LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I5S2_LEIIN
TriTrypDb:
LINF_300029800
Length:
781

Annotations

LeishMANIAdb annotations

Might be a conserved chaperone protein, probably not transmembrane.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5S2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5S2

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 10
GO:0009987 cellular process 1 10
Molecular functions
Term Name Level Count
GO:0005488 binding 1 10
GO:0005515 protein binding 2 10
GO:0030544 Hsp70 protein binding 4 10
GO:0031072 heat shock protein binding 3 10
GO:0051879 Hsp90 protein binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 218 222 PF00656 0.444
CLV_C14_Caspase3-7 233 237 PF00656 0.606
CLV_C14_Caspase3-7 243 247 PF00656 0.451
CLV_C14_Caspase3-7 25 29 PF00656 0.569
CLV_C14_Caspase3-7 736 740 PF00656 0.683
CLV_NRD_NRD_1 357 359 PF00675 0.594
CLV_NRD_NRD_1 513 515 PF00675 0.378
CLV_NRD_NRD_1 519 521 PF00675 0.385
CLV_NRD_NRD_1 526 528 PF00675 0.403
CLV_NRD_NRD_1 574 576 PF00675 0.390
CLV_NRD_NRD_1 677 679 PF00675 0.582
CLV_PCSK_FUR_1 675 679 PF00082 0.516
CLV_PCSK_KEX2_1 359 361 PF00082 0.559
CLV_PCSK_KEX2_1 513 515 PF00082 0.377
CLV_PCSK_KEX2_1 518 520 PF00082 0.384
CLV_PCSK_KEX2_1 526 528 PF00082 0.405
CLV_PCSK_KEX2_1 574 576 PF00082 0.390
CLV_PCSK_KEX2_1 675 677 PF00082 0.575
CLV_PCSK_PC1ET2_1 359 361 PF00082 0.558
CLV_PCSK_PC1ET2_1 518 520 PF00082 0.410
CLV_PCSK_PC7_1 514 520 PF00082 0.386
CLV_PCSK_SKI1_1 211 215 PF00082 0.459
CLV_PCSK_SKI1_1 503 507 PF00082 0.314
CLV_PCSK_SKI1_1 610 614 PF00082 0.395
CLV_Separin_Metazoa 98 102 PF03568 0.366
DEG_APCC_DBOX_1 471 479 PF00400 0.424
DEG_APCC_DBOX_1 502 510 PF00400 0.417
DEG_Nend_Nbox_1 1 3 PF02207 0.463
DEG_SPOP_SBC_1 554 558 PF00917 0.566
DEG_SPOP_SBC_1 719 723 PF00917 0.709
DEG_SPOP_SBC_1 734 738 PF00917 0.645
DOC_CKS1_1 628 633 PF01111 0.624
DOC_CYCLIN_RxL_1 476 484 PF00134 0.352
DOC_CYCLIN_yCln2_LP_2 463 469 PF00134 0.401
DOC_MAPK_gen_1 112 120 PF00069 0.344
DOC_MAPK_gen_1 261 268 PF00069 0.279
DOC_MAPK_gen_1 287 295 PF00069 0.302
DOC_MAPK_gen_1 343 353 PF00069 0.468
DOC_MAPK_gen_1 763 772 PF00069 0.687
DOC_MAPK_MEF2A_6 261 268 PF00069 0.335
DOC_MAPK_MEF2A_6 485 492 PF00069 0.454
