PK_1	52	58	PF00069	0.410
MOD_PKA_1	1042	1048	PF00069	0.742
MOD_PKA_2	137	143	PF00069	0.683
MOD_PKA_2	202	208	PF00069	0.794
MOD_PKA_2	342	348	PF00069	0.659
MOD_PKA_2	419	425	PF00069	0.594
MOD_PKA_2	432	438	PF00069	0.377
MOD_PKA_2	441	447	PF00069	0.436
MOD_PKA_2	458	464	PF00069	0.439
MOD_PKA_2	496	502	PF00069	0.784
MOD_PKA_2	598	604	PF00069	0.541
MOD_PKA_2	743	749	PF00069	0.570
MOD_Plk_1	12	18	PF00069	0.431
MOD_Plk_1	363	369	PF00069	0.566
MOD_Plk_1	40	46	PF00069	0.412
MOD_Plk_1	448	454	PF00069	0.592
MOD_Plk_1	769	775	PF00069	0.507
MOD_Plk_1	835	841	PF00069	0.447
MOD_Plk_4	290	296	PF00069	0.610
MOD_Plk_4	52	58	PF00069	0.410
MOD_Plk_4	520	526	PF00069	0.483
MOD_Plk_4	602	608	PF00069	0.482
MOD_Plk_4	626	632	PF00069	0.484
MOD_Plk_4	666	672	PF00069	0.485
MOD_Plk_4	800	806	PF00069	0.514
MOD_Plk_4	825	831	PF00069	0.335
MOD_ProDKin_1	229	235	PF00069	0.675
MOD_ProDKin_1	247	253	PF00069	0.638
MOD_ProDKin_1	497	503	PF00069	0.764
MOD_ProDKin_1	64	70	PF00069	0.400
MOD_ProDKin_1	809	815	PF00069	0.464
MOD_ProDKin_1	870	876	PF00069	0.447
MOD_ProDKin_1	89	95	PF00069	0.423
MOD_SUMO_rev_2	209	213	PF00179	0.633
MOD_SUMO_rev_2	780	790	PF00179	0.464
MOD_SUMO_rev_2	914	919	PF00179	0.390
TRG_ENDOCYTIC_2	332	335	PF00928	0.650
TRG_ENDOCYTIC_2	336	339	PF00928	0.633
TRG_ENDOCYTIC_2	429	432	PF00928	0.460
TRG_ENDOCYTIC_2	947	950	PF00928	0.335
TRG_ER_diArg_1	1023	1026	PF00400	0.475
TRG_ER_diArg_1	136	139	PF00400	0.734
TRG_ER_diArg_1	419	421	PF00400	0.453
TRG_ER_diArg_1	645	647	PF00400	0.501
TRG_ER_diArg_1	944	946	PF00400	0.447
TRG_NLS_MonoExtN_4	107	113	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	863	867	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	897	901	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H1	Leptomonas seymouri	59%	100%
A0A1X0P1J4	Trypanosomatidae	49%	100%
A0A3Q8IS46	Leishmania donovani	99%	100%
A0A3R7M308	Trypanosoma rangeli	49%	100%
A4HII5	Leishmania braziliensis	76%	100%
C9ZR48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B124	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q741	Leishmania major	92%	100%
V5AUZ1	Trypanosoma cruzi	48%	100%