SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5Q9_LEIIN

TriTrypDb:

LINF_300028500

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5Q9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.474
CLV_NRD_NRD_1	175	177	PF00675	0.462
CLV_NRD_NRD_1	237	239	PF00675	0.360
CLV_NRD_NRD_1	240	242	PF00675	0.367
CLV_NRD_NRD_1	36	38	PF00675	0.635
CLV_NRD_NRD_1	372	374	PF00675	0.530
CLV_NRD_NRD_1	392	394	PF00675	0.502
CLV_NRD_NRD_1	455	457	PF00675	0.540
CLV_NRD_NRD_1	67	69	PF00675	0.470
CLV_PCSK_FUR_1	117	121	PF00082	0.503
CLV_PCSK_FUR_1	238	242	PF00082	0.499
CLV_PCSK_KEX2_1	117	119	PF00082	0.399
CLV_PCSK_KEX2_1	175	177	PF00082	0.462
CLV_PCSK_KEX2_1	237	239	PF00082	0.360
CLV_PCSK_KEX2_1	240	242	PF00082	0.367
CLV_PCSK_KEX2_1	250	252	PF00082	0.368
CLV_PCSK_KEX2_1	35	37	PF00082	0.588
CLV_PCSK_KEX2_1	372	374	PF00082	0.504
CLV_PCSK_KEX2_1	391	393	PF00082	0.354
CLV_PCSK_KEX2_1	67	69	PF00082	0.486
CLV_PCSK_KEX2_1	84	86	PF00082	0.459
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.368
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.570
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.270
CLV_PCSK_PC7_1	31	37	PF00082	0.506
CLV_PCSK_SKI1_1	119	123	PF00082	0.428
CLV_PCSK_SKI1_1	164	168	PF00082	0.334
CLV_PCSK_SKI1_1	250	254	PF00082	0.337
CLV_PCSK_SKI1_1	271	275	PF00082	0.393
CLV_PCSK_SKI1_1	31	35	PF00082	0.441
CLV_PCSK_SKI1_1	373	377	PF00082	0.515
CLV_PCSK_SKI1_1	400	404	PF00082	0.518
CLV_Separin_Metazoa	338	342	PF03568	0.391
DEG_SCF_FBW7_1	196	202	PF00400	0.538
DEG_SPOP_SBC_1	450	454	PF00917	0.486
DOC_CKS1_1	165	170	PF01111	0.333
DOC_CKS1_1	183	188	PF01111	0.349
DOC_CKS1_1	196	201	PF01111	0.421
DOC_CYCLIN_yClb5_NLxxxL_5	37	45	PF00134	0.446
DOC_MAPK_gen_1	175	183	PF00069	0.555
DOC_MAPK_gen_1	248	255	PF00069	0.393
DOC_MAPK_gen_1	35	43	PF00069	0.524
DOC_MAPK_MEF2A_6	164	172	PF00069	0.447
DOC_MAPK_MEF2A_6	36	45	PF00069	0.454
DOC_MAPK_MEF2A_6	405	412	PF00069	0.372
DOC_MAPK_NFAT4_5	405	413	PF00069	0.374
DOC_MAPK_RevD_3	21	36	PF00069	0.541
DOC_PP1_RVXF_1	407	413	PF00149	0.427
DOC_PP4_FxxP_1	448	451	PF00568	0.579
DOC_PP4_FxxP_1	78	81	PF00568	0.325
DOC_USP7_MATH_1	192	196	PF00917	0.406
DOC_USP7_MATH_1	451	455	PF00917	0.535
DOC_WW_Pin1_4	164	169	PF00397	0.333
DOC_WW_Pin1_4	182	187	PF00397	0.347
DOC_WW_Pin1_4	195	200	PF00397	0.413
LIG_14-3-3_CanoR_1	222	232	PF00244	0.427
LIG_14-3-3_CanoR_1	414	419	PF00244	0.486
LIG_14-3-3_CanoR_1	449	458	PF00244	0.602
LIG_Actin_WH2_2	69	86	PF00022	0.277
LIG_AP2alpha_1	144	148	PF02296	0.422
LIG_APCC_ABBA_1	145	150	PF00400	0.436
LIG_BRCT_BRCA1_1	102	106	PF00533	0.352
LIG_BRCT_BRCA1_1	148	152	PF00533	0.316
LIG_BRCT_BRCA1_1	429	433	PF00533	0.351
LIG_BRCT_BRCA1_1	49	53	PF00533	0.430
LIG_FHA_1	127	133	PF00498	0.362
LIG_FHA_1	165	171	PF00498	0.399
LIG_FHA_1	183	189	PF00498	0.363
LIG_FHA_1	196	202	PF00498	0.572
LIG_FHA_1	224	230	PF00498	0.436
LIG_FHA_1	351	357	PF00498	0.532
LIG_FHA_1	90	96	PF00498	0.568
LIG_FHA_2	185	191	PF00498	0.481
LIG_FHA_2	252	258	PF00498	0.399
LIG_FHA_2	279	285	PF00498	0.356
LIG_GBD_Chelix_1	395	403	PF00786	0.417
LIG_KLC1_Yacidic_2	319	324	PF13176	0.330
LIG_LIR_Apic_2	213	219	PF02991	0.516
LIG_LIR_Apic_2	445	451	PF02991	0.560
LIG_LIR_Gen_1	142	152	PF02991	0.302
