Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5S6_LEIIN

TriTrypDb:

LINF_300030300

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I5S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.491
CLV_NRD_NRD_1	246	248	PF00675	0.536
CLV_PCSK_KEX2_1	104	106	PF00082	0.458
CLV_PCSK_KEX2_1	246	248	PF00082	0.491
CLV_PCSK_SKI1_1	107	111	PF00082	0.457
CLV_PCSK_SKI1_1	183	187	PF00082	0.350
CLV_PCSK_SKI1_1	225	229	PF00082	0.316
CLV_PCSK_SKI1_1	268	272	PF00082	0.417
CLV_PCSK_SKI1_1	338	342	PF00082	0.346
DEG_COP1_1	273	280	PF00400	0.473
DOC_CKS1_1	113	118	PF01111	0.449
DOC_CYCLIN_yClb5_NLxxxL_5	51	60	PF00134	0.535
DOC_MAPK_MEF2A_6	163	172	PF00069	0.272
DOC_MAPK_MEF2A_6	298	306	PF00069	0.444
DOC_PP2B_LxvP_1	199	202	PF13499	0.324
DOC_PP2B_LxvP_1	302	305	PF13499	0.672
DOC_PP4_FxxP_1	334	337	PF00568	0.359
DOC_USP7_MATH_1	108	112	PF00917	0.339
DOC_USP7_MATH_1	120	124	PF00917	0.410
DOC_USP7_MATH_1	309	313	PF00917	0.599
DOC_USP7_MATH_1	330	334	PF00917	0.326
DOC_USP7_MATH_1	69	73	PF00917	0.301
DOC_USP7_MATH_1	77	81	PF00917	0.369
DOC_USP7_MATH_1	91	95	PF00917	0.225
DOC_WW_Pin1_4	112	117	PF00397	0.398
DOC_WW_Pin1_4	191	196	PF00397	0.432
DOC_WW_Pin1_4	245	250	PF00397	0.382
DOC_WW_Pin1_4	333	338	PF00397	0.336
LIG_14-3-3_CanoR_1	107	116	PF00244	0.388
LIG_14-3-3_CanoR_1	122	131	PF00244	0.357
LIG_14-3-3_CanoR_1	153	157	PF00244	0.345
LIG_14-3-3_CanoR_1	190	195	PF00244	0.365
LIG_14-3-3_CanoR_1	225	230	PF00244	0.443
LIG_Actin_WH2_2	140	155	PF00022	0.313
LIG_Actin_WH2_2	215	232	PF00022	0.418
LIG_BRCT_BRCA1_1	311	315	PF00533	0.491
LIG_BRCT_BRCA1_1	79	83	PF00533	0.263
LIG_eIF4E_1	180	186	PF01652	0.409
LIG_FHA_1	172	178	PF00498	0.306
LIG_FHA_1	212	218	PF00498	0.347
LIG_FHA_1	272	278	PF00498	0.495
LIG_FHA_1	299	305	PF00498	0.503
LIG_FHA_1	339	345	PF00498	0.424
LIG_FHA_1	34	40	PF00498	0.298
LIG_FHA_2	134	140	PF00498	0.383
LIG_Integrin_isoDGR_2	257	259	PF01839	0.314
LIG_LIR_Apic_2	110	116	PF02991	0.446
LIG_LIR_Apic_2	333	337	PF02991	0.412
LIG_LIR_Gen_1	329	337	PF02991	0.312
LIG_LIR_Gen_1	67	78	PF02991	0.453
LIG_LIR_Nem_3	329	334	PF02991	0.357
LIG_LIR_Nem_3	67	73	PF02991	0.435
LIG_MLH1_MIPbox_1	80	84	PF16413	0.386
LIG_PDZ_Class_2	344	349	PF00595	0.331
LIG_Rb_LxCxE_1	228	244	PF01857	0.480
LIG_SH2_CRK	70	74	PF00017	0.535
LIG_SH2_NCK_1	113	117	PF00017	0.446
LIG_SH2_NCK_1	5	9	PF00017	0.448
LIG_SH2_SRC	5	8	PF00017	0.450
LIG_SH2_STAP1	187	191	PF00017	0.443
LIG_SH3_3	125	131	PF00018	0.325
LIG_SH3_3	274	280	PF00018	0.537
LIG_SH3_3	342	348	PF00018	0.375
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.301
LIG_SUMO_SIM_par_1	143	148	PF11976	0.325
LIG_SUMO_SIM_par_1	196	203	PF11976	0.326