DOC_MAPK_MEF2A_6 503 511 PF00069 0.335
DOC_MAPK_MEF2A_6 766 774 PF00069 0.690
DOC_MAPK_RevD_3 504 519 PF00069 0.410
DOC_PP2B_LxvP_1 122 125 PF13499 0.299
DOC_PP2B_LxvP_1 35 38 PF13499 0.425
DOC_PP2B_LxvP_1 637 640 PF13499 0.601
DOC_PP4_FxxP_1 653 656 PF00568 0.534
DOC_PP4_MxPP_1 746 749 PF00568 0.635
DOC_USP7_MATH_1 136 140 PF00917 0.388
DOC_USP7_MATH_1 212 216 PF00917 0.423
DOC_USP7_MATH_1 227 231 PF00917 0.516
DOC_USP7_MATH_1 23 27 PF00917 0.587
DOC_USP7_MATH_1 382 386 PF00917 0.350
DOC_USP7_MATH_1 414 418 PF00917 0.551
DOC_USP7_MATH_1 549 553 PF00917 0.770
DOC_USP7_MATH_1 554 558 PF00917 0.743
DOC_USP7_MATH_1 623 627 PF00917 0.648
DOC_USP7_MATH_1 699 703 PF00917 0.734
DOC_USP7_MATH_1 705 709 PF00917 0.720
DOC_USP7_MATH_1 733 737 PF00917 0.675
DOC_USP7_MATH_1 775 779 PF00917 0.707
DOC_WW_Pin1_4 223 228 PF00397 0.466
DOC_WW_Pin1_4 375 380 PF00397 0.446
DOC_WW_Pin1_4 419 424 PF00397 0.582
DOC_WW_Pin1_4 425 430 PF00397 0.553
DOC_WW_Pin1_4 432 437 PF00397 0.552
DOC_WW_Pin1_4 559 564 PF00397 0.735
DOC_WW_Pin1_4 627 632 PF00397 0.618
DOC_WW_Pin1_4 639 644 PF00397 0.747
LIG_14-3-3_CanoR_1 112 122 PF00244 0.391
LIG_14-3-3_CanoR_1 193 198 PF00244 0.392
LIG_14-3-3_CanoR_1 290 296 PF00244 0.372
LIG_14-3-3_CanoR_1 401 409 PF00244 0.457
LIG_14-3-3_CanoR_1 460 464 PF00244 0.307
LIG_14-3-3_CanoR_1 513 521 PF00244 0.591
LIG_14-3-3_CanoR_1 610 616 PF00244 0.602
LIG_14-3-3_CanoR_1 694 701 PF00244 0.775
LIG_Actin_WH2_2 752 770 PF00022 0.649
LIG_APCC_ABBA_1 264 269 PF00400 0.377
LIG_APCC_ABBAyCdc20_2 263 269 PF00400 0.378
LIG_BIR_III_2 221 225 PF00653 0.394
LIG_BIR_III_2 246 250 PF00653 0.414
LIG_BRCT_BRCA1_1 171 175 PF00533 0.373
LIG_BRCT_BRCA1_1 261 265 PF00533 0.352
LIG_BRCT_BRCA1_1 625 629 PF00533 0.638
LIG_CtBP_PxDLS_1 494 498 PF00389 0.262
LIG_FHA_1 119 125 PF00498 0.355
LIG_FHA_1 376 382 PF00498 0.440
LIG_FHA_1 429 435 PF00498 0.579
LIG_FHA_1 487 493 PF00498 0.457
LIG_FHA_1 499 505 PF00498 0.320
LIG_FHA_1 581 587 PF00498 0.611
LIG_FHA_1 64 70 PF00498 0.353
LIG_FHA_1 662 668 PF00498 0.739
LIG_FHA_1 771 777 PF00498 0.753
LIG_FHA_2 193 199 PF00498 0.438
LIG_FHA_2 231 237 PF00498 0.613
LIG_FHA_2 241 247 PF00498 0.447
LIG_FHA_2 541 547 PF00498 0.689
LIG_FHA_2 628 634 PF00498 0.636
LIG_FHA_2 698 704 PF00498 0.674
