Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5R6_LEIIN

TriTrypDb:

LINF_300029200

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5R6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.525
CLV_NRD_NRD_1	22	24	PF00675	0.425
CLV_NRD_NRD_1	296	298	PF00675	0.634
CLV_NRD_NRD_1	85	87	PF00675	0.523
CLV_PCSK_FUR_1	20	24	PF00082	0.522
CLV_PCSK_KEX2_1	124	126	PF00082	0.533
CLV_PCSK_KEX2_1	22	24	PF00082	0.463
CLV_PCSK_KEX2_1	231	233	PF00082	0.502
CLV_PCSK_KEX2_1	296	298	PF00082	0.634
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.481
CLV_PCSK_SKI1_1	22	26	PF00082	0.470
CLV_PCSK_SKI1_1	35	39	PF00082	0.379
DEG_SPOP_SBC_1	131	135	PF00917	0.510
DOC_PP1_RVXF_1	108	114	PF00149	0.386
DOC_PP1_RVXF_1	33	39	PF00149	0.409
DOC_USP7_MATH_1	131	135	PF00917	0.467
DOC_USP7_MATH_1	200	204	PF00917	0.688
DOC_USP7_MATH_1	3	7	PF00917	0.617
LIG_14-3-3_CanoR_1	124	128	PF00244	0.603
LIG_14-3-3_CanoR_1	178	185	PF00244	0.636
LIG_14-3-3_CanoR_1	199	205	PF00244	0.547
LIG_14-3-3_CanoR_1	22	28	PF00244	0.478
LIG_14-3-3_CanoR_1	84	94	PF00244	0.429
LIG_14-3-3_CterR_2	296	300	PF00244	0.464
LIG_Actin_WH2_2	72	88	PF00022	0.518
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_FHA_1	245	251	PF00498	0.402
LIG_FHA_1	281	287	PF00498	0.443
LIG_FHA_1	80	86	PF00498	0.534
LIG_FHA_1	94	100	PF00498	0.443
LIG_FHA_2	153	159	PF00498	0.462
LIG_FHA_2	214	220	PF00498	0.693
LIG_FHA_2	37	43	PF00498	0.434
LIG_FHA_2	86	92	PF00498	0.514
LIG_NRBOX	264	270	PF00104	0.511
LIG_SH2_NCK_1	235	239	PF00017	0.435
LIG_SUMO_SIM_anti_2	143	153	PF11976	0.403
LIG_SUMO_SIM_anti_2	247	252	PF11976	0.397
LIG_SUMO_SIM_anti_2	5	13	PF11976	0.558
LIG_SUMO_SIM_anti_2	62	68	PF11976	0.463
LIG_TRAF2_1	126	129	PF00917	0.605
LIG_TRAF2_1	225	228	PF00917	0.568
LIG_TRAF2_1	275	278	PF00917	0.417
LIG_UBA3_1	146	154	PF00899	0.512
MOD_CK1_1	207	213	PF00069	0.655
MOD_CK2_1	123	129	PF00069	0.576
MOD_CK2_1	152	158	PF00069	0.454
MOD_CK2_1	25	31	PF00069	0.531
MOD_CK2_1	272	278	PF00069	0.481
MOD_CK2_1	36	42	PF00069	0.468
MOD_CK2_1	85	91	PF00069	0.435
MOD_GlcNHglycan	1	4	PF01048	0.567
MOD_GlcNHglycan	194	197	PF01048	0.665
MOD_GlcNHglycan	206	209	PF01048	0.637
MOD_GlcNHglycan	213	216	PF01048	0.648
MOD_GlcNHglycan	219	224	PF01048	0.523
MOD_GlcNHglycan	5	9	PF01048	0.481
MOD_GSK3_1	119	126	PF00069	0.547
MOD_GSK3_1	200	207	PF00069	0.545
MOD_GSK3_1	268	275	PF00069	0.525
MOD_NEK2_1	161	166	PF00069	0.513
MOD_NEK2_1	204	209	PF00069	0.545
MOD_NEK2_1	25	30	PF00069	0.467
MOD_NEK2_1	268	273	PF00069	0.415
MOD_NEK2_1	85	90	PF00069	0.580
MOD_NEK2_2	200	205	PF00069	0.481
MOD_PIKK_1	25	31	PF00454	0.466
MOD_PIKK_1	85	91	PF00454	0.517
MOD_PKA_2	123	129	PF00069	0.562
MOD_PKA_2	177	183	PF00069	0.623
MOD_PKA_2	85	91	PF00069	0.425
MOD_Plk_1	152	158	PF00069	0.585
MOD_Plk_1	4	10	PF00069	0.457
MOD_SUMO_for_1	150	153	PF00179	0.528
MOD_SUMO_rev_2	227	233	PF00179	0.487
MOD_SUMO_rev_2	28	37	PF00179	0.547
TRG_DiLeu_BaEn_1	145	150	PF01217	0.505
TRG_DiLeu_BaEn_1	264	269	PF01217	0.479
TRG_DiLeu_BaEn_1	42	47	PF01217	0.553
TRG_ER_diArg_1	123	125	PF00400	0.529
TRG_ER_diArg_1	20	23	PF00400	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE9	Leptomonas seymouri	46%	96%
A0A1X0P1M8	Trypanosomatidae	28%	100%
A0A3S7X3N1	Leishmania donovani	100%	100%
A0A422NW57	Trypanosoma rangeli	30%	100%
A4HIG9	Leishmania braziliensis	78%	100%
C9ZR34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B111	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q755	Leishmania major	92%	100%
V5BGW1	Trypanosoma cruzi	32%	100%