Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5R1_LEIIN

TriTrypDb:

LINF_300028700

Length:

349

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5R1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.513
CLV_NRD_NRD_1	255	257	PF00675	0.563
CLV_PCSK_SKI1_1	109	113	PF00082	0.459
CLV_PCSK_SKI1_1	132	136	PF00082	0.420
CLV_PCSK_SKI1_1	215	219	PF00082	0.448
CLV_PCSK_SKI1_1	297	301	PF00082	0.504
DEG_SPOP_SBC_1	35	39	PF00917	0.568
DOC_MAPK_gen_1	107	116	PF00069	0.493
DOC_MAPK_gen_1	297	307	PF00069	0.398
DOC_PP1_RVXF_1	107	114	PF00149	0.441
DOC_PP1_RVXF_1	130	137	PF00149	0.413
DOC_USP7_MATH_1	188	192	PF00917	0.417
DOC_USP7_MATH_1	86	90	PF00917	0.558
DOC_USP7_UBL2_3	297	301	PF12436	0.418
DOC_WW_Pin1_4	27	32	PF00397	0.470
DOC_WW_Pin1_4	65	70	PF00397	0.503
LIG_14-3-3_CanoR_1	107	112	PF00244	0.473
LIG_14-3-3_CanoR_1	115	120	PF00244	0.358
LIG_14-3-3_CanoR_1	132	137	PF00244	0.412
LIG_14-3-3_CanoR_1	163	171	PF00244	0.476
LIG_14-3-3_CanoR_1	20	28	PF00244	0.557
LIG_14-3-3_CanoR_1	249	253	PF00244	0.567
LIG_APCC_ABBA_1	59	64	PF00400	0.446
LIG_BRCT_BRCA1_1	109	113	PF00533	0.527
LIG_deltaCOP1_diTrp_1	296	304	PF00928	0.508
LIG_FHA_1	170	176	PF00498	0.409
LIG_FHA_1	35	41	PF00498	0.670
LIG_FHA_1	54	60	PF00498	0.320
LIG_FHA_2	164	170	PF00498	0.410
LIG_FHA_2	200	206	PF00498	0.457
LIG_LIR_Gen_1	102	113	PF02991	0.464
LIG_LIR_Gen_1	118	125	PF02991	0.414
LIG_LIR_Gen_1	227	235	PF02991	0.445
LIG_LIR_Gen_1	303	312	PF02991	0.503
LIG_LIR_Nem_3	102	108	PF02991	0.433
LIG_LIR_Nem_3	110	116	PF02991	0.435
LIG_LIR_Nem_3	118	122	PF02991	0.394
LIG_LIR_Nem_3	227	233	PF02991	0.457
LIG_LIR_Nem_3	303	307	PF02991	0.379
LIG_MLH1_MIPbox_1	109	113	PF16413	0.527
LIG_NRBOX	202	208	PF00104	0.398
LIG_REV1ctd_RIR_1	110	119	PF16727	0.493
LIG_SH2_STAP1	337	341	PF00017	0.532
LIG_SH2_STAT5	174	177	PF00017	0.392
LIG_SH2_STAT5	337	340	PF00017	0.475
LIG_SH2_STAT5	62	65	PF00017	0.434
LIG_SH2_STAT5	74	77	PF00017	0.433
LIG_SH3_3	131	137	PF00018	0.426
LIG_SH3_3	28	34	PF00018	0.524
LIG_SH3_3	48	54	PF00018	0.291
LIG_TRAF2_1	166	169	PF00917	0.477
LIG_TRAF2_2	137	142	PF00917	0.497
LIG_WRC_WIRS_1	116	121	PF05994	0.454
MOD_CDC14_SPxK_1	30	33	PF00782	0.530
MOD_CDK_SPxK_1	27	33	PF00069	0.511
MOD_CK1_1	89	95	PF00069	0.497
MOD_CK2_1	163	169	PF00069	0.483
MOD_CK2_1	199	205	PF00069	0.457
MOD_CK2_1	49	55	PF00069	0.453
MOD_GlcNHglycan	190	193	PF01048	0.465
MOD_GlcNHglycan	291	296	PF01048	0.560
MOD_GSK3_1	244	251	PF00069	0.519
MOD_GSK3_1	328	335	PF00069	0.619
MOD_GSK3_1	36	43	PF00069	0.465
MOD_GSK3_1	49	56	PF00069	0.528
MOD_N-GLC_1	126	131	PF02516	0.465
MOD_NEK2_1	198	203	PF00069	0.382
MOD_NEK2_1	319	324	PF00069	0.540
MOD_NEK2_1	40	45	PF00069	0.428
MOD_NEK2_2	5	10	PF00069	0.393
MOD_NEK2_2	62	67	PF00069	0.422
MOD_PK_1	107	113	PF00069	0.469
MOD_PKA_2	248	254	PF00069	0.476
MOD_PKA_2	89	95	PF00069	0.475
MOD_Plk_1	126	132	PF00069	0.461
MOD_Plk_1	244	250	PF00069	0.511
MOD_Plk_1	35	41	PF00069	0.550
MOD_Plk_2-3	199	205	PF00069	0.457
MOD_Plk_4	107	113	PF00069	0.571
MOD_Plk_4	36	42	PF00069	0.657
MOD_Plk_4	5	11	PF00069	0.420
MOD_ProDKin_1	27	33	PF00069	0.471
MOD_ProDKin_1	65	71	PF00069	0.498
MOD_SUMO_for_1	217	220	PF00179	0.461
MOD_SUMO_rev_2	13	17	PF00179	0.478
MOD_SUMO_rev_2	259	265	PF00179	0.475
MOD_SUMO_rev_2	267	275	PF00179	0.592
TRG_DiLeu_BaEn_1	36	41	PF01217	0.501
TRG_ER_diArg_1	114	117	PF00400	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P9	Leptomonas seymouri	51%	100%
A0A3Q8II20	Leishmania donovani	100%	100%
A4HIG5	Leishmania braziliensis	68%	100%
E9B106	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q760	Leishmania major	89%	97%