LIG_Integrin_isoDGR_2 92 94 PF01839 0.491
LIG_LIR_Apic_2 626 631 PF02991 0.669
LIG_LIR_Apic_2 651 656 PF02991 0.540
LIG_LIR_Gen_1 135 141 PF02991 0.399
LIG_LIR_Gen_1 188 197 PF02991 0.443
LIG_LIR_Gen_1 262 271 PF02991 0.325
LIG_LIR_Gen_1 348 357 PF02991 0.359
LIG_LIR_Gen_1 614 623 PF02991 0.559
LIG_LIR_Nem_3 116 122 PF02991 0.449
LIG_LIR_Nem_3 135 140 PF02991 0.487
LIG_LIR_Nem_3 151 157 PF02991 0.521
LIG_LIR_Nem_3 188 192 PF02991 0.454
LIG_LIR_Nem_3 202 208 PF02991 0.375
LIG_LIR_Nem_3 262 268 PF02991 0.320
LIG_LIR_Nem_3 348 353 PF02991 0.438
LIG_LIR_Nem_3 462 467 PF02991 0.376
LIG_LIR_Nem_3 543 547 PF02991 0.752
LIG_LIR_Nem_3 614 618 PF02991 0.526
LIG_LIR_Nem_3 619 625 PF02991 0.494
LIG_LIR_Nem_3 626 632 PF02991 0.500
LIG_LIR_Nem_3 84 90 PF02991 0.338
LIG_LYPXL_yS_3 87 90 PF13949 0.379
LIG_MLH1_MIPbox_1 625 629 PF16413 0.563
LIG_PDZ_Class_3 776 781 PF00595 0.717
LIG_Pex14_1 288 292 PF04695 0.322
LIG_Pex14_2 205 209 PF04695 0.372
LIG_Rb_LxCxE_1 368 385 PF01857 0.374
LIG_RPA_C_Fungi 508 520 PF08784 0.441
LIG_SH2_CRK 137 141 PF00017 0.588
LIG_SH2_CRK 154 158 PF00017 0.686
LIG_SH2_CRK 598 602 PF00017 0.371
LIG_SH2_CRK 622 626 PF00017 0.419
LIG_SH2_NCK_1 137 141 PF00017 0.580
LIG_SH2_NCK_1 670 674 PF00017 0.565
LIG_SH2_SRC 219 222 PF00017 0.529
LIG_SH2_SRC 622 625 PF00017 0.356
LIG_SH2_SRC 654 657 PF00017 0.474
LIG_SH2_STAP1 321 325 PF00017 0.544
LIG_SH2_STAT5 119 122 PF00017 0.497
LIG_SH2_STAT5 219 222 PF00017 0.472
LIG_SH2_STAT5 292 295 PF00017 0.378
LIG_SH2_STAT5 337 340 PF00017 0.540
LIG_SH2_STAT5 350 353 PF00017 0.314
LIG_SH2_STAT5 452 455 PF00017 0.440
LIG_SH2_STAT5 624 627 PF00017 0.372
LIG_SH2_STAT5 628 631 PF00017 0.402
LIG_SH2_STAT5 654 657 PF00017 0.398
LIG_SH2_STAT5 658 661 PF00017 0.447
LIG_SH2_STAT5 670 673 PF00017 0.562
LIG_SH3_3 130 136 PF00018 0.408
LIG_SH3_3 221 227 PF00018 0.564
LIG_SH3_3 34 40 PF00018 0.592
LIG_SH3_3 560 566 PF00018 0.659
LIG_SH3_3 637 643 PF00018 0.685
LIG_SUMO_SIM_anti_2 754 760 PF11976 0.582
LIG_SUMO_SIM_par_1 630 636 PF11976 0.517
LIG_SUMO_SIM_par_1 751 757 PF11976 0.644
LIG_SUMO_SIM_par_1 772 779 PF11976 0.620
LIG_TRAF2_1 679 682 PF00917 0.568
LIG_TYR_ITIM 596 601 PF00017 0.404
MOD_CK1_1 113 119 PF00069 0.619
MOD_CK1_1 127 133 PF00069 0.221
MOD_CK1_1 230 236 PF00069 0.742