LIG_LIR_Gen_1	333	344	PF02991	0.428
LIG_LIR_Gen_1	430	439	PF02991	0.344
LIG_LIR_Nem_3	127	133	PF02991	0.354
LIG_LIR_Nem_3	142	147	PF02991	0.268
LIG_LIR_Nem_3	149	155	PF02991	0.308
LIG_LIR_Nem_3	333	339	PF02991	0.438
LIG_LIR_Nem_3	430	436	PF02991	0.345
LIG_Pex14_2	144	148	PF04695	0.422
LIG_Pex14_2	412	416	PF04695	0.484
LIG_REV1ctd_RIR_1	104	114	PF16727	0.328
LIG_SH2_CRK	130	134	PF00017	0.324
LIG_SH2_SRC	136	139	PF00017	0.408
LIG_SH2_SRC	207	210	PF00017	0.449
LIG_SH2_SRC	79	82	PF00017	0.453
LIG_SH2_STAP1	136	140	PF00017	0.397
LIG_SH2_STAT5	207	210	PF00017	0.396
LIG_SH2_STAT5	322	325	PF00017	0.364
LIG_SH2_STAT5	437	440	PF00017	0.479
LIG_SH3_3	2	8	PF00018	0.454
LIG_SH3_3	420	426	PF00018	0.386
LIG_SUMO_SIM_par_1	251	257	PF11976	0.403
LIG_TRAF2_1	358	361	PF00917	0.449
MOD_CK1_1	139	145	PF00069	0.450
MOD_CK1_1	195	201	PF00069	0.569
MOD_CK2_1	278	284	PF00069	0.459
MOD_Cter_Amidation	248	251	PF01082	0.426
MOD_GlcNHglycan	257	261	PF01048	0.361
MOD_GlcNHglycan	294	297	PF01048	0.505
MOD_GlcNHglycan	429	432	PF01048	0.438
MOD_GSK3_1	122	129	PF00069	0.528
MOD_GSK3_1	184	191	PF00069	0.438
MOD_GSK3_1	195	202	PF00069	0.440
MOD_GSK3_1	294	301	PF00069	0.358
MOD_GSK3_1	425	432	PF00069	0.458
MOD_GSK3_1	457	464	PF00069	0.551
MOD_LATS_1	326	332	PF00433	0.405
MOD_LATS_1	455	461	PF00433	0.511
MOD_N-GLC_1	292	297	PF02516	0.397
MOD_NEK2_1	188	193	PF00069	0.410
MOD_NEK2_1	329	334	PF00069	0.502
MOD_NEK2_1	339	344	PF00069	0.405
MOD_NEK2_1	89	94	PF00069	0.461
MOD_NEK2_1	9	14	PF00069	0.414
MOD_PIKK_1	122	128	PF00454	0.544
MOD_PIKK_1	25	31	PF00454	0.570
MOD_PIKK_1	431	437	PF00454	0.334
MOD_PK_1	414	420	PF00069	0.479
MOD_PKA_2	192	198	PF00069	0.517
MOD_PKA_2	236	242	PF00069	0.420
MOD_Plk_1	278	284	PF00069	0.426
MOD_Plk_1	69	75	PF00069	0.430
MOD_Plk_2-3	184	190	PF00069	0.489
MOD_Plk_2-3	279	285	PF00069	0.452
MOD_Plk_4	139	145	PF00069	0.337
MOD_Plk_4	192	198	PF00069	0.398
MOD_Plk_4	251	257	PF00069	0.442
MOD_Plk_4	271	277	PF00069	0.340
MOD_Plk_4	294	300	PF00069	0.409
MOD_Plk_4	350	356	PF00069	0.353
MOD_Plk_4	69	75	PF00069	0.466
MOD_ProDKin_1	164	170	PF00069	0.334
MOD_ProDKin_1	182	188	PF00069	0.348
MOD_ProDKin_1	195	201	PF00069	0.416
MOD_SUMO_rev_2	380	384	PF00179	0.479
TRG_DiLeu_BaEn_1	227	232	PF01217	0.424
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.382
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.530
TRG_ENDOCYTIC_2	130	133	PF00928	0.332
TRG_ER_diArg_1	117	120	PF00400	0.440
TRG_ER_diArg_1	237	240	PF00400	0.354
TRG_ER_diArg_1	312	315	PF00400	0.500
TRG_ER_diArg_1	35	37	PF00400	0.529
TRG_ER_diArg_1	371	373	PF00400	0.537
TRG_ER_diArg_1	392	394	PF00400	0.486
TRG_ER_diArg_1	66	68	PF00400	0.501
TRG_NLS_Bipartite_1	373	395	PF00514	0.433
TRG_NLS_MonoExtC_3	455	461	PF00514	0.511
TRG_NLS_MonoExtN_4	389	395	PF00514	0.417
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P922	Leptomonas seymouri	72%	100%
A0A1X0P2C1	Trypanosomatidae	48%	100%
A0A3S7X3J4	Leishmania donovani	100%	100%
A0A422NW63	Trypanosoma rangeli	48%	100%
A4HIG3	Leishmania braziliensis	87%	100%
C9ZR28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B104	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q762	Leishmania major	94%	100%
V5BGV8	Trypanosoma cruzi	45%	100%