LIG_SxIP_EBH_1	122	133	PF03271	0.304
LIG_WRC_WIRS_1	172	177	PF05994	0.274
MOD_CDC14_SPxK_1	248	251	PF00782	0.343
MOD_CDK_SPK_2	333	338	PF00069	0.427
MOD_CDK_SPxK_1	245	251	PF00069	0.382
MOD_CK1_1	103	109	PF00069	0.362
MOD_CK1_1	193	199	PF00069	0.424
MOD_CK1_1	285	291	PF00069	0.440
MOD_CK1_1	293	299	PF00069	0.529
MOD_CK1_1	333	339	PF00069	0.438
MOD_CK1_1	95	101	PF00069	0.310
MOD_CK2_1	120	126	PF00069	0.305
MOD_CK2_1	133	139	PF00069	0.406
MOD_CK2_1	313	319	PF00069	0.418
MOD_CK2_1	60	66	PF00069	0.437
MOD_CK2_1	69	75	PF00069	0.413
MOD_GlcNHglycan	284	287	PF01048	0.390
MOD_GlcNHglycan	295	298	PF01048	0.526
MOD_GlcNHglycan	311	314	PF01048	0.423
MOD_GlcNHglycan	315	318	PF01048	0.527
MOD_GlcNHglycan	60	63	PF01048	0.508
MOD_GSK3_1	103	110	PF00069	0.466
MOD_GSK3_1	186	193	PF00069	0.442
MOD_GSK3_1	241	248	PF00069	0.531
MOD_GSK3_1	278	285	PF00069	0.405
MOD_GSK3_1	29	36	PF00069	0.446
MOD_GSK3_1	305	312	PF00069	0.584
MOD_GSK3_1	326	333	PF00069	0.401
MOD_GSK3_1	60	67	PF00069	0.446
MOD_GSK3_1	91	98	PF00069	0.335
MOD_N-GLC_1	338	343	PF02516	0.338
MOD_N-GLC_1	39	44	PF02516	0.270
MOD_NEK2_1	152	157	PF00069	0.477
MOD_NEK2_1	186	191	PF00069	0.438
MOD_NEK2_1	20	25	PF00069	0.414
MOD_NEK2_1	241	246	PF00069	0.467
MOD_NEK2_1	290	295	PF00069	0.502
MOD_NEK2_1	34	39	PF00069	0.313
MOD_NEK2_1	47	52	PF00069	0.433
MOD_NEK2_1	60	65	PF00069	0.407
MOD_NEK2_1	78	83	PF00069	0.462
MOD_NEK2_2	108	113	PF00069	0.446
MOD_OFUCOSY	28	33	PF10250	0.293
MOD_PIKK_1	147	153	PF00454	0.519
MOD_PIKK_1	339	345	PF00454	0.446
MOD_PKA_2	103	109	PF00069	0.349
MOD_PKA_2	152	158	PF00069	0.363
MOD_PKA_2	211	217	PF00069	0.270
MOD_PKA_2	290	296	PF00069	0.542
MOD_PKB_1	105	113	PF00069	0.457
MOD_Plk_1	147	153	PF00069	0.427
MOD_Plk_1	318	324	PF00069	0.390
MOD_Plk_1	47	53	PF00069	0.539
MOD_Plk_4	171	177	PF00069	0.351
MOD_Plk_4	194	200	PF00069	0.337
MOD_Plk_4	278	284	PF00069	0.356
MOD_Plk_4	285	291	PF00069	0.304
MOD_Plk_4	34	40	PF00069	0.278
MOD_Plk_4	47	53	PF00069	0.598
MOD_Plk_4	97	103	PF00069	0.490
MOD_ProDKin_1	112	118	PF00069	0.400
MOD_ProDKin_1	191	197	PF00069	0.432
MOD_ProDKin_1	245	251	PF00069	0.382
MOD_ProDKin_1	333	339	PF00069	0.343
TRG_ENDOCYTIC_2	70	73	PF00928	0.534
TRG_ER_diArg_1	104	107	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP9	Leptomonas seymouri	75%	99%
A0A1X0P1L9	Trypanosomatidae	44%	100%
A0A3Q8IF23	Leishmania donovani	100%	100%
A0A3R7LJF8	Trypanosoma rangeli	42%	100%
A4HII3	Leishmania braziliensis	85%	100%
C9ZR45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B122	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q743	Leishmania major	94%	100%
V5CKN5	Trypanosoma cruzi	46%	100%