MOD_CK1_1 237 243 PF00069 0.757
MOD_CK1_1 553 559 PF00069 0.512
MOD_CK1_1 648 654 PF00069 0.482
MOD_CK1_1 680 686 PF00069 0.619
MOD_CK1_1 693 699 PF00069 0.595
MOD_CK1_1 709 715 PF00069 0.769
MOD_CK1_1 717 723 PF00069 0.794
MOD_CK2_1 192 198 PF00069 0.498
MOD_CK2_1 212 218 PF00069 0.522
MOD_CK2_1 401 407 PF00069 0.536
MOD_CK2_1 676 682 PF00069 0.668
MOD_CK2_1 697 703 PF00069 0.626
MOD_GlcNHglycan 150 153 PF01048 0.651
MOD_GlcNHglycan 229 232 PF01048 0.719
MOD_GlcNHglycan 243 246 PF01048 0.726
MOD_GlcNHglycan 25 28 PF01048 0.647
MOD_GlcNHglycan 417 420 PF01048 0.599
MOD_GlcNHglycan 515 518 PF01048 0.544
MOD_GlcNHglycan 552 555 PF01048 0.629
MOD_GlcNHglycan 625 628 PF01048 0.497
MOD_GlcNHglycan 681 685 PF01048 0.798
MOD_GlcNHglycan 83 86 PF01048 0.507
MOD_GlcNHglycan 95 98 PF01048 0.441
MOD_GSK3_1 100 107 PF00069 0.393
MOD_GSK3_1 123 130 PF00069 0.399
MOD_GSK3_1 223 230 PF00069 0.649
MOD_GSK3_1 237 244 PF00069 0.762
MOD_GSK3_1 368 375 PF00069 0.475
MOD_GSK3_1 415 422 PF00069 0.691
MOD_GSK3_1 428 435 PF00069 0.787
MOD_GSK3_1 437 444 PF00069 0.758
MOD_GSK3_1 451 458 PF00069 0.520
MOD_GSK3_1 477 484 PF00069 0.494
MOD_GSK3_1 549 556 PF00069 0.638
MOD_GSK3_1 623 630 PF00069 0.584
MOD_GSK3_1 639 646 PF00069 0.538
MOD_GSK3_1 676 683 PF00069 0.737
MOD_GSK3_1 693 700 PF00069 0.529
MOD_GSK3_1 705 712 PF00069 0.701
MOD_GSK3_1 714 721 PF00069 0.770
MOD_GSK3_1 77 84 PF00069 0.575
MOD_LATS_1 538 544 PF00433 0.583
MOD_N-GLC_1 363 368 PF02516 0.442
MOD_N-GLC_1 81 86 PF02516 0.496
MOD_NEK2_1 1 6 PF00069 0.676
MOD_NEK2_1 118 123 PF00069 0.448
MOD_NEK2_1 42 47 PF00069 0.532
MOD_NEK2_1 481 486 PF00069 0.515
MOD_NEK2_1 507 512 PF00069 0.368
MOD_NEK2_1 555 560 PF00069 0.672
MOD_NEK2_1 63 68 PF00069 0.459
MOD_NEK2_1 690 695 PF00069 0.698
MOD_NEK2_1 83 88 PF00069 0.258
MOD_NEK2_2 382 387 PF00069 0.461
MOD_NEK2_2 498 503 PF00069 0.394
MOD_OFUCOSY 123 128 PF10250 0.465
MOD_OFUCOSY 163 170 PF10250 0.577
MOD_PIKK_1 337 343 PF00454 0.480
MOD_PIKK_1 455 461 PF00454 0.495
MOD_PIKK_1 54 60 PF00454 0.497
MOD_PIKK_1 555 561 PF00454 0.689
MOD_PIKK_1 616 622 PF00454 0.455
MOD_PIKK_1 74 80 PF00454 0.270
MOD_PK_1 235 241 PF00069 0.528
MOD_PKA_1 513 519 PF00069 0.574
MOD_PKA_1 676 682 PF00069 0.771
MOD_PKA_2 100 106 PF00069 0.388
MOD_PKA_2 192 198 PF00069 0.566
MOD_PKA_2 459 465 PF00069 0.365
MOD_PKA_2 513 519 PF00069 0.522
MOD_PKA_2 676 682 PF00069 0.748
MOD_PKA_2 693 699 PF00069 0.648
MOD_PKA_2 709 715 PF00069 0.625
MOD_PKA_2 93 99 PF00069 0.378
MOD_PKB_1 675 683 PF00069 0.533
MOD_Plk_1 143 149 PF00069 0.660
MOD_Plk_1 235 241 PF00069 0.775
MOD_Plk_1 363 369 PF00069 0.446
MOD_Plk_1 42 48 PF00069 0.661
MOD_Plk_1 569 575 PF00069 0.557
MOD_Plk_2-3 697 703 PF00069 0.744
MOD_Plk_4 104 110 PF00069 0.488
MOD_Plk_4 368 374 PF00069 0.581
MOD_Plk_4 382 388 PF00069 0.412
MOD_Plk_4 459 465 PF00069 0.380
MOD_Plk_4 63 69 PF00069 0.526
MOD_Plk_4 648 654 PF00069 0.538
MOD_Plk_4 754 760 PF00069 0.750
MOD_ProDKin_1 223 229 PF00069 0.604
MOD_ProDKin_1 375 381 PF00069 0.557
MOD_ProDKin_1 419 425 PF00069 0.759
MOD_ProDKin_1 432 438 PF00069 0.719
MOD_ProDKin_1 559 565 PF00069 0.685
MOD_ProDKin_1 627 633 PF00069 0.535
MOD_ProDKin_1 639 645 PF00069 0.707
MOD_SUMO_for_1 605 608 PF00179 0.521
MOD_SUMO_rev_2 592 597 PF00179 0.478
MOD_SUMO_rev_2 599 607 PF00179 0.453
TRG_ENDOCYTIC_2 119 122 PF00928 0.396
TRG_ENDOCYTIC_2 137 140 PF00928 0.357
TRG_ENDOCYTIC_2 154 157 PF00928 0.692
TRG_ENDOCYTIC_2 292 295 PF00928 0.395
TRG_ENDOCYTIC_2 350 353 PF00928 0.467
TRG_ENDOCYTIC_2 464 467 PF00928 0.460
TRG_ENDOCYTIC_2 598 601 PF00928 0.376
TRG_ENDOCYTIC_2 615 618 PF00928 0.353
TRG_ENDOCYTIC_2 622 625 PF00928 0.353
TRG_ENDOCYTIC_2 87 90 PF00928 0.396
TRG_ER_diArg_1 260 263 PF00400 0.327
TRG_ER_diArg_1 357 360 PF00400 0.501
TRG_ER_diArg_1 513 515 PF00400 0.473
TRG_ER_diArg_1 519 521 PF00400 0.503
TRG_ER_diArg_1 573 575 PF00400 0.485
TRG_ER_diArg_1 675 678 PF00400 0.755
TRG_Pf-PMV_PEXEL_1 519 523 PF00026 0.498
TRG_Pf-PMV_PEXEL_1 527 532 PF00026 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3V6 Leptomonas seymouri 55% 91%
A0A0S4IQF5 Bodo saltans 29% 100%
A0A1X0P352 Trypanosomatidae 31% 100%
A0A3Q8IJJ7 Leishmania donovani 99% 100%
A0A3R7NPX7 Trypanosoma rangeli 32% 100%
A4HIH5 Leishmania braziliensis 78% 100%
C9ZR41 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9B117 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
Q4Q749 Leishmania major 93% 99%
V5BC99 Trypanosoma cruzi 30% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS